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<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2022-02-16T21:06:15.6883526+00:00 -->
<!-- Version            : 5.0.1.728 -->
<!-- Package ID         : 8b360c43385b4f44bbb9b80b9057de59 -->
<!-- Copyright (c) 2022 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="mtb_ProceedsFromSaleOfEquityAndOtherSecuritiesInvestments" name="ProceedsFromSaleOfEquityAndOtherSecuritiesInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_PaymentsToAcquireEquityAndOtherSecuritiesInvestments" name="PaymentsToAcquireEquityAndOtherSecuritiesInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_NetIncreaseDecreaseInLoanServicingAdvances" name="NetIncreaseDecreaseInLoanServicingAdvances" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_NetIncreaseDecreaseInShortTermBorrowings" name="NetIncreaseDecreaseInShortTermBorrowings" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_ConsolidationSecuritizedTrustsIncreaseInvestmentSecuritiesHeldForSale" name="ConsolidationSecuritizedTrustsIncreaseInvestmentSecuritiesHeldForSale" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_NoncashOperatingLeaseRightOfUseAssets" name="NoncashOperatingLeaseRightOfUseAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_NoncashOperatingLeaseOtherLiabilities" name="NoncashOperatingLeaseOtherLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_ShareBasedCompensationExpenseNet" name="ShareBasedCompensationExpenseNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_NewAccountingPronouncementOrChangeInAccountingPrincipleEffectOfAdoptionQuantification1" name="NewAccountingPronouncementOrChangeInAccountingPrincipleEffectOfAdoptionQuantification1" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_DividendsPerformanceShareUnits" name="DividendsPerformanceShareUnits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_CommonStockIssuableMember" name="CommonStockIssuableMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_SeriesAAndSeriesCMember" name="SeriesAAndSeriesCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_SeriesIPreferredStockMember" name="SeriesIPreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_InternationalActivitiesDisclosureTextBlock" name="InternationalActivitiesDisclosureTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_InternationalActivitiesAbstract" name="InternationalActivitiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_VariableInterestEntitiesAndAssetSecuritizationsTextBlock" name="VariableInterestEntitiesAndAssetSecuritizationsTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_RelationshipWithOtherEntitiesTextBlock" name="RelationshipWithOtherEntitiesTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_TradingAccountPolicyTextBlock" name="TradingAccountPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_TreasuryStockPolicyTextBlock" name="TreasuryStockPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_AmortizedCostAndEstimatedFairValueOfInvestmentSecuritiesTableTextBlock" name="AmortizedCostAndEstimatedFairValueOfInvestmentSecuritiesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_RatingsOfInvestmentSecuritiesTableTextBlock" name="RatingsOfInvestmentSecuritiesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_AmortizedCostAndEstimatedFairValueOfCollateralizedMortgageObligationsTableTextBlock" name="AmortizedCostAndEstimatedFairValueOfCollateralizedMortgageObligationsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_AmortizedCostAndEstimatedFairValueOfDebtSecuritiesByContractualMaturityTableTextBlock" name="AmortizedCostAndEstimatedFairValueOfDebtSecuritiesByContractualMaturityTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_InvestmentSecuritiesInContinuousUnrealizedLossPositionTableTextBlock" name="InvestmentSecuritiesInContinuousUnrealizedLossPositionTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_LoansAndLeasesReceivableTableTextBlock" name="LoansAndLeasesReceivableTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_LoansAndLeasesReceivableNetOfDeferredIncomeByAccrualStatusTableTextBlock" name="LoansAndLeasesReceivableNetOfDeferredIncomeByAccrualStatusTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_SummaryOfOutstandingLoanBalancesRelatedToCovid19ModificationsGrantedTableTextBlock" name="SummaryOfOutstandingLoanBalancesRelatedToCovid19ModificationsGrantedTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_CertainLoansAcquiredInTransferAccountedForAsDebtSecuritiesAccretableYieldAccretionTableTextBlock" name="CertainLoansAcquiredInTransferAccountedForAsDebtSecuritiesAccretableYieldAccretionTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_SummaryOfLeaseFinancingReceivablesTableTextBlock" name="SummaryOfLeaseFinancingReceivablesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_LoanAndLeasesConsideredNonaccrualAndInterestIncomeRecognizedOnLoansTableTextBlock" name="LoanAndLeasesConsideredNonaccrualAndInterestIncomeRecognizedOnLoansTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_SummaryOfLoanGradesAppliedVariousClassesOfCommercialAndRealEstateLoansTableTextBlock" name="SummaryOfLoanGradesAppliedVariousClassesOfCommercialAndRealEstateLoansTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_SummaryOfLoansInAccrualAndNonaccrualStatusTableTextBlock" name="SummaryOfLoansInAccrualAndNonaccrualStatusTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_AssumedWeightedAverageRatesUsedToDetermineBenefitObligationsTableTextBlock" name="AssumedWeightedAverageRatesUsedToDetermineBenefitObligationsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_AssumedWeightedAverageRatesUsedToDetermineNetBenefitExpenseTableTextBlock" name="AssumedWeightedAverageRatesUsedToDetermineNetBenefitExpenseTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_DefinedBenefitPlanFairValueOfPlanAssetsDisclosureTableTextBlock" name="DefinedBenefitPlanFairValueOfPlanAssetsDisclosureTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_ChangesInLevelThreePensionPlanAssetsMeasuredAtFairValueOnRecurringBasisTableTextBlock" name="ChangesInLevelThreePensionPlanAssetsMeasuredAtFairValueOnRecurringBasisTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_ComponentsOfOtherComprehensiveIncomeLossTableTextBlock" name="ComponentsOfOtherComprehensiveIncomeLossTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_ChangesInLevelThreeAssetsAndLiabilitiesMeasuredAtEstimatedFairValueOnRecurringBasisTableTextBlock" name="ChangesInLevelThreeAssetsAndLiabilitiesMeasuredAtEstimatedFairValueOnRecurringBasisTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_QuantitativeInformationRelatedToSignificantUnobservableInputsTableTextBlock" name="QuantitativeInformationRelatedToSignificantUnobservableInputsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_CommitmentsTableTextBlock" name="CommitmentsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_ScheduleOfMinimumCapitalRequiredToBeWellCapitalizedUnderBankingRegulationsTableTextBlock" name="ScheduleOfMinimumCapitalRequiredToBeWellCapitalizedUnderBankingRegulationsTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_DelinquentPeriodOfLoansResultingInAccruedInterestBeingChargedAgainstIncome" name="DelinquentPeriodOfLoansResultingInAccruedInterestBeingChargedAgainstIncome" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_DelinquentPeriodOfLoansSecuredByRealEstateResultingInChargeOff" name="DelinquentPeriodOfLoansSecuredByRealEstateResultingInChargeOff" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_LoansSecuredByRealEstateDelinquentPeriodThresholdForReturnToAccrualStatus" name="LoansSecuredByRealEstateDelinquentPeriodThresholdForReturnToAccrualStatus" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_ConsumerLoanDelinquentPeriodThresholdForConsiderationForChargeOff" name="ConsumerLoanDelinquentPeriodThresholdForConsiderationForChargeOff" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_DelinquentPeriodOfLoansResultingInAccruedInterestBeingChargedAgainstIncomeDescription" name="DelinquentPeriodOfLoansResultingInAccruedInterestBeingChargedAgainstIncomeDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_RegulatoryAssetsAbstract" name="RegulatoryAssetsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_SignificantAccountingPoliciesLineItems" name="SignificantAccountingPoliciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_SignificantAccountingPoliciesTable" name="SignificantAccountingPoliciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_IncomeTaxBenefitRecognitionCriteriaPercentageThreshold" name="IncomeTaxBenefitRecognitionCriteriaPercentageThreshold" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_PeoplesUnitedFinancialIncMember" name="PeoplesUnitedFinancialIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_MTMember" name="MTMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_BusinessCombinationRecognizedIdentifiableAssetsAcquisitionOfLoansOutstanding" name="BusinessCombinationRecognizedIdentifiableAssetsAcquisitionOfLoansOutstanding" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_BusinessCombinationRecognizedIdentifiableAssetsAcquisitionOfDeposits" name="BusinessCombinationRecognizedIdentifiableAssetsAcquisitionOfDeposits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_ReadilyMarketableSecuritiesAtFairValueAmortizedCost" name="ReadilyMarketableSecuritiesAtFairValueAmortizedCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_ReadilyMarketableSecuritiesAtFairValueGrossUnrealizedGains" name="ReadilyMarketableSecuritiesAtFairValueGrossUnrealizedGains" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_ReadilyMarketableSecuritiesAtFairValueGrossUnrealizedLosses" name="ReadilyMarketableSecuritiesAtFairValueGrossUnrealizedLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_ReadilyMarketableSecuritiesAtEstimatedFairValue" name="ReadilyMarketableSecuritiesAtEstimatedFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_InvestmentInDebtSecuritiesAmortizedCost" name="InvestmentInDebtSecuritiesAmortizedCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_InvestmentInDebtSecuritiesGrossUnrealizedGains" name="InvestmentInDebtSecuritiesGrossUnrealizedGains" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_InvestmentInDebtSecuritiesGrossUnrealizedLosses" name="InvestmentInDebtSecuritiesGrossUnrealizedLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_InvestmentInDebtSecuritiesEstimatedFairValue" name="InvestmentInDebtSecuritiesEstimatedFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_EquitySecuritiesGrossUnrealizedGains" name="EquitySecuritiesGrossUnrealizedGains" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_EquitySecuritiesGrossUnrealizedLosses" name="EquitySecuritiesGrossUnrealizedLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_AmortizedCostAndFairValueDebtSecuritiesAbstract" name="AmortizedCostAndFairValueDebtSecuritiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ScheduleOfAmortizedCostAndEstimatedFairValueOfInvestmentSecuritiesLineItems" name="ScheduleOfAmortizedCostAndEstimatedFairValueOfInvestmentSecuritiesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ScheduleOfAmortizedCostAndEstimatedFairValueOfInvestmentSecuritiesTable" name="ScheduleOfAmortizedCostAndEstimatedFairValueOfInvestmentSecuritiesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_NumberOfSingleInvestmentSecuritiesThatExceededTenPercentOfShareholdersEquity" name="NumberOfSingleInvestmentSecuritiesThatExceededTenPercentOfShareholdersEquity" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mtb_FannieMaeAndFreddieMacPreferredStockMember" name="FannieMaeAndFreddieMacPreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_SecuritiesWithDisclosedRatingAmortizedCost" name="SecuritiesWithDisclosedRatingAmortizedCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_SecuritiesWithDisclosedRatingEstimatedFairValue" name="SecuritiesWithDisclosedRatingEstimatedFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_ScheduleOfAvailableForSaleSecuritiesAndHeldToMaturityLineItems" name="ScheduleOfAvailableForSaleSecuritiesAndHeldToMaturityLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ScheduleOfAvailableForSaleSecuritiesAndHeldToMaturityTable" name="ScheduleOfAvailableForSaleSecuritiesAndHeldToMaturityTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_AOrBetterCreditRatingMember" name="AOrBetterCreditRatingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_BBBCreditRatingMember" name="BBBCreditRatingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_BbMember" name="BbMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_BOrLessCreditRatingMember" name="BOrLessCreditRatingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_NotRatedMember" name="NotRatedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CollateralizedMortgageObligationsAmortizedCost" name="CollateralizedMortgageObligationsAmortizedCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_CollateralizedMortgageObligationsEstimatedFairValue" name="CollateralizedMortgageObligationsEstimatedFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_GrossRealizedGainLossOnSecurities" name="GrossRealizedGainLossOnSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_InvestmentSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue" name="InvestmentSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_InvestmentSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsAggregateLosses" name="InvestmentSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsAggregateLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_InvestmentSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue" name="InvestmentSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_InvestmentSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerAggregateLosses" name="InvestmentSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerAggregateLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_NumberOfInvestmentSecuritiesWithGrossLosses" name="NumberOfInvestmentSecuritiesWithGrossLosses" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mtb_InvestmentSecuritiesGrossUnrealizedLosses" name="InvestmentSecuritiesGrossUnrealizedLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_InvestmentSecuritiesPledgedToSecureDebtCarryingValue" name="InvestmentSecuritiesPledgedToSecureDebtCarryingValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_CarryingValueOfAvailableForSaleSecuritiesPledged" name="CarryingValueOfAvailableForSaleSecuritiesPledged" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_LoansReceivableAbstract" name="LoansReceivableAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CommercialFinancialLoanMember" name="CommercialFinancialLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ConsumerRealEstateMember" name="ConsumerRealEstateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CommercialLeaseMember" name="CommercialLeaseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_LoansAndLeasesReceivableLineItems" name="LoansAndLeasesReceivableLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_LoansAndLeasesReceivableTable" name="LoansAndLeasesReceivableTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_DirectorAndCertainOfficersMember" name="DirectorAndCertainOfficersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CommercialLoansAndLeasesMember" name="CommercialLoansAndLeasesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_OtherConsumerLoansMember" name="OtherConsumerLoansMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ResidentialMortgageLoansSecuredByResidentialRealEstateInProcessOfForeclosure" name="ResidentialMortgageLoansSecuredByResidentialRealEstateInProcessOfForeclosure" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_PercentageOfLoansInTheProcessOfForeclosureServicedByOtherEntitiesClassifiedAsGovernmentGuaranteed" name="PercentageOfLoansInTheProcessOfForeclosureServicedByOtherEntitiesClassifiedAsGovernmentGuaranteed" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mtb_CommercialFinancialLeasingMember" name="CommercialFinancialLeasingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CommercialRealEstateExcludingResidentialBuilderAndDeveloperAndOtherConstructionMember" name="CommercialRealEstateExcludingResidentialBuilderAndDeveloperAndOtherConstructionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ResidentialBuilderAndDeveloperMember" name="ResidentialBuilderAndDeveloperMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_OtherCommercialConstructionMember" name="OtherCommercialConstructionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ResidentialRealEstateExcludingAltAMember" name="ResidentialRealEstateExcludingAltAMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ResidentialLimitedDocumentationMember" name="ResidentialLimitedDocumentationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_HomeEquityLinesAndLoansMember" name="HomeEquityLinesAndLoansMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_RecreationalFinanceMember" name="RecreationalFinanceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_OtherLoansMember" name="OtherLoansMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_COVID19Member" name="COVID19Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_GovernmentGuaranteedLoansMember" name="GovernmentGuaranteedLoansMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_OtherModificationsMember" name="OtherModificationsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CombinationOfConcessionTypesMember" name="CombinationOfConcessionTypesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestIncome" name="CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestOtherIncreaseDecrease" name="CertainLoansAcquiredInTransferNotAccountedForAsDebtSecuritiesAccretableYieldInterestOtherIncreaseDecrease" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_PurchasedImpairedMember" name="PurchasedImpairedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_OtherAcquiredLoansMember" name="OtherAcquiredLoansMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_NetInvestmentInDirectFinancingAndLeveragedTypeLeases" name="NetInvestmentInDirectFinancingAndLeveragedTypeLeases" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_CapitalLeasesNetInvestmentInDirectFinancingLeasesGuaranteedResidualValuesOfLeasedProperty" name="CapitalLeasesNetInvestmentInDirectFinancingLeasesGuaranteedResidualValuesOfLeasedProperty" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_FinancingReceivableAllowanceForCreditLossesNetWriteOffsAbstract" name="FinancingReceivableAllowanceForCreditLossesNetWriteOffsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_LoanDelinquentPeriodForNonAccrualStatusClassification" name="LoanDelinquentPeriodForNonAccrualStatusClassification" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_CommercialLoansAndCommercialRealEstateMember" name="CommercialLoansAndCommercialRealEstateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ImpairedFinancingReceivableNonaccrualInterestIncome" name="ImpairedFinancingReceivableNonaccrualInterestIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_FinancingReceivableRecordedInvestmentAccrualOrNonaccrualStatus" name="FinancingReceivableRecordedInvestmentAccrualOrNonaccrualStatus" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_LongTermDebtTwoThousandTwentyOneMember" name="LongTermDebtTwoThousandTwentyOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_LongTermDebtTwoThousandTwentyMember" name="LongTermDebtTwoThousandTwentyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_LongTermDebtTwoThousandNineteenMember" name="LongTermDebtTwoThousandNineteenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_LongTermDebtTwoThousandEighteenMember" name="LongTermDebtTwoThousandEighteenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_LongTermDebtTwoThousandSeventeenMember" name="LongTermDebtTwoThousandSeventeenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_LongTermDebtPriorPeriodMember" name="LongTermDebtPriorPeriodMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CriticizedAccrualMember" name="CriticizedAccrualMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CriticizedNonaccrualMember" name="CriticizedNonaccrualMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_RevolvingLoansConvertedToTermLoansMember" name="RevolvingLoansConvertedToTermLoansMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_LongTermDebtTwoThousandSixteenMember" name="LongTermDebtTwoThousandSixteenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_PropertyPlantAndEquipmentCapitalizedInterestCostsAbstract" name="PropertyPlantAndEquipmentCapitalizedInterestCostsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_OwnedAssetsMember" name="OwnedAssetsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_NoncancelableOperatingLeasePeriod" name="NoncancelableOperatingLeasePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_OtherLeaseCostInformationAbstract" name="OtherLeaseCostInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ServicingAssetAtAmortizedValueOriginations" name="ServicingAssetAtAmortizedValueOriginations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_ServicingAssetAtAmortizedValueAdditionalDisclosuresAbstract" name="ServicingAssetAtAmortizedValueAdditionalDisclosuresAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_MortgageLoansServicedForOthers" name="MortgageLoansServicedForOthers" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_SubServicingLoanMember" name="SubServicingLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_SubServicingLoanOneMember" name="SubServicingLoanOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_AssumptionForFairValueOfInterestsContinuedToBeHeldByTransferorServicingAssetsOrLiabilitiesOptionAdjustedBasisSpreadOnVariableRate" name="AssumptionForFairValueOfInterestsContinuedToBeHeldByTransferorServicingAssetsOrLiabilitiesOptionAdjustedBasisSpreadOnVariableRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_WeightedAverageOptionAdjustedSpreadOverMarketImpliedForwardLondonInterbankOfferedRatesUsedToDetermineDiscountRate" name="WeightedAverageOptionAdjustedSpreadOverMarketImpliedForwardLondonInterbankOfferedRatesUsedToDetermineDiscountRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mtb_IntangibleLiabilityDisclosureAbstract" name="IntangibleLiabilityDisclosureAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_GoodwillAndOtherIntangibleAssetsLineItems" name="GoodwillAndOtherIntangibleAssetsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_GoodwillAndOtherIntangibleAssetsTable" name="GoodwillAndOtherIntangibleAssetsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CoreDepositsAndOtherIntangibleAssetsMember" name="CoreDepositsAndOtherIntangibleAssetsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_BusinessBankingMember" name="BusinessBankingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CommercialBankingMember" name="CommercialBankingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CommercialRealEstateSegmentMember" name="CommercialRealEstateSegmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_DiscretionaryPortfolioMember" name="DiscretionaryPortfolioMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ResidentialMortgageBankingMember" name="ResidentialMortgageBankingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_RetailBankingMember" name="RetailBankingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ShortTermDebtWeightedAverageInterestRateDuringPeriod" name="ShortTermDebtWeightedAverageInterestRateDuringPeriod" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_EquityMethodInvestmentsAndCostMethodInvestmentsAbstract" name="EquityMethodInvestmentsAndCostMethodInvestmentsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ScheduleOfBorrowingsLineItems" name="ScheduleOfBorrowingsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ScheduleOfBorrowingsTable" name="ScheduleOfBorrowingsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_OtherShortTermBorrowingsMember" name="OtherShortTermBorrowingsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_FederalReserveBankOfNewYorkMember" name="FederalReserveBankOfNewYorkMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_SeniorNotesIssuedJulyTwoThousandAndEighteenMember" name="SeniorNotesIssuedJulyTwoThousandAndEighteenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_FloatingRateSeniorNotesMember" name="FloatingRateSeniorNotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_LongTermFixedRateAdvancesFromFhlbMember" name="LongTermFixedRateAdvancesFromFhlbMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_MAndTBankMember" name="MAndTBankMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_VariableRateTermLoansDueTwoThousandAndTwentyThreeMember" name="VariableRateTermLoansDueTwoThousandAndTwentyThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_VariableRateTermLoansDueTwoThousandTwentyOneMember" name="VariableRateTermLoansDueTwoThousandTwentyOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_FixedRateThreePointFiveFivePercentageDueTwoThousandTwentyThreeMember" name="FixedRateThreePointFiveFivePercentageDueTwoThousandTwentyThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_VariableRateTermLoansDueTwoThousandAndTwentyTwoMember" name="VariableRateTermLoansDueTwoThousandAndTwentyTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_FixedRateTermLoansOfTwoPointFiveZeroSeniorNotesDueTwoThousandTwentyTwoMember" name="FixedRateTermLoansOfTwoPointFiveZeroSeniorNotesDueTwoThousandTwentyTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_FixedRateTermLoansOfSeniorNotesDueTwoThousandTwentyFiveMember" name="FixedRateTermLoansOfSeniorNotesDueTwoThousandTwentyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_VariableRateSubordinatedNotesDueTwoThousandAndTwentyOneMember" name="VariableRateSubordinatedNotesDueTwoThousandAndTwentyOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_SubordinatedNotesDueTwoZeroTwoSevenMember" name="SubordinatedNotesDueTwoZeroTwoSevenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_BsbCapitalTrustOneFixedRatesDueTwoZeroTwoEightMember" name="BsbCapitalTrustOneFixedRatesDueTwoZeroTwoEightMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ProvidentTrustOneFixedRatesDueTwoZeroTwoEightMember" name="ProvidentTrustOneFixedRatesDueTwoZeroTwoEightMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_SouthernFinancialStatutoryTrustOneFixedRatesDueTwoZeroThreeZeroMember" name="SouthernFinancialStatutoryTrustOneFixedRatesDueTwoZeroThreeZeroMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_FirstMarylandCapitalOneVariableRatesDueTwoZeroTwoSevenMember" name="FirstMarylandCapitalOneVariableRatesDueTwoZeroTwoSevenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_FirstMarylandCapitalTwoVariableRatesDueTwoZeroTwoSevenMember" name="FirstMarylandCapitalTwoVariableRatesDueTwoZeroTwoSevenMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_AllfirstAssetTrustVariableRatesDueTwoZeroTwoNineMember" name="AllfirstAssetTrustVariableRatesDueTwoZeroTwoNineMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_BsbCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember" name="BsbCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ProvidentTrustThreeStatutoryRateDueTwoZeroThreeThreeMember" name="ProvidentTrustThreeStatutoryRateDueTwoZeroThreeThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_SouthernFinancialCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember" name="SouthernFinancialCapitalTrustThreeVariableRateDueTwoZeroThreeThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_MAndTMember" name="MAndTMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_DebtInstrumentMaturityYear" name="DebtInstrumentMaturityYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_FixedRateTermLoansOfSeniorNotesDueTwoThousandNineteenOneMember" name="FixedRateTermLoansOfSeniorNotesDueTwoThousandNineteenOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_FixedRateTermLoansOfSeniorNotesDueTwoThousandTwentyMember" name="FixedRateTermLoansOfSeniorNotesDueTwoThousandTwentyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_FixedRateTermLoansOfTwoPointZeroFiveSeniorNotesDueTwoThousandTwentyMember" name="FixedRateTermLoansOfTwoPointZeroFiveSeniorNotesDueTwoThousandTwentyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_FixedRateTermLoansOfSeniorNotesDueTwoThousandTwentyOneMember" name="FixedRateTermLoansOfSeniorNotesDueTwoThousandTwentyOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_VariableRateSubordinatedNotesDueTwoThousandAndTwentyMember" name="VariableRateSubordinatedNotesDueTwoThousandAndTwentyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_TrustPreferredSecuritiesIncludedInTierOneCapitalPercent" name="TrustPreferredSecuritiesIncludedInTierOneCapitalPercent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_SeriesEFixedToFloatingRateNonCumulativePerpetualPreferredStockMember" name="SeriesEFixedToFloatingRateNonCumulativePerpetualPreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_SeriesFFixedToFloatingRateNonCumulativePerpetualPreferredStockMember" name="SeriesFFixedToFloatingRateNonCumulativePerpetualPreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_SeriesGFixedRateResetNonCumulativePerpetualPreferredStockMember" name="SeriesGFixedRateResetNonCumulativePerpetualPreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_SeriesIFixedRateResetNonCumulativePerpetualPreferredStockMember" name="SeriesIFixedRateResetNonCumulativePerpetualPreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_PreferredStockRedemptionPeriodAfterStockDisqualifiesAsTierICapital" name="PreferredStockRedemptionPeriodAfterStockDisqualifiesAsTierICapital" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_PreferredStockDividendRateModificationsDateOfChange" name="PreferredStockDividendRateModificationsDateOfChange" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_LondonInterbankOfferedRatePlusBasisPoints" name="LondonInterbankOfferedRatePlusBasisPoints" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mtb_USTreasuryRatePlusAdditionalRate" name="USTreasuryRatePlusAdditionalRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_OtherRevenuesFromOperationsAbstract" name="OtherRevenuesFromOperationsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_RestrictedStockAwardsMember" name="RestrictedStockAwardsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_EmployeeStockPurchasePlanMember" name="EmployeeStockPurchasePlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_EmployeeMember" name="EmployeeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockIssuedInPeriodWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardStockIssuedInPeriodWeightedAverageGrantDateFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardExpirationPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardExpirationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionGrantsInPeriodWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionGrantsInPeriodWeightedAverageGrantDateFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_EmployeeServiceShareBasedCompensationCashReceivedFromEmployeeStockOwnershipPlan" name="EmployeeServiceShareBasedCompensationCashReceivedFromEmployeeStockOwnershipPlan" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_PensionAndOtherPostretirementDefinedBenefitPlansAssetsLiabilitiesNet" name="PensionAndOtherPostretirementDefinedBenefitPlansAssetsLiabilitiesNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_AmountRecognizedInAccumulatedOtherComprehensiveIncomeAbstract" name="AmountRecognizedInAccumulatedOtherComprehensiveIncomeAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ScheduleOfSaleOfSubsidiaryAbstract" name="ScheduleOfSaleOfSubsidiaryAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_PensionPlansPostretirementAndOtherEmployeeBenefitsLineItems" name="PensionPlansPostretirementAndOtherEmployeeBenefitsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_PensionPlansPostretirementAndOtherEmployeeBenefitsTable" name="PensionPlansPostretirementAndOtherEmployeeBenefitsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_SupplementalPensionPlanMember" name="SupplementalPensionPlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_DebtSecurityMember" name="DebtSecurityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_DefinedBenefitPlansAccumulatedOtherComprehensiveIncomeMinimumPensionLiabilityBeforeTax" name="DefinedBenefitPlansAccumulatedOtherComprehensiveIncomeMinimumPensionLiabilityBeforeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeMinimumPensionLiabilityNetOfTax" name="DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeMinimumPensionLiabilityNetOfTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_OtherComprehensiveIncomeMinimumPensionLiabilityNetAdjustmentsBeforeTax" name="OtherComprehensiveIncomeMinimumPensionLiabilityNetAdjustmentsBeforeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitSensitivityRateIncreaseDecreaseDiscountRate" name="DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitSensitivityRateIncreaseDecreaseDiscountRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mtb_DefinedBenefitPlanEffectOfTwentyFiveBasisPointIncreaseInRateOfReturnOnPensionExpense" name="DefinedBenefitPlanEffectOfTwentyFiveBasisPointIncreaseInRateOfReturnOnPensionExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_DefinedBenefitPlanEffectOfTwentyFiveBasisPointDecreaseInRateOfReturnOnPensionExpense" name="DefinedBenefitPlanEffectOfTwentyFiveBasisPointDecreaseInRateOfReturnOnPensionExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_DefinedBenefitPlanIncreaseOfTwentyFiveBasisPointDecreaseInDiscountRateOnBenefitObligation" name="DefinedBenefitPlanIncreaseOfTwentyFiveBasisPointDecreaseInDiscountRateOnBenefitObligation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_DefinedBenefitPlanDecreaseOfTwentyFiveBasisPointIncreaseInDiscountRateOnBenefitObligation" name="DefinedBenefitPlanDecreaseOfTwentyFiveBasisPointIncreaseInDiscountRateOnBenefitObligation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_DefinedBenefitPlanPeriodForApplyingUltimateHealthCareCostTrendRate" name="DefinedBenefitPlanPeriodForApplyingUltimateHealthCareCostTrendRate" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_DefinedBenefitPlanPercentageOfPlanAssets" name="DefinedBenefitPlanPercentageOfPlanAssets" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_PercentageOfInvestmentInMutualFund" name="PercentageOfInvestmentInMutualFund" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_InterestAndDividendReceivableOnPlanAssets" name="InterestAndDividendReceivableOnPlanAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_HighYieldingBondsMember" name="HighYieldingBondsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_InvestmentGradeBondsMember" name="InvestmentGradeBondsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_DefinedBenefitPlanContributionsByEmployerToQualifiedBenefitPensionPlans" name="DefinedBenefitPlanContributionsByEmployerToQualifiedBenefitPensionPlans" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_PercentageOfPensionPlanAssetsThatIsNotExceededByInvestmentInSecurityOfSingleNonUsGovernmentOrGovernmentAgency" name="PercentageOfPensionPlanAssetsThatIsNotExceededByInvestmentInSecurityOfSingleNonUsGovernmentOrGovernmentAgency" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mtb_OtherRealEstatePartnershipsMember" name="OtherRealEstatePartnershipsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_OtherPrivateEquityMember" name="OtherPrivateEquityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_OtherHedgeFundsMember" name="OtherHedgeFundsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_PercentageOfEligibleEmployeesContributionForRetirementSavingsPlan" name="PercentageOfEligibleEmployeesContributionForRetirementSavingsPlan" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_PercentageOfEmployeeBenefitPlanExpectedContributionByEmployer" name="PercentageOfEmployeeBenefitPlanExpectedContributionByEmployer" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_MaximumEmployerContributionOnEmployeesQualifiedContribution" name="MaximumEmployerContributionOnEmployeesQualifiedContribution" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_IncomeTaxesAttributableToGainsOrLossesOnBankInvestmentSecurities" name="IncomeTaxesAttributableToGainsOrLossesOnBankInvestmentSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_IncreaseDecreaseInTaxesAbstract" name="IncreaseDecreaseInTaxesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_DeferredTaxAssetsLossesOnLoansAndOtherAssets" name="DeferredTaxAssetsLossesOnLoansAndOtherAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_DeferredTaxAssetsOperatingLeaseLiabilities" name="DeferredTaxAssetsOperatingLeaseLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsPostretirementAndOtherEmployeeBenefits" name="DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsPostretirementAndOtherEmployeeBenefits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_DeferredTaxLiabilitiesUnrealizedGainsOnInvestmentSecurities" name="DeferredTaxLiabilitiesUnrealizedGainsOnInvestmentSecurities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_DeferredTaxLiabilitiesRetirementBenefits" name="DeferredTaxLiabilitiesRetirementBenefits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_DeferredTaxLiabilityDepreciationAndAmortization" name="DeferredTaxLiabilityDepreciationAndAmortization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_DeferredTaxLiabilitiesInterestOnLoans" name="DeferredTaxLiabilitiesInterestOnLoans" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_DeferredTaxLiabilityGainsOnCashFlowHedges" name="DeferredTaxLiabilityGainsOnCashFlowHedges" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_UnrecognizedFederalStateAndLocalIncomeTaxBenefits" name="UnrecognizedFederalStateAndLocalIncomeTaxBenefits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_ReconciliationOfUnrecognizedTaxBenefitsLineItems" name="ReconciliationOfUnrecognizedTaxBenