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<!-- DFS ActiveDisclosure(SM) XBRL Linkbase Document - http://www.dfsco.com/financial-services/ -->
<!-- Creation Date      : 2017-02-22T17:40:36.0625186+00:00 -->
<!-- Version            : 2.4.1.13 -->
<!-- Package ID         : FA46D0DAEC9290CAFAE577189FC77386-0000036270-001611 -->
<!-- Copyright (c) 2017 Donnelley Financial, LLC. All Rights Reserved. -->
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    <label xml:lang="en-US" xlink:label="mtb_InvestmentSecuritiesFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Total fair value of investments in debt and equity securities.</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_OtherComprehensiveIncomeLossReclassificationAdjustmentForRealizedGainsLossesIncludedInNetIncomeBeforeTax" xlink:type="locator" xlink:label="mtb_OtherComprehensiveIncomeLossReclassificationAdjustmentForRealizedGainsLossesIncludedInNetIncomeBeforeTax" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnHeldToMaturitySecuritiesArisingDuringPeriodTax" xlink:type="locator" xlink:label="mtb_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnHeldToMaturitySecuritiesArisingDuringPeriodTax" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_OtherComprehensiveIncomeLossReclassificationAdjustmentForRealizedGainsLossesIncludedInNetIncomeTax" xlink:type="locator" xlink:label="mtb_OtherComprehensiveIncomeLossReclassificationAdjustmentForRealizedGainsLossesIncludedInNetIncomeTax" />
    <label xml:lang="en-US" xlink:label="mtb_OtherComprehensiveIncomeLossReclassificationAdjustmentForRealizedGainsLossesIncludedInNetIncomeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other Comprehensive Income Loss Reclassification Adjustment For Realized Gains Losses Included In Net Income Tax</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_OtherComprehensiveIncomeAmortizationOfDefinedBenefitPlanActuarialLossRecognizedInNetPeriodicBenefitCostTaxEffect" xlink:type="locator" xlink:label="mtb_OtherComprehensiveIncomeAmortizationOfDefinedBenefitPlanActuarialLossRecognizedInNetPeriodicBenefitCostTaxEffect" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_OtherComprehensiveIncomeLossReclassificationTax" xlink:type="locator" xlink:label="mtb_OtherComprehensiveIncomeLossReclassificationTax" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnHeldToMaturitySecuritiesArisingDuringPeriodNetOfTax" xlink:type="locator" xlink:label="mtb_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnHeldToMaturitySecuritiesArisingDuringPeriodNetOfTax" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_OtherComprehensiveIncomeLossReclassificationAdjustmentForRealizedGainsLossesIncludedInNetIncomeNetOfTax" xlink:type="locator" xlink:label="mtb_OtherComprehensiveIncomeLossReclassificationAdjustmentForRealizedGainsLossesIncludedInNetIncomeNetOfTax" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_OtherComprehensiveIncomeAmortizationOfDefinedBenefitPlanActuarialLossRecognizedInNetPeriodicBenefitCostNetOfTax" xlink:type="locator" xlink:label="mtb_OtherComprehensiveIncomeAmortizationOfDefinedBenefitPlanActuarialLossRecognizedInNetPeriodicBenefitCostNetOfTax" />
    <label xml:lang="en-US" xlink:label="mtb_OtherComprehensiveIncomeAmortizationOfDefinedBenefitPlanActuarialLossRecognizedInNetPeriodicBenefitCostNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other Comprehensive Income Amortization Of Defined Benefit Plan Actuarial Loss Recognized In Net Periodic Benefit Cost Net Of Tax</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_LoansAndLeasesReceivableConsumerInstallmentRevolvingAndHomeEquity" xlink:type="locator" xlink:label="mtb_LoansAndLeasesReceivableConsumerInstallmentRevolvingAndHomeEquity" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_NonInterestExpenseExcludingAmortizationAndDepreciation" xlink:type="locator" xlink:label="mtb_NonInterestExpenseExcludingAmortizationAndDepreciation" />
    <label xml:lang="en-US" xlink:label="mtb_NonInterestExpenseExcludingAmortizationAndDepreciation_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Non interest expense excluding amortization and depreciation.</label>
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    <label xml:lang="en-US" xlink:label="mtb_NoninterestIncomeExpense_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount of noninterest income net of other-than-temporary impairment of marketable securities.</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_DueFromSubsidiaries" xlink:type="locator" xlink:label="mtb_DueFromSubsidiaries" />
    <label xml:lang="en-US" xlink:label="mtb_DueFromSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Total amount of receivables due from an entity that is affiliated with the reporting entity by means of direct or indirect ownership.</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_InvestmentsInConsolidatedBankingSubsidiaries" xlink:type="locator" xlink:label="mtb_InvestmentsInConsolidatedBankingSubsidiaries" />
    <label xml:lang="en-US" xlink:label="mtb_InvestmentsInConsolidatedBankingSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Investments in banks and bank holding companies that are consolidated in the financial statements.</label>
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    <label xml:lang="en-US" xlink:label="mtb_NetChangeInAccruedInterestReceivablePayable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Net change in accrued interest receivable, payable.</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_IncreaseDecreaseInAccruedIncomeAndExpenses" xlink:type="locator" xlink:label="mtb_IncreaseDecreaseInAccruedIncomeAndExpenses" />
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    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_IncreaseDecreaseInAccruedIncomeAndExpenses" xlink:to="mtb_IncreaseDecreaseInAccruedIncomeAndExpenses_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_NetIncreaseDecreaseInLoanServicingAdvances" xlink:type="locator" xlink:label="mtb_NetIncreaseDecreaseInLoanServicingAdvances" />
    <label xml:lang="en-US" xlink:label="mtb_NetIncreaseDecreaseInLoanServicingAdvances_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The net cash outflow or inflow for the increase (decrease) of loan servicing advances.</label>
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    <label xml:lang="en-US" xlink:label="mtb_DocumentAndEntityInformationAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Document and entity information.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DocumentAndEntityInformationAbstract" xlink:to="mtb_DocumentAndEntityInformationAbstract_lbl" />
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    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentType" xlink:type="locator" xlink:label="dei_DocumentType" />
    <label xml:lang="en-US" xlink:label="dei_DocumentType_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Document Type</label>
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    <label xml:lang="en-US" xlink:label="dei_DocumentType_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Document Type</label>
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_AmendmentFlag" xlink:type="locator" xlink:label="dei_AmendmentFlag" />
    <label xml:lang="en-US" xlink:label="dei_AmendmentFlag_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amendment Flag</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_AmendmentFlag" xlink:to="dei_AmendmentFlag_lbl" />
    <label xml:lang="en-US" xlink:label="dei_AmendmentFlag_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Amendment Flag</label>
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentPeriodEndDate" xlink:type="locator" xlink:label="dei_DocumentPeriodEndDate" />
    <label xml:lang="en-US" xlink:label="dei_DocumentPeriodEndDate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Period End Date</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_DocumentPeriodEndDate" xlink:to="dei_DocumentPeriodEndDate_lbl" />
    <label xml:lang="en-US" xlink:label="dei_DocumentPeriodEndDate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Document Period End Date</label>
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentFiscalYearFocus" xlink:type="locator" xlink:label="dei_DocumentFiscalYearFocus" />
    <label xml:lang="en-US" xlink:label="dei_DocumentFiscalYearFocus_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Fiscal Year Focus</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_DocumentFiscalYearFocus" xlink:to="dei_DocumentFiscalYearFocus_lbl" />
    <label xml:lang="en-US" xlink:label="dei_DocumentFiscalYearFocus_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Document Fiscal Year Focus</label>
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentFiscalPeriodFocus" xlink:type="locator" xlink:label="dei_DocumentFiscalPeriodFocus" />
    <label xml:lang="en-US" xlink:label="dei_DocumentFiscalPeriodFocus_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Fiscal Period Focus</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_DocumentFiscalPeriodFocus" xlink:to="dei_DocumentFiscalPeriodFocus_lbl" />
    <label xml:lang="en-US" xlink:label="dei_DocumentFiscalPeriodFocus_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Document Fiscal Period Focus</label>
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_TradingSymbol" xlink:type="locator" xlink:label="dei_TradingSymbol" />
    <label xml:lang="en-US" xlink:label="dei_TradingSymbol_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Trading Symbol</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_TradingSymbol" xlink:to="dei_TradingSymbol_lbl" />
    <label xml:lang="en-US" xlink:label="dei_TradingSymbol_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Trading Symbol</label>
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityRegistrantName" xlink:type="locator" xlink:label="dei_EntityRegistrantName" />
    <label xml:lang="en-US" xlink:label="dei_EntityRegistrantName_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Registrant Name</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityRegistrantName" xlink:to="dei_EntityRegistrantName_lbl" />
    <label xml:lang="en-US" xlink:label="dei_EntityRegistrantName_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Registrant Name</label>
    <label xml:lang="en-US" xlink:label="dei_EntityCentralIndexKey_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Central Index Key</label>
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_CurrentFiscalYearEndDate" xlink:type="locator" xlink:label="dei_CurrentFiscalYearEndDate" />
    <label xml:lang="en-US" xlink:label="dei_CurrentFiscalYearEndDate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current Fiscal Year End Date</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_CurrentFiscalYearEndDate" xlink:to="dei_CurrentFiscalYearEndDate_lbl" />
    <label xml:lang="en-US" xlink:label="dei_CurrentFiscalYearEndDate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Current Fiscal Year End Date</label>
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityWellKnownSeasonedIssuer" xlink:type="locator" xlink:label="dei_EntityWellKnownSeasonedIssuer" />
    <label xml:lang="en-US" xlink:label="dei_EntityWellKnownSeasonedIssuer_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Well-known Seasoned Issuer</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityWellKnownSeasonedIssuer" xlink:to="dei_EntityWellKnownSeasonedIssuer_lbl" />
    <label xml:lang="en-US" xlink:label="dei_EntityWellKnownSeasonedIssuer_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Well Known Seasoned Issuer</label>
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCurrentReportingStatus" xlink:type="locator" xlink:label="dei_EntityCurrentReportingStatus" />
    <label xml:lang="en-US" xlink:label="dei_EntityCurrentReportingStatus_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Current Reporting Status</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityCurrentReportingStatus" xlink:to="dei_EntityCurrentReportingStatus_lbl" />
    <label xml:lang="en-US" xlink:label="dei_EntityCurrentReportingStatus_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Current Reporting Status</label>
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityVoluntaryFilers" xlink:type="locator" xlink:label="dei_EntityVoluntaryFilers" />
    <label xml:lang="en-US" xlink:label="dei_EntityVoluntaryFilers_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Voluntary Filers</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityVoluntaryFilers" xlink:to="dei_EntityVoluntaryFilers_lbl" />
    <label xml:lang="en-US" xlink:label="dei_EntityVoluntaryFilers_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Voluntary Filers</label>
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityFilerCategory" xlink:type="locator" xlink:label="dei_EntityFilerCategory" />
    <label xml:lang="en-US" xlink:label="dei_EntityFilerCategory_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Filer Category</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityFilerCategory" xlink:to="dei_EntityFilerCategory_lbl" />
    <label xml:lang="en-US" xlink:label="dei_EntityFilerCategory_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Filer Category</label>
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCommonStockSharesOutstanding" xlink:type="locator" xlink:label="dei_EntityCommonStockSharesOutstanding" />
    <label xml:lang="en-US" xlink:label="dei_EntityCommonStockSharesOutstanding_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Common Stock, Shares Outstanding</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityCommonStockSharesOutstanding" xlink:to="dei_EntityCommonStockSharesOutstanding_lbl" />
    <label xml:lang="en-US" xlink:label="dei_EntityCommonStockSharesOutstanding_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Common Stock Shares Outstanding</label>
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityPublicFloat" xlink:type="locator" xlink:label="dei_EntityPublicFloat" />
    <label xml:lang="en-US" xlink:label="dei_EntityPublicFloat_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Public Float</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityPublicFloat" xlink:to="dei_EntityPublicFloat_lbl" />
    <label xml:lang="en-US" xlink:label="dei_EntityPublicFloat_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Public Float</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SavingsAndInterestCheckingDeposits" xlink:type="locator" xlink:label="mtb_SavingsAndInterestCheckingDeposits" />
    <label xml:lang="en-US" xlink:label="mtb_SavingsAndInterestCheckingDeposits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount of domestic interest-bearing checking and savings accounts, which may include money market accounts, NOW accounts, interest-bearing corporate checking accounts, brokered deposits and other savings accounts.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SavingsAndInterestCheckingDeposits" xlink:to="mtb_SavingsAndInterestCheckingDeposits_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_CommonStockIssuable" xlink:type="locator" xlink:label="mtb_CommonStockIssuable" />
    <label xml:lang="en-US" xlink:label="mtb_CommonStockIssuable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The obligation to issue shares of Company common stock in connection with deferred compensation plans.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommonStockIssuable" xlink:to="mtb_CommonStockIssuable_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:type="locator" xlink:label="us-gaap_StatementOfFinancialPositionAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_StatementOfFinancialPositionAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Statement Of Financial Position [Abstract]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StatementOfFinancialPositionAbstract" xlink:to="us-gaap_StatementOfFinancialPositionAbstract_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AssetsAbstract" xlink:type="locator" xlink:label="us-gaap_AssetsAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_AssetsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Assets</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AssetsAbstract" xlink:to="us-gaap_AssetsAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AssetsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Assets [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CashAndDueFromBanks" xlink:type="locator" xlink:label="us-gaap_CashAndDueFromBanks" />
    <label xml:lang="en-US" xlink:label="us-gaap_CashAndDueFromBanks_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash and due from banks</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CashAndDueFromBanks" xlink:to="us-gaap_CashAndDueFromBanks_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CashAndDueFromBanks_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Cash And Due From Banks</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestBearingDepositsInBanks" xlink:type="locator" xlink:label="us-gaap_InterestBearingDepositsInBanks" />
    <label xml:lang="en-US" xlink:label="us-gaap_InterestBearingDepositsInBanks_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest-bearing deposits at banks</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestBearingDepositsInBanks" xlink:to="us-gaap_InterestBearingDepositsInBanks_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_InterestBearingDepositsInBanks_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Interest Bearing Deposits In Banks</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TradingSecurities" xlink:type="locator" xlink:label="us-gaap_TradingSecurities" />
    <label xml:lang="en-US" xlink:label="us-gaap_TradingSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Trading account</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TradingSecurities" xlink:to="us-gaap_TradingSecurities_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_TradingSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Trading Securities</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MarketableSecuritiesAbstract" xlink:type="locator" xlink:label="us-gaap_MarketableSecuritiesAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_MarketableSecuritiesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investment securities (includes pledged securities that can be sold or repledged of $1,203,473 at December 31, 2016; $2,136,712 at December 31, 2015)</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_MarketableSecuritiesAbstract" xlink:to="us-gaap_MarketableSecuritiesAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_MarketableSecuritiesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Marketable Securities [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecurities" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecurities" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Available for sale (cost: $13,338,301 at December 31, 2016; $12,138,636 at December 31, 2015)</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecurities" xlink:to="us-gaap_AvailableForSaleSecurities_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HeldToMaturitySecurities" xlink:type="locator" xlink:label="us-gaap_HeldToMaturitySecurities" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Held to maturity (fair value: $2,451,222 at December 31, 2016; $2,864,147 at December 31, 2015)</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_HeldToMaturitySecurities" xlink:to="us-gaap_HeldToMaturitySecurities_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Held To Maturity Securities</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherInvestmentsAndSecuritiesAtCost" xlink:type="locator" xlink:label="us-gaap_OtherInvestmentsAndSecuritiesAtCost" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherInvestmentsAndSecuritiesAtCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other (fair value: $461,118 at December 31, 2016; $554,059 at December 31, 2015)</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherInvestmentsAndSecuritiesAtCost" xlink:to="us-gaap_OtherInvestmentsAndSecuritiesAtCost_lbl" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Investments" xlink:type="locator" xlink:label="us-gaap_Investments" />
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    <label xml:lang="en-US" xlink:label="us-gaap_Investments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Investments</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoansAndLeasesReceivableDeferredIncome" xlink:type="locator" xlink:label="us-gaap_LoansAndLeasesReceivableDeferredIncome" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableDeferredIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Unearned discount</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoansAndLeasesReceivableAllowance" xlink:type="locator" xlink:label="us-gaap_LoansAndLeasesReceivableAllowance" />
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    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableAllowance_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans And Leases Receivable Allowance</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoansAndLeasesReceivableNetReportedAmount" xlink:type="locator" xlink:label="us-gaap_LoansAndLeasesReceivableNetReportedAmount" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableNetReportedAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Loans and leases, net</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoansAndLeasesReceivableNetReportedAmount" xlink:to="us-gaap_LoansAndLeasesReceivableNetReportedAmount_lbl" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:type="locator" xlink:label="us-gaap_PropertyPlantAndEquipmentNet" />
    <label xml:lang="en-US" xlink:label="us-gaap_PropertyPlantAndEquipmentNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Premises and equipment</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PropertyPlantAndEquipmentNet" xlink:to="us-gaap_PropertyPlantAndEquipmentNet_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PropertyPlantAndEquipmentNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Property Plant And Equipment Net</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Goodwill" xlink:type="locator" xlink:label="us-gaap_Goodwill" />
    <label xml:lang="en-US" xlink:label="us-gaap_Goodwill_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Goodwill</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_Goodwill" xlink:to="us-gaap_Goodwill_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_Goodwill_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Goodwill</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:type="locator" xlink:label="us-gaap_FiniteLivedIntangibleAssetsNet" />
    <label xml:lang="en-US" xlink:label="us-gaap_FiniteLivedIntangibleAssetsNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Core deposit and other intangible assets</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FiniteLivedIntangibleAssetsNet" xlink:to="us-gaap_FiniteLivedIntangibleAssetsNet_lbl" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestReceivableAndOtherAssets" xlink:type="locator" xlink:label="us-gaap_InterestReceivableAndOtherAssets" />
    <label xml:lang="en-US" xlink:label="us-gaap_InterestReceivableAndOtherAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accrued interest and other assets</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestReceivableAndOtherAssets" xlink:to="us-gaap_InterestReceivableAndOtherAssets_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_InterestReceivableAndOtherAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Interest Receivable And Other Assets</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Assets" xlink:type="locator" xlink:label="us-gaap_Assets" />
    <label xml:lang="en-US" xlink:label="us-gaap_Assets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total assets</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_Assets" xlink:to="us-gaap_Assets_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_Assets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Assets</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LiabilitiesAbstract" xlink:type="locator" xlink:label="us-gaap_LiabilitiesAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_LiabilitiesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Liabilities</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LiabilitiesAbstract" xlink:to="us-gaap_LiabilitiesAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LiabilitiesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Liabilities [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NoninterestBearingDepositLiabilitiesDomestic" xlink:type="locator" xlink:label="us-gaap_NoninterestBearingDepositLiabilitiesDomestic" />
    <label xml:lang="en-US" xlink:label="us-gaap_NoninterestBearingDepositLiabilitiesDomestic_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Noninterest-bearing deposits</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_NoninterestBearingDepositLiabilitiesDomestic" xlink:to="us-gaap_NoninterestBearingDepositLiabilitiesDomestic_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_NoninterestBearingDepositLiabilitiesDomestic_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Noninterest Bearing Deposit Liabilities Domestic</label>
    <label xml:lang="en-US" xlink:label="mtb_SavingsAndInterestCheckingDeposits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Savings and interest-checking deposits</label>
    <label xml:lang="en-US" xlink:label="mtb_SavingsAndInterestCheckingDeposits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Savings And Interest Checking Deposits</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TimeDeposits" xlink:type="locator" xlink:label="us-gaap_TimeDeposits" />
    <label xml:lang="en-US" xlink:label="us-gaap_TimeDeposits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Time deposits</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TimeDeposits" xlink:to="us-gaap_TimeDeposits_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_TimeDeposits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Time Deposits</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DepositsForeign" xlink:type="locator" xlink:label="us-gaap_DepositsForeign" />
    <label xml:lang="en-US" xlink:label="us-gaap_DepositsForeign_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deposits at Cayman Islands office</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DepositsForeign" xlink:to="us-gaap_DepositsForeign_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DepositsForeign_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Deposits Foreign</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Deposits" xlink:type="locator" xlink:label="us-gaap_Deposits" />
    <label xml:lang="en-US" xlink:label="us-gaap_Deposits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total deposits</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_Deposits" xlink:to="us-gaap_Deposits_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_Deposits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Deposits</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase" xlink:type="locator" xlink:label="us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase" />
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    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase" xlink:to="us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_lbl" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherShortTermBorrowings" xlink:type="locator" xlink:label="us-gaap_OtherShortTermBorrowings" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherShortTermBorrowings_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other short-term borrowings</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherLiabilities" xlink:type="locator" xlink:label="us-gaap_OtherLiabilities" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherLiabilities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accrued interest and other liabilities</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherLiabilities" xlink:to="us-gaap_OtherLiabilities_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherLiabilities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Liabilities</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebt" xlink:type="locator" xlink:label="us-gaap_LongTermDebt" />
    <label xml:lang="en-US" xlink:label="us-gaap_LongTermDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Long-term borrowings</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongTermDebt" xlink:to="us-gaap_LongTermDebt_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LongTermDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Long Term Debt</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Liabilities" xlink:type="locator" xlink:label="us-gaap_Liabilities" />
    <label xml:lang="en-US" xlink:label="us-gaap_Liabilities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total liabilities</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_Liabilities" xlink:to="us-gaap_Liabilities_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_Liabilities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Liabilities</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockholdersEquityAbstract" xlink:type="locator" xlink:label="us-gaap_StockholdersEquityAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockholdersEquityAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Shareholders&apos; equity</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockholdersEquityAbstract" xlink:to="us-gaap_StockholdersEquityAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockholdersEquityAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Stockholders Equity [Abstract]</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_PreferredStockValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Preferred stock, $1.00 par, 1,000,000 shares authorized; Issued and outstanding: Liquidation preference of $1,000 per share: 731,500 shares at December 31, 2016 and December 31, 2015; Liquidation preference of $10,000 per share: 50,000 shares at December 31, 2016 and December 31, 2015</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_CommonStockValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock, $.50 par, 250,000,000 shares authorized, 159,945,678 shares issued at December 31, 2016; 159,563,512 shares issued at December 31, 2015</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_CommonStockValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock Value</label>
    <label xml:lang="en-US" xlink:label="mtb_CommonStockIssuable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock issuable, 32,403 shares at December 31, 2016; 36,644 shares at December 31, 2015</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_AdditionalPaidInCapital_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additional paid-in capital</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_StatementTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Statement [Table]</label>
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    <label xml:lang="en-US" xlink:label="mtb_SeriesAAndSeriesCMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Series A and Series C.</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_StatementLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Statement [Line Items]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SecuritiesHeldAsCollateralAtFairValue" xlink:type="locator" xlink:label="us-gaap_SecuritiesHeldAsCollateralAtFairValue" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesAmortizedCost" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FederalHomeLoanBankStockAndFederalReserveBankStock" xlink:type="locator" xlink:label="us-gaap_FederalHomeLoanBankStockAndFederalReserveBankStock" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PreferredStockParOrStatedValuePerShare" xlink:type="locator" xlink:label="us-gaap_PreferredStockParOrStatedValuePerShare" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_InterestExpensesSavingsAndInterestCheckingDeposits" xlink:type="locator" xlink:label="mtb_InterestExpensesSavingsAndInterestCheckingDeposits" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsToAcquireHeldToMaturitySecurities" xlink:type="locator" xlink:label="us-gaap_PaymentsToAcquireHeldToMaturitySecurities" />
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    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsToAcquireHeldToMaturitySecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Payments To Acquire Held To Maturity Securities</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsToAcquireOtherInvestments" xlink:type="locator" xlink:label="us-gaap_PaymentsToAcquireOtherInvestments" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsToAcquireOtherInvestments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Purchases of investment securities Other</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsToAcquireOtherInvestments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Payments To Acquire Other Investments</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsForProceedsFromLoansAndLeases" xlink:type="locator" xlink:label="us-gaap_PaymentsForProceedsFromLoansAndLeases" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsForProceedsFromLoansAndLeases_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Net increase in loans and leases</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PaymentsForProceedsFromLoansAndLeases" xlink:to="us-gaap_PaymentsForProceedsFromLoansAndLeases_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsForProceedsFromLoansAndLeases_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Payments For Proceeds From Loans And Leases</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromPaymentsForInInterestBearingDepositsInBanks" xlink:type="locator" xlink:label="us-gaap_ProceedsFromPaymentsForInInterestBearingDepositsInBanks" />
    <label xml:lang="en-US" xlink:label="us-gaap_ProceedsFromPaymentsForInInterestBearingDepositsInBanks_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net (increase) decrease in interest-bearing deposits at banks</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_ProceedsFromPaymentsForInInterestBearingDepositsInBanks_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds From Payments For In Interest Bearing Deposits In Banks</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsForProceedsFromProductiveAssets" xlink:type="locator" xlink:label="us-gaap_PaymentsForProceedsFromProductiveAssets" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsForProceedsFromProductiveAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Capital expenditures, net</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsForProceedsFromProductiveAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Payments For Proceeds From Productive Assets</label>
    <label xml:lang="en-US" xlink:label="mtb_NetIncreaseDecreaseInLoanServicingAdvances_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net (increase) decrease in loan servicing advances</label>
    <label xml:lang="en-US" xlink:label="mtb_NetIncreaseDecreaseInLoanServicingAdvances_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Net Increase Decrease In Loan Servicing Advances</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:type="locator" xlink:label="us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Acquisition of bank and bank holding company, net of cash acquired</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Payments To Acquire Businesses Net Of Cash Acquired</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities" xlink:type="locator" xlink:label="us-gaap_PaymentsForProceedsFromOtherInvestingActivities" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsForProceedsFromOtherInvestingActivities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Other, net</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PaymentsForProceedsFromOtherInvestingActivities" xlink:to="us-gaap_PaymentsForProceedsFromOtherInvestingActivities_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsForProceedsFromOtherInvestingActivities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Payments For Proceeds From Other Investing Activities</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations" xlink:type="locator" xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations" />
    <label xml:lang="en-US" xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net cash provided (used) by investing activities</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations" xlink:to="us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Net Cash Provided By Used In Investing Activities Continuing Operations</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract" xlink:type="locator" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash flows from financing activities</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperationsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Net Cash Provided By Used In Financing Activities Continuing Operations [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncreaseDecreaseInDeposits" xlink:type="locator" xlink:label="us-gaap_IncreaseDecreaseInDeposits" />
    <label xml:lang="en-US" xlink:label="us-gaap_IncreaseDecreaseInDeposits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net increase in deposits</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncreaseDecreaseInDeposits" xlink:to="us-gaap_IncreaseDecreaseInDeposits_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_IncreaseDecreaseInDeposits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease In Deposits</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromRepaymentsOfShortTermDebt" xlink:type="locator" xlink:label="us-gaap_ProceedsFromRepaymentsOfShortTermDebt" />
    <label xml:lang="en-US" xlink:label="us-gaap_ProceedsFromRepaymentsOfShortTermDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net decrease in short-term borrowings</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ProceedsFromRepaymentsOfShortTermDebt" xlink:to="us-gaap_ProceedsFromRepaymentsOfShortTermDebt_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ProceedsFromRepaymentsOfShortTermDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds From Repayments Of Short Term Debt</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt" xlink:type="locator" xlink:label="us-gaap_ProceedsFromIssuanceOfLongTermDebt" />
    <label xml:lang="en-US" xlink:label="us-gaap_ProceedsFromIssuanceOfLongTermDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds from long-term borrowings</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ProceedsFromIssuanceOfLongTermDebt" xlink:to="us-gaap_ProceedsFromIssuanceOfLongTermDebt_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ProceedsFromIssuanceOfLongTermDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds From Issuance Of Long Term Debt</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt" xlink:type="locator" xlink:label="us-gaap_RepaymentsOfLongTermDebt" />
    <label xml:lang="en-US" xlink:label="us-gaap_RepaymentsOfLongTermDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Payments on long-term borrowings</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RepaymentsOfLongTermDebt" xlink:to="us-gaap_RepaymentsOfLongTermDebt_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_RepaymentsOfLongTermDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Repayments Of Long Term Debt</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:type="locator" xlink:label="us-gaap_PaymentsForRepurchaseOfCommonStock" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsForRepurchaseOfCommonStock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Purchases of treasury stock</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:to="us-gaap_PaymentsForRepurchaseOfCommonStock_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsForRepurchaseOfCommonStock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Payments For Repurchase Of Common Stock</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsOfDividendsCommonStock" xlink:type="locator" xlink:label="us-gaap_PaymentsOfDividendsCommonStock" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsOfDividendsCommonStock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Dividends paid &#8212; common</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PaymentsOfDividendsCommonStock" xlink:to="us-gaap_PaymentsOfDividendsCommonStock_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsOfDividendsCommonStock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Payments Of Dividends Common Stock</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock" xlink:type="locator" xlink:label="us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Dividends paid &#8212; preferred</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock" xlink:to="us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsOfDividendsPreferredStockAndPreferenceStock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Payments Of Dividends Preferred Stock And Preference Stock</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock" xlink:type="locator" xlink:label="us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Redemption of Series D preferred stock</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock" xlink:to="us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Payments For Repurchase Of Preferred Stock And Preference Stock</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock" xlink:type="locator" xlink:label="us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock" />
    <label xml:lang="en-US" xlink:label="us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Proceeds from issuance of preferred stock</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock" xlink:to="us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds From Issuance Of Preferred Stock And Preference Stock</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities" xlink:type="locator" xlink:label="us-gaap_ProceedsFromPaymentsForOtherFinancingActivities" />
    <label xml:lang="en-US" xlink:label="us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other, net</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ProceedsFromPaymentsForOtherFinancingActivities" xlink:to="us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds From Payments For Other Financing Activities</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations" xlink:type="locator" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations" />
    <label xml:lang="en-US" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net cash provided (used) by financing activities</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations" xlink:to="us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Net Cash Provided By Used In Financing Activities Continuing Operations</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:type="locator" xlink:label="us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:type="locator" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Cash and cash equivalents at beginning of year</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Cash and cash equivalents at end of year</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProceedsFromInterestReceived" xlink:type="locator" xlink:label="us-gaap_ProceedsFromInterestReceived" />
    <label xml:lang="en-US" xlink:label="us-gaap_ProceedsFromInterestReceived_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest received during the year</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ProceedsFromInterestReceived" xlink:to="us-gaap_ProceedsFromInterestReceived_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ProceedsFromInterestReceived_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Proceeds From Interest Received</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestPaid" xlink:type="locator" xlink:label="us-gaap_InterestPaid" />
    <label xml:lang="en-US" xlink:label="us-gaap_InterestPaid_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest paid during the year</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestPaid" xlink:to="us-gaap_InterestPaid_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_InterestPaid_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Interest Paid</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxesPaidNet" xlink:type="locator" xlink:label="us-gaap_IncomeTaxesPaidNet" />
    <label xml:lang="en-US" xlink:label="us-gaap_IncomeTaxesPaidNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Income taxes paid during the year</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncomeTaxesPaidNet" xlink:to="us-gaap_IncomeTaxesPaidNet_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_IncomeTaxesPaidNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Income Taxes Paid Net</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract" xlink:type="locator" xlink:label="us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Supplemental schedule of noncash investing and financing activities</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Cash Flow Noncash Investing And Financing Activities Disclosure [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TransferToOtherRealEstate" xlink:type="locator" xlink:label="us-gaap_TransferToOtherRealEstate" />
    <label xml:lang="en-US" xlink:label="us-gaap_TransferToOtherRealEstate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Real estate acquired in settlement of loans</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TransferToOtherRealEstate" xlink:to="us-gaap_TransferToOtherRealEstate_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_TransferToOtherRealEstate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Transfer To Other Real Estate</label>
    <label xml:lang="en-US" xlink:label="mtb_BusinessAcquisitionsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Acquisition of bank and bank holding company</label>
    <label xml:lang="en-US" xlink:label="mtb_BusinessAcquisitionsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Business Acquisitions [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockIssued1" xlink:type="locator" xlink:label="us-gaap_StockIssued1" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockIssued1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock issued</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockIssued1" xlink:to="us-gaap_StockIssued1_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockIssued1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Stock Issued1</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConversionOfStockAmountConverted1" xlink:type="locator" xlink:label="us-gaap_ConversionOfStockAmountConverted1" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConversionOfStockAmountConverted1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock awards converted</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ConversionOfStockAmountConverted1" xlink:to="us-gaap_ConversionOfStockAmountConverted1_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConversionOfStockAmountConverted1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Conversion Of Stock Amount Converted1</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueOfAssetsAcquired" xlink:type="locator" xlink:label="us-gaap_FairValueOfAssetsAcquired" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueOfAssetsAcquired_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value of Assets acquired (noncash)</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueOfAssetsAcquired" xlink:to="us-gaap_FairValueOfAssetsAcquired_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueOfAssetsAcquired_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Of Assets Acquired</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LiabilitiesAssumed1" xlink:type="locator" xlink:label="us-gaap_LiabilitiesAssumed1" />
    <label xml:lang="en-US" xlink:label="us-gaap_LiabilitiesAssumed1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value of Liabilities assumed</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LiabilitiesAssumed1" xlink:to="us-gaap_LiabilitiesAssumed1_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LiabilitiesAssumed1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Liabilities Assumed1</label>
    <label xml:lang="en-US" xlink:label="mtb_ConsolidationSecuritizedTrustsIncreaseInvestmentSecuritiesHeldForSale_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Securitization of residential mortgage loans allocated to Available-for-sale investment securities</label>
    <label xml:lang="en-US" xlink:label="mtb_ConsolidationSecuritizedTrustsIncreaseInvestmentSecuritiesHeldForSale_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Consolidation Securitized Trusts Increase Investment Securities Held For Sale</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MortgageServicingRightsMSRImpairmentRecovery" xlink:type="locator" xlink:label="us-gaap_MortgageServicingRightsMSRImpairmentRecovery" />
    <label xml:lang="en-US" xlink:label="us-gaap_MortgageServicingRightsMSRImpairmentRecovery_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Securitization of residential mortgage loans allocated to Capitalized servicing rights</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_MortgageServicingRightsMSRImpairmentRecovery" xlink:to="us-gaap_MortgageServicingRightsMSRImpairmentRecovery_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_MortgageServicingRightsMSRImpairmentRecovery_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Mortgage Servicing Rights M S R Impairment Recovery</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ShareBasedCompensationExpenseNet" xlink:type="locator" xlink:label="mtb_ShareBasedCompensationExpenseNet" />
    <label xml:lang="en-US" xlink:label="mtb_ShareBasedCompensationExpenseNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The adjustment to common stock or additional paid in capital for the amount of recognized equity-based compensation during the period.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ShareBasedCompensationExpenseNet" xlink:to="mtb_ShareBasedCompensationExpenseNet_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_IncreaseDecreaseDeferredCompensationPlansNetIncludingDividendEquivalents" xlink:type="locator" xlink:label="mtb_IncreaseDecreaseDeferredCompensationPlansNetIncludingDividendEquivalents" />
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    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_IncreaseDecreaseDeferredCompensationPlansNetIncludingDividendEquivalents" xlink:to="mtb_IncreaseDecreaseDeferredCompensationPlansNetIncludingDividendEquivalents_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_StockBasedCompensationPlansOther" xlink:type="locator" xlink:label="mtb_StockBasedCompensationPlansOther" />
    <label xml:lang="en-US" xlink:label="mtb_StockBasedCompensationPlansOther_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Net change in other stock based compensation plans.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_StockBasedCompensationPlansOther" xlink:to="mtb_StockBasedCompensationPlansOther_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_StockAwardsConvertedDuringPeriodValueAcquisitions" xlink:type="locator" xlink:label="mtb_StockAwardsConvertedDuringPeriodValueAcquisitions" />
    <label xml:lang="en-US" xlink:label="mtb_StockAwardsConvertedDuringPeriodValueAcquisitions_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Value of common stock awards converted pursuant to acquisitions during the period.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_StockAwardsConvertedDuringPeriodValueAcquisitions" xlink:to="mtb_StockAwardsConvertedDuringPeriodValueAcquisitions_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract" xlink:type="locator" xlink:label="us-gaap_StatementOfStockholdersEquityAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_StatementOfStockholdersEquityAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Statement Of Stockholders Equity [Abstract]</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:type="locator" xlink:label="us-gaap_StatementEquityComponentsAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_StatementEquityComponentsAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Equity Components</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StatementEquityComponentsAxis" xlink:to="us-gaap_StatementEquityComponentsAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_StatementEquityComponentsAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Statement Equity Components [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityComponentDomain" xlink:type="locator" xlink:label="us-gaap_EquityComponentDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_EquityComponentDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Equity Component</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquityComponentDomain" xlink:to="us-gaap_EquityComponentDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_EquityComponentDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Equity Component [Domain]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PreferredStockMember" xlink:type="locator" xlink:label="us-gaap_PreferredStockMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_PreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Preferred Stock [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PreferredStockMember" xlink:to="us-gaap_PreferredStockMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommonStockMember" xlink:type="locator" xlink:label="us-gaap_CommonStockMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_CommonStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common Stock [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CommonStockMember" xlink:to="us-gaap_CommonStockMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CommonStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CommonStockIssuableMember" xlink:type="locator" xlink:label="mtb_CommonStockIssuableMember" />
    <label xml:lang="en-US" xlink:label="mtb_CommonStockIssuableMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Common stock issuable.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommonStockIssuableMember" xlink:to="mtb_CommonStockIssuableMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CommonStockIssuableMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common Stock Issuable [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_CommonStockIssuableMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock Issuable [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:type="locator" xlink:label="us-gaap_AdditionalPaidInCapitalMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_AdditionalPaidInCapitalMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additional Paid-in Capital [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AdditionalPaidInCapitalMember" xlink:to="us-gaap_AdditionalPaidInCapitalMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AdditionalPaidInCapitalMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Additional Paid In Capital [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:type="locator" xlink:label="us-gaap_RetainedEarningsMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_RetainedEarningsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Retained Earnings [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RetainedEarningsMember" xlink:to="us-gaap_RetainedEarningsMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_RetainedEarningsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Retained Earnings [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:type="locator" xlink:label="us-gaap_AccumulatedOtherComprehensiveIncomeMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_AccumulatedOtherComprehensiveIncomeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accumulated Other Comprehensive Income (Loss), Net [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:to="us-gaap_AccumulatedOtherComprehensiveIncomeMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AccumulatedOtherComprehensiveIncomeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Accumulated Other Comprehensive Income [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TreasuryStockMember" xlink:type="locator" xlink:label="us-gaap_TreasuryStockMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_TreasuryStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Treasury Stock [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TreasuryStockMember" xlink:to="us-gaap_TreasuryStockMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_TreasuryStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Treasury Stock [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:type="locator" xlink:label="us-gaap_ClassOfWarrantOrRightAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_ClassOfWarrantOrRightAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class of Warrant or Right</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ClassOfWarrantOrRightAxis" xlink:to="us-gaap_ClassOfWarrantOrRightAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ClassOfWarrantOrRightAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:type="locator" xlink:label="us-gaap_ClassOfWarrantOrRightDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_ClassOfWarrantOrRightDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class of Warrant or Right</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_ClassOfWarrantOrRightDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right [Domain]</label>
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    <label xml:lang="en-US" xlink:label="mtb_SeriesAWarrantsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Series A warrants.</label>
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    <label xml:lang="en-US" xlink:label="mtb_SeriesAWarrantsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Series A Warrants [Member]</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SeriesEPreferredStockMember" xlink:type="locator" xlink:label="us-gaap_SeriesEPreferredStockMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_SeriesEPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series E Preferred Stock [Member]</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_SeriesEPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Series E Preferred Stock [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SeriesFPreferredStockMember" xlink:type="locator" xlink:label="us-gaap_SeriesFPreferredStockMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_SeriesFPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series F Preferred Stock [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SeriesFPreferredStockMember" xlink:to="us-gaap_SeriesFPreferredStockMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_SeriesFPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Series F Preferred Stock [Member]</label>
    <label xml:lang="en-US" xlink:label="us-gaap_StockholdersEquity_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Beginning balance</label>
    <label xml:lang="en-US" xlink:label="us-gaap_ComprehensiveIncomeNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Total comprehensive income</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueAcquisitions" xlink:type="locator" xlink:label="us-gaap_StockIssuedDuringPeriodValueAcquisitions" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockIssuedDuringPeriodValueAcquisitions_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Acquisition of Hudson City Bancorp, Inc, common stock issued</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_StockIssuedDuringPeriodValueAcquisitions_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Stock Issued During Period Value Acquisitions</label>
    <label xml:lang="en-US" xlink:label="mtb_StockAwardsConvertedDuringPeriodValueAcquisitions_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Acquisition of Hudson City Bancorp, Inc, common stock awards converted</label>
    <label xml:lang="en-US" xlink:label="mtb_StockAwardsConvertedDuringPeriodValueAcquisitions_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Stock Awards Converted During Period Value Acquisitions</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DividendsPreferredStockCash" xlink:type="locator" xlink:label="us-gaap_DividendsPreferredStockCash" />
    <label xml:lang="en-US" xlink:label="us-gaap_DividendsPreferredStockCash_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Preferred stock cash dividends</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DividendsPreferredStockCash" xlink:to="us-gaap_DividendsPreferredStockCash_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DividendsPreferredStockCash_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Dividends Preferred Stock Cash</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockRedeemedOrCalledDuringPeriodValue" xlink:type="locator" xlink:label="us-gaap_StockRedeemedOrCalledDuringPeriodValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockRedeemedOrCalledDuringPeriodValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Redemption of Series D preferred stock</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockRedeemedOrCalledDuringPeriodValue" xlink:to="us-gaap_StockRedeemedOrCalledDuringPeriodValue_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockRedeemedOrCalledDuringPeriodValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Stock Redeemed Or Called During Period Value</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:type="locator" xlink:label="us-gaap_StockIssuedDuringPeriodValueNewIssues" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockIssuedDuringPeriodValueNewIssues_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Issuance of preferred stock</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:to="us-gaap_StockIssuedDuringPeriodValueNewIssues_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockIssuedDuringPeriodValueNewIssues_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Stock Issued During Period Value New Issues</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities" xlink:type="locator" xlink:label="us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise of stock warrants into common stock</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities" xlink:to="us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Stock Issued During Period Value Conversion Of Convertible Securities</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod" xlink:type="locator" xlink:label="us-gaap_TreasuryStockValueAcquiredCostMethod" />
    <label xml:lang="en-US" xlink:label="us-gaap_TreasuryStockValueAcquiredCostMethod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Purchases of treasury stock</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TreasuryStockValueAcquiredCostMethod" xlink:to="us-gaap_TreasuryStockValueAcquiredCostMethod_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_TreasuryStockValueAcquiredCostMethod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Treasury Stock Value Acquired Cost Method</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensationAbstract" xlink:type="locator" xlink:label="us-gaap_ShareBasedCompensationAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock-based compensation plans:</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ShareBasedCompensationAbstract" xlink:to="us-gaap_ShareBasedCompensationAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation [Abstract]</label>
    <label xml:lang="en-US" xlink:label="mtb_ShareBasedCompensationExpenseNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Compensation expense, net</label>
    <label xml:lang="en-US" xlink:label="mtb_ShareBasedCompensationExpenseNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Expense Net</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xlink:type="locator" xlink:label="us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercises of stock options, net</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xlink:to="us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Stock Issued During Period Value Stock Options Exercised</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan" xlink:type="locator" xlink:label="us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock purchase plan</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan" xlink:to="us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Stock Issued During Period Value Employee Stock Purchase Plan</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockGrantedDuringPeriodValueSharebasedCompensation" xlink:type="locator" xlink:label="us-gaap_StockGrantedDuringPeriodValueSharebasedCompensation" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockGrantedDuringPeriodValueSharebasedCompensation_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Directors&#8217; stock plan</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockGrantedDuringPeriodValueSharebasedCompensation" xlink:to="us-gaap_StockGrantedDuringPeriodValueSharebasedCompensation_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockGrantedDuringPeriodValueSharebasedCompensation_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Stock Granted During Period Value Sharebased Compensation</label>
    <label xml:lang="en-US" xlink:label="mtb_IncreaseDecreaseDeferredCompensationPlansNetIncludingDividendEquivalents_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred compensation plans, net, including dividend equivalents</label>
    <label xml:lang="en-US" xlink:label="mtb_IncreaseDecreaseDeferredCompensationPlansNetIncludingDividendEquivalents_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease Deferred Compensation Plans Net Including Dividend Equivalents</label>
    <label xml:lang="en-US" xlink:label="mtb_StockBasedCompensationPlansOther_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other</label>
    <label xml:lang="en-US" xlink:label="mtb_StockBasedCompensationPlansOther_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Stock Based Compensation Plans Other</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DividendsCommonStockCash" xlink:type="locator" xlink:label="us-gaap_DividendsCommonStockCash" />
    <label xml:lang="en-US" xlink:label="us-gaap_DividendsCommonStockCash_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Common stock cash dividends - $2.80 per share</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DividendsCommonStockCash" xlink:to="us-gaap_DividendsCommonStockCash_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DividendsCommonStockCash_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Dividends Common Stock Cash</label>
    <label xml:lang="en-US" xlink:label="us-gaap_StockholdersEquity_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Ending balance</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:type="locator" xlink:label="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" />
    <label xml:lang="en-US" xlink:label="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise of warrants into shares of common stock</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:to="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities" xlink:type="locator" xlink:label="us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities" />
    <label xml:lang="en-US" xlink:label="us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise of warrants into shares of common stock</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Stock Issued During Period Shares Conversion Of Convertible Securities</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommonStockDividendsPerShareCashPaid" xlink:type="locator" xlink:label="us-gaap_CommonStockDividendsPerShareCashPaid" />
    <label xml:lang="en-US" xlink:label="us-gaap_CommonStockDividendsPerShareCashPaid_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common stock per share dividend amount</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_CommonStockDividendsPerShareCashPaid_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock Dividends Per Share Cash Paid</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:type="locator" xlink:label="us-gaap_AccountingPoliciesAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_AccountingPoliciesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Accounting Policies [Abstract]</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SignificantAccountingPoliciesTextBlock" xlink:type="locator" xlink:label="us-gaap_SignificantAccountingPoliciesTextBlock" />
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    <label xml:lang="en-US" xlink:label="us-gaap_BusinessCombinationsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Business Combinations [Abstract]</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationDisclosureTextBlock" xlink:type="locator" xlink:label="us-gaap_BusinessCombinationDisclosureTextBlock" />
    <label xml:lang="en-US" xlink:label="us-gaap_BusinessCombinationDisclosureTextBlock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Acquisition and divestiture</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_BusinessCombinationDisclosureTextBlock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Business Combination Disclosure [Text Block]</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EarningsPerSharePolicyTextBlock" xlink:type="locator" xlink:label="us-gaap_EarningsPerSharePolicyTextBlock" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_TreasuryStockPolicyTextBlock" xlink:type="locator" xlink:label="mtb_TreasuryStockPolicyTextBlock" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_ScheduleOfAcquiredImpairedLoansTableTextBlock" xlink:type="locator" xlink:label="mtb_ScheduleOfAcquiredImpairedLoansTableTextBlock" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionProFormaInformationTextBlock" xlink:type="locator" xlink:label="us-gaap_BusinessAcquisitionProFormaInformationTextBlock" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_SummaryOfMergerRelatedExpensesAssociatedWithAcquisitionsTableTextBlock" xlink:type="locator" xlink:label="mtb_SummaryOfMergerRelatedExpensesAssociatedWithAcquisitionsTableTextBlock" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_AmortizedCostAndEstimatedFairValueOfCollateralizedMortgageObligationsTableTextBlock" xlink:type="locator" xlink:label="mtb_AmortizedCostAndEstimatedFairValueOfCollateralizedMortgageObligationsTableTextBlock" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_AmortizedCostAndEstimatedFairValueOfDebtSecuritiesByContractualMaturityTableTextBlock" xlink:type="locator" xlink:label="mtb_AmortizedCostAndEstimatedFairValueOfDebtSecuritiesByContractualMaturityTableTextBlock" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_InvestmentSecuritiesInContinuousUnrealizedLossPositionTableTextBlock" xlink:type="locator" xlink:label="mtb_InvestmentSecuritiesInContinuousUnrealizedLossPositionTableTextBlock" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_LoansAndLeasesReceivableTableTextBlock" xlink:type="locator" xlink:label="mtb_LoansAndLeasesReceivableTableTextBlock" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTextBlock" xlink:type="locator" xlink:label="us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTextBlock" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_CertainLoansAcquiredInTransferAccountedForAsDebtSecuritiesAccretableYieldAccretionTableTextBlock" xlink:type="locator" xlink:label="mtb_CertainLoansAcquiredInTransferAccountedForAsDebtSecuritiesAccretableYieldAccretionTableTextBlock" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_LoansAndLeasesReceivableByLoanGradesTableTextBlock" xlink:type="locator" xlink:label="mtb_LoansAndLeasesReceivableByLoanGradesTableTextBlock" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_LoansAndLeasesReceivableAllowanceByImpairmentMethodologyTableTextBlock" xlink:type="locator" xlink:label="mtb_LoansAndLeasesReceivableAllowanceByImpairmentMethodologyTableTextBlock" />
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    <label xml:lang="en-US" xlink:label="mtb_LoansAndLeasesReceivableAllowanceByImpairmentMethodologyTableTextBlock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans And Leases Receivable Allowance By Impairment Methodology Table [Text Block]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_LoansAndLeasesReceivableNetOfDeferredIncomeByImpairmentMethodologyTableTextBlock" xlink:type="locator" xlink:label="mtb_LoansAndLeasesReceivableNetOfDeferredIncomeByImpairmentMethodologyTableTextBlock" />
    <label xml:lang="en-US" xlink:label="mtb_LoansAndLeasesReceivableNetOfDeferredIncomeByImpairmentMethodologyTableTextBlock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Loans And Leases Receivable Net Of Deferred Income By Impairment Methodology [Table Text Block]</label>
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    <label xml:lang="en-US" xlink:label="mtb_LoansAndLeasesReceivableNetOfDeferredIncomeByImpairmentMethodologyTableTextBlock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans And Leases Receivable Net Of Deferred Income By Impairment Methodology Table [Text Block]</label>
    <label xml:lang="en-US" xlink:label="us-gaap_PropertyPlantAndEquipmentAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Property, Plant and Equipment [Abstract]</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_PropertyPlantAndEquipmentTextBlock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Property Plant And Equipment [Text Block]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfServicingAssetsAtAmortizedValueTextBlock" xlink:type="locator" xlink:label="us-gaap_ScheduleOfServicingAssetsAtAmortizedValueTextBlock" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfServicingAssetsAtAmortizedValueTextBlock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Servicing Asset at Amortized Cost</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScheduleOfServicingAssetsAtAmortizedValueTextBlock" xlink:to="us-gaap_ScheduleOfServicingAssetsAtAmortizedValueTextBlock_lbl" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfSensitivityAnalysisOfFairValueOfInterestsContinuedToBeHeldByTransferorServicingAssetsOrServicingLiabilitiesTextBlock" xlink:type="locator" xlink:label="us-gaap_ScheduleOfSensitivityAnalysisOfFairValueOfInterestsContinuedToBeHeldByTransferorServicingAssetsOrServicingLiabilitiesTextBlock" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTableTextBlock" xlink:type="locator" xlink:label="us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTableTextBlock" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock" xlink:type="locator" xlink:label="us-gaap_ScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseTableTextBlock" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfGoodwillTextBlock" xlink:type="locator" xlink:label="us-gaap_ScheduleOfGoodwillTextBlock" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfGoodwillTextBlock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of Goodwill Assigned to Reportable Segments for Purposes of Testing for Impairment</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfShortTermDebtTextBlock" xlink:type="locator" xlink:label="us-gaap_ScheduleOfShortTermDebtTextBlock" />
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    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfShortTermDebtTextBlock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Short Term Debt [Text Block]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock" xlink:type="locator" xlink:label="us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfLineOfCreditFacilitiesTextBlock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Lines of Credit Under Formal Agreements</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfDebtInstrumentsTextBlock" xlink:type="locator" xlink:label="us-gaap_ScheduleOfDebtInstrumentsTextBlock" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfDebtInstrumentsTextBlock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Long-term Borrowings</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock" xlink:type="locator" xlink:label="us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfStockByClassTextBlock" xlink:type="locator" xlink:label="us-gaap_ScheduleOfStockByClassTextBlock" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfSharebasedCompensationRestrictedStockAndRestrictedStockUnitsActivityTableTextBlock" xlink:type="locator" xlink:label="us-gaap_ScheduleOfSharebasedCompensationRestrictedStockAndRestrictedStockUnitsActivityTableTextBlock" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_QuantitativeInformationRelatedToSignificantUnobservableInputsTableTextBlock" xlink:type="locator" xlink:label="mtb_QuantitativeInformationRelatedToSignificantUnobservableInputsTableTextBlock" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTextBlock" xlink:type="locator" xlink:label="us-gaap_FairValueByBalanceSheetGroupingTextBlock" />
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    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueByBalanceSheetGroupingTextBlock" xlink:to="us-gaap_FairValueByBalanceSheetGroupingTextBlock_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueByBalanceSheetGroupingTextBlock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value By Balance Sheet Grouping [Text Block]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CommitmentsTableTextBlock" xlink:type="locator" xlink:label="mtb_CommitmentsTableTextBlock" />
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsTableTextBlock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The tabular disclosure of commitments.</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock" xlink:type="locator" xlink:label="us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Minimum Lease Payments Under Noncancelable Operating Leases</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock" xlink:type="locator" xlink:label="us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock" />
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    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Segment Reporting Information By Segment [Text Block]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ReconciliationOfOtherSignificantReconcilingItemsFromSegmentsToConsolidatedTextBlock" xlink:type="locator" xlink:label="us-gaap_ReconciliationOfOtherSignificantReconcilingItemsFromSegmentsToConsolidatedTextBlock" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_ScheduleOfMinimumCapitalRequiredToBeWellCapitalizedUnderBankingRegulationsTableTextBlock" xlink:type="locator" xlink:label="mtb_ScheduleOfMinimumCapitalRequiredToBeWellCapitalizedUnderBankingRegulationsTableTextBlock" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTextBlock" xlink:type="locator" xlink:label="us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTextBlock" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfCondensedBalanceSheetTableTextBlock" xlink:type="locator" xlink:label="us-gaap_ScheduleOfCondensedBalanceSheetTableTextBlock" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfCondensedIncomeStatementTableTextBlock" xlink:type="locator" xlink:label="us-gaap_ScheduleOfCondensedIncomeStatementTableTextBlock" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_DelinquentPeriodOfLoansResultingInAccruedInterestBeingChargedAgainstIncome" xlink:type="locator" xlink:label="mtb_DelinquentPeriodOfLoansResultingInAccruedInterestBeingChargedAgainstIncome" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_DelinquentPeriodOfLoansSecuredByRealEstateResultingInChargeOff" xlink:type="locator" xlink:label="mtb_DelinquentPeriodOfLoansSecuredByRealEstateResultingInChargeOff" />
    <label xml:lang="en-US" xlink:label="mtb_DelinquentPeriodOfLoansSecuredByRealEstateResultingInChargeOff_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Period of time that a delinquent loan secured by real estate will result in the excess of the loan balance over the net realizable value of the property collateralizing the loan is charged off.</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_LoansSecuredByRealEstateDelinquentPeriodThresholdForReturnToAccrualStatus" xlink:type="locator" xlink:label="mtb_LoansSecuredByRealEstateDelinquentPeriodThresholdForReturnToAccrualStatus" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_ConsumerLoanDelinquentPeriodThresholdForConsiderationForChargeOff" xlink:type="locator" xlink:label="mtb_ConsumerLoanDelinquentPeriodThresholdForConsiderationForChargeOff" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_RegulatoryAssetsAbstract" xlink:type="locator" xlink:label="mtb_RegulatoryAssetsAbstract" />
    <label xml:lang="en-US" xlink:label="mtb_RegulatoryAssetsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Regulatory Assets [Abstract]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_RegulatoryAssetsAbstract" xlink:to="mtb_RegulatoryAssetsAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_RegulatoryAssetsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Regulatory Assets [Abstract]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SignificantAccountingPoliciesLineItems" xlink:type="locator" xlink:label="mtb_SignificantAccountingPoliciesLineItems" />
    <label xml:lang="en-US" xlink:label="mtb_SignificantAccountingPoliciesLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Significant accounting policies.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SignificantAccountingPoliciesLineItems" xlink:to="mtb_SignificantAccountingPoliciesLineItems_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_SignificantAccountingPoliciesTable" xlink:type="locator" xlink:label="mtb_SignificantAccountingPoliciesTable" />
    <label xml:lang="en-US" xlink:label="mtb_SignificantAccountingPoliciesTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Significant accounting policies.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SignificantAccountingPoliciesTable" xlink:to="mtb_SignificantAccountingPoliciesTable_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SignificantAccountingPoliciesTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Significant Accounting Policies [Table]</label>
    <label xml:lang="en-US" xlink:label="mtb_SignificantAccountingPoliciesTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Significant Accounting Policies [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RangeAxis" xlink:type="locator" xlink:label="us-gaap_RangeAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_RangeAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Range</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RangeAxis" xlink:to="us-gaap_RangeAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_RangeAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Range [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RangeMember" xlink:type="locator" xlink:label="us-gaap_RangeMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_RangeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Range</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RangeMember" xlink:to="us-gaap_RangeMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_RangeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Range [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MaximumMember" xlink:type="locator" xlink:label="us-gaap_MaximumMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_MaximumMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Maximum [Member]</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_MaximumMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Maximum [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MinimumMember" xlink:type="locator" xlink:label="us-gaap_MinimumMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_MinimumMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Minimum [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_MinimumMember" xlink:to="us-gaap_MinimumMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_MinimumMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Minimum [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SignificantAccountingPoliciesLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Significant Accounting Policies [Line Items]</label>
    <label xml:lang="en-US" xlink:label="mtb_SignificantAccountingPoliciesLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Significant Accounting Policies [Line Items]</label>
    <label xml:lang="en-US" xlink:label="mtb_DelinquentPeriodOfLoansResultingInAccruedInterestBeingChargedAgainstIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Delinquent period of loans resulting in accrued interest being charged against income</label>
    <label xml:lang="en-US" xlink:label="mtb_DelinquentPeriodOfLoansResultingInAccruedInterestBeingChargedAgainstIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Delinquent Period Of Loans Resulting In Accrued Interest Being Charged Against Income</label>
    <label xml:lang="en-US" xlink:label="mtb_DelinquentPeriodOfLoansSecuredByRealEstateResultingInChargeOff_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Delinquent period of loans secured by real estate resulting in charge off</label>
    <label xml:lang="en-US" xlink:label="mtb_DelinquentPeriodOfLoansSecuredByRealEstateResultingInChargeOff_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Delinquent Period Of Loans Secured By Real Estate Resulting In Charge Off</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansSecuredByRealEstateDelinquentPeriodThresholdForReturnToAccrualStatus_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loans secured by real estate delinquent period threshold for return to accrual status</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansSecuredByRealEstateDelinquentPeriodThresholdForReturnToAccrualStatus_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans Secured By Real Estate Delinquent Period Threshold For Return To Accrual Status</label>
    <label xml:lang="en-US" xlink:label="mtb_ConsumerLoanDelinquentPeriodThresholdForConsiderationForChargeOff_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Consumer loan delinquent period threshold for consideration for charge off</label>
    <label xml:lang="en-US" xlink:label="mtb_ConsumerLoanDelinquentPeriodThresholdForConsiderationForChargeOff_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Consumer Loan Delinquent Period Threshold For Consideration For Charge Off</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife" xlink:type="locator" xlink:label="us-gaap_FiniteLivedIntangibleAssetUsefulLife" />
    <label xml:lang="en-US" xlink:label="us-gaap_FiniteLivedIntangibleAssetUsefulLife_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Estimated useful lives</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FiniteLivedIntangibleAssetUsefulLife" xlink:to="us-gaap_FiniteLivedIntangibleAssetUsefulLife_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FiniteLivedIntangibleAssetUsefulLife_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Finite Lived Intangible Asset Useful Life</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_IncomeTaxBenefitRecognitionCriteriaPercentageThreshold" xlink:type="locator" xlink:label="mtb_IncomeTaxBenefitRecognitionCriteriaPercentageThreshold" />
    <label xml:lang="en-US" xlink:label="mtb_IncomeTaxBenefitRecognitionCriteriaPercentageThreshold_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The percentage threshold of the likelihood of an uncertain tax position being realized upon ultimate settlement for recognition of the benefit.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_IncomeTaxBenefitRecognitionCriteriaPercentageThreshold" xlink:to="mtb_IncomeTaxBenefitRecognitionCriteriaPercentageThreshold_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_IncomeTaxBenefitRecognitionCriteriaPercentageThreshold_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Income tax benefit recognition criteria percentage threshold</label>
    <label xml:lang="en-US" xlink:label="mtb_IncomeTaxBenefitRecognitionCriteriaPercentageThreshold_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Income Tax Benefit Recognition Criteria Percentage Threshold</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_NumberOfBankingOfficesAcquired" xlink:type="locator" xlink:label="mtb_NumberOfBankingOfficesAcquired" />
    <label xml:lang="en-US" xlink:label="mtb_NumberOfBankingOfficesAcquired_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of banking offices acquired.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_NumberOfBankingOfficesAcquired" xlink:to="mtb_NumberOfBankingOfficesAcquired_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:type="locator" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Business Acquisitions By Acquisition [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:to="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Business Acquisitions By Acquisition [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAxis" xlink:type="locator" xlink:label="us-gaap_BusinessAcquisitionAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_BusinessAcquisitionAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Business Acquisition</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_BusinessAcquisitionAxis" xlink:to="us-gaap_BusinessAcquisitionAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_BusinessAcquisitionAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Business Acquisition [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:type="locator" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Business Acquisition, Acquiree</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="us-gaap_BusinessAcquisitionAcquireeDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Business Acquisition Acquiree [Domain]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_HudsonCityMember" xlink:type="locator" xlink:label="mtb_HudsonCityMember" />
    <label xml:lang="en-US" xlink:label="mtb_HudsonCityMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Hudson City.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_HudsonCityMember" xlink:to="mtb_HudsonCityMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_HudsonCityMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Hudson City [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_HudsonCityMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Hudson City [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionLineItems" xlink:type="locator" xlink:label="us-gaap_BusinessAcquisitionLineItems" />
    <label xml:lang="en-US" xlink:label="us-gaap_BusinessAcquisitionLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Business Acquisition [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_BusinessAcquisitionLineItems" xlink:to="us-gaap_BusinessAcquisitionLineItems_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_BusinessAcquisitionLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Business Acquisition [Line Items]</label>
    <label xml:lang="en-US" xlink:label="mtb_NumberOfBankingOfficesAcquired_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of banking offices acquired in New Jersey, Connecticut and New York</label>
    <label xml:lang="en-US" xlink:label="mtb_NumberOfBankingOfficesAcquired_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Banking Offices Acquired</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesGross" xlink:type="locator" xlink:label="us-gaap_PaymentsToAcquireBusinessesGross" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsToAcquireBusinessesGross_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Gross amount of cash paid in the acquisition</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PaymentsToAcquireBusinessesGross" xlink:to="us-gaap_PaymentsToAcquireBusinessesGross_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsToAcquireBusinessesGross_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Payments To Acquire Businesses Gross</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xlink:type="locator" xlink:label="us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" />
    <label xml:lang="en-US" xlink:label="us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Shares issued upon acquisition</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xlink:to="us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Business Acquisition Equity Interests Issued Or Issuable Number Of Shares Issued</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1" xlink:type="locator" xlink:label="us-gaap_BusinessCombinationConsiderationTransferred1" />
    <label xml:lang="en-US" xlink:label="us-gaap_BusinessCombinationConsiderationTransferred1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Business acquisition, purchase price</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_BusinessCombinationConsiderationTransferred1" xlink:to="us-gaap_BusinessCombinationConsiderationTransferred1_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_BusinessCombinationConsiderationTransferred1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Business Combination Consideration Transferred1</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInterestBearingDepositsAtBanks" xlink:type="locator" xlink:label="mtb_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInterestBearingDepositsAtBanks" />
    <label xml:lang="en-US" xlink:label="mtb_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInterestBearingDepositsAtBanks_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount of interest-bearing deposits in other financial institutions for relatively short periods of time including, for example, certificates of deposits, which are presented separately from cash on the balance sheet, acquired at the acquisition date.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInterestBearingDepositsAtBanks" xlink:to="mtb_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInterestBearingDepositsAtBanks_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeposits" xlink:type="locator" xlink:label="mtb_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeposits" />
    <label xml:lang="en-US" xlink:label="mtb_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeposits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The aggregate of all interest-bearing and noninterest-bearing deposit liabilities acquired at the acquisition date.</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedBorrowings" xlink:type="locator" xlink:label="mtb_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedBorrowings" />
    <label xml:lang="en-US" xlink:label="mtb_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedBorrowings_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Carrying amount of short-term and long-term debt acquired at the acquisition date, net of unamortized discount or premium, including current and noncurrent amounts. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedBorrowings" xlink:to="mtb_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedBorrowings_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract" xlink:type="locator" xlink:label="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Identifiable assets:</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract" xlink:to="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Assets [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents" xlink:type="locator" xlink:label="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents" />
    <label xml:lang="en-US" xlink:label="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash and due from banks</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract" xlink:type="locator" xlink:label="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities" xlink:type="locator" xlink:label="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities" />
    <label xml:lang="en-US" xlink:label="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total liabilities</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities" xlink:to="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Liabilities</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" xlink:type="locator" xlink:label="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" />
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    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsToAcquireBusinessesGross_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Cash paid</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable" xlink:type="locator" xlink:label="us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RepaymentsOfDebt" xlink:type="locator" xlink:label="us-gaap_RepaymentsOfDebt" />
    <label xml:lang="en-US" xlink:label="us-gaap_RepaymentsOfDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Repayments of borrowings assumed in acquisition</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_FiniteLivedIntangibleAssetUsefulLife_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Amortization period of core deposit intangible</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CertainLoansAcquiredInTransferAccountedForAsAvailableForSaleDebtSecuritiesAcquiredDuringPeriodDiscount" xlink:type="locator" xlink:label="mtb_CertainLoansAcquiredInTransferAccountedForAsAvailableForSaleDebtSecuritiesAcquiredDuringPeriodDiscount" />
    <label xml:lang="en-US" xlink:label="mtb_CertainLoansAcquiredInTransferAccountedForAsAvailableForSaleDebtSecuritiesAcquiredDuringPeriodDiscount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount of the discount recorded at acquisition on the outstanding customer principal balance receivable at acquisition of acquired loans accounted for as available-for-sale debt securities with evidence of deterioration of credit quality</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CertainLoansAcquiredInTransferAccountedForAsAvailableForSaleDebtSecuritiesAcquiredDuringPeriodContractuallyRequiredPaymentsReceivableAtAcquisition" xlink:type="locator" xlink:label="us-gaap_CertainLoansAcquiredInTransferAccountedForAsAvailableForSaleDebtSecuritiesAcquiredDuringPeriodContractuallyRequiredPaymentsReceivableAtAcquisition" />
    <label xml:lang="en-US" xlink:label="us-gaap_CertainLoansAcquiredInTransferAccountedForAsAvailableForSaleDebtSecuritiesAcquiredDuringPeriodContractuallyRequiredPaymentsReceivableAtAcquisition_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loans acquired</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_CertainLoansAcquiredInTransferAccountedForAsAvailableForSaleDebtSecuritiesAcquiredDuringPeriodContractuallyRequiredPaymentsReceivableAtAcquisition_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Certain Loans Acquired In Transfer Accounted For As Available For Sale Debt Securities Acquired During Period Contractually Required Payments Receivable At Acquisition</label>
    <label xml:lang="en-US" xlink:label="mtb_CertainLoansAcquiredInTransferAccountedForAsAvailableForSaleDebtSecuritiesAcquiredDuringPeriodDiscount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Discount recorded on purchased impaired loans</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_CertainLoansAcquiredDuringPeriodContractualCashFlowsNotExpectedToBeCollectedAtAcquisition" xlink:type="locator" xlink:label="mtb_CertainLoansAcquiredDuringPeriodContractualCashFlowsNotExpectedToBeCollectedAtAcquisition" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_BusinessAcquisitionPurchasePriceAllocationCertainLoansAcquiredAtFairValue" xlink:type="locator" xlink:label="mtb_BusinessAcquisitionPurchasePriceAllocationCertainLoansAcquiredAtFairValue" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CertainLoansAcquiredInTransferAccountedForAsDebtSecuritiesAcquiredDuringPeriodAbstract" xlink:type="locator" xlink:label="us-gaap_CertainLoansAcquiredInTransferAccountedForAsDebtSecuritiesAcquiredDuringPeriodAbstract" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfImpairedFinancingReceivableTable" xlink:type="locator" xlink:label="us-gaap_ScheduleOfImpairedFinancingReceivableTable" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityMethodInvestmentOtherThanTemporaryImpairment" xlink:type="locator" xlink:label="us-gaap_EquityMethodInvestmentOtherThanTemporaryImpairment" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsAdditionalDisclosuresAcquisitionCostExpensed" xlink:type="locator" xlink:label="us-gaap_BusinessCombinationSeparatelyRecognizedTransactionsAdditionalDisclosuresAcquisitionCostExpensed" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BusinessAcquisitionProFormaInformationAbstract" xlink:type="locator" xlink:label="us-gaap_BusinessAcquisitionProFormaInformationAbstract" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_SummaryOfMergerRelatedExpensesAssociatedWithAcquisitionsAbstract" xlink:type="locator" xlink:label="mtb_SummaryOfMergerRelatedExpensesAssociatedWithAcquisitionsAbstract" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationGoodwill1" xlink:type="locator" xlink:label="us-gaap_DisposalGroupIncludingDiscontinuedOperationGoodwill1" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_InvestmentSecuritiesAmortizedCost" xlink:type="locator" xlink:label="mtb_InvestmentSecuritiesAmortizedCost" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_ScheduleOfAvailableForSaleSecuritiesAndHeldToMaturityLineItems" xlink:type="locator" xlink:label="mtb_ScheduleOfAvailableForSaleSecuritiesAndHeldToMaturityLineItems" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_ScheduleOfAvailableForSaleSecuritiesAndHeldToMaturityTable" xlink:type="locator" xlink:label="mtb_ScheduleOfAvailableForSaleSecuritiesAndHeldToMaturityTable" />
    <label xml:lang="en-US" xlink:label="mtb_ScheduleOfAvailableForSaleSecuritiesAndHeldToMaturityTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Schedule Of Available For Sale Securities And Held To Maturity [Table]</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_GainLossOnInvestmentsByCategoryAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investments by Category</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_GainLossOnInvestmentsByCategoryAxis" xlink:to="us-gaap_GainLossOnInvestmentsByCategoryAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_GainLossOnInvestmentsByCategoryAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Gain Loss On Investments By Category [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GainLossOnInvestmentsIncludingMarketableSecuritiesAndInvestmentsHeldAtCostCategoriesOfInvestmentsDomain" xlink:type="locator" xlink:label="us-gaap_GainLossOnInvestmentsIncludingMarketableSecuritiesAndInvestmentsHeldAtCostCategoriesOfInvestmentsDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_GainLossOnInvestmentsIncludingMarketableSecuritiesAndInvestmentsHeldAtCostCategoriesOfInvestmentsDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Marketable Securities and Investments Held at Cost</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_GainLossOnInvestmentsIncludingMarketableSecuritiesAndInvestmentsHeldAtCostCategoriesOfInvestmentsDomain" xlink:to="us-gaap_GainLossOnInvestmentsIncludingMarketableSecuritiesAndInvestmentsHeldAtCostCategoriesOfInvestmentsDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_GainLossOnInvestmentsIncludingMarketableSecuritiesAndInvestmentsHeldAtCostCategoriesOfInvestmentsDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Gain Loss On Investments Including Marketable Securities And Investments Held At Cost Categories Of Investments [Domain]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableforsaleSecuritiesMember" xlink:type="locator" xlink:label="us-gaap_AvailableforsaleSecuritiesMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableforsaleSecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Available-for-Sale Securities [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableforsaleSecuritiesMember" xlink:to="us-gaap_AvailableforsaleSecuritiesMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableforsaleSecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Availableforsale Securities [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InvestmentHoldingsLineItems" xlink:type="locator" xlink:label="us-gaap_InvestmentHoldingsLineItems" />
    <label xml:lang="en-US" xlink:label="us-gaap_InvestmentHoldingsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investment Holdings [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InvestmentHoldingsLineItems" xlink:to="us-gaap_InvestmentHoldingsLineItems_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_InvestmentHoldingsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Investment Holdings [Line Items]</label>
    <label xml:lang="en-US" xlink:label="mtb_NumberOfSingleInvestmentSecuritiesThatExceededTenPercentOfShareholdersEquity_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of investment securities that exceeded ten percent of shareholders&apos; equity</label>
    <label xml:lang="en-US" xlink:label="mtb_NumberOfSingleInvestmentSecuritiesThatExceededTenPercentOfShareholdersEquity_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Number Of Single Investment Securities That Exceeded Ten Percent Of Shareholders Equity</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SecuritiesWithDisclosedRatingAmortizedCost" xlink:type="locator" xlink:label="mtb_SecuritiesWithDisclosedRatingAmortizedCost" />
    <label xml:lang="en-US" xlink:label="mtb_SecuritiesWithDisclosedRatingAmortizedCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Amortized cost of investment securities excluding equities and U.S. government or government agency issued or guaranteed securities.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SecuritiesWithDisclosedRatingAmortizedCost" xlink:to="mtb_SecuritiesWithDisclosedRatingAmortizedCost_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_SecuritiesWithDisclosedRatingEstimatedFairValue" xlink:type="locator" xlink:label="mtb_SecuritiesWithDisclosedRatingEstimatedFairValue" />
    <label xml:lang="en-US" xlink:label="mtb_SecuritiesWithDisclosedRatingEstimatedFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value of investment securities excluding equities and U.S. government or government agency issued or guaranteed securities.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SecuritiesWithDisclosedRatingEstimatedFairValue" xlink:to="mtb_SecuritiesWithDisclosedRatingEstimatedFairValue_lbl" />
    <loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_CreditRatingSourceAxis" xlink:type="locator" xlink:label="invest_CreditRatingSourceAxis" />
    <label xml:lang="en-US" xlink:label="invest_CreditRatingSourceAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Credit Rating Source</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="invest_CreditRatingSourceAxis" xlink:to="invest_CreditRatingSourceAxis_lbl" />
    <label xml:lang="en-US" xlink:label="invest_CreditRatingSourceAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Credit Rating Source [Axis]</label>
    <loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_CreditRatingSourceDomain" xlink:type="locator" xlink:label="invest_CreditRatingSourceDomain" />
    <label xml:lang="en-US" xlink:label="invest_CreditRatingSourceDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Credit Rating Source</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="invest_CreditRatingSourceDomain" xlink:to="invest_CreditRatingSourceDomain_lbl" />
    <label xml:lang="en-US" xlink:label="invest_CreditRatingSourceDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Credit Rating Source [Domain]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_AOrBetterCreditRatingMember" xlink:type="locator" xlink:label="mtb_AOrBetterCreditRatingMember" />
    <label xml:lang="en-US" xlink:label="mtb_AOrBetterCreditRatingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">A or Better Credit Rating.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_AOrBetterCreditRatingMember" xlink:to="mtb_AOrBetterCreditRatingMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_AOrBetterCreditRatingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">A or Better [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_AOrBetterCreditRatingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">A Or Better Credit Rating [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_BBBCreditRatingMember" xlink:type="locator" xlink:label="mtb_BBBCreditRatingMember" />
    <label xml:lang="en-US" xlink:label="mtb_BBBCreditRatingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">B B B Credit Rating [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_BBBCreditRatingMember" xlink:to="mtb_BBBCreditRatingMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_BBBCreditRatingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">BBB [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_BBBCreditRatingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">B B B Credit Rating [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_BbMember" xlink:type="locator" xlink:label="mtb_BbMember" />
    <label xml:lang="en-US" xlink:label="mtb_BbMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">BB.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_BbMember" xlink:to="mtb_BbMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_BbMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">BB [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_BbMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Bb [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_BOrLessCreditRatingMember" xlink:type="locator" xlink:label="mtb_BOrLessCreditRatingMember" />
    <label xml:lang="en-US" xlink:label="mtb_BOrLessCreditRatingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">B or Less Credit Rating.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_BOrLessCreditRatingMember" xlink:to="mtb_BOrLessCreditRatingMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_BOrLessCreditRatingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">B or Less [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_BOrLessCreditRatingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">B Or Less Credit Rating [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_NotRatedMember" xlink:type="locator" xlink:label="mtb_NotRatedMember" />
    <label xml:lang="en-US" xlink:label="mtb_NotRatedMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Not rated.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_NotRatedMember" xlink:to="mtb_NotRatedMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_NotRatedMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Not Rated [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_NotRatedMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Not Rated [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SecuritiesWithDisclosedRatingAmortizedCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Total securities with disclosed rating, Amortized Cost</label>
    <label xml:lang="en-US" xlink:label="mtb_SecuritiesWithDisclosedRatingAmortizedCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Securities With Disclosed Rating Amortized Cost</label>
    <label xml:lang="en-US" xlink:label="mtb_SecuritiesWithDisclosedRatingEstimatedFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Total securities with disclosed rating, Estimated Fair Value</label>
    <label xml:lang="en-US" xlink:label="mtb_SecuritiesWithDisclosedRatingEstimatedFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Securities With Disclosed Rating Estimated Fair Value</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CollateralizedMortgageObligationsAmortizedCost" xlink:type="locator" xlink:label="mtb_CollateralizedMortgageObligationsAmortizedCost" />
    <label xml:lang="en-US" xlink:label="mtb_CollateralizedMortgageObligationsAmortizedCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Amortized cost of collateralized mortgage obligations included in mortgage-backed securities.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CollateralizedMortgageObligationsAmortizedCost" xlink:to="mtb_CollateralizedMortgageObligationsAmortizedCost_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_CollateralizedMortgageObligationsEstimatedFairValue" xlink:type="locator" xlink:label="mtb_CollateralizedMortgageObligationsEstimatedFairValue" />
    <label xml:lang="en-US" xlink:label="mtb_CollateralizedMortgageObligationsEstimatedFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value of collateralized mortgage obligations included in mortgage-backed securities.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CollateralizedMortgageObligationsEstimatedFairValue" xlink:to="mtb_CollateralizedMortgageObligationsEstimatedFairValue_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CollateralizedMortgageObligationsAmortizedCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Collateralized mortgage obligations, Amortized cost</label>
    <label xml:lang="en-US" xlink:label="mtb_CollateralizedMortgageObligationsAmortizedCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Collateralized Mortgage Obligations Amortized Cost</label>
    <label xml:lang="en-US" xlink:label="mtb_CollateralizedMortgageObligationsEstimatedFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Collateralized mortgage obligations, Estimated fair value</label>
    <label xml:lang="en-US" xlink:label="mtb_CollateralizedMortgageObligationsEstimatedFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Collateralized Mortgage Obligations Estimated Fair Value</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_GrossRealizedGainLossOnSaleOfInvestmentSecurities" xlink:type="locator" xlink:label="mtb_GrossRealizedGainLossOnSaleOfInvestmentSecurities" />
    <label xml:lang="en-US" xlink:label="mtb_GrossRealizedGainLossOnSaleOfInvestmentSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The aggregate difference between the carrying value and the sale price of investment securities for which the sale price of the investment security is greater than the carrying value of the investment security. This element refers to the gain included in earnings and not to the cash proceeds of the sale.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_GrossRealizedGainLossOnSaleOfInvestmentSecurities" xlink:to="mtb_GrossRealizedGainLossOnSaleOfInvestmentSecurities_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_GrossRealizedGainLossOnSaleOfInvestmentSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Gross realized gains on sale of investment securities</label>
    <label xml:lang="en-US" xlink:label="mtb_GrossRealizedGainLossOnSaleOfInvestmentSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Gross Realized Gain Loss On Sale Of Investment Securities</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GainOnSaleOfInvestments" xlink:type="locator" xlink:label="us-gaap_GainOnSaleOfInvestments" />
    <label xml:lang="en-US" xlink:label="us-gaap_GainOnSaleOfInvestments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net gain on securities sold</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_GainOnSaleOfInvestments" xlink:to="us-gaap_GainOnSaleOfInvestments_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_GainOnSaleOfInvestments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Gain On Sale Of Investments</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Debt securities available for sale:</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Debt Maturities Amortized Cost [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Due in one year or less</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Debt Maturities Within One Year Amortized Cost</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Due after one year through five years</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Debt Maturities After One Through Five Years Amortized Cost</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Due after five years through ten years</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Debt Maturities After Five Through Ten Years Amortized Cost</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Due after ten years</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Debt Maturities After Ten Years Amortized Cost</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDateAmortizedCostBasis" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDateAmortizedCostBasis" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDateAmortizedCostBasis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total available for sale (amortized cost)</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDateAmortizedCostBasis" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDateAmortizedCostBasis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDateAmortizedCostBasis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Debt Maturities Single Maturity Date Amortized Cost Basis</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateAmortizedCost" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateAmortizedCost" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateAmortizedCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Mortgage-backed securities available for sale</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateAmortizedCost" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateAmortizedCost_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateAmortizedCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Debt Maturities Without Single Maturity Date Amortized Cost</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:to="us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Debt Securities Amortized Cost Basis</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract" xlink:type="locator" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Debt securities held to maturity:</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract" xlink:to="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Held To Maturity Securities Debt Maturities Net Carrying Amount [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearNetCarryingAmount" xlink:type="locator" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearNetCarryingAmount" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearNetCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Due in one year or less</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearNetCarryingAmount" xlink:to="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearNetCarryingAmount_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearNetCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Held To Maturity Securities Debt Maturities Within One Year Net Carrying Amount</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsNetCarryingAmount" xlink:type="locator" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsNetCarryingAmount" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsNetCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Due after one year through five years</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsNetCarryingAmount" xlink:to="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsNetCarryingAmount_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsNetCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Held To Maturity Securities Debt Maturities After One Through Five Years Net Carrying Amount</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsNetCarryingAmount" xlink:type="locator" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsNetCarryingAmount" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsNetCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Due after five years through ten years</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsNetCarryingAmount" xlink:to="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsNetCarryingAmount_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsNetCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Held To Maturity Securities Debt Maturities After Five Through Ten Years Net Carrying Amount</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount" xlink:type="locator" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Due after ten years</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount" xlink:to="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Held To Maturity Securities Debt Maturities After Ten Years Net Carrying Amount</label>
    <label xml:lang="en-US" xlink:label="mtb_HeldToMaturitySecuritiesDebtMaturitiesWithSingleMaturityDateNetCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total available for held to maturity (amortized cost)</label>
    <label xml:lang="en-US" xlink:label="mtb_HeldToMaturitySecuritiesDebtMaturitiesWithSingleMaturityDateNetCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Held To Maturity Securities Debt Maturities With Single Maturity Date Net Carrying Amount</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateNetCarryingAmount" xlink:type="locator" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateNetCarryingAmount" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateNetCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Mortgage-backed securities held to maturity</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateNetCarryingAmount" xlink:to="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateNetCarryingAmount_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateNetCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Held To Maturity Securities Debt Maturities Without Single Maturity Date Net Carrying Amount</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Debt securities available for sale:</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Debt Maturities Fair Value [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Due in one year or less</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Debt Maturities Within One Year Fair Value</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Due after one year through five years</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Debt Maturities After One Through Five Years Fair Value</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Due after five years through ten years</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Debt Maturities After Five Through Ten Years Fair Value</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Due after ten years</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Debt Maturities After Ten Years Fair Value</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total available for sale (fair value)</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesSingleMaturityDate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Debt Maturities Single Maturity Date</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Mortgage-backed securities available for sale</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Debt Maturities Without Single Maturity Date Fair Value</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtSecurities" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:to="us-gaap_AvailableForSaleSecuritiesDebtSecurities_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesDebtSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Debt Securities</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract" xlink:type="locator" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Debt securities held to maturity:</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract" xlink:to="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Held To Maturity Securities Debt Maturities Fair Value [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue" xlink:type="locator" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Due in one year or less</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue" xlink:to="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Held To Maturity Securities Debt Maturities Within One Year Fair Value</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue" xlink:type="locator" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Due after one year through five years</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue" xlink:to="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_lbl" />
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    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesSingleMaturityDateFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Held To Maturity Securities Debt Maturities Single Maturity Date Fair Value</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue" xlink:type="locator" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue" />
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    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Held To Maturity Securities Debt Maturities Without Single Maturity Date Fair Value</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_MortgageBackedSecuritiesIssuedByPrivateEnterprisesResidentialMember" xlink:type="locator" xlink:label="mtb_MortgageBackedSecuritiesIssuedByPrivateEnterprisesResidentialMember" />
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    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Estimated fair value, Less than 12 months</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Available For Sale Securities Continuous Unrealized Losses Position Less Than Twelve Months Aggregate Losses</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" xlink:to="us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Continuous Unrealized Loss Position Less Than12 Months Accumulated Loss</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Estimated fair value, 12 months or more</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue" xlink:to="us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Continuous Unrealized Loss Position Twelve Months Or Longer Fair Value</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss" xlink:type="locator" xlink:label="us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Available For Sale Securities Continuous Unrealized Loss Position Twelve Months Or More Aggregate Losses</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss" xlink:to="us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Available For Sale Securities Continuous Unrealized Loss Position12 Months Or Longer Accumulated Loss</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue" xlink:type="locator" xlink:label="us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Held to maturity, Estimated fair value, Less than 12 months</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Held To Maturity Securities Continuous Unrealized Loss Position Less Than Twelve Months Fair Value</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" xlink:type="locator" xlink:label="us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Held To Maturity Securities Continuous Unrealized Loss Position Less Than12 Months Aggregate Losses</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" xlink:to="us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Held To Maturity Securities Continuous Unrealized Loss Position Less Than12 Months Accumulated Loss</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue" xlink:type="locator" xlink:label="us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Held to maturity, Estimated fair value, 12 months or more</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Held To Maturity Securities Continuous Unrealized Loss Position Twelve Months Or Longer Fair Value</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss" xlink:type="locator" xlink:label="us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Held To Maturity Securities Continuous Unrealized Loss Position12 Months Or Longer Aggregate Losses</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss" xlink:to="us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Held To Maturity Securities Continuous Unrealized Loss Position12 Months Or Longer Accumulated Loss</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_InvestmentSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue" xlink:type="locator" xlink:label="mtb_InvestmentSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue" />
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    <label xml:lang="en-US" xlink:label="mtb_InvestmentSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerAggregateLosses_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount of accumulated unrealized loss on investments in debt and equity securities that have been in a continuous loss position for twelve months or longer.</label>
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    <label xml:lang="en-US" xlink:label="mtb_InvestmentSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Investment Securities Continuous Unrealized Loss Position Less Than Twelve Months Fair Value</label>
    <label xml:lang="en-US" xlink:label="mtb_InvestmentSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsAggregateLosses_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Investment Securities Continuous Unrealized Loss Position Less Than Twelve Months Aggregate Losses</label>
    <label xml:lang="en-US" xlink:label="mtb_InvestmentSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsAggregateLosses_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Investment Securities Continuous Unrealized Loss Position Less Than Twelve Months Aggregate Losses</label>
    <label xml:lang="en-US" xlink:label="mtb_InvestmentSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Total of investment securities, fair value, 12 Months or More</label>
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    <label xml:lang="en-US" xlink:label="mtb_InvestmentSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerAggregateLosses_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Investment Securities Continuous Unrealized Loss Position Twelve Months or Longer Aggregate Losses</label>
    <label xml:lang="en-US" xlink:label="mtb_InvestmentSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerAggregateLosses_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Investment Securities Continuous Unrealized Loss Position Twelve Months Or Longer Aggregate Losses</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CostMethodInvestments" xlink:type="locator" xlink:label="us-gaap_CostMethodInvestments" />
    <label xml:lang="en-US" xlink:label="us-gaap_CostMethodInvestments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cost method investment securities</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CostMethodInvestments" xlink:to="us-gaap_CostMethodInvestments_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CostMethodInvestments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Cost Method Investments</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_InvestmentSecuritiesPledgedToSecureDebtCarryingValue" xlink:type="locator" xlink:label="mtb_InvestmentSecuritiesPledgedToSecureDebtCarryingValue" />
    <label xml:lang="en-US" xlink:label="mtb_InvestmentSecuritiesPledgedToSecureDebtCarryingValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Carrying value of investment securities pledged to secure borrowings from certain various FHLBs, repurchase agreements, governmental deposits, interest rate swap agreements and available lines of credit.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_InvestmentSecuritiesPledgedToSecureDebtCarryingValue" xlink:to="mtb_InvestmentSecuritiesPledgedToSecureDebtCarryingValue_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_InvestmentSecuritiesPledgedToSecureDebtCarryingValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investment securities pledged to secure debt carrying value</label>
    <label xml:lang="en-US" xlink:label="mtb_InvestmentSecuritiesPledgedToSecureDebtCarryingValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Investment Securities Pledged To Secure Debt Carrying Value</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_LoansReceivableAbstract" xlink:type="locator" xlink:label="mtb_LoansReceivableAbstract" />
    <label xml:lang="en-US" xlink:label="mtb_LoansReceivableAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Loans receivable.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_LoansReceivableAbstract" xlink:to="mtb_LoansReceivableAbstract_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_LoansReceivableRealEstateAbstract" xlink:type="locator" xlink:label="mtb_LoansReceivableRealEstateAbstract" />
    <label xml:lang="en-US" xlink:label="mtb_LoansReceivableRealEstateAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Loans receivable real estate.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_LoansReceivableRealEstateAbstract" xlink:to="mtb_LoansReceivableRealEstateAbstract_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_LoansReceivableGross" xlink:type="locator" xlink:label="mtb_LoansReceivableGross" />
    <label xml:lang="en-US" xlink:label="mtb_LoansReceivableGross_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount of loans before allowance. Includes deferred interest and fees, undisbursed portion of loan balance, unamortized costs and premiums and discounts from face amounts.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_LoansReceivableGross" xlink:to="mtb_LoansReceivableGross_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_LoansReceivableAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loans</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansReceivableAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans Receivable [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoansReceivableCommercialFinancialAndAgricultural" xlink:type="locator" xlink:label="us-gaap_LoansReceivableCommercialFinancialAndAgricultural" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansReceivableCommercialFinancialAndAgricultural_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial, financial, etc.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoansReceivableCommercialFinancialAndAgricultural" xlink:to="us-gaap_LoansReceivableCommercialFinancialAndAgricultural_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansReceivableCommercialFinancialAndAgricultural_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans Receivable Commercial Financial And Agricultural</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansReceivableRealEstateAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Real estate:</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansReceivableRealEstateAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans Receivable Real Estate [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoansAndLeasesReceivableConsumerMortgage" xlink:type="locator" xlink:label="us-gaap_LoansAndLeasesReceivableConsumerMortgage" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableConsumerMortgage_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Residential</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoansAndLeasesReceivableConsumerMortgage" xlink:to="us-gaap_LoansAndLeasesReceivableConsumerMortgage_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableConsumerMortgage_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans And Leases Receivable Consumer Mortgage</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoansReceivableCommercialMortgage" xlink:type="locator" xlink:label="us-gaap_LoansReceivableCommercialMortgage" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansReceivableCommercialMortgage_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoansReceivableCommercialMortgage" xlink:to="us-gaap_LoansReceivableCommercialMortgage_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansReceivableCommercialMortgage_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans Receivable Commercial Mortgage</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoansReceivableCommercialConstruction" xlink:type="locator" xlink:label="us-gaap_LoansReceivableCommercialConstruction" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansReceivableCommercialConstruction_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Construction</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoansReceivableCommercialConstruction" xlink:to="us-gaap_LoansReceivableCommercialConstruction_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansReceivableCommercialConstruction_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans Receivable Commercial Construction</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansAndLeasesReceivableConsumerInstallmentRevolvingAndHomeEquity_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Consumer</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansAndLeasesReceivableConsumerInstallmentRevolvingAndHomeEquity_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans And Leases Receivable Consumer Installment Revolving And Home Equity</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansReceivableGross_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total loans</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansReceivableGross_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans Receivable Gross</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LeasesAbstract" xlink:type="locator" xlink:label="us-gaap_LeasesAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeasesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Leases</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LeasesAbstract" xlink:to="us-gaap_LeasesAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeasesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Leases [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LeasesReceivableCommercialLeaseFinancing" xlink:type="locator" xlink:label="us-gaap_LeasesReceivableCommercialLeaseFinancing" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeasesReceivableCommercialLeaseFinancing_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LeasesReceivableCommercialLeaseFinancing" xlink:to="us-gaap_LeasesReceivableCommercialLeaseFinancing_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeasesReceivableCommercialLeaseFinancing_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Leases Receivable Commercial Lease Financing</label>
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableGrossCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total loans and leases</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_LoansAndLeasesReceivableLineItems" xlink:type="locator" xlink:label="mtb_LoansAndLeasesReceivableLineItems" />
    <label xml:lang="en-US" xlink:label="mtb_LoansAndLeasesReceivableLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Loans and Leases Receivable.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_LoansAndLeasesReceivableLineItems" xlink:to="mtb_LoansAndLeasesReceivableLineItems_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_LoansAndLeasesReceivableTable" xlink:type="locator" xlink:label="mtb_LoansAndLeasesReceivableTable" />
    <label xml:lang="en-US" xlink:label="mtb_LoansAndLeasesReceivableTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Loans and Leases receivable.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_LoansAndLeasesReceivableTable" xlink:to="mtb_LoansAndLeasesReceivableTable_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_LoansAndLeasesReceivableTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loans And Leases Receivable [Table]</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansAndLeasesReceivableTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans And Leases Receivable [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:type="locator" xlink:label="us-gaap_FinancialInstrumentAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancialInstrumentAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial Instrument</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancialInstrumentAxis" xlink:to="us-gaap_FinancialInstrumentAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancialInstrumentAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financial Instrument [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:type="locator" xlink:label="us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial Instruments</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:to="us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Transfers And Servicing Of Financial Instruments Types Of Financial Instruments [Domain]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ResidentialMortgageMember" xlink:type="locator" xlink:label="us-gaap_ResidentialMortgageMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_ResidentialMortgageMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Residential Mortgage Loans [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ResidentialMortgageMember" xlink:to="us-gaap_ResidentialMortgageMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ResidentialMortgageMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Residential Mortgage [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:type="locator" xlink:label="us-gaap_FinancingReceivablePortfolioSegmentAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivablePortfolioSegmentAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financing Receivable Portfolio Segment</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:to="us-gaap_FinancingReceivablePortfolioSegmentAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivablePortfolioSegmentAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Portfolio Segment [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:type="locator" xlink:label="us-gaap_FinancingReceivablePortfolioSegmentDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivablePortfolioSegmentDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financing Receivable Portfolio Segment</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:to="us-gaap_FinancingReceivablePortfolioSegmentDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivablePortfolioSegmentDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Portfolio Segment [Domain]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommercialRealEstatePortfolioSegmentMember" xlink:type="locator" xlink:label="us-gaap_CommercialRealEstatePortfolioSegmentMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_CommercialRealEstatePortfolioSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial Real Estate [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CommercialRealEstatePortfolioSegmentMember" xlink:to="us-gaap_CommercialRealEstatePortfolioSegmentMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CommercialRealEstatePortfolioSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commercial Real Estate Portfolio Segment [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:type="locator" xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Related Party</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:to="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Related Party Transactions By Related Party [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:type="locator" xlink:label="us-gaap_RelatedPartyDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_RelatedPartyDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Related Party</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="us-gaap_RelatedPartyDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_RelatedPartyDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Related Party [Domain]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_DirectorAndCertainOfficersMember" xlink:type="locator" xlink:label="mtb_DirectorAndCertainOfficersMember" />
    <label xml:lang="en-US" xlink:label="mtb_DirectorAndCertainOfficersMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Director and Certain Officers [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DirectorAndCertainOfficersMember" xlink:to="mtb_DirectorAndCertainOfficersMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_DirectorAndCertainOfficersMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Director and Certain Officers [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_DirectorAndCertainOfficersMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Director And Certain Officers [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CommercialLoansAndLeasesMember" xlink:type="locator" xlink:label="mtb_CommercialLoansAndLeasesMember" />
    <label xml:lang="en-US" xlink:label="mtb_CommercialLoansAndLeasesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commercial loans and leases.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommercialLoansAndLeasesMember" xlink:to="mtb_CommercialLoansAndLeasesMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CommercialLoansAndLeasesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial Loans and Leases [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_CommercialLoansAndLeasesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commercial Loans And Leases [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_HomeEquityMember" xlink:type="locator" xlink:label="us-gaap_HomeEquityMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_HomeEquityMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Home Equity Loans and Lines of Credit [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_HomeEquityMember" xlink:to="us-gaap_HomeEquityMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_HomeEquityMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Home Equity [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_OtherConsumerLoansMember" xlink:type="locator" xlink:label="mtb_OtherConsumerLoansMember" />
    <label xml:lang="en-US" xlink:label="mtb_OtherConsumerLoansMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other consumer loans.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_OtherConsumerLoansMember" xlink:to="mtb_OtherConsumerLoansMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_OtherConsumerLoansMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other Consumer Loans [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherConsumerLoansMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Consumer Loans [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansAndLeasesReceivableLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loans And Leases Receivable [Line Items]</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansAndLeasesReceivableLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans And Leases Receivable [Line Items]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroupMortgage" xlink:type="locator" xlink:label="us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroupMortgage" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroupMortgage_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Mortgage loans held for sale</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroupMortgage" xlink:to="us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroupMortgage_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroupMortgage_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans Receivable Held For Sale Net Not Part Of Disposal Group Mortgage</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroupCommercialRealEstate" xlink:type="locator" xlink:label="us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroupCommercialRealEstate" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroupCommercialRealEstate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial real estate loans held for sale</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroupCommercialRealEstate" xlink:to="us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroupCommercialRealEstate_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroupCommercialRealEstate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans Receivable Held For Sale Net Not Part Of Disposal Group Commercial Real Estate</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_LoansServicedForOthersSoldWithCreditRecourse" xlink:type="locator" xlink:label="mtb_LoansServicedForOthersSoldWithCreditRecourse" />
    <label xml:lang="en-US" xlink:label="mtb_LoansServicedForOthersSoldWithCreditRecourse_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount of loans serviced for others that were sold with recourse in conjunction with the participation in the Fannie Mae Delegated Underwriting Servicing program.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_LoansServicedForOthersSoldWithCreditRecourse" xlink:to="mtb_LoansServicedForOthersSoldWithCreditRecourse_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_LoansServicedForOthersSoldWithCreditRecourse_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loans serviced for others sold with credit recourse</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansServicedForOthersSoldWithCreditRecourse_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans Serviced For Others Sold With Credit Recourse</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ChargesIncurredForReimbursementOfLoan" xlink:type="locator" xlink:label="mtb_ChargesIncurredForReimbursementOfLoan" />
    <label xml:lang="en-US" xlink:label="mtb_ChargesIncurredForReimbursementOfLoan_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Charges incurred related to reimbursement to loan purchasers for losses incurred, or the repurchase of previously sold residential real estate loans that do not ultimately meet investor sale criteria related to underwriting procedures or loan documentation.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ChargesIncurredForReimbursementOfLoan" xlink:to="mtb_ChargesIncurredForReimbursementOfLoan_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_ChargesIncurredForReimbursementOfLoan_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Charges incurred for reimbursement of loan</label>
    <label xml:lang="en-US" xlink:label="mtb_ChargesIncurredForReimbursementOfLoan_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Charges Incurred For Reimbursement Of Loan</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_AcquiredLoansAtFairValueOutstandingPrincipal" xlink:type="locator" xlink:label="mtb_AcquiredLoansAtFairValueOutstandingPrincipal" />
    <label xml:lang="en-US" xlink:label="mtb_AcquiredLoansAtFairValueOutstandingPrincipal_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The outstanding principal balance of acquired loans that were recorded at fair value at the acquisition date.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_AcquiredLoansAtFairValueOutstandingPrincipal" xlink:to="mtb_AcquiredLoansAtFairValueOutstandingPrincipal_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_AcquiredLoansAtFairValueCarryingAmount" xlink:type="locator" xlink:label="mtb_AcquiredLoansAtFairValueCarryingAmount" />
    <label xml:lang="en-US" xlink:label="mtb_AcquiredLoansAtFairValueCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount included in assets of acquired loans that were recorded at fair value at the acquisition date.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_AcquiredLoansAtFairValueCarryingAmount" xlink:to="mtb_AcquiredLoansAtFairValueCarryingAmount_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfFinancingReceivableAllowanceForCreditLossesTable" xlink:type="locator" xlink:label="us-gaap_ScheduleOfFinancingReceivableAllowanceForCreditLossesTable" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfFinancingReceivableAllowanceForCreditLossesTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Financing Receivable Allowance For Credit Losses [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScheduleOfFinancingReceivableAllowanceForCreditLossesTable" xlink:to="us-gaap_ScheduleOfFinancingReceivableAllowanceForCreditLossesTable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfFinancingReceivableAllowanceForCreditLossesTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Financing Receivable Allowance For Credit Losses [Table]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CommercialFinancialLeasingMember" xlink:type="locator" xlink:label="mtb_CommercialFinancialLeasingMember" />
    <label xml:lang="en-US" xlink:label="mtb_CommercialFinancialLeasingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commercial financial leasing.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommercialFinancialLeasingMember" xlink:to="mtb_CommercialFinancialLeasingMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CommercialFinancialLeasingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial, Financial, Leasing, etc. [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_CommercialFinancialLeasingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commercial Financial Leasing [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ResidentialPortfolioSegmentMember" xlink:type="locator" xlink:label="us-gaap_ResidentialPortfolioSegmentMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_ResidentialPortfolioSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Residential Real Estate [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ResidentialPortfolioSegmentMember" xlink:to="us-gaap_ResidentialPortfolioSegmentMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ResidentialPortfolioSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Residential Portfolio Segment [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConsumerPortfolioSegmentMember" xlink:type="locator" xlink:label="us-gaap_ConsumerPortfolioSegmentMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConsumerPortfolioSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Consumer [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ConsumerPortfolioSegmentMember" xlink:to="us-gaap_ConsumerPortfolioSegmentMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConsumerPortfolioSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Consumer Portfolio Segment [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems" xlink:type="locator" xlink:label="us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financing Receivable, Allowance for Credit Losses [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems" xlink:to="us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Allowance For Credit Losses [Line Items]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivableGrossAllowanceAndNetAbstract" xlink:type="locator" xlink:label="us-gaap_AccountsNotesLoansAndFinancingReceivableGrossAllowanceAndNetAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_AccountsNotesLoansAndFinancingReceivableGrossAllowanceAndNetAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Outstanding principal and carrying value of acquired loans recorded at fair value</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AccountsNotesLoansAndFinancingReceivableGrossAllowanceAndNetAbstract" xlink:to="us-gaap_AccountsNotesLoansAndFinancingReceivableGrossAllowanceAndNetAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AccountsNotesLoansAndFinancingReceivableGrossAllowanceAndNetAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Accounts Notes Loans And Financing Receivable Gross Allowance And Net [Abstract]</label>
    <label xml:lang="en-US" xlink:label="mtb_AcquiredLoansAtFairValueOutstandingPrincipal_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Outstanding principal balance</label>
    <label xml:lang="en-US" xlink:label="mtb_AcquiredLoansAtFairValueOutstandingPrincipal_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Acquired Loans At Fair Value Outstanding Principal</label>
    <label xml:lang="en-US" xlink:label="mtb_AcquiredLoansAtFairValueCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Carrying amount</label>
    <label xml:lang="en-US" xlink:label="mtb_AcquiredLoansAtFairValueCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Acquired Loans At Fair Value Carrying Amount</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_LoansAcquiredInTransferImpairedAsPercentageOfAssets" xlink:type="locator" xlink:label="mtb_LoansAcquiredInTransferImpairedAsPercentageOfAssets" />
    <label xml:lang="en-US" xlink:label="mtb_LoansAcquiredInTransferImpairedAsPercentageOfAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount of purchased impaired loans as a percentage of total assets.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_LoansAcquiredInTransferImpairedAsPercentageOfAssets" xlink:to="mtb_LoansAcquiredInTransferImpairedAsPercentageOfAssets_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAcquiredDuringPeriodAtAcquisitionAtFairValue" xlink:type="locator" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAcquiredDuringPeriodAtAcquisitionAtFairValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAcquiredDuringPeriodAtAcquisitionAtFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Contractual principal and interest payments</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAcquiredDuringPeriodAtAcquisitionAtFairValue" xlink:to="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAcquiredDuringPeriodAtAcquisitionAtFairValue_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAcquiredDuringPeriodAtAcquisitionAtFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Certain Loans Acquired In Transfer Not Accounted For As Debt Securities Acquired During Period At Acquisition At Fair Value</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansAcquiredInTransferImpairedAsPercentageOfAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Purchased impaired loans as a percentage of total assets</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansAcquiredInTransferImpairedAsPercentageOfAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans Acquired In Transfer Impaired As Percentage Of Assets</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestIncome" xlink:type="locator" xlink:label="mtb_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestIncome" />
    <label xml:lang="en-US" xlink:label="mtb_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount of interest from acquired loans included in earnings.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestIncome" xlink:to="mtb_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestIncome_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestOtherIncreaseDecrease" xlink:type="locator" xlink:label="mtb_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestOtherIncreaseDecrease" />
    <label xml:lang="en-US" xlink:label="mtb_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestOtherIncreaseDecrease_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">This item represents other changes in the accretable yield due to changes in expected cash flows including changes in interest rates and prepayment assumptions.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestOtherIncreaseDecrease" xlink:to="mtb_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestOtherIncreaseDecrease_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfCreditDerivativesTable" xlink:type="locator" xlink:label="us-gaap_ScheduleOfCreditDerivativesTable" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfCreditDerivativesTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Credit Derivatives [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScheduleOfCreditDerivativesTable" xlink:to="us-gaap_ScheduleOfCreditDerivativesTable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfCreditDerivativesTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Credit Derivatives [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis" xlink:type="locator" xlink:label="us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class of Financing Receivable, Type</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis" xlink:to="us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Recorded Investment By Class Of Financing Receivable [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:type="locator" xlink:label="us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class of Financing Receivable, Type</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:to="us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Recorded Investment Class Of Financing Receivable [Domain]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_PurchasedImpairedMember" xlink:type="locator" xlink:label="mtb_PurchasedImpairedMember" />
    <label xml:lang="en-US" xlink:label="mtb_PurchasedImpairedMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Purchased Impaired.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_PurchasedImpairedMember" xlink:to="mtb_PurchasedImpairedMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_PurchasedImpairedMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Purchased Impaired [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_PurchasedImpairedMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Purchased Impaired [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_OtherAcquiredLoansMember" xlink:type="locator" xlink:label="mtb_OtherAcquiredLoansMember" />
    <label xml:lang="en-US" xlink:label="mtb_OtherAcquiredLoansMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Balance of acquired loans that were not purchased impaired.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_OtherAcquiredLoansMember" xlink:to="mtb_OtherAcquiredLoansMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_OtherAcquiredLoansMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other Acquired [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherAcquiredLoansMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Acquired Loans [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CreditDerivativesLineItems" xlink:type="locator" xlink:label="us-gaap_CreditDerivativesLineItems" />
    <label xml:lang="en-US" xlink:label="us-gaap_CreditDerivativesLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Credit Derivatives [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CreditDerivativesLineItems" xlink:to="us-gaap_CreditDerivativesLineItems_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CreditDerivativesLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Credit Derivatives [Line Items]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldMovementScheduleRollForward" xlink:type="locator" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldMovementScheduleRollForward" />
    <label xml:lang="en-US" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldMovementScheduleRollForward_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Summary of changes in Accretable Yield for acquired loans</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldMovementScheduleRollForward" xlink:to="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldMovementScheduleRollForward_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldMovementScheduleRollForward_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Certain Loans Acquired In Transfer Not Accounted For As Debt Securities Accretable Yield Movement Schedule Roll Forward</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYield" xlink:type="locator" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYield" />
    <label xml:lang="en-US" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYield_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Balance at beginning of period</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYield" xlink:to="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYield_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYield_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Certain Loans Acquired In Transfer Not Accounted For As Debt Securities Accretable Yield</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldAdditions" xlink:type="locator" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldAdditions" />
    <label xml:lang="en-US" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldAdditions_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Additions</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldAdditions" xlink:to="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldAdditions_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldAdditions_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Certain Loans Acquired In Transfer Not Accounted For As Debt Securities Accretable Yield Additions</label>
    <label xml:lang="en-US" xlink:label="mtb_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Interest income</label>
    <label xml:lang="en-US" xlink:label="mtb_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Certain Loans Acquired In Transfer Not Accounted For As Debt Securities Accretable Yield Interest Income</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldReclassificationsToFromNonaccretableDifference" xlink:type="locator" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldReclassificationsToFromNonaccretableDifference" />
    <label xml:lang="en-US" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldReclassificationsToFromNonaccretableDifference_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Reclassifications from nonaccretable balance</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldReclassificationsToFromNonaccretableDifference" xlink:to="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldReclassificationsToFromNonaccretableDifference_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldReclassificationsToFromNonaccretableDifference_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Certain Loans Acquired In Transfer Not Accounted For As Debt Securities Accretable Yield Reclassifications To From Nonaccretable Difference</label>
    <label xml:lang="en-US" xlink:label="mtb_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestOtherIncreaseDecrease_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other</label>
    <label xml:lang="en-US" xlink:label="mtb_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestOtherIncreaseDecrease_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Certain Loans Acquired In Transfer Not Accounted For As Debt Securities Accretable Yield Interest Other Increase Decrease</label>
    <label xml:lang="en-US" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYield_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Balance at end of period</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:type="locator" xlink:label="us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Accounts Notes Loans And Financing Receivable [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:to="us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Accounts Notes Loans And Financing Receivable [Table]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CommercialRealEstateExcludingResidentialBuilderAndDeveloperAndOtherConstructionMember" xlink:type="locator" xlink:label="mtb_CommercialRealEstateExcludingResidentialBuilderAndDeveloperAndOtherConstructionMember" />
    <label xml:lang="en-US" xlink:label="mtb_CommercialRealEstateExcludingResidentialBuilderAndDeveloperAndOtherConstructionMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commercial real estate excluding residential builder and developer and other construction.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommercialRealEstateExcludingResidentialBuilderAndDeveloperAndOtherConstructionMember" xlink:to="mtb_CommercialRealEstateExcludingResidentialBuilderAndDeveloperAndOtherConstructionMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CommercialRealEstateExcludingResidentialBuilderAndDeveloperAndOtherConstructionMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_CommercialRealEstateExcludingResidentialBuilderAndDeveloperAndOtherConstructionMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commercial Real Estate Excluding Residential Builder And Developer And Other Construction [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ResidentialBuilderAndDeveloperMember" xlink:type="locator" xlink:label="mtb_ResidentialBuilderAndDeveloperMember" />
    <label xml:lang="en-US" xlink:label="mtb_ResidentialBuilderAndDeveloperMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Residential builder and developer.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ResidentialBuilderAndDeveloperMember" xlink:to="mtb_ResidentialBuilderAndDeveloperMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_ResidentialBuilderAndDeveloperMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Residential Builder and Developer [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_ResidentialBuilderAndDeveloperMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Residential Builder And Developer [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_OtherCommercialConstructionMember" xlink:type="locator" xlink:label="mtb_OtherCommercialConstructionMember" />
    <label xml:lang="en-US" xlink:label="mtb_OtherCommercialConstructionMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other commercial construction.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_OtherCommercialConstructionMember" xlink:to="mtb_OtherCommercialConstructionMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_OtherCommercialConstructionMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other Commercial Construction [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherCommercialConstructionMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Commercial Construction [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ResidentialRealEstateExcludingAltAMember" xlink:type="locator" xlink:label="mtb_ResidentialRealEstateExcludingAltAMember" />
    <label xml:lang="en-US" xlink:label="mtb_ResidentialRealEstateExcludingAltAMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Residential real estate excluding Alt-A.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ResidentialRealEstateExcludingAltAMember" xlink:to="mtb_ResidentialRealEstateExcludingAltAMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_ResidentialRealEstateExcludingAltAMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Residential [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_ResidentialRealEstateExcludingAltAMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Residential Real Estate Excluding Alt A [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ResidentialLimitedDocumentationMember" xlink:type="locator" xlink:label="mtb_ResidentialLimitedDocumentationMember" />
    <label xml:lang="en-US" xlink:label="mtb_ResidentialLimitedDocumentationMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Residential Limited Documentation [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ResidentialLimitedDocumentationMember" xlink:to="mtb_ResidentialLimitedDocumentationMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_ResidentialLimitedDocumentationMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Residential Limited Documentation [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_ResidentialLimitedDocumentationMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Residential Limited Documentation [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_HomeEquityLinesAndLoansMember" xlink:type="locator" xlink:label="mtb_HomeEquityLinesAndLoansMember" />
    <label xml:lang="en-US" xlink:label="mtb_HomeEquityLinesAndLoansMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Home equity lines and loans.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_HomeEquityLinesAndLoansMember" xlink:to="mtb_HomeEquityLinesAndLoansMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_HomeEquityLinesAndLoansMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Home Equity Lines and Loans [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_HomeEquityLinesAndLoansMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Home Equity Lines And Loans [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AutomobileLoanMember" xlink:type="locator" xlink:label="us-gaap_AutomobileLoanMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_AutomobileLoanMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Automobile [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AutomobileLoanMember" xlink:to="us-gaap_AutomobileLoanMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AutomobileLoanMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Automobile Loan [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_OtherLoansMember" xlink:type="locator" xlink:label="mtb_OtherLoansMember" />
    <label xml:lang="en-US" xlink:label="mtb_OtherLoansMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other Loans.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_OtherLoansMember" xlink:to="mtb_OtherLoansMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_OtherLoansMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherLoansMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Loans [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InternalCreditAssessmentAxis" xlink:type="locator" xlink:label="us-gaap_InternalCreditAssessmentAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_InternalCreditAssessmentAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Internal Credit Assessment</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InternalCreditAssessmentAxis" xlink:to="us-gaap_InternalCreditAssessmentAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_InternalCreditAssessmentAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Internal Credit Assessment [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InternalCreditAssessmentDomain" xlink:type="locator" xlink:label="us-gaap_InternalCreditAssessmentDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_InternalCreditAssessmentDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Internal Credit Assessment</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InternalCreditAssessmentDomain" xlink:to="us-gaap_InternalCreditAssessmentDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_InternalCreditAssessmentDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Internal Credit Assessment [Domain]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_AcquiredFinancingReceivableAtDiscountMember" xlink:type="locator" xlink:label="mtb_AcquiredFinancingReceivableAtDiscountMember" />
    <label xml:lang="en-US" xlink:label="mtb_AcquiredFinancingReceivableAtDiscountMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Acquired Loans At Discount [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_AcquiredFinancingReceivableAtDiscountMember" xlink:to="mtb_AcquiredFinancingReceivableAtDiscountMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_AcquiredFinancingReceivableAtDiscountMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accruing Loans Acquired at Discount [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_AcquiredFinancingReceivableAtDiscountMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Acquired Financing Receivable At Discount [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:type="locator" xlink:label="us-gaap_AccountsNotesAndLoansReceivableLineItems" />
    <label xml:lang="en-US" xlink:label="us-gaap_AccountsNotesAndLoansReceivableLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accounts, Notes, Loans and Financing Receivable [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:to="us-gaap_AccountsNotesAndLoansReceivableLineItems_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AccountsNotesAndLoansReceivableLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Accounts Notes And Loans Receivable [Line Items]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentCurrent" xlink:type="locator" xlink:label="us-gaap_FinancingReceivableRecordedInvestmentCurrent" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableRecordedInvestmentCurrent_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancingReceivableRecordedInvestmentCurrent" xlink:to="us-gaap_FinancingReceivableRecordedInvestmentCurrent_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableRecordedInvestmentCurrent_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Recorded Investment Current</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansAndLeasesReceivableThirtyToEightyNineDaysPastDue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">30-89 Days Past Due</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansAndLeasesReceivableThirtyToEightyNineDaysPastDue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans And Leases Receivable Thirty To Eighty Nine Days Past Due</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestment90DaysPastDueAndStillAccruing" xlink:type="locator" xlink:label="us-gaap_FinancingReceivableRecordedInvestment90DaysPastDueAndStillAccruing" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableRecordedInvestment90DaysPastDueAndStillAccruing_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accruing Loans Past Due 90 Days or More</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancingReceivableRecordedInvestment90DaysPastDueAndStillAccruing" xlink:to="us-gaap_FinancingReceivableRecordedInvestment90DaysPastDueAndStillAccruing_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableRecordedInvestment90DaysPastDueAndStillAccruing_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Recorded Investment90 Days Past Due And Still Accruing</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesCarryingAmountNet" xlink:type="locator" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesCarryingAmountNet" />
    <label xml:lang="en-US" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesCarryingAmountNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Purchased Impaired</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesCarryingAmountNet" xlink:to="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesCarryingAmountNet_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesCarryingAmountNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Certain Loans Acquired In Transfer Not Accounted For As Debt Securities Carrying Amount Net</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoansAndLeasesReceivableImpairedNonperformingNonaccrualOfInterest" xlink:type="locator" xlink:label="us-gaap_LoansAndLeasesReceivableImpairedNonperformingNonaccrualOfInterest" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableImpairedNonperformingNonaccrualOfInterest_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Nonaccrual</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoansAndLeasesReceivableImpairedNonperformingNonaccrualOfInterest" xlink:to="us-gaap_LoansAndLeasesReceivableImpairedNonperformingNonaccrualOfInterest_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableImpairedNonperformingNonaccrualOfInterest_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans And Leases Receivable Impaired Nonperforming Nonaccrual Of Interest</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_InterestIncomeOnNonaccrualAndRenegotiatedLoansIfAccruingAtOriginalContractTerms" xlink:type="locator" xlink:label="mtb_InterestIncomeOnNonaccrualAndRenegotiatedLoansIfAccruingAtOriginalContractTerms" />
    <label xml:lang="en-US" xlink:label="mtb_InterestIncomeOnNonaccrualAndRenegotiatedLoansIfAccruingAtOriginalContractTerms_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount of interest income that would have been recognized if nonaccrual and renegotiated loans had been accruing interest at their originally contracted terms.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_InterestIncomeOnNonaccrualAndRenegotiatedLoansIfAccruingAtOriginalContractTerms" xlink:to="mtb_InterestIncomeOnNonaccrualAndRenegotiatedLoansIfAccruingAtOriginalContractTerms_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_InterestIncomeOnPeriodEndNonaccrualAndRenegotiatedLoansIncludedInInterestIncome" xlink:type="locator" xlink:label="mtb_InterestIncomeOnPeriodEndNonaccrualAndRenegotiatedLoansIncludedInInterestIncome" />
    <label xml:lang="en-US" xlink:label="mtb_InterestIncomeOnPeriodEndNonaccrualAndRenegotiatedLoansIncludedInInterestIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount of interest income that was included in earnings during the period on loans that were in nonaccrual or renegotiated status as of the end of the period.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_InterestIncomeOnPeriodEndNonaccrualAndRenegotiatedLoansIncludedInInterestIncome" xlink:to="mtb_InterestIncomeOnPeriodEndNonaccrualAndRenegotiatedLoansIncludedInInterestIncome_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_InterestIncomeOnNonaccrualAndRenegotiatedLoansIfAccruingAtOriginalContractTerms_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest income that would have been recognized on nonaccrual and renegotiated loans if those loans were accruing interest at their originally contracted terms</label>
    <label xml:lang="en-US" xlink:label="mtb_InterestIncomeOnNonaccrualAndRenegotiatedLoansIfAccruingAtOriginalContractTerms_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Interest Income On Nonaccrual And Renegotiated Loans If Accruing At Original Contract Terms</label>
    <label xml:lang="en-US" xlink:label="mtb_InterestIncomeOnPeriodEndNonaccrualAndRenegotiatedLoansIncludedInInterestIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest on nonaccrual and renegotiated loans included in interest income</label>
    <label xml:lang="en-US" xlink:label="mtb_InterestIncomeOnPeriodEndNonaccrualAndRenegotiatedLoansIncludedInInterestIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Interest Income On Period End Nonaccrual And Renegotiated Loans Included In Interest Income</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_FinancingEffectsOfModificationsRecordedInvestment" xlink:type="locator" xlink:label="mtb_FinancingEffectsOfModificationsRecordedInvestment" />
    <label xml:lang="en-US" xlink:label="mtb_FinancingEffectsOfModificationsRecordedInvestment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The increase or decrease of the outstanding recorded investment related to financing receivables resulting from the modification by troubled debt restructurings, including principal payments or advances, charge-offs and capitalized escrow arrearages.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_FinancingEffectsOfModificationsRecordedInvestment" xlink:to="mtb_FinancingEffectsOfModificationsRecordedInvestment_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_FinancingReceivableModificationsInterest" xlink:type="locator" xlink:label="mtb_FinancingReceivableModificationsInterest" />
    <label xml:lang="en-US" xlink:label="mtb_FinancingReceivableModificationsInterest_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">This line item represents the present value of interest rate concessions discounted at the effective rate of the original loan.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_FinancingReceivableModificationsInterest" xlink:to="mtb_FinancingReceivableModificationsInterest_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable" xlink:type="locator" xlink:label="us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Financing Receivable Troubled Debt Restructurings [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable" xlink:to="us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfFinancingReceivableTroubledDebtRestructuringsTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Financing Receivable Troubled Debt Restructurings [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoanRestructuringModificationAxis" xlink:type="locator" xlink:label="us-gaap_LoanRestructuringModificationAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoanRestructuringModificationAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loan Restructuring Modification</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoanRestructuringModificationAxis" xlink:to="us-gaap_LoanRestructuringModificationAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoanRestructuringModificationAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loan Restructuring Modification [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoanRestructuringModificationDomain" xlink:type="locator" xlink:label="us-gaap_LoanRestructuringModificationDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoanRestructuringModificationDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loan Restructuring Modification</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoanRestructuringModificationDomain" xlink:to="us-gaap_LoanRestructuringModificationDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoanRestructuringModificationDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loan Restructuring Modification [Domain]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentDeferralMember" xlink:type="locator" xlink:label="us-gaap_PaymentDeferralMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentDeferralMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Principal Deferral [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PaymentDeferralMember" xlink:to="us-gaap_PaymentDeferralMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentDeferralMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Payment Deferral [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CombinationOfConcessionTypesMember" xlink:type="locator" xlink:label="mtb_CombinationOfConcessionTypesMember" />
    <label xml:lang="en-US" xlink:label="mtb_CombinationOfConcessionTypesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Combination of concession types.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CombinationOfConcessionTypesMember" xlink:to="mtb_CombinationOfConcessionTypesMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CombinationOfConcessionTypesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Combination of Concession Types [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_CombinationOfConcessionTypesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Combination Of Concession Types [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ContractualInterestRateReductionMember" xlink:type="locator" xlink:label="us-gaap_ContractualInterestRateReductionMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_ContractualInterestRateReductionMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest Rate Reduction [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ContractualInterestRateReductionMember" xlink:to="us-gaap_ContractualInterestRateReductionMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ContractualInterestRateReductionMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Contractual Interest Rate Reduction [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_OtherModificationsMember" xlink:type="locator" xlink:label="mtb_OtherModificationsMember" />
    <label xml:lang="en-US" xlink:label="mtb_OtherModificationsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other Modifications.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_OtherModificationsMember" xlink:to="mtb_OtherModificationsMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_OtherModificationsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherModificationsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Modifications [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancingReceivableModificationsLineItems" xlink:type="locator" xlink:label="us-gaap_FinancingReceivableModificationsLineItems" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableModificationsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financing Receivable, Modifications [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancingReceivableModificationsLineItems" xlink:to="us-gaap_FinancingReceivableModificationsLineItems_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableModificationsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Modifications [Line Items]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancingReceivableModificationsNumberOfContracts2" xlink:type="locator" xlink:label="us-gaap_FinancingReceivableModificationsNumberOfContracts2" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableModificationsNumberOfContracts2_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of modifications</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancingReceivableModificationsNumberOfContracts2" xlink:to="us-gaap_FinancingReceivableModificationsNumberOfContracts2_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableModificationsNumberOfContracts2_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Modifications Number Of Contracts2</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancingReceivableModificationsPreModificationRecordedInvestment2" xlink:type="locator" xlink:label="us-gaap_FinancingReceivableModificationsPreModificationRecordedInvestment2" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableModificationsPreModificationRecordedInvestment2_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Pre-modification, Recorded Investment</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancingReceivableModificationsPreModificationRecordedInvestment2" xlink:to="us-gaap_FinancingReceivableModificationsPreModificationRecordedInvestment2_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableModificationsPreModificationRecordedInvestment2_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Modifications Pre Modification Recorded Investment2</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancingReceivableModificationsPostModificationRecordedInvestment2" xlink:type="locator" xlink:label="us-gaap_FinancingReceivableModificationsPostModificationRecordedInvestment2" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableModificationsPostModificationRecordedInvestment2_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Post-modification, Recorded Investment</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancingReceivableModificationsPostModificationRecordedInvestment2" xlink:to="us-gaap_FinancingReceivableModificationsPostModificationRecordedInvestment2_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableModificationsPostModificationRecordedInvestment2_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Modifications Post Modification Recorded Investment2</label>
    <label xml:lang="en-US" xlink:label="mtb_FinancingEffectsOfModificationsRecordedInvestment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial Effects of Modification, Recorded Investment</label>
    <label xml:lang="en-US" xlink:label="mtb_FinancingEffectsOfModificationsRecordedInvestment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Effects Of Modifications Recorded Investment</label>
    <label xml:lang="en-US" xlink:label="mtb_FinancingReceivableModificationsInterest_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Financial Effects of Modification, Interest</label>
    <label xml:lang="en-US" xlink:label="mtb_FinancingReceivableModificationsInterest_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Modifications Interest</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoansAndLeasesReceivableRelatedPartiesDescription" xlink:type="locator" xlink:label="us-gaap_LoansAndLeasesReceivableRelatedPartiesDescription" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableRelatedPartiesDescription_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exclusion limit of loans from related party disclosure</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoansAndLeasesReceivableRelatedPartiesDescription" xlink:to="us-gaap_LoansAndLeasesReceivableRelatedPartiesDescription_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableRelatedPartiesDescription_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans And Leases Receivable Related Parties Description</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoansAndLeasesReceivableRelatedParties" xlink:type="locator" xlink:label="us-gaap_LoansAndLeasesReceivableRelatedParties" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableRelatedParties_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Borrowing by directors and certain officers of M&amp;T and its banking subsidiaries and their associates</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoansAndLeasesReceivableRelatedParties" xlink:to="us-gaap_LoansAndLeasesReceivableRelatedParties_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableRelatedParties_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans And Leases Receivable Related Parties</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoansAndLeasesReceivableRelatedPartiesAdditions" xlink:type="locator" xlink:label="us-gaap_LoansAndLeasesReceivableRelatedPartiesAdditions" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableRelatedPartiesAdditions_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">New borrowings by directors, certain officers and their associates</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoansAndLeasesReceivableRelatedPartiesAdditions" xlink:to="us-gaap_LoansAndLeasesReceivableRelatedPartiesAdditions_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableRelatedPartiesAdditions_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans And Leases Receivable Related Parties Additions</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoansAndLeasesReceivableRelatedPartiesProceeds" xlink:type="locator" xlink:label="us-gaap_LoansAndLeasesReceivableRelatedPartiesProceeds" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableRelatedPartiesProceeds_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Repayments and other reductions of borrowings by directors, certain officers and their associates</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoansAndLeasesReceivableRelatedPartiesProceeds" xlink:to="us-gaap_LoansAndLeasesReceivableRelatedPartiesProceeds_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableRelatedPartiesProceeds_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans And Leases Receivable Related Parties Proceeds</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedLoansReceivablePledgedForFederalHomeLoanBankDebt" xlink:type="locator" xlink:label="us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedLoansReceivablePledgedForFederalHomeLoanBankDebt" />
    <label xml:lang="en-US" xlink:label="us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedLoansReceivablePledgedForFederalHomeLoanBankDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loans pledged to secure outstanding borrowings from the FHLB of New York</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedLoansReceivablePledgedForFederalHomeLoanBankDebt" xlink:to="us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedLoansReceivablePledgedForFederalHomeLoanBankDebt_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PledgedFinancialInstrumentsNotSeparatelyReportedLoansReceivablePledgedForFederalHomeLoanBankDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Pledged Financial Instruments Not Separately Reported Loans Receivable Pledged For Federal Home Loan Bank Debt</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_NetInvestmentInDirectFinancingAndLeveragedTypeLeases" xlink:type="locator" xlink:label="mtb_NetInvestmentInDirectFinancingAndLeveragedTypeLeases" />
    <label xml:lang="en-US" xlink:label="mtb_NetInvestmentInDirectFinancingAndLeveragedTypeLeases_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Net investment in direct financing and leveraged type leases.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_NetInvestmentInDirectFinancingAndLeveragedTypeLeases" xlink:to="mtb_NetInvestmentInDirectFinancingAndLeveragedTypeLeases_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesAbstract" xlink:type="locator" xlink:label="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Direct financings:</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesAbstract" xlink:to="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital Leases Net Investment In Direct Financing Leases [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesMinimumPaymentsToBeReceived" xlink:type="locator" xlink:label="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesMinimumPaymentsToBeReceived" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesMinimumPaymentsToBeReceived_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Lease payments receivable</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesMinimumPaymentsToBeReceived" xlink:to="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesMinimumPaymentsToBeReceived_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesMinimumPaymentsToBeReceived_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital Leases Net Investment In Direct Financing Leases Minimum Payments To Be Received</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesUnguaranteedResidualValuesOfLeasedProperty" xlink:type="locator" xlink:label="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesUnguaranteedResidualValuesOfLeasedProperty" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesUnguaranteedResidualValuesOfLeasedProperty_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Estimated residual value of leased assets</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesUnguaranteedResidualValuesOfLeasedProperty" xlink:to="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesUnguaranteedResidualValuesOfLeasedProperty_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesUnguaranteedResidualValuesOfLeasedProperty_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital Leases Net Investment In Direct Financing Leases Unguaranteed Residual Values Of Leased Property</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesDeferredIncome" xlink:type="locator" xlink:label="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesDeferredIncome" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesDeferredIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Unearned income</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesDeferredIncome" xlink:to="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesDeferredIncome_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeasesDeferredIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital Leases Net Investment In Direct Financing Leases Deferred Income</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeases" xlink:type="locator" xlink:label="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeases" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeases_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Investment in direct financings</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeases" xlink:to="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeases_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesNetInvestmentInDirectFinancingLeases_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital Leases Net Investment In Direct Financing Leases</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureInvestmentInLeveragedLeasesNetAbstract" xlink:type="locator" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureInvestmentInLeveragedLeasesNetAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureInvestmentInLeveragedLeasesNetAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Leveraged leases:</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureInvestmentInLeveragedLeasesNetAbstract" xlink:to="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureInvestmentInLeveragedLeasesNetAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureInvestmentInLeveragedLeasesNetAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Leveraged Leases Net Investment In Leveraged Leases Disclosure Investment In Leveraged Leases Net [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureRentalReceivablesNet" xlink:type="locator" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureRentalReceivablesNet" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureRentalReceivablesNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Lease payments receivable</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureRentalReceivablesNet" xlink:to="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureRentalReceivablesNet_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureRentalReceivablesNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Leveraged Leases Net Investment In Leveraged Leases Disclosure Rental Receivables Net</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureResidualValueOfLeasedAssets" xlink:type="locator" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureResidualValueOfLeasedAssets" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureResidualValueOfLeasedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Estimated residual value of leased assets</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureResidualValueOfLeasedAssets" xlink:to="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureResidualValueOfLeasedAssets_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureResidualValueOfLeasedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Leveraged Leases Net Investment In Leveraged Leases Disclosure Residual Value Of Leased Assets</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureDeferredIncome" xlink:type="locator" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureDeferredIncome" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureDeferredIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Unearned income</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureDeferredIncome" xlink:to="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureDeferredIncome_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureDeferredIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Leveraged Leases Net Investment In Leveraged Leases Disclosure Deferred Income</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureInvestmentInLeveragedLeasesNet" xlink:type="locator" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureInvestmentInLeveragedLeasesNet" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureInvestmentInLeveragedLeasesNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Investment in leveraged leases</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureInvestmentInLeveragedLeasesNet" xlink:to="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureInvestmentInLeveragedLeasesNet_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureInvestmentInLeveragedLeasesNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Leveraged Leases Net Investment In Leveraged Leases Disclosure Investment In Leveraged Leases Net</label>
    <label xml:lang="en-US" xlink:label="mtb_NetInvestmentInDirectFinancingAndLeveragedTypeLeases_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total investment in leases</label>
    <label xml:lang="en-US" xlink:label="mtb_NetInvestmentInDirectFinancingAndLeveragedTypeLeases_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Net Investment In Direct Financing And Leveraged Type Leases</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureDeferredTaxesArisingFromLeveragedLeases" xlink:type="locator" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureDeferredTaxesArisingFromLeveragedLeases" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureDeferredTaxesArisingFromLeveragedLeases_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred taxes payable arising from leveraged leases</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureDeferredTaxesArisingFromLeveragedLeases" xlink:to="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureDeferredTaxesArisingFromLeveragedLeases_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureDeferredTaxesArisingFromLeveragedLeases_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Leveraged Leases Net Investment In Leveraged Leases Disclosure Deferred Taxes Arising From Leveraged Leases</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CapitalLeasesNetInvestmentInDirectFinancingLeasesGuaranteedResidualValuesOfLeasedProperty" xlink:type="locator" xlink:label="mtb_CapitalLeasesNetInvestmentInDirectFinancingLeasesGuaranteedResidualValuesOfLeasedProperty" />
    <label xml:lang="en-US" xlink:label="mtb_CapitalLeasesNetInvestmentInDirectFinancingLeasesGuaranteedResidualValuesOfLeasedProperty_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount of residual value associated with direct financing leases that are guaranteed by the lessees or others.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CapitalLeasesNetInvestmentInDirectFinancingLeasesGuaranteedResidualValuesOfLeasedProperty" xlink:to="mtb_CapitalLeasesNetInvestmentInDirectFinancingLeasesGuaranteedResidualValuesOfLeasedProperty_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CapitalLeasesNetInvestmentInDirectFinancingLeasesGuaranteedResidualValuesOfLeasedProperty_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Guaranteed amount included in the estimated residual value of leased assets associated with direct financing leases</label>
    <label xml:lang="en-US" xlink:label="mtb_CapitalLeasesNetInvestmentInDirectFinancingLeasesGuaranteedResidualValuesOfLeasedProperty_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital Leases Net Investment In Direct Financing Leases Guaranteed Residual Values Of Leased Property</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableCurrent" xlink:type="locator" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableCurrent" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableCurrent_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2017</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableCurrent" xlink:to="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableCurrent_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableCurrent_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital Leases Future Minimum Payments Receivable Current</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInTwoYears" xlink:type="locator" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInTwoYears" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInTwoYears_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2018</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInTwoYears" xlink:to="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInTwoYears_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInTwoYears_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital Leases Future Minimum Payments Receivable In Two Years</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInThreeYears" xlink:type="locator" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInThreeYears" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInThreeYears_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2019</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInThreeYears" xlink:to="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInThreeYears_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInThreeYears_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital Leases Future Minimum Payments Receivable In Three Years</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInFourYears" xlink:type="locator" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInFourYears" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInFourYears_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2020</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInFourYears" xlink:to="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInFourYears_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInFourYears_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital Leases Future Minimum Payments Receivable In Four Years</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInFiveYears" xlink:type="locator" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInFiveYears" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInFiveYears_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2021</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInFiveYears" xlink:to="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInFiveYears_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableInFiveYears_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital Leases Future Minimum Payments Receivable In Five Years</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableDueThereafter" xlink:type="locator" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableDueThereafter" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableDueThereafter_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Later years</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableDueThereafter" xlink:to="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableDueThereafter_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivableDueThereafter_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital Leases Future Minimum Payments Receivable Due Thereafter</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsReceivable" xlink:type="locator" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivable" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivable" xlink:to="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalLeasesFutureMinimumPaymentsReceivable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital Leases Future Minimum Payments Receivable</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ResidentialMortgageLoansSecuredByResidentialRealEstateInProcessOfForeclosure" xlink:type="locator" xlink:label="mtb_ResidentialMortgageLoansSecuredByResidentialRealEstateInProcessOfForeclosure" />
    <label xml:lang="en-US" xlink:label="mtb_ResidentialMortgageLoansSecuredByResidentialRealEstateInProcessOfForeclosure_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Residential mortgage loans secured by residential real estate in process of foreclosure.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ResidentialMortgageLoansSecuredByResidentialRealEstateInProcessOfForeclosure" xlink:to="mtb_ResidentialMortgageLoansSecuredByResidentialRealEstateInProcessOfForeclosure_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_ResidentialMortgageLoansSecuredByResidentialRealEstateInProcessOfForeclosureServicedByOtherEntities" xlink:type="locator" xlink:label="mtb_ResidentialMortgageLoansSecuredByResidentialRealEstateInProcessOfForeclosureServicedByOtherEntities" />
    <label xml:lang="en-US" xlink:label="mtb_ResidentialMortgageLoansSecuredByResidentialRealEstateInProcessOfForeclosureServicedByOtherEntities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Loans secured by residential real estate that were in the process of foreclosure, serviced by other entities.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ResidentialMortgageLoansSecuredByResidentialRealEstateInProcessOfForeclosureServicedByOtherEntities" xlink:to="mtb_ResidentialMortgageLoansSecuredByResidentialRealEstateInProcessOfForeclosureServicedByOtherEntities_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_PercentageOfLoansInTheProcessOfForeclosureServicedByOtherEntitiesClassifiedAsPurchasedImpaired" xlink:type="locator" xlink:label="mtb_PercentageOfLoansInTheProcessOfForeclosureServicedByOtherEntitiesClassifiedAsPurchasedImpaired" />
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfLoansInTheProcessOfForeclosureServicedByOtherEntitiesClassifiedAsPurchasedImpaired_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of loans in the process of foreclosure, serviced by other entities, classified as purchased impaired.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_PercentageOfLoansInTheProcessOfForeclosureServicedByOtherEntitiesClassifiedAsPurchasedImpaired" xlink:to="mtb_PercentageOfLoansInTheProcessOfForeclosureServicedByOtherEntitiesClassifiedAsPurchasedImpaired_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_PercentageOfLoansInTheProcessOfForeclosureServicedByOtherEntitiesClassifiedAsGovernmentGuaranteed" xlink:type="locator" xlink:label="mtb_PercentageOfLoansInTheProcessOfForeclosureServicedByOtherEntitiesClassifiedAsGovernmentGuaranteed" />
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfLoansInTheProcessOfForeclosureServicedByOtherEntitiesClassifiedAsGovernmentGuaranteed_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage of loans in the process of foreclosure, serviced by other entities, classified as government guaranteed.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_PercentageOfLoansInTheProcessOfForeclosureServicedByOtherEntitiesClassifiedAsGovernmentGuaranteed" xlink:to="mtb_PercentageOfLoansInTheProcessOfForeclosureServicedByOtherEntitiesClassifiedAsGovernmentGuaranteed_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherRealEstateAndForeclosedAssets" xlink:type="locator" xlink:label="us-gaap_OtherRealEstateAndForeclosedAssets" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherRealEstateAndForeclosedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amount of foreclosed residential real estate property held</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherRealEstateAndForeclosedAssets" xlink:to="us-gaap_OtherRealEstateAndForeclosedAssets_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherRealEstateAndForeclosedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Real Estate And Foreclosed Assets</label>
    <label xml:lang="en-US" xlink:label="mtb_ResidentialMortgageLoansSecuredByResidentialRealEstateInProcessOfForeclosure_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loans secured by residential real estate that were in the process of foreclosure</label>
    <label xml:lang="en-US" xlink:label="mtb_ResidentialMortgageLoansSecuredByResidentialRealEstateInProcessOfForeclosure_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Residential Mortgage Loans Secured By Residential Real Estate In Process Of Foreclosure</label>
    <label xml:lang="en-US" xlink:label="mtb_ResidentialMortgageLoansSecuredByResidentialRealEstateInProcessOfForeclosureServicedByOtherEntities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loans secured by residential real estate that were in the process of foreclosure, serviced by other entities</label>
    <label xml:lang="en-US" xlink:label="mtb_ResidentialMortgageLoansSecuredByResidentialRealEstateInProcessOfForeclosureServicedByOtherEntities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Residential Mortgage Loans Secured By Residential Real Estate In Process Of Foreclosure Serviced By Other Entities</label>
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfLoansInTheProcessOfForeclosureServicedByOtherEntitiesClassifiedAsPurchasedImpaired_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage loans in the process of foreclosure, serviced by other entities, classified as purchased impaired</label>
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfLoansInTheProcessOfForeclosureServicedByOtherEntitiesClassifiedAsPurchasedImpaired_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Percentage Of Loans In The Process Of Foreclosure Serviced By Other Entities Classified As Purchased Impaired</label>
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfLoansInTheProcessOfForeclosureServicedByOtherEntitiesClassifiedAsGovernmentGuaranteed_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage loans in the process of foreclosure, serviced by other entities, classified as government guaranteed</label>
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfLoansInTheProcessOfForeclosureServicedByOtherEntitiesClassifiedAsGovernmentGuaranteed_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Percentage Of Loans In The Process Of Foreclosure Serviced By Other Entities Classified As Government Guaranteed</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_FinancingReceivableAllowanceForCreditLossesNetWriteOffsAbstract" xlink:type="locator" xlink:label="mtb_FinancingReceivableAllowanceForCreditLossesNetWriteOffsAbstract" />
    <label xml:lang="en-US" xlink:label="mtb_FinancingReceivableAllowanceForCreditLossesNetWriteOffsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Financing receivable allowance for credit losses net write offs.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_FinancingReceivableAllowanceForCreditLossesNetWriteOffsAbstract" xlink:to="mtb_FinancingReceivableAllowanceForCreditLossesNetWriteOffsAbstract_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_UnallocatedFinancingReceivablesMember" xlink:type="locator" xlink:label="us-gaap_UnallocatedFinancingReceivablesMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_UnallocatedFinancingReceivablesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Unallocated [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_UnallocatedFinancingReceivablesMember" xlink:to="us-gaap_UnallocatedFinancingReceivablesMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_UnallocatedFinancingReceivablesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Unallocated Financing Receivables [Member]</label>
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableAllowance_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Beginning balance</label>
    <label xml:lang="en-US" xlink:label="mtb_FinancingReceivableAllowanceForCreditLossesNetWriteOffsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net charge-offs</label>
    <label xml:lang="en-US" xlink:label="mtb_FinancingReceivableAllowanceForCreditLossesNetWriteOffsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Allowance For Credit Losses Net Write Offs [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs" xlink:type="locator" xlink:label="us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Charge-offs</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs" xlink:to="us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Allowance For Credit Losses Write Offs</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesRecovery" xlink:type="locator" xlink:label="us-gaap_FinancingReceivableAllowanceForCreditLossesRecovery" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableAllowanceForCreditLossesRecovery_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Recoveries</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancingReceivableAllowanceForCreditLossesRecovery" xlink:to="us-gaap_FinancingReceivableAllowanceForCreditLossesRecovery_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableAllowanceForCreditLossesRecovery_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Allowance For Credit Losses Recovery</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AllowanceForLoanAndLeaseLossesWriteoffsNet" xlink:type="locator" xlink:label="us-gaap_AllowanceForLoanAndLeaseLossesWriteoffsNet" />
    <label xml:lang="en-US" xlink:label="us-gaap_AllowanceForLoanAndLeaseLossesWriteoffsNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel">Net (charge-offs) recoveries</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AllowanceForLoanAndLeaseLossesWriteoffsNet" xlink:to="us-gaap_AllowanceForLoanAndLeaseLossesWriteoffsNet_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AllowanceForLoanAndLeaseLossesWriteoffsNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Allowance For Loan And Lease Losses Writeoffs Net</label>
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableAllowance_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Ending balance</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_LoanDelinquentPeriodForNonAccrualStatusClassification" xlink:type="locator" xlink:label="mtb_LoanDelinquentPeriodForNonAccrualStatusClassification" />
    <label xml:lang="en-US" xlink:label="mtb_LoanDelinquentPeriodForNonAccrualStatusClassification_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The threshold number of days in delinquency at which criticized loans are generally classified as non-accrual.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_LoanDelinquentPeriodForNonAccrualStatusClassification" xlink:to="mtb_LoanDelinquentPeriodForNonAccrualStatusClassification_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_LoanDelinquentPeriodForNonAccrualStatusClassification_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loan delinquent period</label>
    <label xml:lang="en-US" xlink:label="mtb_LoanDelinquentPeriodForNonAccrualStatusClassification_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loan Delinquent Period For Non Accrual Status Classification</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceRecordedInvestment" xlink:type="locator" xlink:label="us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceRecordedInvestment" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceRecordedInvestment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Recorded investment with related allowance</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceRecordedInvestment" xlink:to="us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceRecordedInvestment_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceRecordedInvestment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Impaired Financing Receivable With Related Allowance Recorded Investment</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceUnpaidPrincipalBalance" xlink:type="locator" xlink:label="us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceUnpaidPrincipalBalance" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceUnpaidPrincipalBalance_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Unpaid principal balance with related allowance</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceUnpaidPrincipalBalance" xlink:to="us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceUnpaidPrincipalBalance_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceUnpaidPrincipalBalance_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Impaired Financing Receivable With Related Allowance Unpaid Principal Balance</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ImpairedFinancingReceivableRelatedAllowance" xlink:type="locator" xlink:label="us-gaap_ImpairedFinancingReceivableRelatedAllowance" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableRelatedAllowance_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Related allowance</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ImpairedFinancingReceivableRelatedAllowance" xlink:to="us-gaap_ImpairedFinancingReceivableRelatedAllowance_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableRelatedAllowance_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Impaired Financing Receivable Related Allowance</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceRecordedInvestment" xlink:type="locator" xlink:label="us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceRecordedInvestment" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceRecordedInvestment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Recorded investment with no related allowance</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceRecordedInvestment" xlink:to="us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceRecordedInvestment_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceRecordedInvestment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Impaired Financing Receivable With No Related Allowance Recorded Investment</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceUnpaidPrincipalBalance" xlink:type="locator" xlink:label="us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceUnpaidPrincipalBalance" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceUnpaidPrincipalBalance_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Unpaid principal balance with no related allowance</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceUnpaidPrincipalBalance" xlink:to="us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceUnpaidPrincipalBalance_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceUnpaidPrincipalBalance_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Impaired Financing Receivable With No Related Allowance Unpaid Principal Balance</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ImpairedFinancingReceivableRecordedInvestment" xlink:type="locator" xlink:label="us-gaap_ImpairedFinancingReceivableRecordedInvestment" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableRecordedInvestment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Recorded investment</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ImpairedFinancingReceivableRecordedInvestment" xlink:to="us-gaap_ImpairedFinancingReceivableRecordedInvestment_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableRecordedInvestment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Impaired Financing Receivable Recorded Investment</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ImpairedFinancingReceivableUnpaidPrincipalBalance" xlink:type="locator" xlink:label="us-gaap_ImpairedFinancingReceivableUnpaidPrincipalBalance" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableUnpaidPrincipalBalance_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Unpaid principal balance</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ImpairedFinancingReceivableUnpaidPrincipalBalance" xlink:to="us-gaap_ImpairedFinancingReceivableUnpaidPrincipalBalance_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableUnpaidPrincipalBalance_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Impaired Financing Receivable Unpaid Principal Balance</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ImpairedFinancingReceivableAverageRecordedInvestment" xlink:type="locator" xlink:label="us-gaap_ImpairedFinancingReceivableAverageRecordedInvestment" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableAverageRecordedInvestment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Average recorded investment</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ImpairedFinancingReceivableAverageRecordedInvestment" xlink:to="us-gaap_ImpairedFinancingReceivableAverageRecordedInvestment_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableAverageRecordedInvestment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Impaired Financing Receivable Average Recorded Investment</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ImpairedFinancingReceivableInterestIncomeAccrualMethod" xlink:type="locator" xlink:label="us-gaap_ImpairedFinancingReceivableInterestIncomeAccrualMethod" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableInterestIncomeAccrualMethod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest income recognized, Total</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ImpairedFinancingReceivableInterestIncomeAccrualMethod" xlink:to="us-gaap_ImpairedFinancingReceivableInterestIncomeAccrualMethod_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableInterestIncomeAccrualMethod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Impaired Financing Receivable Interest Income Accrual Method</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ImpairedFinancingReceivableInterestIncomeCashBasisMethod" xlink:type="locator" xlink:label="us-gaap_ImpairedFinancingReceivableInterestIncomeCashBasisMethod" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableInterestIncomeCashBasisMethod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest income recognized, Cash basis</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ImpairedFinancingReceivableInterestIncomeCashBasisMethod" xlink:to="us-gaap_ImpairedFinancingReceivableInterestIncomeCashBasisMethod_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ImpairedFinancingReceivableInterestIncomeCashBasisMethod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Impaired Financing Receivable Interest Income Cash Basis Method</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable" xlink:type="locator" xlink:label="us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Financing Receivable Recorded Investment Credit Quality Indicator [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable" xlink:to="us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Financing Receivable Recorded Investment Credit Quality Indicator [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PassMember" xlink:type="locator" xlink:label="us-gaap_PassMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_PassMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Pass [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PassMember" xlink:to="us-gaap_PassMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PassMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Pass [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CriticizedAccrualMember" xlink:type="locator" xlink:label="mtb_CriticizedAccrualMember" />
    <label xml:lang="en-US" xlink:label="mtb_CriticizedAccrualMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Criticized accrual.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CriticizedAccrualMember" xlink:to="mtb_CriticizedAccrualMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CriticizedAccrualMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Criticized Accrual [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_CriticizedAccrualMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Criticized Accrual [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CriticizedNonaccrualMember" xlink:type="locator" xlink:label="mtb_CriticizedNonaccrualMember" />
    <label xml:lang="en-US" xlink:label="mtb_CriticizedNonaccrualMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Criticized nonaccrual.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CriticizedNonaccrualMember" xlink:to="mtb_CriticizedNonaccrualMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CriticizedNonaccrualMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Criticized Nonaccrual [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_CriticizedNonaccrualMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Criticized Nonaccrual [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancingReceivableRecordedInvestmentLineItems" xlink:type="locator" xlink:label="us-gaap_FinancingReceivableRecordedInvestmentLineItems" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableRecordedInvestmentLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financing Receivable, Recorded Investment [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancingReceivableRecordedInvestmentLineItems" xlink:to="us-gaap_FinancingReceivableRecordedInvestmentLineItems_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableRecordedInvestmentLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Recorded Investment [Line Items]</label>
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loans and leases, net of unearned discount</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_MinimumDelinquencyPeriodForLoanLevelCollectabilityAnalysisConsumerMortgage" xlink:type="locator" xlink:label="mtb_MinimumDelinquencyPeriodForLoanLevelCollectabilityAnalysisConsumerMortgage" />
    <label xml:lang="en-US" xlink:label="mtb_MinimumDelinquencyPeriodForLoanLevelCollectabilityAnalysisConsumerMortgage_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Minimum delinquency period threshold at which residential real estate loans and outstanding balances of home equity lines of credit are generally evaluated for collectability on a loan-by-loan basis giving consideration to estimated collateral values.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_MinimumDelinquencyPeriodForLoanLevelCollectabilityAnalysisConsumerMortgage" xlink:to="mtb_MinimumDelinquencyPeriodForLoanLevelCollectabilityAnalysisConsumerMortgage_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_LoansAndLeasesReceivableNetOfPartialChargeOff" xlink:type="locator" xlink:label="mtb_LoansAndLeasesReceivableNetOfPartialChargeOff" />
    <label xml:lang="en-US" xlink:label="mtb_LoansAndLeasesReceivableNetOfPartialChargeOff_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Loans and leases receivable net of partial charge off.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_LoansAndLeasesReceivableNetOfPartialChargeOff" xlink:to="mtb_LoansAndLeasesReceivableNetOfPartialChargeOff_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_MortgageLoansOnRealEstateNotRequiringChargeOffDueToCollateralCarryingAmount" xlink:type="locator" xlink:label="mtb_MortgageLoansOnRealEstateNotRequiringChargeOffDueToCollateralCarryingAmount" />
    <label xml:lang="en-US" xlink:label="mtb_MortgageLoansOnRealEstateNotRequiringChargeOffDueToCollateralCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The carrying amount of the outstanding balance due under mortgage loans that were more than 150 days past due but did not require a partial charge off because the net realizable value of the collateral exceeded the outstanding customer balance.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_MortgageLoansOnRealEstateNotRequiringChargeOffDueToCollateralCarryingAmount" xlink:to="mtb_MortgageLoansOnRealEstateNotRequiringChargeOffDueToCollateralCarryingAmount_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_MinimumDelinquencyPeriodForLoanLevelCollectabilityAnalysisConsumerMortgage_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Minimum delinquency period for loan level collectability analysis consumer mortgage</label>
    <label xml:lang="en-US" xlink:label="mtb_MinimumDelinquencyPeriodForLoanLevelCollectabilityAnalysisConsumerMortgage_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Minimum Delinquency Period For Loan Level Collectability Analysis Consumer Mortgage</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansAndLeasesReceivableNetOfPartialChargeOff_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Carrying value of loans for which partial charge-off has been recognized</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansAndLeasesReceivableNetOfPartialChargeOff_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans And Leases Receivable Net Of Partial Charge Off</label>
    <label xml:lang="en-US" xlink:label="mtb_MortgageLoansOnRealEstateNotRequiringChargeOffDueToCollateralCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Mortgage loans on real real estate not requiring charge off due to collateral carrying amount</label>
    <label xml:lang="en-US" xlink:label="mtb_MortgageLoansOnRealEstateNotRequiringChargeOffDueToCollateralCarryingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Mortgage Loans On Real Estate Not Requiring Charge Off Due To Collateral Carrying Amount</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommercialRealEstateMember" xlink:type="locator" xlink:label="us-gaap_CommercialRealEstateMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_CommercialRealEstateMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial Real Estate [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CommercialRealEstateMember" xlink:to="us-gaap_CommercialRealEstateMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CommercialRealEstateMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commercial Real Estate [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConsumerLoanMember" xlink:type="locator" xlink:label="us-gaap_ConsumerLoanMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConsumerLoanMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Consumer Loans [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ConsumerLoanMember" xlink:to="us-gaap_ConsumerLoanMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConsumerLoanMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Consumer Loan [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_AllocatedMember" xlink:type="locator" xlink:label="mtb_AllocatedMember" />
    <label xml:lang="en-US" xlink:label="mtb_AllocatedMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Allocated.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_AllocatedMember" xlink:to="mtb_AllocatedMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_AllocatedMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Allocated [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_AllocatedMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Allocated [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityAxis" xlink:type="locator" xlink:label="us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Receivables Acquired with Deteriorated Credit Quality</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityAxis" xlink:to="us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Receivables Acquired With Deteriorated Credit Quality [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityDomain" xlink:type="locator" xlink:label="us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Receivables Acquired with Deteriorated Credit Quality</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityDomain" xlink:to="us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Receivables Acquired With Deteriorated Credit Quality [Domain]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityMember" xlink:type="locator" xlink:label="us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Receivables Acquired with Deteriorated Credit Quality [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityMember" xlink:to="us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ReceivablesAcquiredWithDeterioratedCreditQualityMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Receivables Acquired With Deteriorated Credit Quality [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesIndividuallyEvaluatedForImpairment1" xlink:type="locator" xlink:label="us-gaap_FinancingReceivableAllowanceForCreditLossesIndividuallyEvaluatedForImpairment1" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableAllowanceForCreditLossesIndividuallyEvaluatedForImpairment1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Allowance for credit losses</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancingReceivableAllowanceForCreditLossesIndividuallyEvaluatedForImpairment1" xlink:to="us-gaap_FinancingReceivableAllowanceForCreditLossesIndividuallyEvaluatedForImpairment1_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableAllowanceForCreditLossesIndividuallyEvaluatedForImpairment1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Allowance For Credit Losses Individually Evaluated For Impairment1</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesCollectivelyEvaluatedForImpairment" xlink:type="locator" xlink:label="us-gaap_FinancingReceivableAllowanceForCreditLossesCollectivelyEvaluatedForImpairment" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableAllowanceForCreditLossesCollectivelyEvaluatedForImpairment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Allowance for credit losses</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancingReceivableAllowanceForCreditLossesCollectivelyEvaluatedForImpairment" xlink:to="us-gaap_FinancingReceivableAllowanceForCreditLossesCollectivelyEvaluatedForImpairment_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancingReceivableAllowanceForCreditLossesCollectivelyEvaluatedForImpairment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financing Receivable Allowance For Credit Losses Collectively Evaluated For Impairment</label>
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableAllowance_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Allowance for credit losses</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_IndividuallyEvaluatedForImpairmentMember" xlink:type="locator" xlink:label="mtb_IndividuallyEvaluatedForImpairmentMember" />
    <label xml:lang="en-US" xlink:label="mtb_IndividuallyEvaluatedForImpairmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Individually evaluated for impairment.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_IndividuallyEvaluatedForImpairmentMember" xlink:to="mtb_IndividuallyEvaluatedForImpairmentMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_IndividuallyEvaluatedForImpairmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Individually Evaluated for Impairment [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_IndividuallyEvaluatedForImpairmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Individually Evaluated For Impairment [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CollectivelyEvaluatedForImpairmentMember" xlink:type="locator" xlink:label="mtb_CollectivelyEvaluatedForImpairmentMember" />
    <label xml:lang="en-US" xlink:label="mtb_CollectivelyEvaluatedForImpairmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Collectively evaluated for impairment.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CollectivelyEvaluatedForImpairmentMember" xlink:to="mtb_CollectivelyEvaluatedForImpairmentMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CollectivelyEvaluatedForImpairmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Collectively Evaluated for Impairment [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_CollectivelyEvaluatedForImpairmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Collectively Evaluated For Impairment [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_PropertyPlantAndEquipmentCapitalizedInterestCostsAbstract" xlink:type="locator" xlink:label="mtb_PropertyPlantAndEquipmentCapitalizedInterestCostsAbstract" />
    <label xml:lang="en-US" xlink:label="mtb_PropertyPlantAndEquipmentCapitalizedInterestCostsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Property plant and equipment capitalized interest costs.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_PropertyPlantAndEquipmentCapitalizedInterestCostsAbstract" xlink:to="mtb_PropertyPlantAndEquipmentCapitalizedInterestCostsAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_PropertyPlantAndEquipmentCapitalizedInterestCostsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Property Plant And Equipment Capitalized Interest Costs [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:type="locator" xlink:label="us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Property Plant And Equipment [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:to="us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Property Plant And Equipment [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:type="locator" xlink:label="us-gaap_PropertyPlantAndEquipmentByTypeAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_PropertyPlantAndEquipmentByTypeAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Property, Plant and Equipment, Type</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:to="us-gaap_PropertyPlantAndEquipmentByTypeAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PropertyPlantAndEquipmentByTypeAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Property Plant And Equipment By Type [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:type="locator" xlink:label="us-gaap_PropertyPlantAndEquipmentTypeDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_PropertyPlantAndEquipmentTypeDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Property, Plant and Equipment, Type</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:to="us-gaap_PropertyPlantAndEquipmentTypeDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PropertyPlantAndEquipmentTypeDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Property Plant And Equipment Type [Domain]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_OwnedAssetsMember" xlink:type="locator" xlink:label="mtb_OwnedAssetsMember" />
    <label xml:lang="en-US" xlink:label="mtb_OwnedAssetsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Owned assets.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_OwnedAssetsMember" xlink:to="mtb_OwnedAssetsMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_OwnedAssetsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Owned Assets [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_OwnedAssetsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Owned Assets [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AssetsHeldUnderCapitalLeasesMember" xlink:type="locator" xlink:label="us-gaap_AssetsHeldUnderCapitalLeasesMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_AssetsHeldUnderCapitalLeasesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Capital Leases [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AssetsHeldUnderCapitalLeasesMember" xlink:to="us-gaap_AssetsHeldUnderCapitalLeasesMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AssetsHeldUnderCapitalLeasesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Assets Held Under Capital Leases [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:type="locator" xlink:label="us-gaap_PropertyPlantAndEquipmentLineItems" />
    <label xml:lang="en-US" xlink:label="us-gaap_PropertyPlantAndEquipmentLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Property, Plant and Equipment [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PropertyPlantAndEquipmentLineItems" xlink:to="us-gaap_PropertyPlantAndEquipmentLineItems_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PropertyPlantAndEquipmentLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Property Plant And Equipment [Line Items]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Land" xlink:type="locator" xlink:label="us-gaap_Land" />
    <label xml:lang="en-US" xlink:label="us-gaap_Land_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Land</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_Land" xlink:to="us-gaap_Land_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_Land_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Land</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BuildingsAndImprovementsGross" xlink:type="locator" xlink:label="us-gaap_BuildingsAndImprovementsGross" />
    <label xml:lang="en-US" xlink:label="us-gaap_BuildingsAndImprovementsGross_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Buildings</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_BuildingsAndImprovementsGross" xlink:to="us-gaap_BuildingsAndImprovementsGross_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_BuildingsAndImprovementsGross_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Buildings And Improvements Gross</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LeaseholdImprovementsGross" xlink:type="locator" xlink:label="us-gaap_LeaseholdImprovementsGross" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeaseholdImprovementsGross_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Leasehold improvements</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LeaseholdImprovementsGross" xlink:to="us-gaap_LeaseholdImprovementsGross_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeaseholdImprovementsGross_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Leasehold Improvements Gross</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FurnitureAndFixturesGross" xlink:type="locator" xlink:label="us-gaap_FurnitureAndFixturesGross" />
    <label xml:lang="en-US" xlink:label="us-gaap_FurnitureAndFixturesGross_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Furniture and equipment</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FurnitureAndFixturesGross" xlink:to="us-gaap_FurnitureAndFixturesGross_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FurnitureAndFixturesGross_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Furniture And Fixtures Gross</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:type="locator" xlink:label="us-gaap_PropertyPlantAndEquipmentGross" />
    <label xml:lang="en-US" xlink:label="us-gaap_PropertyPlantAndEquipmentGross_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Premises and equipment, gross</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PropertyPlantAndEquipmentGross" xlink:to="us-gaap_PropertyPlantAndEquipmentGross_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PropertyPlantAndEquipmentGross_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Property Plant And Equipment Gross</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:type="locator" xlink:label="us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" />
    <label xml:lang="en-US" xlink:label="us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Less: accumulated depreciation and amortization</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:to="us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Accumulated Depreciation Depletion And Amortization Property Plant And Equipment</label>
    <label xml:lang="en-US" xlink:label="us-gaap_PropertyPlantAndEquipmentNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Premises and equipment, net</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LeaseAndRentalExpense" xlink:type="locator" xlink:label="us-gaap_LeaseAndRentalExpense" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeaseAndRentalExpense_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net lease expense for all operating leases</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LeaseAndRentalExpense" xlink:to="us-gaap_LeaseAndRentalExpense_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LeaseAndRentalExpense_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Lease And Rental Expense</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ServicingAssetAtAmortizedValueOriginations" xlink:type="locator" xlink:label="mtb_ServicingAssetAtAmortizedValueOriginations" />
    <label xml:lang="en-US" xlink:label="mtb_ServicingAssetAtAmortizedValueOriginations_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount of contract to service financial assets originated during the period, under which the benefits of servicing are expected to more than adequately compensate the servicer.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ServicingAssetAtAmortizedValueOriginations" xlink:to="mtb_ServicingAssetAtAmortizedValueOriginations_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_ServicingAssetsAtAmortizedValuePurchases" xlink:type="locator" xlink:label="mtb_ServicingAssetsAtAmortizedValuePurchases" />
    <label xml:lang="en-US" xlink:label="mtb_ServicingAssetsAtAmortizedValuePurchases_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount of contract to service financial assets purchased during the period, under which the benefits of servicing are expected to more than adequately compensate the servicer.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ServicingAssetsAtAmortizedValuePurchases" xlink:to="mtb_ServicingAssetsAtAmortizedValuePurchases_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_ServicingAssetAtAmortizedValueAdditionalDisclosuresAbstract" xlink:type="locator" xlink:label="mtb_ServicingAssetAtAmortizedValueAdditionalDisclosuresAbstract" />
    <label xml:lang="en-US" xlink:label="mtb_ServicingAssetAtAmortizedValueAdditionalDisclosuresAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Servicing Asset At Amortized Value Additional Disclosures [Abstract]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ServicingAssetAtAmortizedValueAdditionalDisclosuresAbstract" xlink:to="mtb_ServicingAssetAtAmortizedValueAdditionalDisclosuresAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_ServicingAssetAtAmortizedValueAdditionalDisclosuresAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Servicing Asset At Amortized Value Additional Disclosures [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ServicingAssetsAtAmortizedValueTable" xlink:type="locator" xlink:label="us-gaap_ServicingAssetsAtAmortizedValueTable" />
    <label xml:lang="en-US" xlink:label="us-gaap_ServicingAssetsAtAmortizedValueTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Servicing Assets At Amortized Value [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ServicingAssetsAtAmortizedValueTable" xlink:to="us-gaap_ServicingAssetsAtAmortizedValueTable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ServicingAssetsAtAmortizedValueTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Servicing Assets At Amortized Value [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CommercialLoanMember" xlink:type="locator" xlink:label="us-gaap_CommercialLoanMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_CommercialLoanMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial Mortgage Loans [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CommercialLoanMember" xlink:to="us-gaap_CommercialLoanMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CommercialLoanMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commercial Loan [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_OtherMemberMember" xlink:type="locator" xlink:label="mtb_OtherMemberMember" />
    <label xml:lang="en-US" xlink:label="mtb_OtherMemberMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other Member [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_OtherMemberMember" xlink:to="mtb_OtherMemberMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_OtherMemberMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherMemberMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Member [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ServicingAssetsAtAmortizedValueLineItems" xlink:type="locator" xlink:label="us-gaap_ServicingAssetsAtAmortizedValueLineItems" />
    <label xml:lang="en-US" xlink:label="us-gaap_ServicingAssetsAtAmortizedValueLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Servicing Asset at Amortized Cost [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ServicingAssetsAtAmortizedValueLineItems" xlink:to="us-gaap_ServicingAssetsAtAmortizedValueLineItems_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ServicingAssetsAtAmortizedValueLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Servicing Assets At Amortized Value [Line Items]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ServicingAssetAtAmortizedValue" xlink:type="locator" xlink:label="us-gaap_ServicingAssetAtAmortizedValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_ServicingAssetAtAmortizedValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Amortized value, Beginning balance</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ServicingAssetAtAmortizedValue" xlink:to="us-gaap_ServicingAssetAtAmortizedValue_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ServicingAssetAtAmortizedValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Servicing Asset At Amortized Value</label>
    <label xml:lang="en-US" xlink:label="mtb_ServicingAssetAtAmortizedValueOriginations_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Originations</label>
    <label xml:lang="en-US" xlink:label="mtb_ServicingAssetAtAmortizedValueOriginations_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Servicing Asset At Amortized Value Originations</label>
    <label xml:lang="en-US" xlink:label="mtb_ServicingAssetsAtAmortizedValuePurchases_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Purchases</label>
    <label xml:lang="en-US" xlink:label="mtb_ServicingAssetsAtAmortizedValuePurchases_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Servicing Assets At Amortized Value Purchases</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ServicingAssetAtAmortizedValueAmortization1" xlink:type="locator" xlink:label="us-gaap_ServicingAssetAtAmortizedValueAmortization1" />
    <label xml:lang="en-US" xlink:label="us-gaap_ServicingAssetAtAmortizedValueAmortization1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Amortization</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ServicingAssetAtAmortizedValueAmortization1" xlink:to="us-gaap_ServicingAssetAtAmortizedValueAmortization1_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ServicingAssetAtAmortizedValueAmortization1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Servicing Asset At Amortized Value Amortization1</label>
    <label xml:lang="en-US" xlink:label="us-gaap_ServicingAssetAtAmortizedValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Amortized value, ending balance</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ServicingAssetAtAmortizedValueValuationAllowance" xlink:type="locator" xlink:label="us-gaap_ServicingAssetAtAmortizedValueValuationAllowance" />
    <label xml:lang="en-US" xlink:label="us-gaap_ServicingAssetAtAmortizedValueValuationAllowance_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Valuation allowance</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ServicingAssetAtAmortizedValueValuationAllowance" xlink:to="us-gaap_ServicingAssetAtAmortizedValueValuationAllowance_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ServicingAssetAtAmortizedValueValuationAllowance_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Servicing Asset At Amortized Value Valuation Allowance</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ServicingAssetAtAmortizedValueFairValue" xlink:type="locator" xlink:label="us-gaap_ServicingAssetAtAmortizedValueFairValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_ServicingAssetAtAmortizedValueFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Ending balance, net</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ServicingAssetAtAmortizedValueFairValue" xlink:to="us-gaap_ServicingAssetAtAmortizedValueFairValue_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ServicingAssetAtAmortizedValueFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Servicing Asset At Amortized Value Fair Value</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_MortgageLoansServicedForOthers" xlink:type="locator" xlink:label="mtb_MortgageLoansServicedForOthers" />
    <label xml:lang="en-US" xlink:label="mtb_MortgageLoansServicedForOthers_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Mortgage loans serviced for others.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_MortgageLoansServicedForOthers" xlink:to="mtb_MortgageLoansServicedForOthers_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ServicingAssetsAtFairValueTable" xlink:type="locator" xlink:label="us-gaap_ServicingAssetsAtFairValueTable" />
    <label xml:lang="en-US" xlink:label="us-gaap_ServicingAssetsAtFairValueTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Servicing Assets At Fair Value [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ServicingAssetsAtFairValueTable" xlink:to="us-gaap_ServicingAssetsAtFairValueTable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ServicingAssetsAtFairValueTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Servicing Assets At Fair Value [Table]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SubServicingLoanMember" xlink:type="locator" xlink:label="mtb_SubServicingLoanMember" />
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    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SubServicingLoanMember" xlink:to="mtb_SubServicingLoanMember_lbl" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:type="locator" xlink:label="us-gaap_FiniteLivedIntangibleAssetsLineItems" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross" xlink:type="locator" xlink:label="us-gaap_FiniteLivedIntangibleAssetsGross" />
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    <label xml:lang="en-US" xlink:label="us-gaap_FiniteLivedIntangibleAssetsGross_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Finite Lived Intangible Assets Gross</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:type="locator" xlink:label="us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" />
    <label xml:lang="en-US" xlink:label="us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accumulated Amortization</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:to="us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Finite Lived Intangible Assets Accumulated Amortization</label>
    <label xml:lang="en-US" xlink:label="us-gaap_FiniteLivedIntangibleAssetsNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Net Carrying Amount</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_GoodwillAndOtherIntangibleAssetsLineItems" xlink:type="locator" xlink:label="mtb_GoodwillAndOtherIntangibleAssetsLineItems" />
    <label xml:lang="en-US" xlink:label="mtb_GoodwillAndOtherIntangibleAssetsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Goodwill And Other Intangible Assets [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_GoodwillAndOtherIntangibleAssetsLineItems" xlink:to="mtb_GoodwillAndOtherIntangibleAssetsLineItems_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_GoodwillAndOtherIntangibleAssetsTable" xlink:type="locator" xlink:label="mtb_GoodwillAndOtherIntangibleAssetsTable" />
    <label xml:lang="en-US" xlink:label="mtb_GoodwillAndOtherIntangibleAssetsTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Goodwill And Other Intangible Assets [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_GoodwillAndOtherIntangibleAssetsTable" xlink:to="mtb_GoodwillAndOtherIntangibleAssetsTable_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_GoodwillAndOtherIntangibleAssetsTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Goodwill And Other Intangible Assets [Table]</label>
    <label xml:lang="en-US" xlink:label="mtb_GoodwillAndOtherIntangibleAssetsTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Goodwill And Other Intangible Assets [Table]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CoreDepositsAndOtherIntangibleAssetsMember" xlink:type="locator" xlink:label="mtb_CoreDepositsAndOtherIntangibleAssetsMember" />
    <label xml:lang="en-US" xlink:label="mtb_CoreDepositsAndOtherIntangibleAssetsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Core deposits and other intangible assets .</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CoreDepositsAndOtherIntangibleAssetsMember" xlink:to="mtb_CoreDepositsAndOtherIntangibleAssetsMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CoreDepositsAndOtherIntangibleAssetsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Core Deposit and Other Intangible Assets [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_CoreDepositsAndOtherIntangibleAssetsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Core Deposits And Other Intangible Assets [Member]</label>
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    <label xml:lang="en-US" xlink:label="mtb_GoodwillAndOtherIntangibleAssetsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Goodwill And Other Intangible Assets [Line Items]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsRemainingAmortizationPeriod1" xlink:type="locator" xlink:label="us-gaap_FiniteLivedIntangibleAssetsRemainingAmortizationPeriod1" />
    <label xml:lang="en-US" xlink:label="us-gaap_FiniteLivedIntangibleAssetsRemainingAmortizationPeriod1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Remaining weighted-average amortization period</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_FiniteLivedIntangibleAssetsRemainingAmortizationPeriod1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Finite Lived Intangible Assets Remaining Amortization Period1</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" xlink:type="locator" xlink:label="us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" />
    <label xml:lang="en-US" xlink:label="us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2017</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Finite Lived Intangible Assets Amortization Expense Next Twelve Months</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" xlink:type="locator" xlink:label="us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" />
    <label xml:lang="en-US" xlink:label="us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2018</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree" xlink:type="locator" xlink:label="us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree" />
    <label xml:lang="en-US" xlink:label="us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2019</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour" xlink:type="locator" xlink:label="us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour" />
    <label xml:lang="en-US" xlink:label="us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2020</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive" xlink:type="locator" xlink:label="us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive" />
    <label xml:lang="en-US" xlink:label="us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2021</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive" xlink:type="locator" xlink:label="us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive" />
    <label xml:lang="en-US" xlink:label="us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Later years</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:type="locator" xlink:label="us-gaap_StatementBusinessSegmentsAxis" />
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    <label xml:lang="en-US" xlink:label="us-gaap_SegmentDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Segments</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_BusinessBankingMember" xlink:type="locator" xlink:label="mtb_BusinessBankingMember" />
    <label xml:lang="en-US" xlink:label="mtb_BusinessBankingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Business banking segment.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_BusinessBankingMember" xlink:to="mtb_BusinessBankingMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_BusinessBankingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Business Banking [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_BusinessBankingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Business Banking [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CommercialBankingMember" xlink:type="locator" xlink:label="mtb_CommercialBankingMember" />
    <label xml:lang="en-US" xlink:label="mtb_CommercialBankingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commercial banking segment.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommercialBankingMember" xlink:to="mtb_CommercialBankingMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CommercialBankingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial Banking [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_CommercialBankingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commercial Banking [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CommercialRealEstateSegmentMember" xlink:type="locator" xlink:label="mtb_CommercialRealEstateSegmentMember" />
    <label xml:lang="en-US" xlink:label="mtb_CommercialRealEstateSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commercial real estate segment.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommercialRealEstateSegmentMember" xlink:to="mtb_CommercialRealEstateSegmentMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CommercialRealEstateSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial Real Estate [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_CommercialRealEstateSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commercial Real Estate Segment [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_DiscretionaryPortfolioMember" xlink:type="locator" xlink:label="mtb_DiscretionaryPortfolioMember" />
    <label xml:lang="en-US" xlink:label="mtb_DiscretionaryPortfolioMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Discretionary portfolio segment.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DiscretionaryPortfolioMember" xlink:to="mtb_DiscretionaryPortfolioMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_DiscretionaryPortfolioMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Discretionary Portfolio [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_DiscretionaryPortfolioMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Discretionary Portfolio [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ResidentialMortgageBankingMember" xlink:type="locator" xlink:label="mtb_ResidentialMortgageBankingMember" />
    <label xml:lang="en-US" xlink:label="mtb_ResidentialMortgageBankingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Residential mortgage banking segment.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ResidentialMortgageBankingMember" xlink:to="mtb_ResidentialMortgageBankingMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_ResidentialMortgageBankingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Residential Mortgage Banking [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_ResidentialMortgageBankingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Residential Mortgage Banking [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_RetailBankingMember" xlink:type="locator" xlink:label="mtb_RetailBankingMember" />
    <label xml:lang="en-US" xlink:label="mtb_RetailBankingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Retail banking segment.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_RetailBankingMember" xlink:to="mtb_RetailBankingMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_RetailBankingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Retail Banking [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_RetailBankingMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Retail Banking [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AllOtherSegmentsMember" xlink:type="locator" xlink:label="us-gaap_AllOtherSegmentsMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_AllOtherSegmentsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">All Other [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AllOtherSegmentsMember" xlink:to="us-gaap_AllOtherSegmentsMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AllOtherSegmentsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">All Other Segments [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GoodwillLineItems" xlink:type="locator" xlink:label="us-gaap_GoodwillLineItems" />
    <label xml:lang="en-US" xlink:label="us-gaap_GoodwillLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Goodwill [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_GoodwillLineItems" xlink:to="us-gaap_GoodwillLineItems_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_GoodwillLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Goodwill [Line Items]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ShortTermDebtWeightedAverageInterestRateDuringPeriod" xlink:type="locator" xlink:label="mtb_ShortTermDebtWeightedAverageInterestRateDuringPeriod" />
    <label xml:lang="en-US" xlink:label="mtb_ShortTermDebtWeightedAverageInterestRateDuringPeriod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The weighted average interest of short-term borrowings during the period.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ShortTermDebtWeightedAverageInterestRateDuringPeriod" xlink:to="mtb_ShortTermDebtWeightedAverageInterestRateDuringPeriod_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_EquityMethodInvestmentsAndCostMethodInvestmentsAbstract" xlink:type="locator" xlink:label="mtb_EquityMethodInvestmentsAndCostMethodInvestmentsAbstract" />
    <label xml:lang="en-US" xlink:label="mtb_EquityMethodInvestmentsAndCostMethodInvestmentsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity Method Investments And Cost Method Investments [Abstract]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_EquityMethodInvestmentsAndCostMethodInvestmentsAbstract" xlink:to="mtb_EquityMethodInvestmentsAndCostMethodInvestmentsAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_EquityMethodInvestmentsAndCostMethodInvestmentsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Equity Method Investments And Cost Method Investments [Abstract]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ScheduleOfBorrowingsLineItems" xlink:type="locator" xlink:label="mtb_ScheduleOfBorrowingsLineItems" />
    <label xml:lang="en-US" xlink:label="mtb_ScheduleOfBorrowingsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Schedule of borrowings.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ScheduleOfBorrowingsLineItems" xlink:to="mtb_ScheduleOfBorrowingsLineItems_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_ScheduleOfBorrowingsTable" xlink:type="locator" xlink:label="mtb_ScheduleOfBorrowingsTable" />
    <label xml:lang="en-US" xlink:label="mtb_ScheduleOfBorrowingsTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Schedule of borrowings.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ScheduleOfBorrowingsTable" xlink:to="mtb_ScheduleOfBorrowingsTable_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_ScheduleOfBorrowingsTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Borrowings [Table]</label>
    <label xml:lang="en-US" xlink:label="mtb_ScheduleOfBorrowingsTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Borrowings [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShortTermDebtTypeAxis" xlink:type="locator" xlink:label="us-gaap_ShortTermDebtTypeAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShortTermDebtTypeAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Short-term Debt, Type</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ShortTermDebtTypeAxis" xlink:to="us-gaap_ShortTermDebtTypeAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShortTermDebtTypeAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Short Term Debt Type [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShortTermDebtTypeDomain" xlink:type="locator" xlink:label="us-gaap_ShortTermDebtTypeDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShortTermDebtTypeDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Short-term Debt, Type</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ShortTermDebtTypeDomain" xlink:to="us-gaap_ShortTermDebtTypeDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShortTermDebtTypeDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Short Term Debt Type [Domain]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FederalFundsPurchasedMember" xlink:type="locator" xlink:label="us-gaap_FederalFundsPurchasedMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_FederalFundsPurchasedMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Federal Funds Purchased and Repurchase Agreements [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FederalFundsPurchasedMember" xlink:to="us-gaap_FederalFundsPurchasedMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FederalFundsPurchasedMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Federal Funds Purchased [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_OtherShortTermBorrowingsMember" xlink:type="locator" xlink:label="mtb_OtherShortTermBorrowingsMember" />
    <label xml:lang="en-US" xlink:label="mtb_OtherShortTermBorrowingsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other short term borrowings.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_OtherShortTermBorrowingsMember" xlink:to="mtb_OtherShortTermBorrowingsMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_OtherShortTermBorrowingsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other Short-term Borrowings [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherShortTermBorrowingsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Short Term Borrowings [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_ScheduleOfBorrowingsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Borrowings [Line Items]</label>
    <label xml:lang="en-US" xlink:label="mtb_ScheduleOfBorrowingsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Borrowings [Line Items]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShortTermDebtWeightedAverageInterestRate" xlink:type="locator" xlink:label="us-gaap_ShortTermDebtWeightedAverageInterestRate" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShortTermDebtWeightedAverageInterestRate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted-average interest rate</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ShortTermDebtWeightedAverageInterestRate" xlink:to="us-gaap_ShortTermDebtWeightedAverageInterestRate_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShortTermDebtWeightedAverageInterestRate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Short Term Debt Weighted Average Interest Rate</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShorttermDebtMaximumMonthendOutstandingAmount" xlink:type="locator" xlink:label="us-gaap_ShorttermDebtMaximumMonthendOutstandingAmount" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShorttermDebtMaximumMonthendOutstandingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Highest amount at a month-end</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ShorttermDebtMaximumMonthendOutstandingAmount" xlink:to="us-gaap_ShorttermDebtMaximumMonthendOutstandingAmount_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShorttermDebtMaximumMonthendOutstandingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Shortterm Debt Maximum Monthend Outstanding Amount</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShorttermDebtAverageOutstandingAmount" xlink:type="locator" xlink:label="us-gaap_ShorttermDebtAverageOutstandingAmount" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShorttermDebtAverageOutstandingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Daily-average amount outstanding</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ShorttermDebtAverageOutstandingAmount" xlink:to="us-gaap_ShorttermDebtAverageOutstandingAmount_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShorttermDebtAverageOutstandingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Shortterm Debt Average Outstanding Amount</label>
    <label xml:lang="en-US" xlink:label="mtb_ShortTermDebtWeightedAverageInterestRateDuringPeriod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted-average interest rate</label>
    <label xml:lang="en-US" xlink:label="mtb_ShortTermDebtWeightedAverageInterestRateDuringPeriod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Short Term Debt Weighted Average Interest Rate During Period</label>
    <label xml:lang="en-US" xlink:label="us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Federal Funds Purchased and Repurchase Agreements</label>
    <label xml:lang="en-US" xlink:label="us-gaap_OtherShortTermBorrowings_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/positiveLabel">Other Short-term Borrowings</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShortTermBorrowings" xlink:type="locator" xlink:label="us-gaap_ShortTermBorrowings" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShortTermBorrowings_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Federal funds purchased and short term borrowings</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ShortTermBorrowings" xlink:to="us-gaap_ShortTermBorrowings_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShortTermBorrowings_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Short Term Borrowings</label>
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_LegalEntityAxis" xlink:type="locator" xlink:label="dei_LegalEntityAxis" />
    <label xml:lang="en-US" xlink:label="dei_LegalEntityAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">M&amp;T Bank [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_LegalEntityAxis" xlink:to="dei_LegalEntityAxis_lbl" />
    <label xml:lang="en-US" xlink:label="dei_LegalEntityAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Legal Entity [Axis]</label>
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:type="locator" xlink:label="dei_EntityDomain" />
    <label xml:lang="en-US" xlink:label="dei_EntityDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityDomain" xlink:to="dei_EntityDomain_lbl" />
    <label xml:lang="en-US" xlink:label="dei_EntityDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity [Domain]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_MAndTBankMember" xlink:type="locator" xlink:label="mtb_MAndTBankMember" />
    <label xml:lang="en-US" xlink:label="mtb_MAndTBankMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">M&amp;T Bank.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_MAndTBankMember" xlink:to="mtb_MAndTBankMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_MAndTBankMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">M&amp;T Bank [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_MAndTBankMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">M And T Bank [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCredit" xlink:type="locator" xlink:label="us-gaap_LineOfCredit" />
    <label xml:lang="en-US" xlink:label="us-gaap_LineOfCredit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Outstanding borrowings</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LineOfCredit" xlink:to="us-gaap_LineOfCredit_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LineOfCredit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Line Of Credit</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity" xlink:type="locator" xlink:label="us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity" />
    <label xml:lang="en-US" xlink:label="us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Unused</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity" xlink:to="us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Line Of Credit Facility Remaining Borrowing Capacity</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:type="locator" xlink:label="us-gaap_LongtermDebtTypeAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_LongtermDebtTypeAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Long-term Debt, Type</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongtermDebtTypeAxis" xlink:to="us-gaap_LongtermDebtTypeAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LongtermDebtTypeAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Longterm Debt Type [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:type="locator" xlink:label="us-gaap_LongtermDebtTypeDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_LongtermDebtTypeDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Long-term Debt, Type</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongtermDebtTypeDomain" xlink:to="us-gaap_LongtermDebtTypeDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LongtermDebtTypeDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Longterm Debt Type [Domain]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMember" xlink:type="locator" xlink:label="us-gaap_FederalHomeLoanBankAdvancesMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_FederalHomeLoanBankAdvancesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">FHLBs Facility [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FederalHomeLoanBankAdvancesMember" xlink:to="us-gaap_FederalHomeLoanBankAdvancesMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FederalHomeLoanBankAdvancesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Federal Home Loan Bank Advances [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_FederalReserveBankOfNewYorkMember" xlink:type="locator" xlink:label="mtb_FederalReserveBankOfNewYorkMember" />
    <label xml:lang="en-US" xlink:label="mtb_FederalReserveBankOfNewYorkMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Federal reserve bank of New York.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_FederalReserveBankOfNewYorkMember" xlink:to="mtb_FederalReserveBankOfNewYorkMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_FederalReserveBankOfNewYorkMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Federal Reserve Bank of New York [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_FederalReserveBankOfNewYorkMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Federal Reserve Bank Of New York [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_FloatingRateSeniorNotesMember" xlink:type="locator" xlink:label="mtb_FloatingRateSeniorNotesMember" />
    <label xml:lang="en-US" xlink:label="mtb_FloatingRateSeniorNotesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Floating rate senior notes.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_FloatingRateSeniorNotesMember" xlink:to="mtb_FloatingRateSeniorNotesMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_FloatingRateSeniorNotesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Variable Rate Senior Notes [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_FloatingRateSeniorNotesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Floating Rate Senior Notes [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_LongTermFixedRateAdvancesFromFhlbMember" xlink:type="locator" xlink:label="mtb_LongTermFixedRateAdvancesFromFhlbMember" />
    <label xml:lang="en-US" xlink:label="mtb_LongTermFixedRateAdvancesFromFhlbMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Long-term fixed rate advances from the FHLB.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_LongTermFixedRateAdvancesFromFhlbMember" xlink:to="mtb_LongTermFixedRateAdvancesFromFhlbMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_LongTermFixedRateAdvancesFromFhlbMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Long-term Fixed Rate Advances From FHLB [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_LongTermFixedRateAdvancesFromFhlbMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Long Term Fixed Rate Advances From Fhlb [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_WeightedAverageMember" xlink:type="locator" xlink:label="us-gaap_WeightedAverageMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_WeightedAverageMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted Average [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_WeightedAverageMember" xlink:to="us-gaap_WeightedAverageMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_WeightedAverageMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Weighted Average [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubordinatedDebtMember" xlink:type="locator" xlink:label="us-gaap_SubordinatedDebtMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_SubordinatedDebtMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Subordinated Capital Notes [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SubordinatedDebtMember" xlink:to="us-gaap_SubordinatedDebtMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_SubordinatedDebtMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Subordinated Debt [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SubordinatedVariableRateNotesDueTwoZeroTwoOneMember" xlink:type="locator" xlink:label="mtb_SubordinatedVariableRateNotesDueTwoZeroTwoOneMember" />
    <label xml:lang="en-US" xlink:label="mtb_SubordinatedVariableRateNotesDueTwoZeroTwoOneMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Subordinated variable rate notes due two zero two one.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SubordinatedVariableRateNotesDueTwoZeroTwoOneMember" xlink:to="mtb_SubordinatedVariableRateNotesDueTwoZeroTwoOneMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SubordinatedVariableRateNotesDueTwoZeroTwoOneMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Subordinated Variable Rate Notes Due 2021 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SubordinatedVariableRateNotesDueTwoZeroTwoOneMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Subordinated Variable Rate Notes Due Two Zero Two One [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_JuniorSubordinatedDebtMember" xlink:type="locator" xlink:label="us-gaap_JuniorSubordinatedDebtMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_JuniorSubordinatedDebtMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Junior Subordinated Debt [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_JuniorSubordinatedDebtMember" xlink:to="us-gaap_JuniorSubordinatedDebtMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_JuniorSubordinatedDebtMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Junior Subordinated Debt [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:type="locator" xlink:label="us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" />
    <label xml:lang="en-US" xlink:label="us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Borrowing facilities available with FHLB&apos;s amount</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:to="us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Line Of Credit Facility Maximum Borrowing Capacity</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LineOfCreditFacilityCurrentBorrowingCapacity" xlink:type="locator" xlink:label="us-gaap_LineOfCreditFacilityCurrentBorrowingCapacity" />
    <label xml:lang="en-US" xlink:label="us-gaap_LineOfCreditFacilityCurrentBorrowingCapacity_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Line of credit facility</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LineOfCreditFacilityCurrentBorrowingCapacity" xlink:to="us-gaap_LineOfCreditFacilityCurrentBorrowingCapacity_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LineOfCreditFacilityCurrentBorrowingCapacity_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Line Of Credit Facility Current Borrowing Capacity</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_VariableRateNotesDueTwoThousandSixteenMember" xlink:type="locator" xlink:label="mtb_VariableRateNotesDueTwoThousandSixteenMember" />
    <label xml:lang="en-US" xlink:label="mtb_VariableRateNotesDueTwoThousandSixteenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Variable rate notes due two thousand sixteen.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_VariableRateNotesDueTwoThousandSixteenMember" xlink:to="mtb_VariableRateNotesDueTwoThousandSixteenMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_VariableRateNotesDueTwoThousandSixteenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Variable Rate Notes Due 2016 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_VariableRateNotesDueTwoThousandSixteenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Variable Rate Notes Due Two Thousand Sixteen [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_VariableRateTermLoansDueTwoThousandSeventeenMember" xlink:type="locator" xlink:label="mtb_VariableRateTermLoansDueTwoThousandSeventeenMember" />
    <label xml:lang="en-US" xlink:label="mtb_VariableRateTermLoansDueTwoThousandSeventeenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Variable rate term loans due two thousand seventeen.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_VariableRateTermLoansDueTwoThousandSeventeenMember" xlink:to="mtb_VariableRateTermLoansDueTwoThousandSeventeenMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_VariableRateTermLoansDueTwoThousandSeventeenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Variable Rate Term Loans Due 2017 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_VariableRateTermLoansDueTwoThousandSeventeenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Variable Rate Term Loans Due Two Thousand Seventeen [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SeniorNotesDueTwoThousandSeventeenOneMember" xlink:type="locator" xlink:label="mtb_SeniorNotesDueTwoThousandSeventeenOneMember" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandSeventeenOneMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Senior notes due two thousand seventeen one.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SeniorNotesDueTwoThousandSeventeenOneMember" xlink:to="mtb_SeniorNotesDueTwoThousandSeventeenOneMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandSeventeenOneMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">1.25% Due 2017 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandSeventeenOneMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Senior Notes Due Two Thousand Seventeen One [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SeniorNotesDueTwoThousandSeventeenTwoMember" xlink:type="locator" xlink:label="mtb_SeniorNotesDueTwoThousandSeventeenTwoMember" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandSeventeenTwoMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Senior notes due two thousand seventeen two.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SeniorNotesDueTwoThousandSeventeenTwoMember" xlink:to="mtb_SeniorNotesDueTwoThousandSeventeenTwoMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandSeventeenTwoMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">1.40% Due 2017 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandSeventeenTwoMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Senior Notes Due Two Thousand Seventeen Two [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SeniorNotesDueTwoThousandEighteenMember" xlink:type="locator" xlink:label="mtb_SeniorNotesDueTwoThousandEighteenMember" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandEighteenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Senior notes due two thousand eighteen.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SeniorNotesDueTwoThousandEighteenMember" xlink:to="mtb_SeniorNotesDueTwoThousandEighteenMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandEighteenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">1.45% Due 2018 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandEighteenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Senior Notes Due Two Thousand Eighteen [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SeniorNotesDueTwoThousandNineteenOneMember" xlink:type="locator" xlink:label="mtb_SeniorNotesDueTwoThousandNineteenOneMember" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandNineteenOneMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Senior notes due two thousand nineteen one.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SeniorNotesDueTwoThousandNineteenOneMember" xlink:to="mtb_SeniorNotesDueTwoThousandNineteenOneMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandNineteenOneMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2.25% Due 2019 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandNineteenOneMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Senior Notes Due Two Thousand Nineteen One [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SeniorNotesDueTwoThousandNineteenTwoMember" xlink:type="locator" xlink:label="mtb_SeniorNotesDueTwoThousandNineteenTwoMember" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandNineteenTwoMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Senior notes due two thousand nineteen two.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SeniorNotesDueTwoThousandNineteenTwoMember" xlink:to="mtb_SeniorNotesDueTwoThousandNineteenTwoMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandNineteenTwoMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2.30% Due 2019 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandNineteenTwoMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Senior Notes Due Two Thousand Nineteen Two [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SeniorNotesDueTwoThousandTwentyMember" xlink:type="locator" xlink:label="mtb_SeniorNotesDueTwoThousandTwentyMember" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandTwentyMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Senior notes due two thousand twenty.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SeniorNotesDueTwoThousandTwentyMember" xlink:to="mtb_SeniorNotesDueTwoThousandTwentyMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandTwentyMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2.10% Due 2020 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandTwentyMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Senior Notes Due Two Thousand Twenty [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SeniorNotesDueTwoThousandTwentyFiveMember" xlink:type="locator" xlink:label="mtb_SeniorNotesDueTwoThousandTwentyFiveMember" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandTwentyFiveMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Senior notes due two thousand twenty five.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SeniorNotesDueTwoThousandTwentyFiveMember" xlink:to="mtb_SeniorNotesDueTwoThousandTwentyFiveMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandTwentyFiveMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2.90% Due 2025 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandTwentyFiveMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Senior Notes Due Two Thousand Twenty Five [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_WilmingtonDueTwoZeroOneEightMember" xlink:type="locator" xlink:label="mtb_WilmingtonDueTwoZeroOneEightMember" />
    <label xml:lang="en-US" xlink:label="mtb_WilmingtonDueTwoZeroOneEightMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Wilmington due two zero one eight.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_WilmingtonDueTwoZeroOneEightMember" xlink:to="mtb_WilmingtonDueTwoZeroOneEightMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_WilmingtonDueTwoZeroOneEightMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">8.5% due 2018 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_WilmingtonDueTwoZeroOneEightMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Wilmington Due Two Zero One Eight [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SubordinatedNotesDueTwoZeroOneSevenMember" xlink:type="locator" xlink:label="mtb_SubordinatedNotesDueTwoZeroOneSevenMember" />
    <label xml:lang="en-US" xlink:label="mtb_SubordinatedNotesDueTwoZeroOneSevenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">6.625% due 2017.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SubordinatedNotesDueTwoZeroOneSevenMember" xlink:to="mtb_SubordinatedNotesDueTwoZeroOneSevenMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SubordinatedNotesDueTwoZeroOneSevenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">6.625% due 2017 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SubordinatedNotesDueTwoZeroOneSevenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Subordinated Notes Due Two Zero One Seven [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SubordinatedNotesDueTwoZeroTwoZeroVariableRateCommencingTwoZeroOneFiveMember" xlink:type="locator" xlink:label="mtb_SubordinatedNotesDueTwoZeroTwoZeroVariableRateCommencingTwoZeroOneFiveMember" />
    <label xml:lang="en-US" xlink:label="mtb_SubordinatedNotesDueTwoZeroTwoZeroVariableRateCommencingTwoZeroOneFiveMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">5.585% due 2020, variable rate commencing 2015.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SubordinatedNotesDueTwoZeroTwoZeroVariableRateCommencingTwoZeroOneFiveMember" xlink:to="mtb_SubordinatedNotesDueTwoZeroTwoZeroVariableRateCommencingTwoZeroOneFiveMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SubordinatedNotesDueTwoZeroTwoZeroVariableRateCommencingTwoZeroOneFiveMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">5.585% due 2020, Variable Rate Commenced 2015 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SubordinatedNotesDueTwoZeroTwoZeroVariableRateCommencingTwoZeroOneFiveMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Subordinated Notes Due Two Zero Two Zero Variable Rate Commencing Two Zero One Five [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SubordinatedNotesDueTwoZeroTwoOneVariableRateCommencedTwoZeroOneSixMember" xlink:type="locator" xlink:label="mtb_SubordinatedNotesDueTwoZeroTwoOneVariableRateCommencedTwoZeroOneSixMember" />
    <label xml:lang="en-US" xlink:label="mtb_SubordinatedNotesDueTwoZeroTwoOneVariableRateCommencedTwoZeroOneSixMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">5.629% due 2021, variable rate commenced 2016.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SubordinatedNotesDueTwoZeroTwoOneVariableRateCommencedTwoZeroOneSixMember" xlink:to="mtb_SubordinatedNotesDueTwoZeroTwoOneVariableRateCommencedTwoZeroOneSixMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SubordinatedNotesDueTwoZeroTwoOneVariableRateCommencedTwoZeroOneSixMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">5.629% due 2021, Variable Rate Commenced 2016 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SubordinatedNotesDueTwoZeroTwoOneVariableRateCommencedTwoZeroOneSixMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Subordinated Notes Due Two Zero Two One Variable Rate Commenced Two Zero One Six [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_BsbCapitalTrustOneFixedRatesDueTwoZeroTwoEightMember" xlink:type="locator" xlink:label="mtb_BsbCapitalTrustOneFixedRatesDueTwoZeroTwoEightMember" />
    <label xml:lang="en-US" xlink:label="mtb_BsbCapitalTrustOneFixedRatesDueTwoZeroTwoEightMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">BSB Capital Trust I - 8.125%, due 2028.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_BsbCapitalTrustOneFixedRatesDueTwoZeroTwoEightMember" xlink:to="mtb_BsbCapitalTrustOneFixedRatesDueTwoZeroTwoEightMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_BsbCapitalTrustOneFixedRatesDueTwoZeroTwoEightMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">BSB Capital Trust I - 8.125%, due 2028 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_BsbCapitalTrustOneFixedRatesDueTwoZeroTwoEightMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Bsb Capital Trust One Fixed Rates Due Two Zero Two Eight [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ProvidentTrustOneFixedRatesDueTwoZeroTwoEightMember" xlink:type="locator" xlink:label="mtb_ProvidentTrustOneFixedRatesDueTwoZeroTwoEightMember" />
    <label xml:lang="en-US" xlink:label="mtb_ProvidentTrustOneFixedRatesDueTwoZeroTwoEightMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Provident Trust I - 8.29%, due 2028.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ProvidentTrustOneFixedRatesDueTwoZeroTwoEightMember" xlink:to="mtb_ProvidentTrustOneFixedRatesDueTwoZeroTwoEightMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_ProvidentTrustOneFixedRatesDueTwoZeroTwoEightMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Provident Trust I - 8.29%, due 2028 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_ProvidentTrustOneFixedRatesDueTwoZeroTwoEightMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Provident Trust One Fixed Rates Due Two Zero Two Eight [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SouthernFinancialStatutoryTrustOneFixedRatesDueTwoZeroThreeZeroMember" xlink:type="locator" xlink:label="mtb_SouthernFinancialStatutoryTrustOneFixedRatesDueTwoZeroThreeZeroMember" />
    <label xml:lang="en-US" xlink:label="mtb_SouthernFinancialStatutoryTrustOneFixedRatesDueTwoZeroThreeZeroMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Southern Financial Statutory Trust I - 10.60%, due 2030.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SouthernFinancialStatutoryTrustOneFixedRatesDueTwoZeroThreeZeroMember" xlink:to="mtb_SouthernFinancialStatutoryTrustOneFixedRatesDueTwoZeroThreeZeroMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SouthernFinancialStatutoryTrustOneFixedRatesDueTwoZeroThreeZeroMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Southern Financial Statutory Trust I - 10.60%, due 2030 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SouthernFinancialStatutoryTrustOneFixedRatesDueTwoZeroThreeZeroMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Southern Financial Statutory Trust One Fixed Rates Due Two Zero Three Zero [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_FirstMarylandCapitalOneVariableRatesDueTwoZeroTwoSevenMember" xlink:type="locator" xlink:label="mtb_FirstMarylandCapitalOneVariableRatesDueTwoZeroTwoSevenMember" />
    <label xml:lang="en-US" xlink:label="mtb_FirstMarylandCapitalOneVariableRatesDueTwoZeroTwoSevenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">First Maryland Capital I variable rates due 2027.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_FirstMarylandCapitalOneVariableRatesDueTwoZeroTwoSevenMember" xlink:to="mtb_FirstMarylandCapitalOneVariableRatesDueTwoZeroTwoSevenMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_FirstMarylandCapitalOneVariableRatesDueTwoZeroTwoSevenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">First Maryland Capital I - due 2027 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_FirstMarylandCapitalOneVariableRatesDueTwoZeroTwoSevenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">First Maryland Capital One Variable Rates Due Two Zero Two Seven [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_FirstMarylandCapitalTwoVariableRatesDueTwoZeroTwoSevenMember" xlink:type="locator" xlink:label="mtb_FirstMarylandCapitalTwoVariableRatesDueTwoZeroTwoSevenMember" />
    <label xml:lang="en-US" xlink:label="mtb_FirstMarylandCapitalTwoVariableRatesDueTwoZeroTwoSevenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">First Maryland Capital II - due 2027.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_FirstMarylandCapitalTwoVariableRatesDueTwoZeroTwoSevenMember" xlink:to="mtb_FirstMarylandCapitalTwoVariableRatesDueTwoZeroTwoSevenMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_FirstMarylandCapitalTwoVariableRatesDueTwoZeroTwoSevenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">First Maryland Capital II - due 2027 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_FirstMarylandCapitalTwoVariableRatesDueTwoZeroTwoSevenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">First Maryland Capital Two Variable Rates Due Two Zero Two Seven [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_AllfirstAssetTrustVariableRatesDueTwoZeroTwoNineMember" xlink:type="locator" xlink:label="mtb_AllfirstAssetTrustVariableRatesDueTwoZeroTwoNineMember" />
    <label xml:lang="en-US" xlink:label="mtb_AllfirstAssetTrustVariableRatesDueTwoZeroTwoNineMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Allfirst Asset Trust - due 2029.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_AllfirstAssetTrustVariableRatesDueTwoZeroTwoNineMember" xlink:to="mtb_AllfirstAssetTrustVariableRatesDueTwoZeroTwoNineMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_AllfirstAssetTrustVariableRatesDueTwoZeroTwoNineMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Allfirst Asset Trust - due 2029 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_AllfirstAssetTrustVariableRatesDueTwoZeroTwoNineMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Allfirst Asset Trust Variable Rates Due Two Zero Two Nine [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_BsbCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember" xlink:type="locator" xlink:label="mtb_BsbCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember" />
    <label xml:lang="en-US" xlink:label="mtb_BsbCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">BSB Capital Trust III - due 2033.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_BsbCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember" xlink:to="mtb_BsbCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_BsbCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">BSB Capital Trust III - due 2033 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_BsbCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Bsb Capital Trust Three Variable Rate Due Two Zero Three Three [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ProvidentTrustThreeStatutoryRateDueTwoZeroThreeThreeMember" xlink:type="locator" xlink:label="mtb_ProvidentTrustThreeStatutoryRateDueTwoZeroThreeThreeMember" />
    <label xml:lang="en-US" xlink:label="mtb_ProvidentTrustThreeStatutoryRateDueTwoZeroThreeThreeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Provident Trust three statutory rate due two zero three three.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ProvidentTrustThreeStatutoryRateDueTwoZeroThreeThreeMember" xlink:to="mtb_ProvidentTrustThreeStatutoryRateDueTwoZeroThreeThreeMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_ProvidentTrustThreeStatutoryRateDueTwoZeroThreeThreeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Provident Statutory Trust III - Due 2033 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_ProvidentTrustThreeStatutoryRateDueTwoZeroThreeThreeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Provident Trust Three Statutory Rate Due Two Zero Three Three [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SouthernFinancialCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember" xlink:type="locator" xlink:label="mtb_SouthernFinancialCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember" />
    <label xml:lang="en-US" xlink:label="mtb_SouthernFinancialCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Southern Financial Capital Trust III - due 2033.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SouthernFinancialCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember" xlink:to="mtb_SouthernFinancialCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SouthernFinancialCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Southern Financial Capital Trust III - due 2033 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SouthernFinancialCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Southern Financial Capital Trust Three Variable Rate Due Two Zero Three Three [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_UnsecuredDebt" xlink:type="locator" xlink:label="us-gaap_UnsecuredDebt" />
    <label xml:lang="en-US" xlink:label="us-gaap_UnsecuredDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Variable rates</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_UnsecuredDebt" xlink:to="us-gaap_UnsecuredDebt_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_UnsecuredDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Unsecured Debt</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryByInterestRateTypeFixedRate" xlink:type="locator" xlink:label="us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryByInterestRateTypeFixedRate" />
    <label xml:lang="en-US" xlink:label="us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryByInterestRateTypeFixedRate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fixed rates</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryByInterestRateTypeFixedRate" xlink:to="us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryByInterestRateTypeFixedRate_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FederalHomeLoanBankAdvancesMaturitiesSummaryByInterestRateTypeFixedRate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Federal Home Loan Bank Advances Maturities Summary By Interest Rate Type Fixed Rate</label>
    <loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentRepurchaseAgreementAmountToBeReceived" xlink:type="locator" xlink:label="invest_InvestmentRepurchaseAgreementAmountToBeReceived" />
    <label xml:lang="en-US" xlink:label="invest_InvestmentRepurchaseAgreementAmountToBeReceived_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Agreements to repurchase securities</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="invest_InvestmentRepurchaseAgreementAmountToBeReceived" xlink:to="invest_InvestmentRepurchaseAgreementAmountToBeReceived_lbl" />
    <label xml:lang="en-US" xlink:label="invest_InvestmentRepurchaseAgreementAmountToBeReceived_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Investment Repurchase Agreement Amount To Be Received</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SubordinatedDebt" xlink:type="locator" xlink:label="us-gaap_SubordinatedDebt" />
    <label xml:lang="en-US" xlink:label="us-gaap_SubordinatedDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Subordinated notes</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SubordinatedDebt" xlink:to="us-gaap_SubordinatedDebt_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_SubordinatedDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Subordinated Debt</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_JuniorSubordinatedDebentureOwedToUnconsolidatedSubsidiaryTrust" xlink:type="locator" xlink:label="us-gaap_JuniorSubordinatedDebentureOwedToUnconsolidatedSubsidiaryTrust" />
    <label xml:lang="en-US" xlink:label="us-gaap_JuniorSubordinatedDebentureOwedToUnconsolidatedSubsidiaryTrust_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Junior subordinated debentures associated with preferred capital securities</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_JuniorSubordinatedDebentureOwedToUnconsolidatedSubsidiaryTrust" xlink:to="us-gaap_JuniorSubordinatedDebentureOwedToUnconsolidatedSubsidiaryTrust_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_JuniorSubordinatedDebentureOwedToUnconsolidatedSubsidiaryTrust_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Junior Subordinated Debenture Owed To Unconsolidated Subsidiary Trust</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherLongTermDebt" xlink:type="locator" xlink:label="us-gaap_OtherLongTermDebt" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherLongTermDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherLongTermDebt" xlink:to="us-gaap_OtherLongTermDebt_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherLongTermDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Long Term Debt</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_DebtInstrumentMaturityYear" xlink:type="locator" xlink:label="mtb_DebtInstrumentMaturityYear" />
    <label xml:lang="en-US" xlink:label="mtb_DebtInstrumentMaturityYear_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Debt instrument maturity year.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DebtInstrumentMaturityYear" xlink:to="mtb_DebtInstrumentMaturityYear_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_SeniorNotesDueTwoThousandAndSixteenMember" xlink:type="locator" xlink:label="mtb_SeniorNotesDueTwoThousandAndSixteenMember" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandAndSixteenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Senior notes due two thousand and sixteen.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SeniorNotesDueTwoThousandAndSixteenMember" xlink:to="mtb_SeniorNotesDueTwoThousandAndSixteenMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandAndSixteenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Variable Rate Due 2016 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandAndSixteenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Senior Notes Due Two Thousand And Sixteen [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SeniorNotesDueTwoThousandAndSeventeenMember" xlink:type="locator" xlink:label="mtb_SeniorNotesDueTwoThousandAndSeventeenMember" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandAndSeventeenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Senior notes due two thousand and seventeen.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SeniorNotesDueTwoThousandAndSeventeenMember" xlink:to="mtb_SeniorNotesDueTwoThousandAndSeventeenMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandAndSeventeenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Senior Notes Due 2017 [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SeniorNotesDueTwoThousandAndSeventeenMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Senior Notes Due Two Thousand And Seventeen [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_DebtInstrumentMaturityYear_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Debt maturity date</label>
    <label xml:lang="en-US" xlink:label="mtb_DebtInstrumentMaturityYear_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Debt Instrument Maturity Year</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:type="locator" xlink:label="us-gaap_DebtInstrumentInterestRateStatedPercentage" />
    <label xml:lang="en-US" xlink:label="us-gaap_DebtInstrumentInterestRateStatedPercentage_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest rate of debt instrument</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:to="us-gaap_DebtInstrumentInterestRateStatedPercentage_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DebtInstrumentInterestRateStatedPercentage_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Debt Instrument Interest Rate Stated Percentage</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DebtInstrumentMaturityDateRangeStart1" xlink:type="locator" xlink:label="us-gaap_DebtInstrumentMaturityDateRangeStart1" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_WeightedAverageContractualInterestRatesOfLongTermAgreementsToRepurchaseSecurities" xlink:type="locator" xlink:label="mtb_WeightedAverageContractualInterestRatesOfLongTermAgreementsToRepurchaseSecurities" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_RepurchaseDatesOfLongTermAgreementsOutstanding" xlink:type="locator" xlink:label="mtb_RepurchaseDatesOfLongTermAgreementsOutstanding" />
    <label xml:lang="en-US" xlink:label="mtb_RepurchaseDatesOfLongTermAgreementsOutstanding_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Latest year in which includes a repurchase date to repurchase securities resulting from long term agreements.</label>
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    <label xml:lang="en-US" xlink:label="mtb_MaximumContractualInterestRatesOfLongTermAgreementsToRepurchaseSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Maximum contractual interest rates of long-term agreements to repurchase securities</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseFairValueOfCollateral" xlink:type="locator" xlink:label="us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseFairValueOfCollateral" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_TrustPreferredSecuritiesIncludedInTierOneCapitalPercent" xlink:type="locator" xlink:label="mtb_TrustPreferredSecuritiesIncludedInTierOneCapitalPercent" />
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    <label xml:lang="en-US" xlink:label="us-gaap_DebtInstrumentMaturityDateRangeStart1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Debt Maturity, Start Year</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths" xlink:type="locator" xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths" />
    <label xml:lang="en-US" xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2017</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo" xlink:type="locator" xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo" />
    <label xml:lang="en-US" xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2018</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree" xlink:type="locator" xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour" xlink:type="locator" xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive" xlink:type="locator" xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive" />
    <label xml:lang="en-US" xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2021</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Later years</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_ClassOfStockLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class of Stock [Line Items]</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_ClassOfStockLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Stock [Line Items]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SeriesAFixedRateCumulativePerpetualPreferredStockMember" xlink:type="locator" xlink:label="mtb_SeriesAFixedRateCumulativePerpetualPreferredStockMember" />
    <label xml:lang="en-US" xlink:label="mtb_SeriesAFixedRateCumulativePerpetualPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Series A fixed rate cumulative perpetual preferred stock.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SeriesAFixedRateCumulativePerpetualPreferredStockMember" xlink:to="mtb_SeriesAFixedRateCumulativePerpetualPreferredStockMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SeriesAFixedRateCumulativePerpetualPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series A Fixed Rate Cumulative Perpetual Preferred Stock [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SeriesAFixedRateCumulativePerpetualPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Series A Fixed Rate Cumulative Perpetual Preferred Stock [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SeriesCFixedRateCumulativePerpetualPreferredStockMember" xlink:type="locator" xlink:label="mtb_SeriesCFixedRateCumulativePerpetualPreferredStockMember" />
    <label xml:lang="en-US" xlink:label="mtb_SeriesCFixedRateCumulativePerpetualPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Series C fixed rate cumulative perpetual preferred stock.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SeriesCFixedRateCumulativePerpetualPreferredStockMember" xlink:to="mtb_SeriesCFixedRateCumulativePerpetualPreferredStockMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SeriesCFixedRateCumulativePerpetualPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series C Fixed Rate Cumulative Perpetual Preferred Stock [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SeriesCFixedRateCumulativePerpetualPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Series C Fixed Rate Cumulative Perpetual Preferred Stock [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SeriesDFixedRateNonCumulativePerpetualPreferredStockMember" xlink:type="locator" xlink:label="mtb_SeriesDFixedRateNonCumulativePerpetualPreferredStockMember" />
    <label xml:lang="en-US" xlink:label="mtb_SeriesDFixedRateNonCumulativePerpetualPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Series D fixed rate non-cumulative perpetual preferred stock.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SeriesDFixedRateNonCumulativePerpetualPreferredStockMember" xlink:to="mtb_SeriesDFixedRateNonCumulativePerpetualPreferredStockMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SeriesDFixedRateNonCumulativePerpetualPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series D Fixed Rate Non-cumulative Perpetual Preferred Stock [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SeriesDFixedRateNonCumulativePerpetualPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Series D Fixed Rate Non Cumulative Perpetual Preferred Stock [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SeriesEFixedToFloatingRateNonCumulativePerpetualPreferredStockMember" xlink:type="locator" xlink:label="mtb_SeriesEFixedToFloatingRateNonCumulativePerpetualPreferredStockMember" />
    <label xml:lang="en-US" xlink:label="mtb_SeriesEFixedToFloatingRateNonCumulativePerpetualPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Series E fixed to floating rate non cumulative perpetual preferred stock.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SeriesEFixedToFloatingRateNonCumulativePerpetualPreferredStockMember" xlink:to="mtb_SeriesEFixedToFloatingRateNonCumulativePerpetualPreferredStockMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SeriesEFixedToFloatingRateNonCumulativePerpetualPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series E Fixed-to-Floating Rate Non-Cumulative Perpetual Preferred Stock [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SeriesEFixedToFloatingRateNonCumulativePerpetualPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Series E Fixed To Floating Rate Non Cumulative Perpetual Preferred Stock [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SeriesFFixedToFloatingRateNonCumulativePerpetualPreferredStockMember" xlink:type="locator" xlink:label="mtb_SeriesFFixedToFloatingRateNonCumulativePerpetualPreferredStockMember" />
    <label xml:lang="en-US" xlink:label="mtb_SeriesFFixedToFloatingRateNonCumulativePerpetualPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Series F fixed-to-floating rate non-cumulative perpetual preferred stock.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SeriesFFixedToFloatingRateNonCumulativePerpetualPreferredStockMember" xlink:to="mtb_SeriesFFixedToFloatingRateNonCumulativePerpetualPreferredStockMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SeriesFFixedToFloatingRateNonCumulativePerpetualPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Series F Fixed-to-Floating Rate Non-Cumulative Perpetual Preferred Stock [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SeriesFFixedToFloatingRateNonCumulativePerpetualPreferredStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Series F Fixed To Floating Rate Non Cumulative Perpetual Preferred Stock [Member]</label>
    <label xml:lang="en-US" xlink:label="us-gaap_PreferredStockSharesIssued_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Preferred stock, Shares Issued</label>
    <label xml:lang="en-US" xlink:label="us-gaap_PreferredStockSharesOutstanding_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Preferred stock, Shares Outstanding</label>
    <label xml:lang="en-US" xlink:label="us-gaap_PreferredStockValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Carrying value</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ClassOfWarrantOrRightExpirationYear" xlink:type="locator" xlink:label="mtb_ClassOfWarrantOrRightExpirationYear" />
    <label xml:lang="en-US" xlink:label="mtb_ClassOfWarrantOrRightExpirationYear_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Class Of Warrant Or Right Expiration Year</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ClassOfWarrantOrRightExpirationYear" xlink:to="mtb_ClassOfWarrantOrRightExpirationYear_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PreferredStockDividendRatePercentage" xlink:type="locator" xlink:label="us-gaap_PreferredStockDividendRatePercentage" />
    <label xml:lang="en-US" xlink:label="us-gaap_PreferredStockDividendRatePercentage_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Preferred stock dividend rate</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PreferredStockDividendRatePercentage" xlink:to="us-gaap_PreferredStockDividendRatePercentage_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PreferredStockDividendRatePercentage_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock Dividend Rate Percentage</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:type="locator" xlink:label="us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" />
    <label xml:lang="en-US" xlink:label="us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Exercise price of each class of warrants or rights outstanding</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:to="us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ClassOfWarrantOrRightOutstanding" xlink:type="locator" xlink:label="us-gaap_ClassOfWarrantOrRightOutstanding" />
    <label xml:lang="en-US" xlink:label="us-gaap_ClassOfWarrantOrRightOutstanding_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrants and rights outstanding</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ClassOfWarrantOrRightOutstanding" xlink:to="us-gaap_ClassOfWarrantOrRightOutstanding_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ClassOfWarrantOrRightOutstanding_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Outstanding</label>
    <label xml:lang="en-US" xlink:label="mtb_ClassOfWarrantOrRightExpirationYear_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Warrants, year of expiration</label>
    <label xml:lang="en-US" xlink:label="mtb_ClassOfWarrantOrRightExpirationYear_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Class Of Warrant Or Right Expiration Year</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_PreferredStockRedemptionPeriodAfterStockDisqualifiesAsTierICapital" xlink:type="locator" xlink:label="mtb_PreferredStockRedemptionPeriodAfterStockDisqualifiesAsTierICapital" />
    <label xml:lang="en-US" xlink:label="mtb_PreferredStockRedemptionPeriodAfterStockDisqualifiesAsTierICapital_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Preferred stock redemption period after stock disqualifies as tier I capital</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_PreferredStockRedemptionPeriodAfterStockDisqualifiesAsTierICapital" xlink:to="mtb_PreferredStockRedemptionPeriodAfterStockDisqualifiesAsTierICapital_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_PreferredStockDividendRateModificationsDateOfChange" xlink:type="locator" xlink:label="mtb_PreferredStockDividendRateModificationsDateOfChange" />
    <label xml:lang="en-US" xlink:label="mtb_PreferredStockDividendRateModificationsDateOfChange_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The date at which the preferred stock dividend rate or the frequency of dividend payments, or both, will change.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_PreferredStockDividendRateModificationsDateOfChange" xlink:to="mtb_PreferredStockDividendRateModificationsDateOfChange_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_LondonInterbankOfferedRatePlusBasisPoints" xlink:type="locator" xlink:label="mtb_LondonInterbankOfferedRatePlusBasisPoints" />
    <label xml:lang="en-US" xlink:label="mtb_LondonInterbankOfferedRatePlusBasisPoints_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of basis points, or hundredths of one percent, added to the three month London Interbank Offered Rate to determine the dividend rate on Series E preferred stock after February 14, 2024.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_LondonInterbankOfferedRatePlusBasisPoints" xlink:to="mtb_LondonInterbankOfferedRatePlusBasisPoints_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_PreferredStockDividendRateModificationsDateOfChange_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Date of change in the dividend rate</label>
    <label xml:lang="en-US" xlink:label="mtb_PreferredStockDividendRateModificationsDateOfChange_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock Dividend Rate Modifications Date Of Change</label>
    <label xml:lang="en-US" xlink:label="mtb_LondonInterbankOfferedRatePlusBasisPoints_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">London Interbank offered rate plus basis points</label>
    <label xml:lang="en-US" xlink:label="mtb_LondonInterbankOfferedRatePlusBasisPoints_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">London Interbank Offered Rate Plus Basis Points</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PreferredStockRedemptionDate" xlink:type="locator" xlink:label="us-gaap_PreferredStockRedemptionDate" />
    <label xml:lang="en-US" xlink:label="us-gaap_PreferredStockRedemptionDate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Preferred shares redemption date</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PreferredStockRedemptionDate" xlink:to="us-gaap_PreferredStockRedemptionDate_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PreferredStockRedemptionDate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock Redemption Date</label>
    <label xml:lang="en-US" xlink:label="mtb_PreferredStockRedemptionPeriodAfterStockDisqualifiesAsTierICapital_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Preferred Stock, Redemption Feature, Redemption Term</label>
    <label xml:lang="en-US" xlink:label="mtb_PreferredStockRedemptionPeriodAfterStockDisqualifiesAsTierICapital_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock Redemption Period After Stock Disqualifies As Tier I Capital</label>
    <label xml:lang="en-US" xlink:label="us-gaap_ClassOfWarrantOrRightOutstanding_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Warrant to purchase common stock</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:type="locator" xlink:label="us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:to="us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AwardTypeAxis" xlink:type="locator" xlink:label="us-gaap_AwardTypeAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_AwardTypeAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Award Type</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AwardTypeAxis" xlink:to="us-gaap_AwardTypeAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AwardTypeAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Award Type [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:type="locator" xlink:label="us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Equity Award</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:to="us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RestrictedStockMember" xlink:type="locator" xlink:label="us-gaap_RestrictedStockMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_RestrictedStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Restricted Stock [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RestrictedStockMember" xlink:to="us-gaap_RestrictedStockMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_RestrictedStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Restricted Stock [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_RestrictedStockAwardsMember" xlink:type="locator" xlink:label="mtb_RestrictedStockAwardsMember" />
    <label xml:lang="en-US" xlink:label="mtb_RestrictedStockAwardsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Restricted Stock Awards [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_RestrictedStockAwardsMember" xlink:to="mtb_RestrictedStockAwardsMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_RestrictedStockAwardsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Restricted Stock Awards [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_RestrictedStockAwardsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Restricted Stock Awards [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember" xlink:type="locator" xlink:label="us-gaap_RestrictedStockUnitsRSUMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_RestrictedStockUnitsRSUMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Restricted Stock Units (RSUs) [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RestrictedStockUnitsRSUMember" xlink:to="us-gaap_RestrictedStockUnitsRSUMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_RestrictedStockUnitsRSUMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Restricted Stock Units R S U [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:type="locator" xlink:label="us-gaap_EmployeeStockOptionMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_EmployeeStockOptionMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock Option Awards [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EmployeeStockOptionMember" xlink:to="us-gaap_EmployeeStockOptionMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_EmployeeStockOptionMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Employee Stock Option [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PlanNameAxis" xlink:type="locator" xlink:label="us-gaap_PlanNameAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_PlanNameAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Plan Name</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_PlanNameAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Plan Name [Axis]</label>
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    <label xml:lang="en-US" xlink:label="mtb_EmployeeStockPurchasePlanMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Employee stock purchase plan.</label>
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    <label xml:lang="en-US" xlink:label="mtb_EmployeeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Employee.</label>
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    <label xml:lang="en-US" xlink:label="mtb_EmployeeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred Bonus Plan [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_EmployeeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Employee [Member]</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_DirectorMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Directors Stock Plan [Member]</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_DirectorMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Director [Member]</label>
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    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:to="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award [Line Items]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:type="locator" xlink:label="us-gaap_AllocatedShareBasedCompensationExpense" />
    <label xml:lang="en-US" xlink:label="us-gaap_AllocatedShareBasedCompensationExpense_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock-based compensation expense</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_AllocatedShareBasedCompensationExpense_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Allocated Share Based Compensation Expense</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense" xlink:type="locator" xlink:label="us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense" />
    <label xml:lang="en-US" xlink:label="us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Recognized income tax benefits related to stock-based compensation</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense" xlink:to="us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Employee Service Share Based Compensation Tax Benefit From Compensation Expense</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:type="locator" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Shares under equity incentive compensation plan for future grant</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:to="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockIssuedInPeriodWeightedAverageGrantDateFairValue" xlink:type="locator" xlink:label="mtb_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockIssuedInPeriodWeightedAverageGrantDateFairValue" />
    <label xml:lang="en-US" xlink:label="mtb_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockIssuedInPeriodWeightedAverageGrantDateFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Share based compensation arrangement by share based payment award stock issued in period weighted average grant date fair value.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockIssuedInPeriodWeightedAverageGrantDateFairValue" xlink:to="mtb_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockIssuedInPeriodWeightedAverageGrantDateFairValue_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" xlink:type="locator" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Vesting period</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" xlink:type="locator" xlink:label="us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" />
    <label xml:lang="en-US" xlink:label="us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Unrecognized compensation cost expected to be recognized over a weighted-average period (in years)</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized" xlink:type="locator" xlink:label="us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized" />
    <label xml:lang="en-US" xlink:label="us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Unrecognized compensation cost related to non-vested awards</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized" xlink:to="us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod" xlink:type="locator" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Shares issued</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Shares Issued In Period</label>
    <label xml:lang="en-US" xlink:label="mtb_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockIssuedInPeriodWeightedAverageGrantDateFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted-average grant date fair value</label>
    <label xml:lang="en-US" xlink:label="mtb_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockIssuedInPeriodWeightedAverageGrantDateFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Stock Issued In Period Weighted Average Grant Date Fair Value</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" xlink:type="locator" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Restricted Stock Outstanding, Unvested, Beginning balance</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" xlink:to="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" xlink:type="locator" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Restricted Stock Outstanding, Granted</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" xlink:to="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod" xlink:type="locator" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Restricted Stock Outstanding, Vested</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod" xlink:to="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod" xlink:type="locator" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Restricted Stock Outstanding, Cancelled</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod" xlink:to="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeited In Period</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue" xlink:type="locator" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue" />
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    <label xml:lang="en-US" xlink:label="us-gaap_DeferredCompensationArrangementWithIndividualSharesIssued_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Shares issued in connection with deferred compensation plans</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_CompensationAndRetirementDisclosureAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Compensation And Retirement Disclosure [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable" xlink:type="locator" xlink:label="us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlansDisclosuresDefinedBenefitPlansAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Defined Benefit Plans and Other Postretirement Benefit Plans</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlansDomain" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlansDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlansDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Defined Benefit Plan and Other Postretirement Benefit Plan</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PensionPlansDefinedBenefitMember" xlink:type="locator" xlink:label="us-gaap_PensionPlansDefinedBenefitMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_PensionPlansDefinedBenefitMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Pension Benefits [Member]</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember" xlink:type="locator" xlink:label="us-gaap_OtherPostretirementBenefitPlansDefinedBenefitMember" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_DefinedBenefitPlanAmendmentsAndCurtailments" xlink:type="locator" xlink:label="mtb_DefinedBenefitPlanAmendmentsAndCurtailments" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_AmountRecognizedInAccumulatedOtherComprehensiveIncomeAbstract" xlink:type="locator" xlink:label="mtb_AmountRecognizedInAccumulatedOtherComprehensiveIncomeAbstract" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_ScheduleOfSaleOfSubsidiaryAbstract" xlink:type="locator" xlink:label="mtb_ScheduleOfSaleOfSubsidiaryAbstract" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Change in benefit obligation:</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Change In Benefit Obligation Roll Forward</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanBenefitObligation" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanBenefitObligation" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanBenefitObligation_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Benefit obligation at beginning of year</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanInterestCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Interest cost</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanContributionsByPlanParticipants" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanContributionsByPlanParticipants" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanContributionsByPlanParticipants_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Plan participants&#8217; contributions</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanContributionsByPlanParticipants_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Contributions By Plan Participants</label>
    <label xml:lang="en-US" xlink:label="mtb_DefinedBenefitPlanAmendmentsAndCurtailments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Amendments and curtailments</label>
    <label xml:lang="en-US" xlink:label="mtb_DefinedBenefitPlanAmendmentsAndCurtailments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Amendments And Curtailments</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanActuarialGainLoss" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanActuarialGainLoss" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanActuarialGainLoss_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Actuarial (gain) loss</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanActuarialGainLoss" xlink:to="us-gaap_DefinedBenefitPlanActuarialGainLoss_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanActuarialGainLoss_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Actuarial Gain Loss</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsBenefitObligation" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsBenefitObligation" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsBenefitObligation_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Business combinations</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsBenefitObligation_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Business Combinations And Acquisitions Benefit Obligation</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanGrossPrescriptionDrugSubsidyReceiptsReceived" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanGrossPrescriptionDrugSubsidyReceiptsReceived" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanGrossPrescriptionDrugSubsidyReceiptsReceived_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Medicare Part D reimbursement</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanGrossPrescriptionDrugSubsidyReceiptsReceived" xlink:to="us-gaap_DefinedBenefitPlanGrossPrescriptionDrugSubsidyReceiptsReceived_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanGrossPrescriptionDrugSubsidyReceiptsReceived_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Gross Prescription Drug Subsidy Receipts Received</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanBenefitsPaid" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanBenefitsPaid" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanBenefitsPaid_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Benefits paid</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanBenefitsPaid" xlink:to="us-gaap_DefinedBenefitPlanBenefitsPaid_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanBenefitsPaid_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Benefits Paid</label>
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanBenefitObligation_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Benefit obligation at end of year</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Change in plan assets:</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward" xlink:to="us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Change In Fair Value Of Plan Assets Roll Forward</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanFairValueOfPlanAssets" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanFairValueOfPlanAssets" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Fair value of plan assets at beginning of year</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanFairValueOfPlanAssets" xlink:to="us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Fair Value Of Plan Assets</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanActualReturnOnPlanAssets" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanActualReturnOnPlanAssets" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanActualReturnOnPlanAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Actual return on plan assets</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanActualReturnOnPlanAssets" xlink:to="us-gaap_DefinedBenefitPlanActualReturnOnPlanAssets_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanActualReturnOnPlanAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Actual Return On Plan Assets</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanContributionsByEmployer" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanContributionsByEmployer" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanContributionsByEmployer_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Employer contributions</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanContributionsByEmployer" xlink:to="us-gaap_DefinedBenefitPlanContributionsByEmployer_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanContributionsByEmployer_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Contributions By Employer</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsPlanAssets" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsPlanAssets" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsPlanAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Business combinations</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsPlanAssets" xlink:to="us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsPlanAssets_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsPlanAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Business Combinations And Acquisitions Plan Assets</label>
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Fair value of plan assets at end of year</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanFundedStatusOfPlan" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanFundedStatusOfPlan" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanFundedStatusOfPlan_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Funded status</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanFundedStatusOfPlan" xlink:to="us-gaap_DefinedBenefitPlanFundedStatusOfPlan_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanFundedStatusOfPlan_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Funded Status Of Plan</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesCurrentAndNoncurrent" xlink:type="locator" xlink:label="us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesCurrentAndNoncurrent" />
    <label xml:lang="en-US" xlink:label="us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesCurrentAndNoncurrent_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Accrued liabilities recognized in the consolidated balance sheet</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesCurrentAndNoncurrent" xlink:to="us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesCurrentAndNoncurrent_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PensionAndOtherPostretirementDefinedBenefitPlansLiabilitiesCurrentAndNoncurrent_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Pension And Other Postretirement Defined Benefit Plans Liabilities Current And Noncurrent</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Net loss (gain)</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax" xlink:to="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Accumulated Other Comprehensive Income Net Gains Losses Before Tax</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net prior service cost (credit)</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax" xlink:to="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Accumulated Other Comprehensive Income Net Prior Service Cost Credit Before Tax</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Pre-tax adjustment to AOCI</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax" xlink:to="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Accumulated Other Comprehensive Income Before Tax</label>
    <label xml:lang="en-US" xlink:label="mtb_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Taxes</label>
    <label xml:lang="en-US" xlink:label="mtb_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Accumulated Other Comprehensive Income Tax</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossDefinedBenefitPensionAndOtherPostretirementPlansNetOfTax" xlink:type="locator" xlink:label="us-gaap_AccumulatedOtherComprehensiveIncomeLossDefinedBenefitPensionAndOtherPostretirementPlansNetOfTax" />
    <label xml:lang="en-US" xlink:label="us-gaap_AccumulatedOtherComprehensiveIncomeLossDefinedBenefitPensionAndOtherPostretirementPlansNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net adjustment to AOCI</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AccumulatedOtherComprehensiveIncomeLossDefinedBenefitPensionAndOtherPostretirementPlansNetOfTax" xlink:to="us-gaap_AccumulatedOtherComprehensiveIncomeLossDefinedBenefitPensionAndOtherPostretirementPlansNetOfTax_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AccumulatedOtherComprehensiveIncomeLossDefinedBenefitPensionAndOtherPostretirementPlansNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Accumulated Other Comprehensive Income Loss Defined Benefit Pension And Other Postretirement Plans Net Of Tax</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_SupplementalPensionPlanMember" xlink:type="locator" xlink:label="mtb_SupplementalPensionPlanMember" />
    <label xml:lang="en-US" xlink:label="mtb_SupplementalPensionPlanMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Supplemental pension plan.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SupplementalPensionPlanMember" xlink:to="mtb_SupplementalPensionPlanMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_SupplementalPensionPlanMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Supplemental Pension Plan [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_SupplementalPensionPlanMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Supplemental Pension Plan [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Defined Benefit Plan, Asset Categories</label>
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    <label xml:lang="en-US" xlink:label="mtb_DebtSecurityMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Debt security.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DebtSecurityMember" xlink:to="mtb_DebtSecurityMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_DebtSecurityMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Total Debt Securities [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_DebtSecurityMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Debt Security [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_OtherSecuritiesMember" xlink:type="locator" xlink:label="mtb_OtherSecuritiesMember" />
    <label xml:lang="en-US" xlink:label="mtb_OtherSecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other securities.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_OtherSecuritiesMember" xlink:to="mtb_OtherSecuritiesMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_OtherSecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other Securities [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherSecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Securities [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_MAndTEquitySecuritiesMember" xlink:type="locator" xlink:label="mtb_MAndTEquitySecuritiesMember" />
    <label xml:lang="en-US" xlink:label="mtb_MAndTEquitySecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">M and t equity securities.</label>
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    <label xml:lang="en-US" xlink:label="mtb_MAndTEquitySecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">M And T Equity Securities [Member]</label>
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanBenefitObligation_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Projected benefit obligation</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accumulated benefit obligation</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation" xlink:to="us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAccumulatedBenefitObligation_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Accumulated Benefit Obligation</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_OtherComprehensiveIncomeMinimumPensionLiabilityNetAdjustmentsBeforeTax" xlink:type="locator" xlink:label="mtb_OtherComprehensiveIncomeMinimumPensionLiabilityNetAdjustmentsBeforeTax" />
    <label xml:lang="en-US" xlink:label="mtb_OtherComprehensiveIncomeMinimumPensionLiabilityNetAdjustmentsBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other comprehensive income minimum pension liability net adjustments before tax.</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_OtherComprehensiveIncomeMinimumPensionLiabilityNetAdjustmentNetOfTaxes" xlink:type="locator" xlink:label="mtb_OtherComprehensiveIncomeMinimumPensionLiabilityNetAdjustmentNetOfTaxes" />
    <label xml:lang="en-US" xlink:label="mtb_OtherComprehensiveIncomeMinimumPensionLiabilityNetAdjustmentNetOfTaxes_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other comprehensive income minimum pension liability net adjustment net of taxes.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_OtherComprehensiveIncomeMinimumPensionLiabilityNetAdjustmentNetOfTaxes" xlink:to="mtb_OtherComprehensiveIncomeMinimumPensionLiabilityNetAdjustmentNetOfTaxes_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeMinimumPensionLiabilityNetOfTax" xlink:type="locator" xlink:label="mtb_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeMinimumPensionLiabilityNetOfTax" />
    <label xml:lang="en-US" xlink:label="mtb_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeMinimumPensionLiabilityNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Defined benefit plan accumulated other comprehensive income minimum pension liability net of tax.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeMinimumPensionLiabilityNetOfTax" xlink:to="mtb_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeMinimumPensionLiabilityNetOfTax_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeMinimumPensionLiabilityBeforeTax" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeMinimumPensionLiabilityBeforeTax" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeMinimumPensionLiabilityBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Minimum pension liability</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeMinimumPensionLiabilityBeforeTax" xlink:to="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeMinimumPensionLiabilityBeforeTax_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeMinimumPensionLiabilityBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Accumulated Other Comprehensive Income Minimum Pension Liability Before Tax</label>
    <label xml:lang="en-US" xlink:label="mtb_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeMinimumPensionLiabilityNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Minimum pension liability adjustment net of tax</label>
    <label xml:lang="en-US" xlink:label="mtb_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeMinimumPensionLiabilityNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Accumulated Other Comprehensive Income Minimum Pension Liability Net Of Tax</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherComprehensiveIncomeMinimumPensionLiabilityNetAdjustmentsBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Decrease in minimum liability adjustment</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherComprehensiveIncomeMinimumPensionLiabilityNetAdjustmentsBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Comprehensive Income Minimum Pension Liability Net Adjustments Before Tax</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherComprehensiveIncomeMinimumPensionLiabilityNetAdjustmentNetOfTaxes_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase in minimum pension liability adjustment net of tax</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherComprehensiveIncomeMinimumPensionLiabilityNetAdjustmentNetOfTaxes_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Comprehensive Income Minimum Pension Liability Net Adjustment Net Of Taxes</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax" xlink:type="locator" xlink:label="us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Net loss (gain)</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax" xlink:to="us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Comprehensive Income Loss Pension And Other Postretirement Benefit Plans Net Unamortized Gain Loss Arising During Period Before Tax</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossFinalizationOfPensionAndNonPensionPostretirementPlanValuationBeforeTax" xlink:type="locator" xlink:label="us-gaap_OtherComprehensiveIncomeLossFinalizationOfPensionAndNonPensionPostretirementPlanValuationBeforeTax" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherComprehensiveIncomeLossFinalizationOfPensionAndNonPensionPostretirementPlanValuationBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Amendments and curtailments</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherComprehensiveIncomeLossFinalizationOfPensionAndNonPensionPostretirementPlanValuationBeforeTax" xlink:to="us-gaap_OtherComprehensiveIncomeLossFinalizationOfPensionAndNonPensionPostretirementPlanValuationBeforeTax_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherComprehensiveIncomeLossFinalizationOfPensionAndNonPensionPostretirementPlanValuationBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Comprehensive Income Loss Finalization Of Pension And Non Pension Postretirement Plan Valuation Before Tax</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax" xlink:type="locator" xlink:label="us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Amortization of prior service credit</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax" xlink:to="us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Comprehensive Income Loss Amortization Adjustment From A O C I Pension And Other Postretirement Benefit Plans For Net Prior Service Cost Credit Before Tax</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax" xlink:type="locator" xlink:label="us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amortization of actuarial loss</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax" xlink:to="us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetGainLossBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Comprehensive Income Loss Reclassification Adjustment From A O C I Pension And Other Postretirement Benefit Plans For Net Gain Loss Before Tax</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeLossNetGainLossBeforeTax" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeLossNetGainLossBeforeTax" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeLossNetGainLossBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel">Total recognized in other comprehensive income, pre-tax</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAmountsRecognizedInOtherComprehensiveIncomeLossNetGainLossBeforeTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Amounts Recognized In Other Comprehensive Income Loss Net Gain Loss Before Tax</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanFutureAmortizationOfPriorServiceCostCredit" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanFutureAmortizationOfPriorServiceCostCredit" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanFutureAmortizationOfPriorServiceCostCredit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amortization of net prior service cost (credit)</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanFutureAmortizationOfPriorServiceCostCredit" xlink:to="us-gaap_DefinedBenefitPlanFutureAmortizationOfPriorServiceCostCredit_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanFutureAmortizationOfPriorServiceCostCredit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Future Amortization Of Prior Service Cost Credit</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanFutureAmortizationOfGainLoss" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanFutureAmortizationOfGainLoss" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanFutureAmortizationOfGainLoss_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Amortization of net loss (gain)</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanFutureAmortizationOfGainLoss" xlink:to="us-gaap_DefinedBenefitPlanFutureAmortizationOfGainLoss_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanFutureAmortizationOfGainLoss_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Future Amortization Of Gain Loss</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PensionAndOtherPostretirementBenefitExpense" xlink:type="locator" xlink:label="us-gaap_PensionAndOtherPostretirementBenefitExpense" />
    <label xml:lang="en-US" xlink:label="us-gaap_PensionAndOtherPostretirementBenefitExpense_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Defined contribution pension and retirement savings plans total expense</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PensionAndOtherPostretirementBenefitExpense" xlink:to="us-gaap_PensionAndOtherPostretirementBenefitExpense_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PensionAndOtherPostretirementBenefitExpense_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Pension And Other Postretirement Benefit Expense</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationDiscountRate" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationDiscountRate" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationDiscountRate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Discount rate</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationDiscountRate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Assumptions Used Calculating Benefit Obligation Discount Rate</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationRateOfCompensationIncrease" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationRateOfCompensationIncrease" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostDiscountRate" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostDiscountRate" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostDiscountRate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Discount rate</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostDiscountRate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Assumptions Used Calculating Net Periodic Benefit Cost Discount Rate</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostExpectedLongTermReturnOnAssets" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostExpectedLongTermReturnOnAssets" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostExpectedLongTermReturnOnAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Long-term rate of return on plan assets</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostExpectedLongTermReturnOnAssets" xlink:to="us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostExpectedLongTermReturnOnAssets_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostExpectedLongTermReturnOnAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Assumptions Used Calculating Net Periodic Benefit Cost Expected Long Term Return On Assets</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostRateOfCompensationIncrease" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostRateOfCompensationIncrease" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostRateOfCompensationIncrease_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Rate of increase in future compensation levels</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostRateOfCompensationIncrease" xlink:to="us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostRateOfCompensationIncrease_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostRateOfCompensationIncrease_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Assumptions Used Calculating Net Periodic Benefit Cost Rate Of Compensation Increase</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_DefinedBenefitPlanPeriodForApplyingUltimateHealthCareCostTrendRate" xlink:type="locator" xlink:label="mtb_DefinedBenefitPlanPeriodForApplyingUltimateHealthCareCostTrendRate" />
    <label xml:lang="en-US" xlink:label="mtb_DefinedBenefitPlanPeriodForApplyingUltimateHealthCareCostTrendRate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Defined benefit plan period for applying ultimate health care cost trend rate.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DefinedBenefitPlanPeriodForApplyingUltimateHealthCareCostTrendRate" xlink:to="mtb_DefinedBenefitPlanPeriodForApplyingUltimateHealthCareCostTrendRate_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanHealthCareCostTrendRateAssumedForNextFiscalYear" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanHealthCareCostTrendRateAssumedForNextFiscalYear" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanHealthCareCostTrendRateAssumedForNextFiscalYear_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Annual rate of increase in health care cost assumed for next fiscal year</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanHealthCareCostTrendRateAssumedForNextFiscalYear" xlink:to="us-gaap_DefinedBenefitPlanHealthCareCostTrendRateAssumedForNextFiscalYear_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanHealthCareCostTrendRateAssumedForNextFiscalYear_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Health Care Cost Trend Rate Assumed For Next Fiscal Year</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanUltimateHealthCareCostTrendRate" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanUltimateHealthCareCostTrendRate" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanUltimateHealthCareCostTrendRate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Defined Benefit Plan, ultimate health care cost trend rate</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanUltimateHealthCareCostTrendRate" xlink:to="us-gaap_DefinedBenefitPlanUltimateHealthCareCostTrendRate_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanUltimateHealthCareCostTrendRate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Ultimate Health Care Cost Trend Rate</label>
    <label xml:lang="en-US" xlink:label="mtb_DefinedBenefitPlanPeriodForApplyingUltimateHealthCareCostTrendRate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Period for decreasing the annual rate</label>
    <label xml:lang="en-US" xlink:label="mtb_DefinedBenefitPlanPeriodForApplyingUltimateHealthCareCostTrendRate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Period For Applying Ultimate Health Care Cost Trend Rate</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointIncreaseOnServiceAndInterestCostComponents" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointIncreaseOnServiceAndInterestCostComponents" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointIncreaseOnServiceAndInterestCostComponents_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Service and interest cost</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointIncreaseOnServiceAndInterestCostComponents" xlink:to="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointIncreaseOnServiceAndInterestCostComponents_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointIncreaseOnServiceAndInterestCostComponents_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Effect Of One Percentage Point Increase On Service And Interest Cost Components</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointIncreaseOnAccumulatedPostretirementBenefitObligation" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointIncreaseOnAccumulatedPostretirementBenefitObligation" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointIncreaseOnAccumulatedPostretirementBenefitObligation_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accumulated postretirement benefit obligation</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointIncreaseOnAccumulatedPostretirementBenefitObligation" xlink:to="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointIncreaseOnAccumulatedPostretirementBenefitObligation_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointIncreaseOnAccumulatedPostretirementBenefitObligation_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Effect Of One Percentage Point Increase On Accumulated Postretirement Benefit Obligation</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointDecreaseOnServiceAndInterestCostComponents1" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointDecreaseOnServiceAndInterestCostComponents1" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointDecreaseOnServiceAndInterestCostComponents1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Service and interest cost</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointDecreaseOnServiceAndInterestCostComponents1" xlink:to="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointDecreaseOnServiceAndInterestCostComponents1_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointDecreaseOnServiceAndInterestCostComponents1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Effect Of One Percentage Point Decrease On Service And Interest Cost Components1</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointDecreaseOnAccumulatedPostretirementBenefitObligation1" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointDecreaseOnAccumulatedPostretirementBenefitObligation1" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointDecreaseOnAccumulatedPostretirementBenefitObligation1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Accumulated postretirement benefit obligation</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointDecreaseOnAccumulatedPostretirementBenefitObligation1" xlink:to="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointDecreaseOnAccumulatedPostretirementBenefitObligation1_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanEffectOfOnePercentagePointDecreaseOnAccumulatedPostretirementBenefitObligation1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Effect Of One Percentage Point Decrease On Accumulated Postretirement Benefit Obligation1</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_DefinedBenefitPlanPercentageOfPlanAssets" xlink:type="locator" xlink:label="mtb_DefinedBenefitPlanPercentageOfPlanAssets" />
    <label xml:lang="en-US" xlink:label="mtb_DefinedBenefitPlanPercentageOfPlanAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount of defined benefit pension plan assets that consist of real estate, private equity and other investments, as a percentage of the total defined benefit pension plan assets.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DefinedBenefitPlanPercentageOfPlanAssets" xlink:to="mtb_DefinedBenefitPlanPercentageOfPlanAssets_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanTargetPlanAssetAllocationsRangeMinimum" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanTargetPlanAssetAllocationsRangeMinimum" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanTargetPlanAssetAllocationsRangeMinimum_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Target allocations for plan assets, minimum range</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanTargetPlanAssetAllocationsRangeMinimum" xlink:to="us-gaap_DefinedBenefitPlanTargetPlanAssetAllocationsRangeMinimum_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanTargetPlanAssetAllocationsRangeMinimum_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Target Plan Asset Allocations Range Minimum</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanTargetPlanAssetAllocationsRangeMaximum" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanTargetPlanAssetAllocationsRangeMaximum" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanTargetPlanAssetAllocationsRangeMaximum_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Target allocations for plan assets, maximum range</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanTargetPlanAssetAllocationsRangeMaximum" xlink:to="us-gaap_DefinedBenefitPlanTargetPlanAssetAllocationsRangeMaximum_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanTargetPlanAssetAllocationsRangeMaximum_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Target Plan Asset Allocations Range Maximum</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanBenefitObligationPeriodIncreaseDecrease" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanBenefitObligationPeriodIncreaseDecrease" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanBenefitObligationPeriodIncreaseDecrease_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Defined benefit pension plans</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanBenefitObligationPeriodIncreaseDecrease" xlink:to="us-gaap_DefinedBenefitPlanBenefitObligationPeriodIncreaseDecrease_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanBenefitObligationPeriodIncreaseDecrease_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Benefit Obligation Period Increase Decrease</label>
    <label xml:lang="en-US" xlink:label="mtb_DefinedBenefitPlanPercentageOfPlanAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of total assets</label>
    <label xml:lang="en-US" xlink:label="mtb_DefinedBenefitPlanPercentageOfPlanAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Percentage Of Plan Assets</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MoneyMarketFundsMember" xlink:type="locator" xlink:label="us-gaap_MoneyMarketFundsMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_MoneyMarketFundsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Money-Market Funds [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_MoneyMarketFundsMember" xlink:to="us-gaap_MoneyMarketFundsMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_MoneyMarketFundsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Money Market Funds [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_DomesticEquitySecuritiesMember" xlink:type="locator" xlink:label="mtb_DomesticEquitySecuritiesMember" />
    <label xml:lang="en-US" xlink:label="mtb_DomesticEquitySecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Domestic equity securities.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DomesticEquitySecuritiesMember" xlink:to="mtb_DomesticEquitySecuritiesMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_DomesticEquitySecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Domestic Equity Securities [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_DomesticEquitySecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Domestic Equity Securities [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_InternationalEquitySecuritiesMember" xlink:type="locator" xlink:label="mtb_InternationalEquitySecuritiesMember" />
    <label xml:lang="en-US" xlink:label="mtb_InternationalEquitySecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">International equity securities.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_InternationalEquitySecuritiesMember" xlink:to="mtb_InternationalEquitySecuritiesMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_InternationalEquitySecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">International Equity Securities [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_InternationalEquitySecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">International Equity Securities [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_DomesticMutualFundEquitySecuritiesMember" xlink:type="locator" xlink:label="mtb_DomesticMutualFundEquitySecuritiesMember" />
    <label xml:lang="en-US" xlink:label="mtb_DomesticMutualFundEquitySecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Domestic mutual fund equity securities.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DomesticMutualFundEquitySecuritiesMember" xlink:to="mtb_DomesticMutualFundEquitySecuritiesMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_DomesticMutualFundEquitySecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Domestic Mutual Fund Equity securities [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_DomesticMutualFundEquitySecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Domestic Mutual Fund Equity Securities [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_InternationalMutualFundEquitySecuritiesMember" xlink:type="locator" xlink:label="mtb_InternationalMutualFundEquitySecuritiesMember" />
    <label xml:lang="en-US" xlink:label="mtb_InternationalMutualFundEquitySecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">International mutual fund equity securities.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_InternationalMutualFundEquitySecuritiesMember" xlink:to="mtb_InternationalMutualFundEquitySecuritiesMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_InternationalMutualFundEquitySecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">International Mutual Fund Equity Securities [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_InternationalMutualFundEquitySecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">International Mutual Fund Equity Securities [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember" xlink:type="locator" xlink:label="us-gaap_CorporateDebtSecuritiesMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_CorporateDebtSecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Corporate Debt Securities [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CorporateDebtSecuritiesMember" xlink:to="us-gaap_CorporateDebtSecuritiesMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CorporateDebtSecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Corporate Debt Securities [Member]</label>
    <label xml:lang="en-US" xlink:label="us-gaap_USGovernmentAgenciesDebtSecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Government Debt Securities [Member]</label>
    <label xml:lang="en-US" xlink:label="us-gaap_ForeignGovernmentDebtSecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">International Debt securities [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_DomesticMutualFundDebtSecuritiesMember" xlink:type="locator" xlink:label="mtb_DomesticMutualFundDebtSecuritiesMember" />
    <label xml:lang="en-US" xlink:label="mtb_DomesticMutualFundDebtSecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Domestic mutual fund debt securities.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DomesticMutualFundDebtSecuritiesMember" xlink:to="mtb_DomesticMutualFundDebtSecuritiesMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_DomesticMutualFundDebtSecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Domestic Mutual Fund Debt Securities [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_DomesticMutualFundDebtSecuritiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Domestic Mutual Fund Debt Securities [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_OtherDiversifiedMutualFundMember" xlink:type="locator" xlink:label="mtb_OtherDiversifiedMutualFundMember" />
    <label xml:lang="en-US" xlink:label="mtb_OtherDiversifiedMutualFundMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other Diversified Mutual Fund [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_OtherDiversifiedMutualFundMember" xlink:to="mtb_OtherDiversifiedMutualFundMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_OtherDiversifiedMutualFundMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other Diversified Mutual Fund [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherDiversifiedMutualFundMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Diversified Mutual Fund [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_OtherRealEstatePartnershipsMember" xlink:type="locator" xlink:label="mtb_OtherRealEstatePartnershipsMember" />
    <label xml:lang="en-US" xlink:label="mtb_OtherRealEstatePartnershipsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other real estate partnerships.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_OtherRealEstatePartnershipsMember" xlink:to="mtb_OtherRealEstatePartnershipsMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_OtherRealEstatePartnershipsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other Real Estate Partnerships [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherRealEstatePartnershipsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Real Estate Partnerships [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_OtherPrivateEquityMember" xlink:type="locator" xlink:label="mtb_OtherPrivateEquityMember" />
    <label xml:lang="en-US" xlink:label="mtb_OtherPrivateEquityMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other private equity.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_OtherPrivateEquityMember" xlink:to="mtb_OtherPrivateEquityMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_OtherPrivateEquityMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other Private Equity [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherPrivateEquityMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Private Equity [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_OtherHedgeFundsMember" xlink:type="locator" xlink:label="mtb_OtherHedgeFundsMember" />
    <label xml:lang="en-US" xlink:label="mtb_OtherHedgeFundsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other hedge funds.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_OtherHedgeFundsMember" xlink:to="mtb_OtherHedgeFundsMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_OtherHedgeFundsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other Hedge Funds [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherHedgeFundsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Hedge Funds [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_GuaranteedDepositFundMember" xlink:type="locator" xlink:label="mtb_GuaranteedDepositFundMember" />
    <label xml:lang="en-US" xlink:label="mtb_GuaranteedDepositFundMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Guaranteed deposit fund.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_GuaranteedDepositFundMember" xlink:to="mtb_GuaranteedDepositFundMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_GuaranteedDepositFundMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Guaranteed Deposit Fund [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_GuaranteedDepositFundMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Guaranteed Deposit Fund [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:type="locator" xlink:label="us-gaap_FairValueByFairValueHierarchyLevelAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueByFairValueHierarchyLevelAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Quoted Prices in Active Markets for Identical Assets (Level 1) [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:to="us-gaap_FairValueByFairValueHierarchyLevelAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueByFairValueHierarchyLevelAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value By Fair Value Hierarchy Level [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:type="locator" xlink:label="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueMeasurementsFairValueHierarchyDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair Value Hierarchy</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:to="us-gaap_FairValueMeasurementsFairValueHierarchyDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueMeasurementsFairValueHierarchyDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Measurements Fair Value Hierarchy [Domain]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:type="locator" xlink:label="us-gaap_FairValueInputsLevel1Member" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueInputsLevel1Member_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Quoted Prices in Active Markets for Identical Assets (Level 1) [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueInputsLevel1Member" xlink:to="us-gaap_FairValueInputsLevel1Member_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueInputsLevel1Member_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Inputs Level1 [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:type="locator" xlink:label="us-gaap_FairValueInputsLevel2Member" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueInputsLevel2Member_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Significant Observable Inputs (Level 2) [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueInputsLevel2Member" xlink:to="us-gaap_FairValueInputsLevel2Member_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueInputsLevel2Member_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Inputs Level2 [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:type="locator" xlink:label="us-gaap_FairValueInputsLevel3Member" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueInputsLevel3Member_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Significant Unobservable Inputs (Level 3) [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueInputsLevel3Member" xlink:to="us-gaap_FairValueInputsLevel3Member_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueInputsLevel3Member_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Inputs Level3 [Member]</label>
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Defined benefit plan fair value of plan assets</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_PercentageOfInvestmentInMutualFund" xlink:type="locator" xlink:label="mtb_PercentageOfInvestmentInMutualFund" />
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfInvestmentInMutualFund_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The investment of pension plan assets in a mutual fund investment category as a percentage of total investment in mutual funds.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_PercentageOfInvestmentInMutualFund" xlink:to="mtb_PercentageOfInvestmentInMutualFund_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_InterestAndDividendReceivableOnPlanAssets" xlink:type="locator" xlink:label="mtb_InterestAndDividendReceivableOnPlanAssets" />
    <label xml:lang="en-US" xlink:label="mtb_InterestAndDividendReceivableOnPlanAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The amount of interest and dividends receivable on pension plan assets, which have been excluded in the determination of the fair value of plan assets.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_InterestAndDividendReceivableOnPlanAssets" xlink:to="mtb_InterestAndDividendReceivableOnPlanAssets_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InvestmentTypeAxis" xlink:type="locator" xlink:label="us-gaap_InvestmentTypeAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_InvestmentTypeAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investment Type</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InvestmentTypeAxis" xlink:to="us-gaap_InvestmentTypeAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_InvestmentTypeAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Investment Type [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:type="locator" xlink:label="us-gaap_InvestmentTypeCategorizationMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_InvestmentTypeCategorizationMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investments</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InvestmentTypeCategorizationMember" xlink:to="us-gaap_InvestmentTypeCategorizationMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_InvestmentTypeCategorizationMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Investment Type Categorization [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_InvestmentGradeBondsMember" xlink:type="locator" xlink:label="mtb_InvestmentGradeBondsMember" />
    <label xml:lang="en-US" xlink:label="mtb_InvestmentGradeBondsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Investment grade bonds.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_InvestmentGradeBondsMember" xlink:to="mtb_InvestmentGradeBondsMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_InvestmentGradeBondsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investment Grade Bonds [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_InvestmentGradeBondsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Investment Grade Bonds [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_HighYieldingBondsMember" xlink:type="locator" xlink:label="mtb_HighYieldingBondsMember" />
    <label xml:lang="en-US" xlink:label="mtb_HighYieldingBondsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">High yielding bonds.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_HighYieldingBondsMember" xlink:to="mtb_HighYieldingBondsMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_HighYieldingBondsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">High-Yielding Bonds [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_HighYieldingBondsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">High Yielding Bonds [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfInvestmentInMutualFund_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investment in mutual funds</label>
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfInvestmentInMutualFund_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Percentage Of Investment In Mutual Fund</label>
    <label xml:lang="en-US" xlink:label="mtb_InterestAndDividendReceivableOnPlanAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest and dividend receivable on plan assets</label>
    <label xml:lang="en-US" xlink:label="mtb_InterestAndDividendReceivableOnPlanAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Interest And Dividend Receivable On Plan Assets</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_DefinedBenefitPlanContributionsByEmployerToQualifiedBenefitPensionPlans" xlink:type="locator" xlink:label="mtb_DefinedBenefitPlanContributionsByEmployerToQualifiedBenefitPensionPlans" />
    <label xml:lang="en-US" xlink:label="mtb_DefinedBenefitPlanContributionsByEmployerToQualifiedBenefitPensionPlans_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Defined benefit plan contributions by employer to qualified benefit pension plans.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DefinedBenefitPlanContributionsByEmployerToQualifiedBenefitPensionPlans" xlink:to="mtb_DefinedBenefitPlanContributionsByEmployerToQualifiedBenefitPensionPlans_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_PercentageOfPensionPlanAssetsThatIsNotExceededByInvestmentInSecurityOfSingleNonUsGovernmentOrGovernmentAgency" xlink:type="locator" xlink:label="mtb_PercentageOfPensionPlanAssetsThatIsNotExceededByInvestmentInSecurityOfSingleNonUsGovernmentOrGovernmentAgency" />
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfPensionPlanAssetsThatIsNotExceededByInvestmentInSecurityOfSingleNonUsGovernmentOrGovernmentAgency_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Percentage Of Pension Plan Assets That Is Not Exceeded By Investment In Security Of Single Non Us Government Or Government Agency</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_PercentageOfPensionPlanAssetsThatIsNotExceededByInvestmentInSecurityOfSingleNonUsGovernmentOrGovernmentAgency" xlink:to="mtb_PercentageOfPensionPlanAssetsThatIsNotExceededByInvestmentInSecurityOfSingleNonUsGovernmentOrGovernmentAgency_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanWeightedAverageAssetAllocations" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanWeightedAverageAssetAllocations" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanWeightedAverageAssetAllocations_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of common stock in total plan assets</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanWeightedAverageAssetAllocations" xlink:to="us-gaap_DefinedBenefitPlanWeightedAverageAssetAllocations_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanWeightedAverageAssetAllocations_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Weighted Average Asset Allocations</label>
    <label xml:lang="en-US" xlink:label="mtb_DefinedBenefitPlanContributionsByEmployerToQualifiedBenefitPensionPlans_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Qualified benefit pension plans</label>
    <label xml:lang="en-US" xlink:label="mtb_DefinedBenefitPlanContributionsByEmployerToQualifiedBenefitPensionPlans_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Contributions By Employer To Qualified Benefit Pension Plans</label>
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfPensionPlanAssetsThatIsNotExceededByInvestmentInSecurityOfSingleNonUsGovernmentOrGovernmentAgency_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of pension plan assets that is not exceeded by investment in security of single Non-US Government of Government agency</label>
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfPensionPlanAssetsThatIsNotExceededByInvestmentInSecurityOfSingleNonUsGovernmentOrGovernmentAgency_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Percentage Of Pension Plan Assets That Is Not Exceeded By Investment In Security Of Single Non Us Government Or Government Agency</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_OtherPrivateRealEstateMember" xlink:type="locator" xlink:label="mtb_OtherPrivateRealEstateMember" />
    <label xml:lang="en-US" xlink:label="mtb_OtherPrivateRealEstateMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other private real estate.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_OtherPrivateRealEstateMember" xlink:to="mtb_OtherPrivateRealEstateMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_OtherPrivateRealEstateMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other Private Real Estate [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherPrivateRealEstateMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Private Real Estate [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanPurchasesSalesAndSettlements" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanPurchasesSalesAndSettlements" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanPurchasesSalesAndSettlements_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Purchase(Sales)</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanPurchasesSalesAndSettlements" xlink:to="us-gaap_DefinedBenefitPlanPurchasesSalesAndSettlements_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanPurchasesSalesAndSettlements_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Purchases Sales And Settlements</label>
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanActualReturnOnPlanAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Total Realized/Unrealized Gains (Losses)</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2017</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths" xlink:to="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Expected Future Benefit Payments Next Twelve Months</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2018</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo" xlink:to="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Expected Future Benefit Payments Year Two</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2019</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree" xlink:to="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Expected Future Benefit Payments Year Three</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2020</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour" xlink:to="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Expected Future Benefit Payments Year Four</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2021</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive" xlink:to="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Expected Future Benefit Payments Year Five</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter" xlink:type="locator" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2022 through 2026</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter" xlink:to="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Benefit Plan Expected Future Benefit Payments Five Fiscal Years Thereafter</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_PercentageOfEligibleEmployeesContributionForRetirementSavingsPlan" xlink:type="locator" xlink:label="mtb_PercentageOfEligibleEmployeesContributionForRetirementSavingsPlan" />
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfEligibleEmployeesContributionForRetirementSavingsPlan_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Maximum percentage of qualified compensation that eligible employees may contribute to the defined contribution plan.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_PercentageOfEligibleEmployeesContributionForRetirementSavingsPlan" xlink:to="mtb_PercentageOfEligibleEmployeesContributionForRetirementSavingsPlan_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_PercentageOfEmployeeBenefitPlanExpectedContributionByEmployer" xlink:type="locator" xlink:label="mtb_PercentageOfEmployeeBenefitPlanExpectedContributionByEmployer" />
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfEmployeeBenefitPlanExpectedContributionByEmployer_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Maximum amount of employer matching contributions to the defined contribution plan for an eligible employee stated as a percentage of the eligible employee&apos;s contribution.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_PercentageOfEmployeeBenefitPlanExpectedContributionByEmployer" xlink:to="mtb_PercentageOfEmployeeBenefitPlanExpectedContributionByEmployer_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_MaximumEmployerContributionOnEmployeesQualifiedContribution" xlink:type="locator" xlink:label="mtb_MaximumEmployerContributionOnEmployeesQualifiedContribution" />
    <label xml:lang="en-US" xlink:label="mtb_MaximumEmployerContributionOnEmployeesQualifiedContribution_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Maximum amount of employer matching contributions to the defined contribution plan for an eligible employee stated as a percentage of the eligible employee&apos;s qualified compensation.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_MaximumEmployerContributionOnEmployeesQualifiedContribution" xlink:to="mtb_MaximumEmployerContributionOnEmployeesQualifiedContribution_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfEligibleEmployeesContributionForRetirementSavingsPlan_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of eligible employees contribution for Retirement Savings Plan</label>
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfEligibleEmployeesContributionForRetirementSavingsPlan_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Percentage Of Eligible Employees Contribution For Retirement Savings Plan</label>
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfEmployeeBenefitPlanExpectedContributionByEmployer_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percentage of employer matching contribution to employee&apos;s contribution</label>
    <label xml:lang="en-US" xlink:label="mtb_PercentageOfEmployeeBenefitPlanExpectedContributionByEmployer_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Percentage Of Employee Benefit Plan Expected Contribution By Employer</label>
    <label xml:lang="en-US" xlink:label="mtb_MaximumEmployerContributionOnEmployeesQualifiedContribution_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Maximum employer contribution on Employee&apos;s qualified contribution</label>
    <label xml:lang="en-US" xlink:label="mtb_MaximumEmployerContributionOnEmployeesQualifiedContribution_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Maximum Employer Contribution On Employees Qualified Contribution</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DefinedContributionPlanCostRecognized" xlink:type="locator" xlink:label="us-gaap_DefinedContributionPlanCostRecognized" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedContributionPlanCostRecognized_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Qualified defined contribution plans expense during the period</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DefinedContributionPlanCostRecognized" xlink:to="us-gaap_DefinedContributionPlanCostRecognized_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DefinedContributionPlanCostRecognized_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Defined Contribution Plan Cost Recognized</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:type="locator" xlink:label="us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:to="us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Current Income Tax Expense Benefit Continuing Operations [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CurrentFederalTaxExpenseBenefit" xlink:type="locator" xlink:label="us-gaap_CurrentFederalTaxExpenseBenefit" />
    <label xml:lang="en-US" xlink:label="us-gaap_CurrentFederalTaxExpenseBenefit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Federal</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CurrentFederalTaxExpenseBenefit" xlink:to="us-gaap_CurrentFederalTaxExpenseBenefit_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CurrentFederalTaxExpenseBenefit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Current Federal Tax Expense Benefit</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit" xlink:type="locator" xlink:label="us-gaap_CurrentStateAndLocalTaxExpenseBenefit" />
    <label xml:lang="en-US" xlink:label="us-gaap_CurrentStateAndLocalTaxExpenseBenefit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">State and city</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CurrentStateAndLocalTaxExpenseBenefit" xlink:to="us-gaap_CurrentStateAndLocalTaxExpenseBenefit_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CurrentStateAndLocalTaxExpenseBenefit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Current State And Local Tax Expense Benefit</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit" xlink:type="locator" xlink:label="us-gaap_CurrentIncomeTaxExpenseBenefit" />
    <label xml:lang="en-US" xlink:label="us-gaap_CurrentIncomeTaxExpenseBenefit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total current</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CurrentIncomeTaxExpenseBenefit" xlink:to="us-gaap_CurrentIncomeTaxExpenseBenefit_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CurrentIncomeTaxExpenseBenefit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Current Income Tax Expense Benefit</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:type="locator" xlink:label="us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Deferred</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:to="us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Income Tax Expense Benefit Continuing Operations [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit" xlink:type="locator" xlink:label="us-gaap_DeferredFederalIncomeTaxExpenseBenefit" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredFederalIncomeTaxExpenseBenefit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Federal</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DeferredFederalIncomeTaxExpenseBenefit" xlink:to="us-gaap_DeferredFederalIncomeTaxExpenseBenefit_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredFederalIncomeTaxExpenseBenefit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Federal Income Tax Expense Benefit</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit" xlink:type="locator" xlink:label="us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">State and city</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit" xlink:to="us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Deferred State And Local Income Tax Expense Benefit</label>
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredIncomeTaxExpenseBenefit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total deferred</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AmortizationMethodQualifiedAffordableHousingProjectInvestmentsAmortization" xlink:type="locator" xlink:label="us-gaap_AmortizationMethodQualifiedAffordableHousingProjectInvestmentsAmortization" />
    <label xml:lang="en-US" xlink:label="us-gaap_AmortizationMethodQualifiedAffordableHousingProjectInvestmentsAmortization_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amortization of investments in qualified affordable housing projects</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AmortizationMethodQualifiedAffordableHousingProjectInvestmentsAmortization" xlink:to="us-gaap_AmortizationMethodQualifiedAffordableHousingProjectInvestmentsAmortization_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AmortizationMethodQualifiedAffordableHousingProjectInvestmentsAmortization_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Amortization Method Qualified Affordable Housing Project Investments Amortization</label>
    <label xml:lang="en-US" xlink:label="us-gaap_IncomeTaxExpenseBenefit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Income taxes</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAllowanceForDoubtfulAccounts" xlink:type="locator" xlink:label="us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAllowanceForDoubtfulAccounts" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAllowanceForDoubtfulAccounts_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Tax bad debt reserve</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAllowanceForDoubtfulAccounts" xlink:to="us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAllowanceForDoubtfulAccounts_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAllowanceForDoubtfulAccounts_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Tax Assets Tax Deferred Expense Reserves And Accruals Allowance For Doubtful Accounts</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_IncomeTaxesAttributableToGainsOrLossesOnBankInvestmentSecurities" xlink:type="locator" xlink:label="mtb_IncomeTaxesAttributableToGainsOrLossesOnBankInvestmentSecurities" />
    <label xml:lang="en-US" xlink:label="mtb_IncomeTaxesAttributableToGainsOrLossesOnBankInvestmentSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Income taxes attributable to gains or losses on bank investment securities.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_IncomeTaxesAttributableToGainsOrLossesOnBankInvestmentSecurities" xlink:to="mtb_IncomeTaxesAttributableToGainsOrLossesOnBankInvestmentSecurities_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_MinimumAlternativeTaxExpenseRecognizedForGainsOrLossesOnBankInvestmentSecurities" xlink:type="locator" xlink:label="mtb_MinimumAlternativeTaxExpenseRecognizedForGainsOrLossesOnBankInvestmentSecurities" />
    <label xml:lang="en-US" xlink:label="mtb_MinimumAlternativeTaxExpenseRecognizedForGainsOrLossesOnBankInvestmentSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Minimum alternative tax expense recognized for gains or losses on bank investment securities.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_MinimumAlternativeTaxExpenseRecognizedForGainsOrLossesOnBankInvestmentSecurities" xlink:to="mtb_MinimumAlternativeTaxExpenseRecognizedForGainsOrLossesOnBankInvestmentSecurities_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_IncomeTaxesAttributableToGainsOrLossesOnBankInvestmentSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Income taxes attributable to gains or losses on bank investment securities</label>
    <label xml:lang="en-US" xlink:label="mtb_IncomeTaxesAttributableToGainsOrLossesOnBankInvestmentSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Income Taxes Attributable To Gains Or Losses On Bank Investment Securities</label>
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    <label xml:lang="en-US" xlink:label="mtb_MinimumAlternativeTaxExpenseRecognizedForGainsOrLossesOnBankInvestmentSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Minimum Alternative Tax Expense Recognized For Gains Or Losses On Bank Investment Securities</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_IncreaseDecreaseInTaxesAbstract" xlink:type="locator" xlink:label="mtb_IncreaseDecreaseInTaxesAbstract" />
    <label xml:lang="en-US" xlink:label="mtb_IncreaseDecreaseInTaxesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase decrease in taxes.</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate" xlink:type="locator" xlink:label="us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate" />
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    <label xml:lang="en-US" xlink:label="mtb_AmountOfAffordableHousingTaxCredits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Qualified affordable housing project federal tax credits, net</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_IncomeTaxReconciliationOtherReconcilingItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsPostretirementAndOtherEmployeeBenefits" xlink:type="locator" xlink:label="mtb_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsPostretirementAndOtherEmployeeBenefits" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_DeferredTaxAssetsInterestOnLoans" xlink:type="locator" xlink:label="mtb_DeferredTaxAssetsInterestOnLoans" />
    <label xml:lang="en-US" xlink:label="mtb_DeferredTaxAssetsInterestOnLoans_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount of deferred tax asset attributable to taxable temporary differences from interest on loans.</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_DeferredTaxAssetsUnrealizedLossesOnInvestmentSecurities" xlink:type="locator" xlink:label="mtb_DeferredTaxAssetsUnrealizedLossesOnInvestmentSecurities" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_DeferredTaxAssetsDepreciationAndAmortization" xlink:type="locator" xlink:label="mtb_DeferredTaxAssetsDepreciationAndAmortization" />
    <label xml:lang="en-US" xlink:label="mtb_DeferredTaxAssetsDepreciationAndAmortization_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount of deferred tax asset attributable to taxable temporary differences from depreciation and amortization expenses.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DeferredTaxAssetsDepreciationAndAmortization" xlink:to="mtb_DeferredTaxAssetsDepreciationAndAmortization_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_DeferredTaxLiabilitiesUnrealizedGainsOnInvestmentSecurities" xlink:type="locator" xlink:label="mtb_DeferredTaxLiabilitiesUnrealizedGainsOnInvestmentSecurities" />
    <label xml:lang="en-US" xlink:label="mtb_DeferredTaxLiabilitiesUnrealizedGainsOnInvestmentSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount of deferred tax liability attributable to taxable temporary differences from unrealized gains on investment securities.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DeferredTaxLiabilitiesUnrealizedGainsOnInvestmentSecurities" xlink:to="mtb_DeferredTaxLiabilitiesUnrealizedGainsOnInvestmentSecurities_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_DeferredTaxLiabilityDepreciationAndAmortization" xlink:type="locator" xlink:label="mtb_DeferredTaxLiabilityDepreciationAndAmortization" />
    <label xml:lang="en-US" xlink:label="mtb_DeferredTaxLiabilityDepreciationAndAmortization_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Deferred tax liability depreciation and amortization</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DeferredTaxLiabilityDepreciationAndAmortization" xlink:to="mtb_DeferredTaxLiabilityDepreciationAndAmortization_lbl" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeBenefits" xlink:type="locator" xlink:label="us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeBenefits" />
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    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeBenefits" xlink:to="us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeBenefits_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeBenefits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Employee Benefits</label>
    <label xml:lang="en-US" xlink:label="mtb_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsPostretirementAndOtherEmployeeBenefits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Postretirement and other employee benefits</label>
    <label xml:lang="en-US" xlink:label="mtb_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsPostretirementAndOtherEmployeeBenefits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Postretirement And Other Employee Benefits</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation" xlink:type="locator" xlink:label="us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsEmployeeCompensation_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Incentive and other compensation plans</label>
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    <label xml:lang="en-US" xlink:label="mtb_DeferredTaxAssetsInterestOnLoans_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest on loans</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost" xlink:type="locator" xlink:label="us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Stock-based compensation</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost" xlink:to="us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredTaxAssetsOther" xlink:type="locator" xlink:label="us-gaap_DeferredTaxAssetsOther" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredTaxAssetsOther_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_DeferredTaxAssetsOther_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Tax Assets Other</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredTaxLiabilitiesLeasingArrangements" xlink:type="locator" xlink:label="us-gaap_DeferredTaxLiabilitiesLeasingArrangements" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredTaxLiabilitiesLeasingArrangements_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Leasing transactions</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_DeferredTaxLiabilitiesLeasingArrangements_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Tax Liabilities Leasing Arrangements</label>
    <label xml:lang="en-US" xlink:label="mtb_DeferredTaxLiabilitiesUnrealizedGainsOnInvestmentSecurities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Unrealized investment gains</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredTaxLiabilitiesMortgageServicingRights" xlink:type="locator" xlink:label="us-gaap_DeferredTaxLiabilitiesMortgageServicingRights" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredTaxLiabilitiesMortgageServicingRights_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Capitalized servicing rights</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DeferredTaxLiabilitiesMortgageServicingRights" xlink:to="us-gaap_DeferredTaxLiabilitiesMortgageServicingRights_lbl" />
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    <label xml:lang="en-US" xlink:label="mtb_DeferredTaxLiabilityDepreciationAndAmortization_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Depreciation and amortization</label>
    <label xml:lang="en-US" xlink:label="mtb_DeferredTaxLiabilityDepreciationAndAmortization_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Tax Liability Depreciation And Amortization</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredTaxLiabilitiesOther" xlink:type="locator" xlink:label="us-gaap_DeferredTaxLiabilitiesOther" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredTaxLiabilitiesOther_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Other</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DeferredTaxLiabilitiesOther" xlink:to="us-gaap_DeferredTaxLiabilitiesOther_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredTaxLiabilitiesOther_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Tax Liabilities Other</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities" xlink:type="locator" xlink:label="us-gaap_DeferredIncomeTaxLiabilities" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredIncomeTaxLiabilities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel">Gross deferred tax liabilities</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DeferredIncomeTaxLiabilities" xlink:to="us-gaap_DeferredIncomeTaxLiabilities_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredIncomeTaxLiabilities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Income Tax Liabilities</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet" xlink:type="locator" xlink:label="us-gaap_DeferredTaxAssetsLiabilitiesNet" />
    <label xml:lang="en-US" xlink:label="us-gaap_DeferredTaxAssetsLiabilitiesNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net deferred tax asset</label>
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    <label xml:lang="en-US" xlink:label="us-gaap_DeferredTaxAssetsLiabilitiesNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Deferred Tax Assets Liabilities Net</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_UnrecognizedTaxBenefitsAcquiredInBusinessCombination" xlink:type="locator" xlink:label="mtb_UnrecognizedTaxBenefitsAcquiredInBusinessCombination" />
    <label xml:lang="en-US" xlink:label="mtb_UnrecognizedTaxBenefitsAcquiredInBusinessCombination_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Unrecognized tax benefits acquired in business combination.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_UnrecognizedTaxBenefitsAcquiredInBusinessCombination" xlink:to="mtb_UnrecognizedTaxBenefitsAcquiredInBusinessCombination_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_UnrecognizedFederalStateAndLocalIncomeTaxBenefits" xlink:type="locator" xlink:label="mtb_UnrecognizedFederalStateAndLocalIncomeTaxBenefits" />
    <label xml:lang="en-US" xlink:label="mtb_UnrecognizedFederalStateAndLocalIncomeTaxBenefits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Net amount of federal, state and local income tax benefit that would be realized if the gross unrecognized tax benefits were to be recognized, including the federal income tax reduction that would result from the payment of the accrued interest on a previously unrecognized tax benefit. This amount reduces the unrecognized tax benefits that, if recognized, would impact the effective income tax rate.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_UnrecognizedFederalStateAndLocalIncomeTaxBenefits" xlink:to="mtb_UnrecognizedFederalStateAndLocalIncomeTaxBenefits_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_ReconciliationOfUnrecognizedTaxBenefitsLineItems" xlink:type="locator" xlink:label="mtb_ReconciliationOfUnrecognizedTaxBenefitsLineItems" />
    <label xml:lang="en-US" xlink:label="mtb_ReconciliationOfUnrecognizedTaxBenefitsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Reconciliation of unrecognized tax benefits.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ReconciliationOfUnrecognizedTaxBenefitsLineItems" xlink:to="mtb_ReconciliationOfUnrecognizedTaxBenefitsLineItems_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_ReconciliationOfUnrecognizedTaxBenefitsTable" xlink:type="locator" xlink:label="mtb_ReconciliationOfUnrecognizedTaxBenefitsTable" />
    <label xml:lang="en-US" xlink:label="mtb_ReconciliationOfUnrecognizedTaxBenefitsTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Reconciliation Of Unrecognized Tax Benefits [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ReconciliationOfUnrecognizedTaxBenefitsTable" xlink:to="mtb_ReconciliationOfUnrecognizedTaxBenefitsTable_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_ReconciliationOfUnrecognizedTaxBenefitsTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Reconciliation Of Unrecognized Tax Benefits [Table]</label>
    <label xml:lang="en-US" xlink:label="mtb_ReconciliationOfUnrecognizedTaxBenefitsTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Reconciliation Of Unrecognized Tax Benefits [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis" xlink:type="locator" xlink:label="us-gaap_IncomeTaxAuthorityAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_IncomeTaxAuthorityAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Income Tax Authority</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncomeTaxAuthorityAxis" xlink:to="us-gaap_IncomeTaxAuthorityAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_IncomeTaxAuthorityAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Income Tax Authority [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:type="locator" xlink:label="us-gaap_IncomeTaxAuthorityDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_IncomeTaxAuthorityDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Income Tax Authority</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncomeTaxAuthorityDomain" xlink:to="us-gaap_IncomeTaxAuthorityDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_IncomeTaxAuthorityDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Income Tax Authority [Domain]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_FederalStateAndLocalTaxMember" xlink:type="locator" xlink:label="mtb_FederalStateAndLocalTaxMember" />
    <label xml:lang="en-US" xlink:label="mtb_FederalStateAndLocalTaxMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Federal state and local tax.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_FederalStateAndLocalTaxMember" xlink:to="mtb_FederalStateAndLocalTaxMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_FederalStateAndLocalTaxMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Federal, State and Local Tax [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_FederalStateAndLocalTaxMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Federal State And Local Tax [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_AccruedInterestMember" xlink:type="locator" xlink:label="mtb_AccruedInterestMember" />
    <label xml:lang="en-US" xlink:label="mtb_AccruedInterestMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Accrued interest.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_AccruedInterestMember" xlink:to="mtb_AccruedInterestMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_AccruedInterestMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accrued Interest [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_AccruedInterestMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Accrued Interest [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_UnrecognizedIncomeTaxBenefitsMember" xlink:type="locator" xlink:label="mtb_UnrecognizedIncomeTaxBenefitsMember" />
    <label xml:lang="en-US" xlink:label="mtb_UnrecognizedIncomeTaxBenefitsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Unrecognized income tax benefits.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_UnrecognizedIncomeTaxBenefitsMember" xlink:to="mtb_UnrecognizedIncomeTaxBenefitsMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_UnrecognizedIncomeTaxBenefitsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Unrecognized Income Tax Benefits [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_UnrecognizedIncomeTaxBenefitsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Unrecognized Income Tax Benefits [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_ReconciliationOfUnrecognizedTaxBenefitsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Reconciliation Of Unrecognized Tax Benefits [Line Items]</label>
    <label xml:lang="en-US" xlink:label="mtb_ReconciliationOfUnrecognizedTaxBenefitsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Reconciliation Of Unrecognized Tax Benefits [Line Items]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_UnrecognizedTaxBenefits" xlink:type="locator" xlink:label="us-gaap_UnrecognizedTaxBenefits" />
    <label xml:lang="en-US" xlink:label="us-gaap_UnrecognizedTaxBenefits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel">Beginning Balance</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_UnrecognizedTaxBenefits" xlink:to="us-gaap_UnrecognizedTaxBenefits_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_UnrecognizedTaxBenefits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Unrecognized Tax Benefits</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions" xlink:type="locator" xlink:label="us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions" />
    <label xml:lang="en-US" xlink:label="us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increases as a result of tax positions taken during the period</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions" xlink:to="us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Unrecognized Tax Benefits Increases Resulting From Current Period Tax Positions</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions" xlink:type="locator" xlink:label="us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions" />
    <label xml:lang="en-US" xlink:label="us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increases as a result of tax positions taken in prior years</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions" xlink:to="us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Unrecognized Tax Benefits Increases Resulting From Prior Period Tax Positions</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities" xlink:type="locator" xlink:label="us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities" />
    <label xml:lang="en-US" xlink:label="us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Decreases as a result of settlements with taxing authorities</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities" xlink:to="us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Unrecognized Tax Benefits Decreases Resulting From Settlements With Taxing Authorities</label>
    <label xml:lang="en-US" xlink:label="mtb_UnrecognizedTaxBenefitsAcquiredInBusinessCombination_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Unrealized tax benefits acquired in a business combination</label>
    <label xml:lang="en-US" xlink:label="mtb_UnrecognizedTaxBenefitsAcquiredInBusinessCombination_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Unrecognized Tax Benefits Acquired In Business Combination</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions" xlink:type="locator" xlink:label="us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions" />
    <label xml:lang="en-US" xlink:label="us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Decreases as a result of tax positions taken in prior years</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions" xlink:to="us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Unrecognized Tax Benefits Decreases Resulting From Prior Period Tax Positions</label>
    <label xml:lang="en-US" xlink:label="us-gaap_UnrecognizedTaxBenefits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Ending Balance</label>
    <label xml:lang="en-US" xlink:label="mtb_UnrecognizedFederalStateAndLocalIncomeTaxBenefits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Less: Federal, state and local income tax benefits</label>
    <label xml:lang="en-US" xlink:label="mtb_UnrecognizedFederalStateAndLocalIncomeTaxBenefits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Unrecognized Federal State And Local Income Tax Benefits</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate" xlink:type="locator" xlink:label="us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate" />
    <label xml:lang="en-US" xlink:label="us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net unrecognized tax benefits that, if recognized, would impact the effective income tax rate</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate" xlink:to="us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Unrecognized Tax Benefits That Would Impact Effective Tax Rate</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_NumberOfStateAndLocalJurisdictionsWhereCompanyFilesIncomeTaxReturns" xlink:type="locator" xlink:label="mtb_NumberOfStateAndLocalJurisdictionsWhereCompanyFilesIncomeTaxReturns" />
    <label xml:lang="en-US" xlink:label="mtb_NumberOfStateAndLocalJurisdictionsWhereCompanyFilesIncomeTaxReturns_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of state and local jurisdictions where company files income tax returns.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_NumberOfStateAndLocalJurisdictionsWhereCompanyFilesIncomeTaxReturns" xlink:to="mtb_NumberOfStateAndLocalJurisdictionsWhereCompanyFilesIncomeTaxReturns_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_NumberOfStateAndLocalJurisdictionsWhereCompanyFilesIncomeTaxReturns_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Number of state and local jurisdictions where company files income tax returns</label>
    <label xml:lang="en-US" xlink:label="mtb_NumberOfStateAndLocalJurisdictionsWhereCompanyFilesIncomeTaxReturns_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Number Of State And Local Jurisdictions Where Company Files Income Tax Returns</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_NetIncomeLossAvailableToCommonStockholdersBasicBeforeUnvestedStockBasedCompensationAwardsAdjustment" xlink:type="locator" xlink:label="mtb_NetIncomeLossAvailableToCommonStockholdersBasicBeforeUnvestedStockBasedCompensationAwardsAdjustment" />
    <label xml:lang="en-US" xlink:label="mtb_NetIncomeLossAvailableToCommonStockholdersBasicBeforeUnvestedStockBasedCompensationAwardsAdjustment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Net income loss available to common stockholders before unvested stock based compensation awards adjustment as used in the determination of basic earnings per common share.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_NetIncomeLossAvailableToCommonStockholdersBasicBeforeUnvestedStockBasedCompensationAwardsAdjustment" xlink:to="mtb_NetIncomeLossAvailableToCommonStockholdersBasicBeforeUnvestedStockBasedCompensationAwardsAdjustment_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_IncomeAttributableToUnvestedStockBasedCompensationAwardsBasic" xlink:type="locator" xlink:label="mtb_IncomeAttributableToUnvestedStockBasedCompensationAwardsBasic" />
    <label xml:lang="en-US" xlink:label="mtb_IncomeAttributableToUnvestedStockBasedCompensationAwardsBasic_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Income attributable to unvested stock based compensation awards. This amount is used as a reduction to net income available to common equity in the calculation of net income available to common shareholders as used in the determination of basic earnings per common share.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_IncomeAttributableToUnvestedStockBasedCompensationAwardsBasic" xlink:to="mtb_IncomeAttributableToUnvestedStockBasedCompensationAwardsBasic_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_CommonSharesOutstandingIncludingCommonStockIssuableAndUnvestedStockBasedCompensationAwards" xlink:type="locator" xlink:label="mtb_CommonSharesOutstandingIncludingCommonStockIssuableAndUnvestedStockBasedCompensationAwards" />
    <label xml:lang="en-US" xlink:label="mtb_CommonSharesOutstandingIncludingCommonStockIssuableAndUnvestedStockBasedCompensationAwards_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The weighted average number of common shares outstanding (including common stock issuable) and unvested stock-based compensation awards.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommonSharesOutstandingIncludingCommonStockIssuableAndUnvestedStockBasedCompensationAwards" xlink:to="mtb_CommonSharesOutstandingIncludingCommonStockIssuableAndUnvestedStockBasedCompensationAwards_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_UnvestedStockBasedCompensationAwards" xlink:type="locator" xlink:label="mtb_UnvestedStockBasedCompensationAwards" />
    <label xml:lang="en-US" xlink:label="mtb_UnvestedStockBasedCompensationAwards_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Number of shares related to unvested stock-based compensation awards. This amount is a reduction in the calculation of weighted average shares outstanding for the earnings per share calculation.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_UnvestedStockBasedCompensationAwards" xlink:to="mtb_UnvestedStockBasedCompensationAwards_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Income available to common shareholders:</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PreferredStockDividendsIncomeStatementImpact" xlink:type="locator" xlink:label="us-gaap_PreferredStockDividendsIncomeStatementImpact" />
    <label xml:lang="en-US" xlink:label="us-gaap_PreferredStockDividendsIncomeStatementImpact_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Less: Preferred stock dividends</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PreferredStockDividendsIncomeStatementImpact" xlink:to="us-gaap_PreferredStockDividendsIncomeStatementImpact_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PreferredStockDividendsIncomeStatementImpact_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Preferred Stock Dividends Income Statement Impact</label>
    <label xml:lang="en-US" xlink:label="mtb_NetIncomeLossAvailableToCommonStockholdersBasicBeforeUnvestedStockBasedCompensationAwardsAdjustment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net income available to common equity</label>
    <label xml:lang="en-US" xlink:label="mtb_NetIncomeLossAvailableToCommonStockholdersBasicBeforeUnvestedStockBasedCompensationAwardsAdjustment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Net Income Loss Available To Common Stockholders Basic Before Unvested Stock Based Compensation Awards Adjustment</label>
    <label xml:lang="en-US" xlink:label="mtb_IncomeAttributableToUnvestedStockBasedCompensationAwardsBasic_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Less: Income attributable to unvested stock-based compensation awards</label>
    <label xml:lang="en-US" xlink:label="mtb_IncomeAttributableToUnvestedStockBasedCompensationAwardsBasic_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Income Attributable To Unvested Stock Based Compensation Awards Basic</label>
    <label xml:lang="en-US" xlink:label="us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Net income available to common shareholders</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasicAbstract" xlink:type="locator" xlink:label="us-gaap_WeightedAverageNumberOfSharesOutstandingBasicAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_WeightedAverageNumberOfSharesOutstandingBasicAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Weighted-average shares outstanding:</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_WeightedAverageNumberOfSharesOutstandingBasicAbstract" xlink:to="us-gaap_WeightedAverageNumberOfSharesOutstandingBasicAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_WeightedAverageNumberOfSharesOutstandingBasicAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Weighted Average Number Of Shares Outstanding Basic [Abstract]</label>
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    <label xml:lang="en-US" xlink:label="mtb_CommonSharesOutstandingIncludingCommonStockIssuableAndUnvestedStockBasedCompensationAwards_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Common Shares Outstanding Including Common Stock Issuable And Unvested Stock Based Compensation Awards</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" xlink:type="locator" xlink:label="us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" />
    <label xml:lang="en-US" xlink:label="us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Plus: Incremental shares from assumed conversion of stock-based compensation awards and warrants to purchase common stock</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:type="locator" xlink:label="us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" />
    <label xml:lang="en-US" xlink:label="us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Adjusted weighted-average shares outstanding</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:to="us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_lbl" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:type="locator" xlink:label="us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:type="locator" xlink:label="us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Statement Of Income And Comprehensive Income [Abstract]</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_AccumulatedNetUnrealizedInvestmentGainLossWithOTTIMember" xlink:type="locator" xlink:label="mtb_AccumulatedNetUnrealizedInvestmentGainLossWithOTTIMember" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_AccumulatedNetUnrealizedInvestmentGainLossAllOtherMember" xlink:type="locator" xlink:label="mtb_AccumulatedNetUnrealizedInvestmentGainLossAllOtherMember" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember" xlink:type="locator" xlink:label="us-gaap_AccumulatedDefinedBenefitPlansAdjustmentMember" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_AccumulatedOtherMember" xlink:type="locator" xlink:label="mtb_AccumulatedOtherMember" />
    <label xml:lang="en-US" xlink:label="mtb_AccumulatedOtherMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Accumulated other.</label>
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    <label xml:lang="en-US" xlink:label="mtb_AccumulatedOtherMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Accumulated Other [Member]</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossBeforeTax1" xlink:type="locator" xlink:label="us-gaap_AccumulatedOtherComprehensiveIncomeLossBeforeTax1" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax" xlink:type="locator" xlink:label="us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossBeforeReclassificationAndTax" xlink:type="locator" xlink:label="us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossBeforeReclassificationAndTax" />
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    <label xml:lang="en-US" xlink:label="mtb_OtherComprehensiveIncomeLossReclassificationAdjustmentForRealizedGainsLossesIncludedInNetIncomeNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Gains (losses) realized in net income, net of tax</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherComprehensiveIncomeLossReclassificationAdjustmentForRealizedGainsLossesIncludedInNetIncomeNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Comprehensive Income Loss Reclassification Adjustment For Realized Gains Losses Included In Net Income Net Of Tax</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIOnDerivativesNetOfTax" xlink:type="locator" xlink:label="us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIOnDerivativesNetOfTax" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIOnDerivativesNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Accretion of net gain on terminated cash flow hedges, net of tax</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIOnDerivativesNetOfTax" xlink:to="us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIOnDerivativesNetOfTax_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIOnDerivativesNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Comprehensive Income Loss Reclassification Adjustment From A O C I On Derivatives Net Of Tax</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditNetOfTax" xlink:type="locator" xlink:label="us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditNetOfTax" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amortization of prior service credit, net of tax</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditNetOfTax" xlink:to="us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditNetOfTax_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Comprehensive Income Loss Amortization Adjustment From A O C I Pension And Other Postretirement Benefit Plans For Net Prior Service Cost Credit Net Of Tax</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherComprehensiveIncomeAmortizationOfDefinedBenefitPlanActuarialLossRecognizedInNetPeriodicBenefitCostNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amortization of actuarial losses, net of tax</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherComprehensiveIncomeAmortizationOfDefinedBenefitPlanActuarialLossRecognizedInNetPeriodicBenefitCostNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Comprehensive Income Amortization Of Defined Benefit Plan Actuarial Loss Recognized In Net Periodic Benefit Cost Net Of Tax</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax" xlink:type="locator" xlink:label="us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax" />
    <label xml:lang="en-US" xlink:label="us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel">Total reclassifications, net of tax</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax" xlink:to="us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Reclassification From Accumulated Other Comprehensive Income Current Period Net Of Tax</label>
    <label xml:lang="en-US" xlink:label="us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel">Ending balance, net of tax</label>
    <label xml:lang="en-US" xlink:label="mtb_AccumulatedNetUnrealizedInvestmentGainLossWithOTTIMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Investment securities With OTTI [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_AccumulatedNetUnrealizedInvestmentGainLossAllOtherMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Investment securities All Other [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_AccumulatedOtherAdjustmentMember" xlink:type="locator" xlink:label="mtb_AccumulatedOtherAdjustmentMember" />
    <label xml:lang="en-US" xlink:label="mtb_AccumulatedOtherAdjustmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Accumulated Other Adjustment [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_AccumulatedOtherAdjustmentMember" xlink:to="mtb_AccumulatedOtherAdjustmentMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_AccumulatedOtherAdjustmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accumulated Other Adjustment [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_AccumulatedOtherAdjustmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Accumulated Other Adjustment [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SecuritiesInvestmentMember" xlink:type="locator" xlink:label="us-gaap_SecuritiesInvestmentMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_SecuritiesInvestmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investment Securities [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SecuritiesInvestmentMember" xlink:to="us-gaap_SecuritiesInvestmentMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_SecuritiesInvestmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Securities Investment [Member]</label>
    <label xml:lang="en-US" xlink:label="us-gaap_OtherComprehensiveIncomeLossNetOfTax_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net gain (loss) during period</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CreditRelatedFeeIncome" xlink:type="locator" xlink:label="mtb_CreditRelatedFeeIncome" />
    <label xml:lang="en-US" xlink:label="mtb_CreditRelatedFeeIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Credit related fee income.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CreditRelatedFeeIncome" xlink:to="mtb_CreditRelatedFeeIncome_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_LetterOfCreditFees" xlink:type="locator" xlink:label="mtb_LetterOfCreditFees" />
    <label xml:lang="en-US" xlink:label="mtb_LetterOfCreditFees_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Letter of credit fees.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_LetterOfCreditFees" xlink:to="mtb_LetterOfCreditFees_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherIncomeAndExpensesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Income And Expenses [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherIncomeAbstract" xlink:type="locator" xlink:label="us-gaap_OtherIncomeAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherIncomeAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other income:</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherIncomeAbstract" xlink:to="us-gaap_OtherIncomeAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherIncomeAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Income [Abstract]</label>
    <label xml:lang="en-US" xlink:label="mtb_CreditRelatedFeeIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Credit-related fee income</label>
    <label xml:lang="en-US" xlink:label="mtb_CreditRelatedFeeIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Credit Related Fee Income</label>
    <label xml:lang="en-US" xlink:label="mtb_LetterOfCreditFees_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Letter of credit fees</label>
    <label xml:lang="en-US" xlink:label="mtb_LetterOfCreditFees_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Letter Of Credit Fees</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_BankOwnedLifeInsuranceIncome" xlink:type="locator" xlink:label="us-gaap_BankOwnedLifeInsuranceIncome" />
    <label xml:lang="en-US" xlink:label="us-gaap_BankOwnedLifeInsuranceIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Bank owned life insurance</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_BankOwnedLifeInsuranceIncome" xlink:to="us-gaap_BankOwnedLifeInsuranceIncome_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_BankOwnedLifeInsuranceIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Bank Owned Life Insurance Income</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherExpensesAbstract" xlink:type="locator" xlink:label="us-gaap_OtherExpensesAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherExpensesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other expense:</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherExpensesAbstract" xlink:to="us-gaap_OtherExpensesAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherExpensesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Expenses [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ProfessionalFees" xlink:type="locator" xlink:label="us-gaap_ProfessionalFees" />
    <label xml:lang="en-US" xlink:label="us-gaap_ProfessionalFees_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Professional services</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ProfessionalFees" xlink:to="us-gaap_ProfessionalFees_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ProfessionalFees_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Professional Fees</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_RevenuesFromInternationalTrustRelatedServices" xlink:type="locator" xlink:label="mtb_RevenuesFromInternationalTrustRelatedServices" />
    <label xml:lang="en-US" xlink:label="mtb_RevenuesFromInternationalTrustRelatedServices_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount of revenues related to international trust related services, including wealth management services, offered internationally.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_RevenuesFromInternationalTrustRelatedServices" xlink:to="mtb_RevenuesFromInternationalTrustRelatedServices_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_InternationalActivitiesLineItems" xlink:type="locator" xlink:label="mtb_InternationalActivitiesLineItems" />
    <label xml:lang="en-US" xlink:label="mtb_InternationalActivitiesLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">International Activities [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_InternationalActivitiesLineItems" xlink:to="mtb_InternationalActivitiesLineItems_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_InternationalActivitiesTable" xlink:type="locator" xlink:label="mtb_InternationalActivitiesTable" />
    <label xml:lang="en-US" xlink:label="mtb_InternationalActivitiesTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">International Activities [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_InternationalActivitiesTable" xlink:to="mtb_InternationalActivitiesTable_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_InternationalActivitiesTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">International Activities [Table]</label>
    <label xml:lang="en-US" xlink:label="mtb_InternationalActivitiesTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">International Activities [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:type="locator" xlink:label="us-gaap_ConcentrationRiskByTypeAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConcentrationRiskByTypeAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Concentration Risk Type</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ConcentrationRiskByTypeAxis" xlink:to="us-gaap_ConcentrationRiskByTypeAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConcentrationRiskByTypeAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Concentration Risk By Type [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:type="locator" xlink:label="us-gaap_ConcentrationRiskTypeDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConcentrationRiskTypeDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Concentration Risk Type</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ConcentrationRiskTypeDomain" xlink:to="us-gaap_ConcentrationRiskTypeDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConcentrationRiskTypeDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Concentration Risk Type [Domain]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GeographicConcentrationRiskMember" xlink:type="locator" xlink:label="us-gaap_GeographicConcentrationRiskMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_GeographicConcentrationRiskMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Geographic Concentration Risk [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_GeographicConcentrationRiskMember" xlink:to="us-gaap_GeographicConcentrationRiskMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_GeographicConcentrationRiskMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Geographic Concentration Risk [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:type="locator" xlink:label="us-gaap_ConcentrationRiskByBenchmarkAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConcentrationRiskByBenchmarkAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Concentration Risk Benchmark</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:to="us-gaap_ConcentrationRiskByBenchmarkAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConcentrationRiskByBenchmarkAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Concentration Risk By Benchmark [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:type="locator" xlink:label="us-gaap_ConcentrationRiskBenchmarkDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConcentrationRiskBenchmarkDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Concentration Risk Benchmark</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ConcentrationRiskBenchmarkDomain" xlink:to="us-gaap_ConcentrationRiskBenchmarkDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConcentrationRiskBenchmarkDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Concentration Risk Benchmark [Domain]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AssetsTotalMember" xlink:type="locator" xlink:label="us-gaap_AssetsTotalMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_AssetsTotalMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Assets, Total [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AssetsTotalMember" xlink:to="us-gaap_AssetsTotalMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AssetsTotalMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Assets Total [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SalesRevenueNetMember" xlink:type="locator" xlink:label="us-gaap_SalesRevenueNetMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_SalesRevenueNetMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Sales Revenue, Net [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SalesRevenueNetMember" xlink:to="us-gaap_SalesRevenueNetMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_SalesRevenueNetMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Sales Revenue Net [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GeographicDistributionAxis" xlink:type="locator" xlink:label="us-gaap_GeographicDistributionAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_GeographicDistributionAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Geographic Distribution</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_GeographicDistributionAxis" xlink:to="us-gaap_GeographicDistributionAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_GeographicDistributionAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Geographic Distribution [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GeographicDistributionDomain" xlink:type="locator" xlink:label="us-gaap_GeographicDistributionDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_GeographicDistributionDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Geographic Distribution</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_GeographicDistributionDomain" xlink:to="us-gaap_GeographicDistributionDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_GeographicDistributionDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Geographic Distribution [Domain]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GeographicDistributionForeignMember" xlink:type="locator" xlink:label="us-gaap_GeographicDistributionForeignMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_GeographicDistributionForeignMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Geographic Distribution, Foreign [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_GeographicDistributionForeignMember" xlink:to="us-gaap_GeographicDistributionForeignMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_GeographicDistributionForeignMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Geographic Distribution Foreign [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementGeographicalAxis" xlink:type="locator" xlink:label="us-gaap_StatementGeographicalAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_StatementGeographicalAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Geographical</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StatementGeographicalAxis" xlink:to="us-gaap_StatementGeographicalAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_StatementGeographicalAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Statement Geographical [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentGeographicalDomain" xlink:type="locator" xlink:label="us-gaap_SegmentGeographicalDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_SegmentGeographicalDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Geographical</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SegmentGeographicalDomain" xlink:to="us-gaap_SegmentGeographicalDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_SegmentGeographicalDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Segment Geographical [Domain]</label>
    <loc xlink:href="http://xbrl.sec.gov/country/2016/country-2016-01-31.xsd#country_KY" xlink:type="locator" xlink:label="country_KY" />
    <label xml:lang="en-US" xlink:label="country_KY_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cayman Islands [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="country_KY" xlink:to="country_KY_lbl" />
    <label xml:lang="en-US" xlink:label="country_KY_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">CAYMAN ISLANDS</label>
    <loc xlink:href="http://xbrl.sec.gov/country/2016/country-2016-01-31.xsd#country_CA" xlink:type="locator" xlink:label="country_CA" />
    <label xml:lang="en-US" xlink:label="country_CA_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Canada [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="country_CA" xlink:to="country_CA_lbl" />
    <label xml:lang="en-US" xlink:label="country_CA_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">CANADA</label>
    <label xml:lang="en-US" xlink:label="mtb_InternationalActivitiesLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">International Activities [Line Items]</label>
    <label xml:lang="en-US" xlink:label="mtb_InternationalActivitiesLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">International Activities [Line Items]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:type="locator" xlink:label="us-gaap_ConcentrationRiskPercentage1" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConcentrationRiskPercentage1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Concentration risk percentage</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ConcentrationRiskPercentage1" xlink:to="us-gaap_ConcentrationRiskPercentage1_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConcentrationRiskPercentage1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Concentration Risk Percentage1</label>
    <label xml:lang="en-US" xlink:label="mtb_RevenuesFromInternationalTrustRelatedServices_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Revenues from international trust-related services</label>
    <label xml:lang="en-US" xlink:label="mtb_RevenuesFromInternationalTrustRelatedServices_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Revenues From International Trust Related Services</label>
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableNetReportedAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loans to foreign borrowers</label>
    <label xml:lang="en-US" xlink:label="us-gaap_DepositsForeign_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Deposits at foreign office</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_AverageNotionalAmountOfInterestRateFairValueHedgeDerivatives" xlink:type="locator" xlink:label="mtb_AverageNotionalAmountOfInterestRateFairValueHedgeDerivatives" />
    <label xml:lang="en-US" xlink:label="mtb_AverageNotionalAmountOfInterestRateFairValueHedgeDerivatives_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The average notional amounts of interest rate swap agreement impacting net interest income that were entered into for interest rate risk management purposes.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_AverageNotionalAmountOfInterestRateFairValueHedgeDerivatives" xlink:to="mtb_AverageNotionalAmountOfInterestRateFairValueHedgeDerivatives_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OffsettingAbstract" xlink:type="locator" xlink:label="us-gaap_OffsettingAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_OffsettingAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Offsetting [Abstract]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OffsettingAbstract" xlink:to="us-gaap_OffsettingAbstract_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeTable" xlink:type="locator" xlink:label="us-gaap_DerivativeTable" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Derivative [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeTable" xlink:to="us-gaap_DerivativeTable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Derivative [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:type="locator" xlink:label="us-gaap_DerivativeInstrumentRiskAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeInstrumentRiskAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Derivative Instrument</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeInstrumentRiskAxis" xlink:to="us-gaap_DerivativeInstrumentRiskAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeInstrumentRiskAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Derivative Instrument Risk [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:type="locator" xlink:label="us-gaap_DerivativeContractTypeDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeContractTypeDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Derivative Contract</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeContractTypeDomain" xlink:to="us-gaap_DerivativeContractTypeDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeContractTypeDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Derivative Contract Type [Domain]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:type="locator" xlink:label="us-gaap_InterestRateSwapMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_InterestRateSwapMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest Rate Swap Agreements [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestRateSwapMember" xlink:to="us-gaap_InterestRateSwapMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_InterestRateSwapMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Interest Rate Swap [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestRateContractMember" xlink:type="locator" xlink:label="us-gaap_InterestRateContractMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_InterestRateContractMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest Rate Contracts [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestRateContractMember" xlink:to="us-gaap_InterestRateContractMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_InterestRateContractMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Interest Rate Contract [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ForeignCurrencyAndOtherOptionAndFuturesContractsMember" xlink:type="locator" xlink:label="mtb_ForeignCurrencyAndOtherOptionAndFuturesContractsMember" />
    <label xml:lang="en-US" xlink:label="mtb_ForeignCurrencyAndOtherOptionAndFuturesContractsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Foreign Currency And Other Option And Futures Contracts [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ForeignCurrencyAndOtherOptionAndFuturesContractsMember" xlink:to="mtb_ForeignCurrencyAndOtherOptionAndFuturesContractsMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_ForeignCurrencyAndOtherOptionAndFuturesContractsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Foreign Currency and Other Option and Futures Contracts [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_ForeignCurrencyAndOtherOptionAndFuturesContractsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Foreign Currency And Other Option And Futures Contracts [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CounterpartiesMember" xlink:type="locator" xlink:label="mtb_CounterpartiesMember" />
    <label xml:lang="en-US" xlink:label="mtb_CounterpartiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Counterparties.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CounterpartiesMember" xlink:to="mtb_CounterpartiesMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CounterpartiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Counterparties [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_CounterpartiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Counterparties [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CreditRiskDerivativeMember" xlink:type="locator" xlink:label="mtb_CreditRiskDerivativeMember" />
    <label xml:lang="en-US" xlink:label="mtb_CreditRiskDerivativeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Credit risk derivative.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CreditRiskDerivativeMember" xlink:to="mtb_CreditRiskDerivativeMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CreditRiskDerivativeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Credit Risk Derivative [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_CreditRiskDerivativeMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Credit Risk Derivative [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ClearinghouseCreditFacilitiesMember" xlink:type="locator" xlink:label="mtb_ClearinghouseCreditFacilitiesMember" />
    <label xml:lang="en-US" xlink:label="mtb_ClearinghouseCreditFacilitiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Clearinghouse Credit Facilities [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ClearinghouseCreditFacilitiesMember" xlink:to="mtb_ClearinghouseCreditFacilitiesMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_ClearinghouseCreditFacilitiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Clearinghouse Credit Facilities [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_ClearinghouseCreditFacilitiesMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Clearinghouse Credit Facilities [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeLineItems" xlink:type="locator" xlink:label="us-gaap_DerivativeLineItems" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Derivative [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeLineItems" xlink:to="us-gaap_DerivativeLineItems_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Derivative [Line Items]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortionNet" xlink:type="locator" xlink:label="us-gaap_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortionNet" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortionNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase in net interest income due to interest rate swap agreements</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortionNet" xlink:to="us-gaap_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortionNet_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortionNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Derivative Instruments Gain Loss Reclassified From Accumulated O C I Into Income Effective Portion Net</label>
    <label xml:lang="en-US" xlink:label="mtb_AverageNotionalAmountOfInterestRateFairValueHedgeDerivatives_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Average notional amounts of interest rate swap agreements impacting net interest income, contract entered into for interest rate risk management purposes</label>
    <label xml:lang="en-US" xlink:label="mtb_AverageNotionalAmountOfInterestRateFairValueHedgeDerivatives_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Average Notional Amount Of Interest Rate Fair Value Hedge Derivatives</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TradingActivityByTypeAxis" xlink:type="locator" xlink:label="us-gaap_TradingActivityByTypeAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_TradingActivityByTypeAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Trading Activity</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TradingActivityByTypeAxis" xlink:to="us-gaap_TradingActivityByTypeAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_TradingActivityByTypeAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Trading Activity By Type [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TradingActivityByTypeDomain" xlink:type="locator" xlink:label="us-gaap_TradingActivityByTypeDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_TradingActivityByTypeDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Trading Activity, by Type</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TradingActivityByTypeDomain" xlink:to="us-gaap_TradingActivityByTypeDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_TradingActivityByTypeDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Trading Activity By Type [Domain]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_FixedRateLongTermBorrowingsMember" xlink:type="locator" xlink:label="mtb_FixedRateLongTermBorrowingsMember" />
    <label xml:lang="en-US" xlink:label="mtb_FixedRateLongTermBorrowingsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Fixed rate long-term borrowings [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_FixedRateLongTermBorrowingsMember" xlink:to="mtb_FixedRateLongTermBorrowingsMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_FixedRateLongTermBorrowingsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fixed Rate Long-Term Borrowings [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_FixedRateLongTermBorrowingsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Fixed Rate Long Term Borrowings [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis" xlink:type="locator" xlink:label="us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Hedging Relationship</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis" xlink:to="us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_lbl" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_DerivativeNotionalAmountToExpireInNextTwelveMonths" xlink:type="locator" xlink:label="mtb_DerivativeNotionalAmountToExpireInNextTwelveMonths" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_DerivativeNotionalAmountToExpireInYearTwo" xlink:type="locator" xlink:label="mtb_DerivativeNotionalAmountToExpireInYearTwo" />
    <label xml:lang="en-US" xlink:label="mtb_DerivativeNotionalAmountToExpireInYearTwo_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The notional amount of interest rate swap agreements entered into for risk management purposes that mature during the second year after the balance sheet date.</label>
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    <label xml:lang="en-US" xlink:label="mtb_DerivativeNotionalAmountToExpireInNextTwelveMonths_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2017</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_MortgageRelatedCommitmentsToOriginateRealEstateLoansForSaleMember" xlink:type="locator" xlink:label="mtb_MortgageRelatedCommitmentsToOriginateRealEstateLoansForSaleMember" />
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    <label xml:lang="en-US" xlink:label="mtb_ForeignExchangeAndOtherOptionAndFuturesContractsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Foreign exchange and other option and futures contracts.</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable" xlink:type="locator" xlink:label="us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeGainLossOnDerivativeNet" xlink:type="locator" xlink:label="us-gaap_DerivativeGainLossOnDerivativeNet" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_GainLossOnDerivativeInstrumentsHeldForTradingPurposesNet" xlink:type="locator" xlink:label="us-gaap_GainLossOnDerivativeInstrumentsHeldForTradingPurposesNet" />
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    <label xml:lang="en-US" xlink:label="us-gaap_GainLossOnDerivativeInstrumentsHeldForTradingPurposesNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Gain Loss On Derivative Instruments Held For Trading Purposes Net</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_DerivativeHedgedLoans" xlink:type="locator" xlink:label="mtb_DerivativeHedgedLoans" />
    <label xml:lang="en-US" xlink:label="mtb_DerivativeHedgedLoans_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">As of the balance sheet date of the net amount of unrealized pre-tax gains and losses from hedged loans, that are held for sale, commitments to originate loans for sale and commitments to sell loans, and that meet the criteria of being accounted for as derivative instruments.</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountNotOffsetAgainstCollateral" xlink:type="locator" xlink:label="us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountNotOffsetAgainstCollateral" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountNotOffsetAgainstCollateral_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Aggregate fair value of derivative financial instruments in a liability position</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountNotOffsetAgainstCollateral" xlink:to="us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountNotOffsetAgainstCollateral_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountNotOffsetAgainstCollateral_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Derivative Fair Value Of Derivative Liability Amount Not Offset Against Collateral</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral" xlink:type="locator" xlink:label="us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net liability positions with counterparties</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral" xlink:to="us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Derivative Fair Value Of Derivative Liability Amount Offset Against Collateral</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeLiabilityFairValueOfCollateral" xlink:type="locator" xlink:label="us-gaap_DerivativeLiabilityFairValueOfCollateral" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeLiabilityFairValueOfCollateral_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Post collateral requirements relating to positions</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeLiabilityFairValueOfCollateral" xlink:to="us-gaap_DerivativeLiabilityFairValueOfCollateral_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeLiabilityFairValueOfCollateral_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Derivative Liability Fair Value Of Collateral</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeNetLiabilityPositionAggregateFairValue" xlink:type="locator" xlink:label="us-gaap_DerivativeNetLiabilityPositionAggregateFairValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeNetLiabilityPositionAggregateFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Aggregate fair value of derivative financial instruments in a net liability position</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeNetLiabilityPositionAggregateFairValue" xlink:to="us-gaap_DerivativeNetLiabilityPositionAggregateFairValue_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeNetLiabilityPositionAggregateFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Derivative Net Liability Position Aggregate Fair Value</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AdditionalCollateralAggregateFairValue" xlink:type="locator" xlink:label="us-gaap_AdditionalCollateralAggregateFairValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_AdditionalCollateralAggregateFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair value of additional collateral to be posted for derivative financial instruments</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AdditionalCollateralAggregateFairValue" xlink:to="us-gaap_AdditionalCollateralAggregateFairValue_lbl" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAssetAmountNotOffsetAgainstCollateral" xlink:type="locator" xlink:label="us-gaap_DerivativeFairValueOfDerivativeAssetAmountNotOffsetAgainstCollateral" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeFairValueOfDerivativeAssetAmountNotOffsetAgainstCollateral_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Aggregate fair value of derivative financial instruments in asset position</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeFairValueOfDerivativeAssetAmountNotOffsetAgainstCollateral" xlink:to="us-gaap_DerivativeFairValueOfDerivativeAssetAmountNotOffsetAgainstCollateral_lbl" />
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral" xlink:type="locator" xlink:label="us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral" />
    <label xml:lang="en-US" xlink:label="us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net fair value of derivative financial instruments in a net asset position</label>
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    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CollateralAlreadyPostedAggregateFairValue" xlink:type="locator" xlink:label="us-gaap_CollateralAlreadyPostedAggregateFairValue" />
    <label xml:lang="en-US" xlink:label="us-gaap_CollateralAlreadyPostedAggregateFairValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amount of initial margin posted</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_PrincipalAmountsOutstandingOnLoansSecuritized" xlink:type="locator" xlink:label="mtb_PrincipalAmountsOutstandingOnLoansSecuritized" />
    <label xml:lang="en-US" xlink:label="mtb_PrincipalAmountsOutstandingOnLoansSecuritized_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Principal amounts outstanding on loans securitized.</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_CarryingValueOfLoansInSecuritizationTrusts" xlink:type="locator" xlink:label="mtb_CarryingValueOfLoansInSecuritizationTrusts" />
    <label xml:lang="en-US" xlink:label="mtb_CarryingValueOfLoansInSecuritizationTrusts_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Carrying value of loans in a residential mortgage loan securitization trust which the reporting entity has determined that it is the primary beneficiary.</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_CombinedOutstandingPrincipalAmountOfMortgageBackedSecuritiesIssuedByQualifiedSpecialPurposeTrustsHeldByUnrelatedParties" xlink:type="locator" xlink:label="mtb_CombinedOutstandingPrincipalAmountOfMortgageBackedSecuritiesIssuedByQualifiedSpecialPurposeTrustsHeldByUnrelatedParties" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_VariableInterestEntityDisclosureAbstract" xlink:type="locator" xlink:label="mtb_VariableInterestEntityDisclosureAbstract" />
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    <label xml:lang="en-US" xlink:label="mtb_CarryingValueOfLoansInSecuritizationTrusts_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Carrying Value Of Loans In Securitization Trusts</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_OtherAssetsForItsInvestmentInCommonSecuritiesRecognizedByCompanyOfVariousTrusts" xlink:type="locator" xlink:label="mtb_OtherAssetsForItsInvestmentInCommonSecuritiesRecognizedByCompanyOfVariousTrusts" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_MaximumExposureToLossOfInvestmentsInRealEstatePartnerships" xlink:type="locator" xlink:label="mtb_MaximumExposureToLossOfInvestmentsInRealEstatePartnerships" />
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    <loc xlink:href="mtb-20161231.xsd#mtb_UnfundedCommitmentsIncludedInCompanysMaximumExposureToLossOfInvestmentsInRealEstatePartnerships" xlink:type="locator" xlink:label="mtb_UnfundedCommitmentsIncludedInCompanysMaximumExposureToLossOfInvestmentsInRealEstatePartnerships" />
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    <label xml:lang="en-US" xlink:label="us-gaap_FairValueInputsProbabilityOfDefault_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Probability of default</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueInputsProbabilityOfDefault" xlink:to="us-gaap_FairValueInputsProbabilityOfDefault_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueInputsProbabilityOfDefault_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Inputs Probability Of Default</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueInputsLossSeverity" xlink:type="locator" xlink:label="us-gaap_FairValueInputsLossSeverity" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueInputsLossSeverity_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loss severity</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueInputsLossSeverity" xlink:to="us-gaap_FairValueInputsLossSeverity_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueInputsLossSeverity_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Inputs Loss Severity</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_OtherFinancialInstrumentsAbstract" xlink:type="locator" xlink:label="mtb_OtherFinancialInstrumentsAbstract" />
    <label xml:lang="en-US" xlink:label="mtb_OtherFinancialInstrumentsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other financial instruments.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_OtherFinancialInstrumentsAbstract" xlink:to="mtb_OtherFinancialInstrumentsAbstract_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_CommitmentsToOriginateRealEstateLoansForSale" xlink:type="locator" xlink:label="mtb_CommitmentsToOriginateRealEstateLoansForSale" />
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToOriginateRealEstateLoansForSale_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commitments to originate real estate loans for sale.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommitmentsToOriginateRealEstateLoansForSale" xlink:to="mtb_CommitmentsToOriginateRealEstateLoansForSale_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_CommitmentsToSellRealEstateLoansNet" xlink:type="locator" xlink:label="mtb_CommitmentsToSellRealEstateLoansNet" />
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToSellRealEstateLoansNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commitments To Sell Real Estate Loans Net</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_OtherCreditRelatedCommitments" xlink:type="locator" xlink:label="mtb_OtherCreditRelatedCommitments" />
    <label xml:lang="en-US" xlink:label="mtb_OtherCreditRelatedCommitments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Other credit-related commitments.</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_InterestRateSwapAgreementsUsedForInterestRateRiskManagement" xlink:type="locator" xlink:label="mtb_InterestRateSwapAgreementsUsedForInterestRateRiskManagement" />
    <label xml:lang="en-US" xlink:label="mtb_InterestRateSwapAgreementsUsedForInterestRateRiskManagement_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Interest rate swap agreements used for interest rate risk management.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_InterestRateSwapAgreementsUsedForInterestRateRiskManagement" xlink:to="mtb_InterestRateSwapAgreementsUsedForInterestRateRiskManagement_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTable" xlink:type="locator" xlink:label="us-gaap_FairValueByBalanceSheetGroupingTable" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueByBalanceSheetGroupingTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair Value By Balance Sheet Grouping [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueByBalanceSheetGroupingTable" xlink:to="us-gaap_FairValueByBalanceSheetGroupingTable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueByBalanceSheetGroupingTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value By Balance Sheet Grouping [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:type="locator" xlink:label="us-gaap_FairValueByMeasurementBasisAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueByMeasurementBasisAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Measurement Basis</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueByMeasurementBasisAxis" xlink:to="us-gaap_FairValueByMeasurementBasisAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueByMeasurementBasisAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value By Measurement Basis [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:type="locator" xlink:label="us-gaap_PortionAtFairValueFairValueDisclosureMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_PortionAtFairValueFairValueDisclosureMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Portion at Fair Value Measurement [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:to="us-gaap_PortionAtFairValueFairValueDisclosureMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PortionAtFairValueFairValueDisclosureMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Portion At Fair Value Fair Value Disclosure [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:type="locator" xlink:label="us-gaap_CarryingReportedAmountFairValueDisclosureMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_CarryingReportedAmountFairValueDisclosureMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Carrying Amount [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:to="us-gaap_CarryingReportedAmountFairValueDisclosureMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CarryingReportedAmountFairValueDisclosureMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Carrying Reported Amount Fair Value Disclosure [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember" xlink:type="locator" xlink:label="us-gaap_EstimateOfFairValueFairValueDisclosureMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_EstimateOfFairValueFairValueDisclosureMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Estimate Fair Value [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EstimateOfFairValueFairValueDisclosureMember" xlink:to="us-gaap_EstimateOfFairValueFairValueDisclosureMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_EstimateOfFairValueFairValueDisclosureMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Estimate Of Fair Value Fair Value Disclosure [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:type="locator" xlink:label="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:to="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract" xlink:type="locator" xlink:label="us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial assets:</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract" xlink:to="us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financial Instruments Financial Assets Balance Sheet Groupings [Abstract]</label>
    <label xml:lang="en-US" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash and cash equivalents</label>
    <label xml:lang="en-US" xlink:label="us-gaap_Investments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investment securities</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoansAndLeasesReceivableGrossCarryingAmountAbstract" xlink:type="locator" xlink:label="us-gaap_LoansAndLeasesReceivableGrossCarryingAmountAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableGrossCarryingAmountAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loans and leases:</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoansAndLeasesReceivableGrossCarryingAmountAbstract" xlink:to="us-gaap_LoansAndLeasesReceivableGrossCarryingAmountAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableGrossCarryingAmountAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans And Leases Receivable Gross Carrying Amount [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoansReceivableCommercialAndIndustrial" xlink:type="locator" xlink:label="us-gaap_LoansReceivableCommercialAndIndustrial" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansReceivableCommercialAndIndustrial_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial loans and leases</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoansReceivableCommercialAndIndustrial" xlink:to="us-gaap_LoansReceivableCommercialAndIndustrial_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansReceivableCommercialAndIndustrial_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans Receivable Commercial And Industrial</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LoansReceivableCommercialRealEstate" xlink:type="locator" xlink:label="us-gaap_LoansReceivableCommercialRealEstate" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansReceivableCommercialRealEstate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial real estate loans</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoansReceivableCommercialRealEstate" xlink:to="us-gaap_LoansReceivableCommercialRealEstate_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LoansReceivableCommercialRealEstate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loans Receivable Commercial Real Estate</label>
    <label xml:lang="en-US" xlink:label="us-gaap_LoansAndLeasesReceivableConsumerMortgage_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Residential real estate loans</label>
    <label xml:lang="en-US" xlink:label="mtb_LoansAndLeasesReceivableConsumerInstallmentRevolvingAndHomeEquity_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Consumer loans</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccruedInvestmentIncomeReceivable" xlink:type="locator" xlink:label="us-gaap_AccruedInvestmentIncomeReceivable" />
    <label xml:lang="en-US" xlink:label="us-gaap_AccruedInvestmentIncomeReceivable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accrued interest receivable</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AccruedInvestmentIncomeReceivable" xlink:to="us-gaap_AccruedInvestmentIncomeReceivable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AccruedInvestmentIncomeReceivable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Accrued Investment Income Receivable</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract" xlink:type="locator" xlink:label="us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial liabilities:</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract" xlink:to="us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Financial Instruments Financial Liabilities Balance Sheet Groupings [Abstract]</label>
    <label xml:lang="en-US" xlink:label="us-gaap_NoninterestBearingDepositLiabilitiesDomestic_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Noninterest-bearing deposits</label>
    <label xml:lang="en-US" xlink:label="mtb_SavingsAndInterestCheckingDeposits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Savings and interest-checking deposits</label>
    <label xml:lang="en-US" xlink:label="us-gaap_TimeDeposits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Time deposits</label>
    <label xml:lang="en-US" xlink:label="us-gaap_DepositsForeign_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Deposits at Cayman Islands office</label>
    <label xml:lang="en-US" xlink:label="us-gaap_FederalFundsPurchasedAndSecuritiesSoldUnderAgreementsToRepurchase_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Short-term borrowings</label>
    <label xml:lang="en-US" xlink:label="us-gaap_LongTermDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Long-term borrowings</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InterestPayableCurrentAndNoncurrent" xlink:type="locator" xlink:label="us-gaap_InterestPayableCurrentAndNoncurrent" />
    <label xml:lang="en-US" xlink:label="us-gaap_InterestPayableCurrentAndNoncurrent_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Accrued interest payable</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestPayableCurrentAndNoncurrent" xlink:to="us-gaap_InterestPayableCurrentAndNoncurrent_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_InterestPayableCurrentAndNoncurrent_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Interest Payable Current And Noncurrent</label>
    <label xml:lang="en-US" xlink:label="us-gaap_TradingLiabilitiesFairValueDisclosure_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Trading account liabilities</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherFinancialInstrumentsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other financial instruments:</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherFinancialInstrumentsAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Financial Instruments [Abstract]</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToOriginateRealEstateLoansForSale_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commitments to originate real estate loans for sale</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToOriginateRealEstateLoansForSale_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commitments To Originate Real Estate Loans For Sale</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToSellRealEstateLoansNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commitments to sell real estate loans</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToSellRealEstateLoansNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commitments To Sell Real Estate Loans Net</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherCreditRelatedCommitments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedLabel">Other credit-related commitments</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherCreditRelatedCommitments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Credit Related Commitments</label>
    <label xml:lang="en-US" xlink:label="mtb_InterestRateSwapAgreementsUsedForInterestRateRiskManagement_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Interest rate swap agreements used for interest rate risk management</label>
    <label xml:lang="en-US" xlink:label="mtb_InterestRateSwapAgreementsUsedForInterestRateRiskManagement_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Interest Rate Swap Agreements Used For Interest Rate Risk Management</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CommitmentsToExtendCreditAbstract" xlink:type="locator" xlink:label="mtb_CommitmentsToExtendCreditAbstract" />
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commitments to Extend Credit.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommitmentsToExtendCreditAbstract" xlink:to="mtb_CommitmentsToExtendCreditAbstract_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_CommitmentsToExtendCreditForHomeEquityLinesOfCredit" xlink:type="locator" xlink:label="mtb_CommitmentsToExtendCreditForHomeEquityLinesOfCredit" />
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForHomeEquityLinesOfCredit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commitments to extend credit for Home equity lines of credit.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommitmentsToExtendCreditForHomeEquityLinesOfCredit" xlink:to="mtb_CommitmentsToExtendCreditForHomeEquityLinesOfCredit_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_CommitmentsToExtendCreditForCommercialRealEstateLoansToBeSold" xlink:type="locator" xlink:label="mtb_CommitmentsToExtendCreditForCommercialRealEstateLoansToBeSold" />
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForCommercialRealEstateLoansToBeSold_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commitments to extend credit for Commercial real estate loans to be sold.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommitmentsToExtendCreditForCommercialRealEstateLoansToBeSold" xlink:to="mtb_CommitmentsToExtendCreditForCommercialRealEstateLoansToBeSold_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_CommitmentsToExtendCreditForOtherCommercialRealEstate" xlink:type="locator" xlink:label="mtb_CommitmentsToExtendCreditForOtherCommercialRealEstate" />
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForOtherCommercialRealEstate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commitments to extend credit for other commercial real estate.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommitmentsToExtendCreditForOtherCommercialRealEstate" xlink:to="mtb_CommitmentsToExtendCreditForOtherCommercialRealEstate_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_CommitmentsToExtendCreditForResidentialRealEstateLoansToBeSold" xlink:type="locator" xlink:label="mtb_CommitmentsToExtendCreditForResidentialRealEstateLoansToBeSold" />
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForResidentialRealEstateLoansToBeSold_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commitments to extend credit for Residential real estate loans to be sold.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommitmentsToExtendCreditForResidentialRealEstateLoansToBeSold" xlink:to="mtb_CommitmentsToExtendCreditForResidentialRealEstateLoansToBeSold_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_CommitmentsToExtendCreditForOtherResidentialRealEstate" xlink:type="locator" xlink:label="mtb_CommitmentsToExtendCreditForOtherResidentialRealEstate" />
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForOtherResidentialRealEstate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commitments to extend credit for Other residential real estate.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommitmentsToExtendCreditForOtherResidentialRealEstate" xlink:to="mtb_CommitmentsToExtendCreditForOtherResidentialRealEstate_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_CommitmentsToExtendCreditForCommercialAndOther" xlink:type="locator" xlink:label="mtb_CommitmentsToExtendCreditForCommercialAndOther" />
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForCommercialAndOther_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commitments to extend credit for Commercial and other.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommitmentsToExtendCreditForCommercialAndOther" xlink:to="mtb_CommitmentsToExtendCreditForCommercialAndOther_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_CommitmentsRegardingCommercialLettersOfCredit" xlink:type="locator" xlink:label="mtb_CommitmentsRegardingCommercialLettersOfCredit" />
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsRegardingCommercialLettersOfCredit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commitments regarding Commercial letters of credit.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommitmentsRegardingCommercialLettersOfCredit" xlink:to="mtb_CommitmentsRegardingCommercialLettersOfCredit_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_CommitmentsRegardingFinancialGuaranteesAndIndemnificationContracts" xlink:type="locator" xlink:label="mtb_CommitmentsRegardingFinancialGuaranteesAndIndemnificationContracts" />
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsRegardingFinancialGuaranteesAndIndemnificationContracts_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commitments regarding Financial guarantees and indemnification contracts.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommitmentsRegardingFinancialGuaranteesAndIndemnificationContracts" xlink:to="mtb_CommitmentsRegardingFinancialGuaranteesAndIndemnificationContracts_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_CommitmentsToSellRealEstateLoansNotionalAmount" xlink:type="locator" xlink:label="mtb_CommitmentsToSellRealEstateLoansNotionalAmount" />
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToSellRealEstateLoansNotionalAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commitments To Sell Real Estate Loans Notional Amount.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommitmentsToSellRealEstateLoansNotionalAmount" xlink:to="mtb_CommitmentsToSellRealEstateLoansNotionalAmount_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commitments to extend credit</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commitments To Extend Credit [Abstract]</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForHomeEquityLinesOfCredit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Home equity lines of credit</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForHomeEquityLinesOfCredit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commitments To Extend Credit For Home Equity Lines Of Credit</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForCommercialRealEstateLoansToBeSold_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial real estate loans to be sold</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForCommercialRealEstateLoansToBeSold_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commitments To Extend Credit For Commercial Real Estate Loans To Be Sold</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForOtherCommercialRealEstate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other commercial real estate</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForOtherCommercialRealEstate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commitments To Extend Credit For Other Commercial Real Estate</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForResidentialRealEstateLoansToBeSold_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Residential real estate loans to be sold</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForResidentialRealEstateLoansToBeSold_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commitments To Extend Credit For Residential Real Estate Loans To Be Sold</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForOtherResidentialRealEstate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other residential real estate</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForOtherResidentialRealEstate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commitments To Extend Credit For Other Residential Real Estate</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForCommercialAndOther_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial and other</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToExtendCreditForCommercialAndOther_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commitments To Extend Credit For Commercial And Other</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LettersOfCreditOutstandingAmount" xlink:type="locator" xlink:label="us-gaap_LettersOfCreditOutstandingAmount" />
    <label xml:lang="en-US" xlink:label="us-gaap_LettersOfCreditOutstandingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Standby letters of credit</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LettersOfCreditOutstandingAmount" xlink:to="us-gaap_LettersOfCreditOutstandingAmount_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LettersOfCreditOutstandingAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Letters Of Credit Outstanding Amount</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsRegardingCommercialLettersOfCredit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial letters of credit</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsRegardingCommercialLettersOfCredit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commitments Regarding Commercial Letters Of Credit</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsRegardingFinancialGuaranteesAndIndemnificationContracts_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Financial guarantees and indemnification contracts</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsRegardingFinancialGuaranteesAndIndemnificationContracts_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commitments Regarding Financial Guarantees And Indemnification Contracts</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToSellRealEstateLoansNotionalAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commitments to sell real estate loans</label>
    <label xml:lang="en-US" xlink:label="mtb_CommitmentsToSellRealEstateLoansNotionalAmount_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commitments To Sell Real Estate Loans Notional Amount</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_MaximumCreditRiskForRecourseAssociatedWithLoansSoldUnderFederalNationalMortgageAssociationDelegatedUnderwritingAndServicingProgram" xlink:type="locator" xlink:label="mtb_MaximumCreditRiskForRecourseAssociatedWithLoansSoldUnderFederalNationalMortgageAssociationDelegatedUnderwritingAndServicingProgram" />
    <label xml:lang="en-US" xlink:label="mtb_MaximumCreditRiskForRecourseAssociatedWithLoansSoldUnderFederalNationalMortgageAssociationDelegatedUnderwritingAndServicingProgram_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Maximum credit risk for recourse associated with loans sold under Federal National Mortgage Association Delegated Underwriting and Servicing program.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_MaximumCreditRiskForRecourseAssociatedWithLoansSoldUnderFederalNationalMortgageAssociationDelegatedUnderwritingAndServicingProgram" xlink:to="mtb_MaximumCreditRiskForRecourseAssociatedWithLoansSoldUnderFederalNationalMortgageAssociationDelegatedUnderwritingAndServicingProgram_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LossContingenciesTable" xlink:type="locator" xlink:label="us-gaap_LossContingenciesTable" />
    <label xml:lang="en-US" xlink:label="us-gaap_LossContingenciesTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loss Contingencies [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LossContingenciesTable" xlink:to="us-gaap_LossContingenciesTable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LossContingenciesTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loss Contingencies [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LossContingenciesLineItems" xlink:type="locator" xlink:label="us-gaap_LossContingenciesLineItems" />
    <label xml:lang="en-US" xlink:label="us-gaap_LossContingenciesLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Loss Contingencies [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LossContingenciesLineItems" xlink:to="us-gaap_LossContingenciesLineItems_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LossContingenciesLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loss Contingencies [Line Items]</label>
    <label xml:lang="en-US" xlink:label="mtb_MaximumCreditRiskForRecourseAssociatedWithLoansSoldUnderFederalNationalMortgageAssociationDelegatedUnderwritingAndServicingProgram_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Maximum credit risk for recourse associated with loans sold under Federal National Mortgage Association Delegated Underwriting and Servicing program</label>
    <label xml:lang="en-US" xlink:label="mtb_MaximumCreditRiskForRecourseAssociatedWithLoansSoldUnderFederalNationalMortgageAssociationDelegatedUnderwritingAndServicingProgram_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Maximum Credit Risk For Recourse Associated With Loans Sold Under Federal National Mortgage Association Delegated Underwriting And Servicing Program</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_NoncancelableOperatingLeasePeriod" xlink:type="locator" xlink:label="mtb_NoncancelableOperatingLeasePeriod" />
    <label xml:lang="en-US" xlink:label="mtb_NoncancelableOperatingLeasePeriod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Noncancelable operating lease period in years.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_NoncancelableOperatingLeasePeriod" xlink:to="mtb_NoncancelableOperatingLeasePeriod_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_NoncancelableOperatingLeasePeriod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Period of noncancelable operating lease in years</label>
    <label xml:lang="en-US" xlink:label="mtb_NoncancelableOperatingLeasePeriod_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Noncancelable Operating Lease Period</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:type="locator" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" />
    <label xml:lang="en-US" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2017</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:to="us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Operating Leases Future Minimum Payments Due Current</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears" xlink:type="locator" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears" />
    <label xml:lang="en-US" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2018</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears" xlink:to="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Operating Leases Future Minimum Payments Due In Two Years</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears" xlink:type="locator" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears" />
    <label xml:lang="en-US" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2019</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears" xlink:to="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Operating Leases Future Minimum Payments Due In Three Years</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears" xlink:type="locator" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears" />
    <label xml:lang="en-US" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2020</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears" xlink:to="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Operating Leases Future Minimum Payments Due In Four Years</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears" xlink:type="locator" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears" />
    <label xml:lang="en-US" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">2021</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears" xlink:to="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Operating Leases Future Minimum Payments Due In Five Years</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter" xlink:type="locator" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter" />
    <label xml:lang="en-US" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Later years</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter" xlink:to="us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Operating Leases Future Minimum Payments Due Thereafter</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:type="locator" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDue" />
    <label xml:lang="en-US" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:to="us-gaap_OperatingLeasesFutureMinimumPaymentsDue_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OperatingLeasesFutureMinimumPaymentsDue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Operating Leases Future Minimum Payments Due</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsForLegalSettlements" xlink:type="locator" xlink:label="us-gaap_PaymentsForLegalSettlements" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsForLegalSettlements_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Payment of litigation settlement expense</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PaymentsForLegalSettlements" xlink:to="us-gaap_PaymentsForLegalSettlements_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsForLegalSettlements_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Payments For Legal Settlements</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_LossContingencyEstimateOfPossibleLoss" xlink:type="locator" xlink:label="us-gaap_LossContingencyEstimateOfPossibleLoss" />
    <label xml:lang="en-US" xlink:label="us-gaap_LossContingencyEstimateOfPossibleLoss_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Range of reasonably possible losses</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LossContingencyEstimateOfPossibleLoss" xlink:to="us-gaap_LossContingencyEstimateOfPossibleLoss_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_LossContingencyEstimateOfPossibleLoss_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Loss Contingency Estimate Of Possible Loss</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_IncreaseDecreaseInNetInterestIncome" xlink:type="locator" xlink:label="mtb_IncreaseDecreaseInNetInterestIncome" />
    <label xml:lang="en-US" xlink:label="mtb_IncreaseDecreaseInNetInterestIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase decrease in net interest income.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_IncreaseDecreaseInNetInterestIncome" xlink:to="mtb_IncreaseDecreaseInNetInterestIncome_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_IncreaseDecreaseInNetIncome" xlink:type="locator" xlink:label="mtb_IncreaseDecreaseInNetIncome" />
    <label xml:lang="en-US" xlink:label="mtb_IncreaseDecreaseInNetIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Increase decrease in net income.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_IncreaseDecreaseInNetIncome" xlink:to="mtb_IncreaseDecreaseInNetIncome_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable" xlink:type="locator" xlink:label="us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Segment Reporting Information By Segment [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable" xlink:to="us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Segment Reporting Information By Segment [Table]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_DiscretionaryPortfolioSegmentMember" xlink:type="locator" xlink:label="mtb_DiscretionaryPortfolioSegmentMember" />
    <label xml:lang="en-US" xlink:label="mtb_DiscretionaryPortfolioSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Discretionary portfolio segment.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DiscretionaryPortfolioSegmentMember" xlink:to="mtb_DiscretionaryPortfolioSegmentMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_DiscretionaryPortfolioSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Discretionary Portfolio [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_DiscretionaryPortfolioSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Discretionary Portfolio Segment [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_SegmentReportingInformationLineItems" xlink:type="locator" xlink:label="us-gaap_SegmentReportingInformationLineItems" />
    <label xml:lang="en-US" xlink:label="us-gaap_SegmentReportingInformationLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Segment Reporting Information [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SegmentReportingInformationLineItems" xlink:to="us-gaap_SegmentReportingInformationLineItems_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_SegmentReportingInformationLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Segment Reporting Information [Line Items]</label>
    <label xml:lang="en-US" xlink:label="mtb_IncreaseDecreaseInNetInterestIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase (decrease) in net interest income</label>
    <label xml:lang="en-US" xlink:label="mtb_IncreaseDecreaseInNetInterestIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease In Net Interest Income</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncreaseDecreaseInIncomeTaxes" xlink:type="locator" xlink:label="us-gaap_IncreaseDecreaseInIncomeTaxes" />
    <label xml:lang="en-US" xlink:label="us-gaap_IncreaseDecreaseInIncomeTaxes_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase (decrease) in income tax expense</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncreaseDecreaseInIncomeTaxes" xlink:to="us-gaap_IncreaseDecreaseInIncomeTaxes_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_IncreaseDecreaseInIncomeTaxes_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease In Income Taxes</label>
    <label xml:lang="en-US" xlink:label="mtb_IncreaseDecreaseInNetIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Increase (decrease) in net income</label>
    <label xml:lang="en-US" xlink:label="mtb_IncreaseDecreaseInNetIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Increase Decrease In Net Income</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_AverageAssets" xlink:type="locator" xlink:label="mtb_AverageAssets" />
    <label xml:lang="en-US" xlink:label="mtb_AverageAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">The average balance of assets during the period calculated as the average of the asset balances as of the end of each day in the period.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_AverageAssets" xlink:to="mtb_AverageAssets_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_BusinessBankingSegmentMember" xlink:type="locator" xlink:label="mtb_BusinessBankingSegmentMember" />
    <label xml:lang="en-US" xlink:label="mtb_BusinessBankingSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Business banking segment.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_BusinessBankingSegmentMember" xlink:to="mtb_BusinessBankingSegmentMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_BusinessBankingSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Business Banking [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_BusinessBankingSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Business Banking Segment [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CommercialBankingSegmentMember" xlink:type="locator" xlink:label="mtb_CommercialBankingSegmentMember" />
    <label xml:lang="en-US" xlink:label="mtb_CommercialBankingSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Commercial banking segment.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommercialBankingSegmentMember" xlink:to="mtb_CommercialBankingSegmentMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CommercialBankingSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Commercial Banking [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_CommercialBankingSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Commercial Banking Segment [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConsolidationItemsAxis" xlink:type="locator" xlink:label="us-gaap_ConsolidationItemsAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConsolidationItemsAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Consolidation Items</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ConsolidationItemsAxis" xlink:to="us-gaap_ConsolidationItemsAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConsolidationItemsAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Consolidation Items [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:type="locator" xlink:label="us-gaap_ConsolidationItemsDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConsolidationItemsDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Consolidation Items</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ConsolidationItemsDomain" xlink:to="us-gaap_ConsolidationItemsDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ConsolidationItemsDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Consolidation Items [Domain]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OperatingSegmentsMember" xlink:type="locator" xlink:label="us-gaap_OperatingSegmentsMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_OperatingSegmentsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Operating Segments [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OperatingSegmentsMember" xlink:to="us-gaap_OperatingSegmentsMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OperatingSegmentsMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Operating Segments [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ResidentialMortgageBankingSegmentMember" xlink:type="locator" xlink:label="mtb_ResidentialMortgageBankingSegmentMember" />
    <label xml:lang="en-US" xlink:label="mtb_ResidentialMortgageBankingSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Residential mortgage banking segment.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ResidentialMortgageBankingSegmentMember" xlink:to="mtb_ResidentialMortgageBankingSegmentMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_ResidentialMortgageBankingSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Residential Mortgage Banking [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_ResidentialMortgageBankingSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Residential Mortgage Banking Segment [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_RetailBankingSegmentMember" xlink:type="locator" xlink:label="mtb_RetailBankingSegmentMember" />
    <label xml:lang="en-US" xlink:label="mtb_RetailBankingSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Retail banking segment.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_RetailBankingSegmentMember" xlink:to="mtb_RetailBankingSegmentMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_RetailBankingSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Retail Banking [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_RetailBankingSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Retail Banking Segment [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CorporateNonSegmentMember" xlink:type="locator" xlink:label="us-gaap_CorporateNonSegmentMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_CorporateNonSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">All Other [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CorporateNonSegmentMember" xlink:to="us-gaap_CorporateNonSegmentMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CorporateNonSegmentMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Corporate Non Segment [Member]</label>
    <label xml:lang="en-US" xlink:label="us-gaap_InterestIncomeExpenseNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Net interest income</label>
    <label xml:lang="en-US" xlink:label="mtb_NoninterestIncomeExpense_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Noninterest income</label>
    <label xml:lang="en-US" xlink:label="mtb_NoninterestIncomeExpense_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Noninterest Income Expense</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Revenues" xlink:type="locator" xlink:label="us-gaap_Revenues" />
    <label xml:lang="en-US" xlink:label="us-gaap_Revenues_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total income</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_Revenues" xlink:to="us-gaap_Revenues_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_Revenues_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Revenues</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherDepreciationAndAmortization" xlink:type="locator" xlink:label="us-gaap_OtherDepreciationAndAmortization" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherDepreciationAndAmortization_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Depreciation and other amortization</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherDepreciationAndAmortization" xlink:to="us-gaap_OtherDepreciationAndAmortization_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherDepreciationAndAmortization_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Depreciation And Amortization</label>
    <label xml:lang="en-US" xlink:label="mtb_NonInterestExpenseExcludingAmortizationAndDepreciation_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other noninterest expense</label>
    <label xml:lang="en-US" xlink:label="mtb_NonInterestExpenseExcludingAmortizationAndDepreciation_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Non Interest Expense Excluding Amortization And Depreciation</label>
    <label xml:lang="en-US" xlink:label="us-gaap_IncomeTaxExpenseBenefit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Income tax expense (benefit)</label>
    <label xml:lang="en-US" xlink:label="mtb_AverageAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Average total assets</label>
    <label xml:lang="en-US" xlink:label="mtb_AverageAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Average Assets</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_PaymentsToAcquireProductiveAssets" xlink:type="locator" xlink:label="us-gaap_PaymentsToAcquireProductiveAssets" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsToAcquireProductiveAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Capital expenditures</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PaymentsToAcquireProductiveAssets" xlink:to="us-gaap_PaymentsToAcquireProductiveAssets_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_PaymentsToAcquireProductiveAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Payments To Acquire Productive Assets</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_TaxableEquivalentAdjustment" xlink:type="locator" xlink:label="mtb_TaxableEquivalentAdjustment" />
    <label xml:lang="en-US" xlink:label="mtb_TaxableEquivalentAdjustment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Taxable equivalent adjustment.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_TaxableEquivalentAdjustment" xlink:to="mtb_TaxableEquivalentAdjustment_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_TaxableEquivalentAdjustment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Taxable-equivalent adjustment</label>
    <label xml:lang="en-US" xlink:label="mtb_TaxableEquivalentAdjustment_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Taxable Equivalent Adjustment</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_Expenses" xlink:type="locator" xlink:label="mtb_Expenses" />
    <label xml:lang="en-US" xlink:label="mtb_Expenses_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Total aggregate amount of all interest and noninterest expenses.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_Expenses" xlink:to="mtb_Expenses_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IntersegmentEliminationMember" xlink:type="locator" xlink:label="us-gaap_IntersegmentEliminationMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_IntersegmentEliminationMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Intersegment Activity Eliminated in Consolidated Totals [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IntersegmentEliminationMember" xlink:to="us-gaap_IntersegmentEliminationMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_IntersegmentEliminationMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Intersegment Elimination [Member]</label>
    <label xml:lang="en-US" xlink:label="us-gaap_Revenues_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Revenues</label>
    <label xml:lang="en-US" xlink:label="mtb_Expenses_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expenses</label>
    <label xml:lang="en-US" xlink:label="mtb_Expenses_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Expenses</label>
    <label xml:lang="en-US" xlink:label="us-gaap_IncomeTaxExpenseBenefit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/positiveVerboseLabel">Income taxes (benefit)</label>
    <label xml:lang="en-US" xlink:label="us-gaap_NetIncomeLoss_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/positiveVerboseLabel">Net income (loss)</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_PercentOfMaximumRevenueFromSingleCustomerOnRevenue" xlink:type="locator" xlink:label="mtb_PercentOfMaximumRevenueFromSingleCustomerOnRevenue" />
    <label xml:lang="en-US" xlink:label="mtb_PercentOfMaximumRevenueFromSingleCustomerOnRevenue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Maximum percentage of total consolidated revenues generated from a single external customer.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_PercentOfMaximumRevenueFromSingleCustomerOnRevenue" xlink:to="mtb_PercentOfMaximumRevenueFromSingleCustomerOnRevenue_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_PercentOfMaximumRevenueFromSingleCustomerOnRevenue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Percent of maximum revenue from single customer on total revenues</label>
    <label xml:lang="en-US" xlink:label="mtb_PercentOfMaximumRevenueFromSingleCustomerOnRevenue_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Percent Of Maximum Revenue From Single Customer On Revenue</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_FundsAvailableForPaymentOfDividendsToParentCompanyFromBankingSubsidiaries" xlink:type="locator" xlink:label="mtb_FundsAvailableForPaymentOfDividendsToParentCompanyFromBankingSubsidiaries" />
    <label xml:lang="en-US" xlink:label="mtb_FundsAvailableForPaymentOfDividendsToParentCompanyFromBankingSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount of dividends available for payment to parent company after computation of banking subsidiaries earnings for the current year and preceding two years.</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_AssetsRequiredToSubmitAnnualCapitalPlansPerFederalReserveBoard" xlink:type="locator" xlink:label="mtb_AssetsRequiredToSubmitAnnualCapitalPlansPerFederalReserveBoard" />
    <label xml:lang="en-US" xlink:label="mtb_AssetsRequiredToSubmitAnnualCapitalPlansPerFederalReserveBoard_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Federal Reserve Bank&apos;s minimum balance threshold of total consolidated assets that will require submission of annual capital plans.</label>
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    <loc xlink:href="mtb-20161231.xsd#mtb_FeesAndCommissionsIncomeAbstract" xlink:type="locator" xlink:label="mtb_FeesAndCommissionsIncomeAbstract" />
    <label xml:lang="en-US" xlink:label="mtb_FeesAndCommissionsIncomeAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Fees And Commissions Income [Abstract]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_FeesAndCommissionsIncomeAbstract" xlink:to="mtb_FeesAndCommissionsIncomeAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_FeesAndCommissionsIncomeAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Fees And Commissions Income [Abstract]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable" xlink:type="locator" xlink:label="us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Compliance With Regulatory Capital Requirements Under Banking Regulations [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable" xlink:to="us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Compliance With Regulatory Capital Requirements Under Banking Regulations [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:type="locator" xlink:label="us-gaap_StatementScenarioAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_StatementScenarioAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Scenario</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StatementScenarioAxis" xlink:to="us-gaap_StatementScenarioAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_StatementScenarioAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Statement Scenario [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:type="locator" xlink:label="us-gaap_ScenarioUnspecifiedDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScenarioUnspecifiedDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Scenario, Unspecified</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScenarioUnspecifiedDomain" xlink:to="us-gaap_ScenarioUnspecifiedDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScenarioUnspecifiedDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Scenario Unspecified [Domain]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScenarioForecastMember" xlink:type="locator" xlink:label="us-gaap_ScenarioForecastMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScenarioForecastMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Scenario Forecast [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScenarioForecastMember" xlink:to="us-gaap_ScenarioForecastMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScenarioForecastMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Scenario Forecast [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:type="locator" xlink:label="us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" />
    <label xml:lang="en-US" xlink:label="us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Compliance with Regulatory Capital Requirements under Banking Regulations [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:to="us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Compliance With Regulatory Capital Requirements Under Banking Regulations [Line Items]</label>
    <label xml:lang="en-US" xlink:label="mtb_FundsAvailableForPaymentOfDividendsToParentCompanyFromBankingSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Funds available for payment of dividends to M&amp;T from banking subsidiaries</label>
    <label xml:lang="en-US" xlink:label="mtb_FundsAvailableForPaymentOfDividendsToParentCompanyFromBankingSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Funds Available For Payment Of Dividends To Parent Company From Banking Subsidiaries</label>
    <label xml:lang="en-US" xlink:label="mtb_AssetsRequiredToSubmitAnnualCapitalPlansPerFederalReserveBoard_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Consolidated assets required per Federal Reserve Board to submit annual capital plans</label>
    <label xml:lang="en-US" xlink:label="mtb_AssetsRequiredToSubmitAnnualCapitalPlansPerFederalReserveBoard_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Assets Required To Submit Annual Capital Plans Per Federal Reserve Board</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_AverageDailyBalanceOfRequiredNoninterestReservesAgainstCertainDeposits" xlink:type="locator" xlink:label="mtb_AverageDailyBalanceOfRequiredNoninterestReservesAgainstCertainDeposits" />
    <label xml:lang="en-US" xlink:label="mtb_AverageDailyBalanceOfRequiredNoninterestReservesAgainstCertainDeposits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Average daily balance of reserves held against certain deposits to meet mandated regulated thresholds.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_AverageDailyBalanceOfRequiredNoninterestReservesAgainstCertainDeposits" xlink:to="mtb_AverageDailyBalanceOfRequiredNoninterestReservesAgainstCertainDeposits_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_AverageDailyBalanceOfRequiredNoninterestReservesAgainstCertainDeposits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Required subsidiary noninterest-earning reserves against certain deposit liabilities</label>
    <label xml:lang="en-US" xlink:label="mtb_AverageDailyBalanceOfRequiredNoninterestReservesAgainstCertainDeposits_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Average Daily Balance Of Required Noninterest Reserves Against Certain Deposits</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CommonEquityTierOneRiskBasedCapitalToRiskWeightedAssets" xlink:type="locator" xlink:label="mtb_CommonEquityTierOneRiskBasedCapitalToRiskWeightedAssets" />
    <label xml:lang="en-US" xlink:label="mtb_CommonEquityTierOneRiskBasedCapitalToRiskWeightedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Common equity tier one risk based capital divided by risk weighted assets as defined by regulations.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommonEquityTierOneRiskBasedCapitalToRiskWeightedAssets" xlink:to="mtb_CommonEquityTierOneRiskBasedCapitalToRiskWeightedAssets_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CommonEquityTierOneRiskBasedCapitalToRiskWeightedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common equity Tier 1 ("CET1") to risk-weighted assets, Minimum</label>
    <label xml:lang="en-US" xlink:label="mtb_CommonEquityTierOneRiskBasedCapitalToRiskWeightedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Common Equity Tier One Risk Based Capital To Risk Weighted Assets</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TierOneRiskBasedCapitalToRiskWeightedAssets" xlink:type="locator" xlink:label="us-gaap_TierOneRiskBasedCapitalToRiskWeightedAssets" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneRiskBasedCapitalToRiskWeightedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Tier 1 capital to risk-weighted assets, Minimum</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TierOneRiskBasedCapitalToRiskWeightedAssets" xlink:to="us-gaap_TierOneRiskBasedCapitalToRiskWeightedAssets_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneRiskBasedCapitalToRiskWeightedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Tier One Risk Based Capital To Risk Weighted Assets</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CapitalToRiskWeightedAssets" xlink:type="locator" xlink:label="us-gaap_CapitalToRiskWeightedAssets" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalToRiskWeightedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Total capital to risk-weighted assets, Minimum</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CapitalToRiskWeightedAssets" xlink:to="us-gaap_CapitalToRiskWeightedAssets_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalToRiskWeightedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital To Risk Weighted Assets</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacyToAverageAssets" xlink:type="locator" xlink:label="us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacyToAverageAssets" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacyToAverageAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Leverage &#8212; Tier 1 capital to average total assets, as defined, Minimum</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacyToAverageAssets" xlink:to="us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacyToAverageAssets_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacyToAverageAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Tier One Leverage Capital Required For Capital Adequacy To Average Assets</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CommonEquityTierOneRiskBasedCapitalToWellCapitalizedToRiskWeightedAssets" xlink:type="locator" xlink:label="mtb_CommonEquityTierOneRiskBasedCapitalToWellCapitalizedToRiskWeightedAssets" />
    <label xml:lang="en-US" xlink:label="mtb_CommonEquityTierOneRiskBasedCapitalToWellCapitalizedToRiskWeightedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Common equity tier one risk based capital to well capitalized to risk weighted assets.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommonEquityTierOneRiskBasedCapitalToWellCapitalizedToRiskWeightedAssets" xlink:to="mtb_CommonEquityTierOneRiskBasedCapitalToWellCapitalizedToRiskWeightedAssets_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CommonEquityTierOneRiskBasedCapitalToWellCapitalizedToRiskWeightedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common equity Tier 1 ("CET1") to risk-weighted assets, Well Capitalized</label>
    <label xml:lang="en-US" xlink:label="mtb_CommonEquityTierOneRiskBasedCapitalToWellCapitalizedToRiskWeightedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Common Equity Tier One Risk Based Capital To Well Capitalized To Risk Weighted Assets</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TierOneRiskBasedCapitalRequiredToBeWellCapitalizedToRiskWeightedAssets" xlink:type="locator" xlink:label="us-gaap_TierOneRiskBasedCapitalRequiredToBeWellCapitalizedToRiskWeightedAssets" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneRiskBasedCapitalRequiredToBeWellCapitalizedToRiskWeightedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Tier 1 capital to risk-weighted assets, Well capitalized</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TierOneRiskBasedCapitalRequiredToBeWellCapitalizedToRiskWeightedAssets" xlink:to="us-gaap_TierOneRiskBasedCapitalRequiredToBeWellCapitalizedToRiskWeightedAssets_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneRiskBasedCapitalRequiredToBeWellCapitalizedToRiskWeightedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Tier One Risk Based Capital Required To Be Well Capitalized To Risk Weighted Assets</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CapitalRequiredToBeWellCapitalizedToRiskWeightedAssets" xlink:type="locator" xlink:label="us-gaap_CapitalRequiredToBeWellCapitalizedToRiskWeightedAssets" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalRequiredToBeWellCapitalizedToRiskWeightedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Total capital to risk-weighted assets, Well capitalized</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CapitalRequiredToBeWellCapitalizedToRiskWeightedAssets" xlink:to="us-gaap_CapitalRequiredToBeWellCapitalizedToRiskWeightedAssets_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalRequiredToBeWellCapitalizedToRiskWeightedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital Required To Be Well Capitalized To Risk Weighted Assets</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TierOneLeverageCapitalRequiredToBeWellCapitalizedToAverageAssets" xlink:type="locator" xlink:label="us-gaap_TierOneLeverageCapitalRequiredToBeWellCapitalizedToAverageAssets" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneLeverageCapitalRequiredToBeWellCapitalizedToAverageAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Leverage &#8212; Tier 1 capital to average total assets, as defined, Well capitalized</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TierOneLeverageCapitalRequiredToBeWellCapitalizedToAverageAssets" xlink:to="us-gaap_TierOneLeverageCapitalRequiredToBeWellCapitalizedToAverageAssets_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneLeverageCapitalRequiredToBeWellCapitalizedToAverageAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Tier One Leverage Capital Required To Be Well Capitalized To Average Assets</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CapitalConservationBufferRatio" xlink:type="locator" xlink:label="mtb_CapitalConservationBufferRatio" />
    <label xml:lang="en-US" xlink:label="mtb_CapitalConservationBufferRatio_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Capital conservation buffer ratio.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CapitalConservationBufferRatio" xlink:to="mtb_CapitalConservationBufferRatio_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_CapitalConservationBufferRatio_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Capital conservation buffer</label>
    <label xml:lang="en-US" xlink:label="mtb_CapitalConservationBufferRatio_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital Conservation Buffer Ratio</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_CommonEquityTierOneRiskBasedCapital" xlink:type="locator" xlink:label="mtb_CommonEquityTierOneRiskBasedCapital" />
    <label xml:lang="en-US" xlink:label="mtb_CommonEquityTierOneRiskBasedCapital_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Common Equity Tier One Risk Based Capital</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommonEquityTierOneRiskBasedCapital" xlink:to="mtb_CommonEquityTierOneRiskBasedCapital_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_CommonEquityTierOneRiskBasedCapitalRequiredForCapitalAdequacy" xlink:type="locator" xlink:label="mtb_CommonEquityTierOneRiskBasedCapitalRequiredForCapitalAdequacy" />
    <label xml:lang="en-US" xlink:label="mtb_CommonEquityTierOneRiskBasedCapitalRequiredForCapitalAdequacy_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Common Equity Tier One Risk Based Capital Required For Capital Adequacy</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_CommonEquityTierOneRiskBasedCapitalRequiredForCapitalAdequacy" xlink:to="mtb_CommonEquityTierOneRiskBasedCapitalRequiredForCapitalAdequacy_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_MAndTMember" xlink:type="locator" xlink:label="mtb_MAndTMember" />
    <label xml:lang="en-US" xlink:label="mtb_MAndTMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">M&amp;T.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_MAndTMember" xlink:to="mtb_MAndTMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_MAndTMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">M&amp;T (Consolidated) [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_MAndTMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">M And T [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_WilmingtonTrustNaMember" xlink:type="locator" xlink:label="mtb_WilmingtonTrustNaMember" />
    <label xml:lang="en-US" xlink:label="mtb_WilmingtonTrustNaMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Wilmington Trust N.A.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_WilmingtonTrustNaMember" xlink:to="mtb_WilmingtonTrustNaMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_WilmingtonTrustNaMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Wilmington Trust, N.A. [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_WilmingtonTrustNaMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Wilmington Trust Na [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_CommonEquityTierOneRiskBasedCapital_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amount</label>
    <label xml:lang="en-US" xlink:label="mtb_CommonEquityTierOneRiskBasedCapital_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Common Equity Tier One Risk Based Capital</label>
    <label xml:lang="en-US" xlink:label="mtb_CommonEquityTierOneRiskBasedCapitalToRiskWeightedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Ratio</label>
    <label xml:lang="en-US" xlink:label="mtb_CommonEquityTierOneRiskBasedCapitalRequiredForCapitalAdequacy_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Minimum required amount</label>
    <label xml:lang="en-US" xlink:label="mtb_CommonEquityTierOneRiskBasedCapitalRequiredForCapitalAdequacy_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Common Equity Tier One Risk Based Capital Required For Capital Adequacy</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TierOneRiskBasedCapital" xlink:type="locator" xlink:label="us-gaap_TierOneRiskBasedCapital" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneRiskBasedCapital_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amount</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TierOneRiskBasedCapital" xlink:to="us-gaap_TierOneRiskBasedCapital_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneRiskBasedCapital_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Tier One Risk Based Capital</label>
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneRiskBasedCapitalToRiskWeightedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Ratio</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TierOneRiskBasedCapitalRequiredForCapitalAdequacy" xlink:type="locator" xlink:label="us-gaap_TierOneRiskBasedCapitalRequiredForCapitalAdequacy" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneRiskBasedCapitalRequiredForCapitalAdequacy_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Minimum required amount</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TierOneRiskBasedCapitalRequiredForCapitalAdequacy" xlink:to="us-gaap_TierOneRiskBasedCapitalRequiredForCapitalAdequacy_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneRiskBasedCapitalRequiredForCapitalAdequacy_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Tier One Risk Based Capital Required For Capital Adequacy</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Capital" xlink:type="locator" xlink:label="us-gaap_Capital" />
    <label xml:lang="en-US" xlink:label="us-gaap_Capital_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amount</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_Capital" xlink:to="us-gaap_Capital_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_Capital_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital</label>
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalToRiskWeightedAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Ratio</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_CapitalRequiredForCapitalAdequacy" xlink:type="locator" xlink:label="us-gaap_CapitalRequiredForCapitalAdequacy" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalRequiredForCapitalAdequacy_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Minimum required amount</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CapitalRequiredForCapitalAdequacy" xlink:to="us-gaap_CapitalRequiredForCapitalAdequacy_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_CapitalRequiredForCapitalAdequacy_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Capital Required For Capital Adequacy</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TierOneLeverageCapital" xlink:type="locator" xlink:label="us-gaap_TierOneLeverageCapital" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneLeverageCapital_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amount</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TierOneLeverageCapital" xlink:to="us-gaap_TierOneLeverageCapital_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneLeverageCapital_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Tier One Leverage Capital</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TierOneLeverageCapitalToAverageAssets" xlink:type="locator" xlink:label="us-gaap_TierOneLeverageCapitalToAverageAssets" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneLeverageCapitalToAverageAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Ratio</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TierOneLeverageCapitalToAverageAssets" xlink:to="us-gaap_TierOneLeverageCapitalToAverageAssets_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneLeverageCapitalToAverageAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Tier One Leverage Capital To Average Assets</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacy" xlink:type="locator" xlink:label="us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacy" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacy_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Minimum required amount</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacy" xlink:to="us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacy_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacy_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Tier One Leverage Capital Required For Capital Adequacy</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityMethodInvestmentsAndJointVenturesAbstract" xlink:type="locator" xlink:label="us-gaap_EquityMethodInvestmentsAndJointVenturesAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_EquityMethodInvestmentsAndJointVenturesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Equity Method Investments And Joint Ventures [Abstract]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquityMethodInvestmentsAndJointVenturesAbstract" xlink:to="us-gaap_EquityMethodInvestmentsAndJointVenturesAbstract_lbl" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsTable" xlink:type="locator" xlink:label="us-gaap_ScheduleOfEquityMethodInvestmentsTable" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfEquityMethodInvestmentsTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule Of Equity Method Investments [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScheduleOfEquityMethodInvestmentsTable" xlink:to="us-gaap_ScheduleOfEquityMethodInvestmentsTable_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfEquityMethodInvestmentsTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Equity Method Investments [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:type="locator" xlink:label="us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investment, Name</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:to="us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Equity Method Investment Equity Method Investee Name [Axis]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityMethodInvesteeNameDomain" xlink:type="locator" xlink:label="us-gaap_EquityMethodInvesteeNameDomain" />
    <label xml:lang="en-US" xlink:label="us-gaap_EquityMethodInvesteeNameDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investment, Name</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquityMethodInvesteeNameDomain" xlink:to="us-gaap_EquityMethodInvesteeNameDomain_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_EquityMethodInvesteeNameDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Equity Method Investee Name [Domain]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_BayviewLendingGroupMember" xlink:type="locator" xlink:label="mtb_BayviewLendingGroupMember" />
    <label xml:lang="en-US" xlink:label="mtb_BayviewLendingGroupMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Bayview Lending Group [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_BayviewLendingGroupMember" xlink:to="mtb_BayviewLendingGroupMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_BayviewLendingGroupMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Bayview Lending Group [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_BayviewLendingGroupMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Bayview Lending Group [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_BayviewLendingGroupAndBayviewFinancialMember" xlink:type="locator" xlink:label="mtb_BayviewLendingGroupAndBayviewFinancialMember" />
    <label xml:lang="en-US" xlink:label="mtb_BayviewLendingGroupAndBayviewFinancialMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Bayview Lending Group And Bayview Financial [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_BayviewLendingGroupAndBayviewFinancialMember" xlink:to="mtb_BayviewLendingGroupAndBayviewFinancialMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_BayviewLendingGroupAndBayviewFinancialMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Bayview Lending Group and Bayview Financial [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_BayviewLendingGroupAndBayviewFinancialMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Bayview Lending Group And Bayview Financial [Member]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_BayviewFinancialMember" xlink:type="locator" xlink:label="mtb_BayviewFinancialMember" />
    <label xml:lang="en-US" xlink:label="mtb_BayviewFinancialMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Bayview Financial [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_BayviewFinancialMember" xlink:to="mtb_BayviewFinancialMember_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_BayviewFinancialMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Bayview Financial [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_BayviewFinancialMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Bayview Financial [Member]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ScheduleOfEquityMethodInvestmentsLineItems" xlink:type="locator" xlink:label="us-gaap_ScheduleOfEquityMethodInvestmentsLineItems" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Schedule of Equity Method Investments [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScheduleOfEquityMethodInvestmentsLineItems" xlink:to="us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ScheduleOfEquityMethodInvestmentsLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Schedule Of Equity Method Investments [Line Items]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:type="locator" xlink:label="us-gaap_EquityMethodInvestmentOwnershipPercentage" />
    <label xml:lang="en-US" xlink:label="us-gaap_EquityMethodInvestmentOwnershipPercentage_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Minority interest in Bayview Lending Group LLC</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:to="us-gaap_EquityMethodInvestmentOwnershipPercentage_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_EquityMethodInvestmentOwnershipPercentage_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Equity Method Investment Ownership Percentage</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_EquityMethodInvestments" xlink:type="locator" xlink:label="us-gaap_EquityMethodInvestments" />
    <label xml:lang="en-US" xlink:label="us-gaap_EquityMethodInvestments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Carrying value of minority interest investment in Bayview Lending Group LLC</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquityMethodInvestments" xlink:to="us-gaap_EquityMethodInvestments_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_EquityMethodInvestments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Equity Method Investments</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_MortgageLoansOfPrivatelyHeldCompany" xlink:type="locator" xlink:label="mtb_MortgageLoansOfPrivatelyHeldCompany" />
    <label xml:lang="en-US" xlink:label="mtb_MortgageLoansOfPrivatelyHeldCompany_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Mortgage servicing rights of commercial mortgage loans with outstanding principal balances of privately held commercial mortgage company.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_MortgageLoansOfPrivatelyHeldCompany" xlink:to="mtb_MortgageLoansOfPrivatelyHeldCompany_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_SubServicedResidentialMortgageLoansOfPrivatelyHeldCompany" xlink:type="locator" xlink:label="mtb_SubServicedResidentialMortgageLoansOfPrivatelyHeldCompany" />
    <label xml:lang="en-US" xlink:label="mtb_SubServicedResidentialMortgageLoansOfPrivatelyHeldCompany_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Outstanding principal balance of sub-serviced residential real estate loans for a privately-held specialty mortgage finance company.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_SubServicedResidentialMortgageLoansOfPrivatelyHeldCompany" xlink:to="mtb_SubServicedResidentialMortgageLoansOfPrivatelyHeldCompany_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_RevenuesFromSubservicing" xlink:type="locator" xlink:label="mtb_RevenuesFromSubservicing" />
    <label xml:lang="en-US" xlink:label="mtb_RevenuesFromSubservicing_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Revenues from sub-servicing</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_RevenuesFromSubservicing" xlink:to="mtb_RevenuesFromSubservicing_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_MortgageLoansOfPrivatelyHeldCompany_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Outstanding principal balances of mortgage servicing rights</label>
    <label xml:lang="en-US" xlink:label="mtb_MortgageLoansOfPrivatelyHeldCompany_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Mortgage Loans Of Privately Held Company</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ServicingFeesNet" xlink:type="locator" xlink:label="us-gaap_ServicingFeesNet" />
    <label xml:lang="en-US" xlink:label="us-gaap_ServicingFeesNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Revenues from servicing</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ServicingFeesNet" xlink:to="us-gaap_ServicingFeesNet_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ServicingFeesNet_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Servicing Fees Net</label>
    <label xml:lang="en-US" xlink:label="mtb_SubServicedResidentialMortgageLoansOfPrivatelyHeldCompany_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Outstanding principal balances of residential mortgage loans from Bayview Financial</label>
    <label xml:lang="en-US" xlink:label="mtb_SubServicedResidentialMortgageLoansOfPrivatelyHeldCompany_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Sub Serviced Residential Mortgage Loans Of Privately Held Company</label>
    <label xml:lang="en-US" xlink:label="mtb_RevenuesFromSubservicing_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Revenues from sub-servicing</label>
    <label xml:lang="en-US" xlink:label="mtb_RevenuesFromSubservicing_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Revenues From Subservicing</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_MortgageBackedSecuritiesHeldToMaturityFairValueDisclosure" xlink:type="locator" xlink:label="us-gaap_MortgageBackedSecuritiesHeldToMaturityFairValueDisclosure" />
    <label xml:lang="en-US" xlink:label="us-gaap_MortgageBackedSecuritiesHeldToMaturityFairValueDisclosure_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investment securities in held-to-maturity portfolio securitized by Bayview Financial</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_MortgageBackedSecuritiesHeldToMaturityFairValueDisclosure" xlink:to="us-gaap_MortgageBackedSecuritiesHeldToMaturityFairValueDisclosure_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_MortgageBackedSecuritiesHeldToMaturityFairValueDisclosure_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Mortgage Backed Securities Held To Maturity Fair Value Disclosure</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_DueFromSubsidiariesMoneyMarketSavings" xlink:type="locator" xlink:label="mtb_DueFromSubsidiariesMoneyMarketSavings" />
    <label xml:lang="en-US" xlink:label="mtb_DueFromSubsidiariesMoneyMarketSavings_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Interest bearing deposits held in a money market savings account at subsidiary bank.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DueFromSubsidiariesMoneyMarketSavings" xlink:to="mtb_DueFromSubsidiariesMoneyMarketSavings_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_DueFromSubsidiariesIncomeTaxReceivable" xlink:type="locator" xlink:label="mtb_DueFromSubsidiariesIncomeTaxReceivable" />
    <label xml:lang="en-US" xlink:label="mtb_DueFromSubsidiariesIncomeTaxReceivable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Carrying amount as of the balance sheet date of income taxes previously overpaid to tax authorities by subsidiaries.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_DueFromSubsidiariesIncomeTaxReceivable" xlink:to="mtb_DueFromSubsidiariesIncomeTaxReceivable_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_OtherDuesFromSubsidiaries" xlink:type="locator" xlink:label="mtb_OtherDuesFromSubsidiaries" />
    <label xml:lang="en-US" xlink:label="mtb_OtherDuesFromSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Amount of all other receivables due from an entity that is affiliated with the reporting entity by means of direct or indirect ownership.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_OtherDuesFromSubsidiaries" xlink:to="mtb_OtherDuesFromSubsidiaries_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_InvestmentsInConsolidatedSubsidiariesAbstract" xlink:type="locator" xlink:label="mtb_InvestmentsInConsolidatedSubsidiariesAbstract" />
    <label xml:lang="en-US" xlink:label="mtb_InvestmentsInConsolidatedSubsidiariesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Investments in consolidated subsidiaries.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_InvestmentsInConsolidatedSubsidiariesAbstract" xlink:to="mtb_InvestmentsInConsolidatedSubsidiariesAbstract_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_StockholdersEquityExcludingPortionAttributableToSubsidiariesNoncontrollingInterestAbstract" xlink:type="locator" xlink:label="mtb_StockholdersEquityExcludingPortionAttributableToSubsidiariesNoncontrollingInterestAbstract" />
    <label xml:lang="en-US" xlink:label="mtb_StockholdersEquityExcludingPortionAttributableToSubsidiariesNoncontrollingInterestAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Stockholders Equity Excluding Portion Attributable To Subsidiaries Noncontrolling Interest [Abstract]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_StockholdersEquityExcludingPortionAttributableToSubsidiariesNoncontrollingInterestAbstract" xlink:to="mtb_StockholdersEquityExcludingPortionAttributableToSubsidiariesNoncontrollingInterestAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_StockholdersEquityExcludingPortionAttributableToSubsidiariesNoncontrollingInterestAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Stockholders Equity Excluding Portion Attributable To Subsidiaries Noncontrolling Interest [Abstract]</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_ParentCompanyOnlyFinancialInformationLineItems" xlink:type="locator" xlink:label="mtb_ParentCompanyOnlyFinancialInformationLineItems" />
    <label xml:lang="en-US" xlink:label="mtb_ParentCompanyOnlyFinancialInformationLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Parent Company Only Financial Information [Line Items]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ParentCompanyOnlyFinancialInformationLineItems" xlink:to="mtb_ParentCompanyOnlyFinancialInformationLineItems_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_ParentCompanyOnlyFinancialInformationTable" xlink:type="locator" xlink:label="mtb_ParentCompanyOnlyFinancialInformationTable" />
    <label xml:lang="en-US" xlink:label="mtb_ParentCompanyOnlyFinancialInformationTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Parent Company Only Financial Information [Table]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ParentCompanyOnlyFinancialInformationTable" xlink:to="mtb_ParentCompanyOnlyFinancialInformationTable_lbl" />
    <label xml:lang="en-US" xlink:label="mtb_ParentCompanyOnlyFinancialInformationTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Parent Company Only Financial Information [Table]</label>
    <label xml:lang="en-US" xlink:label="mtb_ParentCompanyOnlyFinancialInformationTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Parent Company Only Financial Information [Table]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_ParentCompanyMember" xlink:type="locator" xlink:label="us-gaap_ParentCompanyMember" />
    <label xml:lang="en-US" xlink:label="us-gaap_ParentCompanyMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Parent Company [Member]</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ParentCompanyMember" xlink:to="us-gaap_ParentCompanyMember_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_ParentCompanyMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Parent Company [Member]</label>
    <label xml:lang="en-US" xlink:label="mtb_ParentCompanyOnlyFinancialInformationLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Parent Company Only Financial Information [Line Items]</label>
    <label xml:lang="en-US" xlink:label="mtb_ParentCompanyOnlyFinancialInformationLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Parent Company Only Financial Information [Line Items]</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_Cash" xlink:type="locator" xlink:label="us-gaap_Cash" />
    <label xml:lang="en-US" xlink:label="us-gaap_Cash_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cash in subsidiary bank</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_Cash" xlink:to="us-gaap_Cash_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_Cash_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Cash</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_DueFromRelatedPartiesUnclassifiedAbstract" xlink:type="locator" xlink:label="us-gaap_DueFromRelatedPartiesUnclassifiedAbstract" />
    <label xml:lang="en-US" xlink:label="us-gaap_DueFromRelatedPartiesUnclassifiedAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Due from consolidated bank subsidiaries</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DueFromRelatedPartiesUnclassifiedAbstract" xlink:to="us-gaap_DueFromRelatedPartiesUnclassifiedAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_DueFromRelatedPartiesUnclassifiedAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Due From Related Parties Unclassified [Abstract]</label>
    <label xml:lang="en-US" xlink:label="mtb_DueFromSubsidiariesMoneyMarketSavings_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Money-market savings</label>
    <label xml:lang="en-US" xlink:label="mtb_DueFromSubsidiariesMoneyMarketSavings_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Due From Subsidiaries Money Market Savings</label>
    <label xml:lang="en-US" xlink:label="mtb_DueFromSubsidiariesIncomeTaxReceivable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Current income tax receivable</label>
    <label xml:lang="en-US" xlink:label="mtb_DueFromSubsidiariesIncomeTaxReceivable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Due From Subsidiaries Income Tax Receivable</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherDuesFromSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other</label>
    <label xml:lang="en-US" xlink:label="mtb_OtherDuesFromSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Dues From Subsidiaries</label>
    <label xml:lang="en-US" xlink:label="mtb_DueFromSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total due from consolidated bank subsidiaries</label>
    <label xml:lang="en-US" xlink:label="mtb_DueFromSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Due From Subsidiaries</label>
    <label xml:lang="en-US" xlink:label="mtb_InvestmentsInConsolidatedSubsidiariesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investments in consolidated subsidiaries</label>
    <label xml:lang="en-US" xlink:label="mtb_InvestmentsInConsolidatedSubsidiariesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Investments In Consolidated Subsidiaries [Abstract]</label>
    <label xml:lang="en-US" xlink:label="mtb_InvestmentsInConsolidatedBankingSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Banks</label>
    <label xml:lang="en-US" xlink:label="mtb_InvestmentsInConsolidatedBankingSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Investments In Consolidated Banking Subsidiaries</label>
    <label xml:lang="en-US" xlink:label="mtb_InvestmentsInConsolidatedOtherSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other</label>
    <label xml:lang="en-US" xlink:label="mtb_InvestmentsInConsolidatedOtherSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Investments In Consolidated Other Subsidiaries</label>
    <label xml:lang="en-US" xlink:label="mtb_InvestmentsInUnconsolidatedSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Investments in unconsolidated subsidiaries (note 19)</label>
    <label xml:lang="en-US" xlink:label="mtb_InvestmentsInUnconsolidatedSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Investments In Unconsolidated Subsidiaries</label>
    <label xml:lang="en-US" xlink:label="us-gaap_EquityMethodInvestments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Investment in Bayview Lending Group LLC</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherAssets" xlink:type="locator" xlink:label="us-gaap_OtherAssets" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other assets</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherAssets" xlink:to="us-gaap_OtherAssets_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherAssets_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Assets</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_AccruedLiabilitiesAndOtherLiabilities" xlink:type="locator" xlink:label="us-gaap_AccruedLiabilitiesAndOtherLiabilities" />
    <label xml:lang="en-US" xlink:label="us-gaap_AccruedLiabilitiesAndOtherLiabilities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Accrued expenses and other liabilities</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AccruedLiabilitiesAndOtherLiabilities" xlink:to="us-gaap_AccruedLiabilitiesAndOtherLiabilities_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_AccruedLiabilitiesAndOtherLiabilities_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Accrued Liabilities And Other Liabilities</label>
    <label xml:lang="en-US" xlink:label="us-gaap_StockholdersEquity_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Shareholders&#8217; equity</label>
    <loc xlink:href="mtb-20161231.xsd#mtb_IncomeLossBeforeExpensesAndTaxCreditsAttributableToParent" xlink:type="locator" xlink:label="mtb_IncomeLossBeforeExpensesAndTaxCreditsAttributableToParent" />
    <label xml:lang="en-US" xlink:label="mtb_IncomeLossBeforeExpensesAndTaxCreditsAttributableToParent_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Reflects the sum of all revenue and income (prior to any tax credits) recognized by the entity in the period, including dividends from consolidated bank subsidiaries, the entity&apos;s proportionate share for the period of the net income (loss) of its investee (such as unconsolidated subsidiaries and joint ventures) to which the equity method of accounting is applied, and all other revenue and income recognized by the entity.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_IncomeLossBeforeExpensesAndTaxCreditsAttributableToParent" xlink:to="mtb_IncomeLossBeforeExpensesAndTaxCreditsAttributableToParent_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_InterestAndNoninterestExpensesAttributableToParent" xlink:type="locator" xlink:label="mtb_InterestAndNoninterestExpensesAttributableToParent" />
    <label xml:lang="en-US" xlink:label="mtb_InterestAndNoninterestExpensesAttributableToParent_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Aggregate amount of interest paid or due and all noninterest expense.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_InterestAndNoninterestExpensesAttributableToParent" xlink:to="mtb_InterestAndNoninterestExpensesAttributableToParent_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_IncomeLossBeforeIncomeTaxesAndEquityInUndistributedIncomeOfSubsidiaries" xlink:type="locator" xlink:label="mtb_IncomeLossBeforeIncomeTaxesAndEquityInUndistributedIncomeOfSubsidiaries" />
    <label xml:lang="en-US" xlink:label="mtb_IncomeLossBeforeIncomeTaxesAndEquityInUndistributedIncomeOfSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Income (loss) before income taxes and equity in undistributed income of subsidiaries.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_IncomeLossBeforeIncomeTaxesAndEquityInUndistributedIncomeOfSubsidiaries" xlink:to="mtb_IncomeLossBeforeIncomeTaxesAndEquityInUndistributedIncomeOfSubsidiaries_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_ExpenseAbstract" xlink:type="locator" xlink:label="mtb_ExpenseAbstract" />
    <label xml:lang="en-US" xlink:label="mtb_ExpenseAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Expense.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_ExpenseAbstract" xlink:to="mtb_ExpenseAbstract_lbl" />
    <loc xlink:href="mtb-20161231.xsd#mtb_EquityInUndistributedIncomeOfSubsidiariesAbstract" xlink:type="locator" xlink:label="mtb_EquityInUndistributedIncomeOfSubsidiariesAbstract" />
    <label xml:lang="en-US" xlink:label="mtb_EquityInUndistributedIncomeOfSubsidiariesAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation">Equity in undistributed income of subsidiaries.</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="mtb_EquityInUndistributedIncomeOfSubsidiariesAbstract" xlink:to="mtb_EquityInUndistributedIncomeOfSubsidiariesAbstract_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_NoninterestIncomeAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Income</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_InvestmentsInAndAdvancesToAffiliatesDividendOrInterestCreditedToIncome" xlink:type="locator" xlink:label="us-gaap_InvestmentsInAndAdvancesToAffiliatesDividendOrInterestCreditedToIncome" />
    <label xml:lang="en-US" xlink:label="us-gaap_InvestmentsInAndAdvancesToAffiliatesDividendOrInterestCreditedToIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Dividends from consolidated bank subsidiaries</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InvestmentsInAndAdvancesToAffiliatesDividendOrInterestCreditedToIncome" xlink:to="us-gaap_InvestmentsInAndAdvancesToAffiliatesDividendOrInterestCreditedToIncome_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_InvestmentsInAndAdvancesToAffiliatesDividendOrInterestCreditedToIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Investments In And Advances To Affiliates Dividend Or Interest Credited To Income</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments" xlink:type="locator" xlink:label="us-gaap_IncomeLossFromEquityMethodInvestments" />
    <label xml:lang="en-US" xlink:label="us-gaap_IncomeLossFromEquityMethodInvestments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Equity in earnings of Bayview Lending Group LLC</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncomeLossFromEquityMethodInvestments" xlink:to="us-gaap_IncomeLossFromEquityMethodInvestments_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_IncomeLossFromEquityMethodInvestments_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Income Loss From Equity Method Investments</label>
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2016/elts/us-gaap-2016-01-31.xsd#us-gaap_OtherIncome" xlink:type="locator" xlink:label="us-gaap_OtherIncome" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other income</label>
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherIncome" xlink:to="us-gaap_OtherIncome_lbl" />
    <label xml:lang="en-US" xlink:label="us-gaap_OtherIncome_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Other Income</label>
    <label xml:lang="en-US" xlink:label="mtb_IncomeLossBeforeExpensesAndTaxCreditsAttributableToParent_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total income</label>
    <label xml:lang="en-US" xlink:label="mtb_IncomeLossBeforeExpensesAndTaxCreditsAttributableToParent_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Income Loss Before Expenses And Tax Credits Attributable To Parent</label>
    <label xml:lang="en-US" xlink:label="mtb_ExpenseAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Expense</label>
    <label xml:lang="en-US" xlink:label="mtb_ExpenseAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Expense [Abstract]</label>
    <label xml:lang="en-US" xlink:label="us-gaap_InterestExpenseLongTermDebt_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Interest on long-term borrowings</label>
    <label xml:lang="en-US" xlink:label="us-gaap_NoninterestExpense_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Other expense</label>
    <label xml:lang="en-US" xlink:label="mtb_InterestAndNoninterestExpensesAttributableToParent_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Total expense</label>
    <label xml:lang="en-US" xlink:label="mtb_InterestAndNoninterestExpensesAttributableToParent_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Interest And Noninterest Expenses Attributable To Parent</label>
    <label xml:lang="en-US" xlink:label="mtb_IncomeLossBeforeIncomeTaxesAndEquityInUndistributedIncomeOfSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Income before income taxes and equity in undistributed income of subsidiaries</label>
    <label xml:lang="en-US" xlink:label="mtb_IncomeLossBeforeIncomeTaxesAndEquityInUndistributedIncomeOfSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Income Loss Before Income Taxes And Equity In Undistributed Income Of Subsidiaries</label>
    <label xml:lang="en-US" xlink:label="us-gaap_IncomeTaxExpenseBenefit_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel">Income tax credits</label>
    <label xml:lang="en-US" xlink:label="mtb_IncomeLossBeforeEquityInUndistributedIncomeOfSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/totalLabel">Income before equity in undistributed income of subsidiaries</label>
    <label xml:lang="en-US" xlink:label="mtb_IncomeLossBeforeEquityInUndistributedIncomeOfSubsidiaries_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Income Loss Before Equity In Undistributed Income Of Subsidiaries</label>
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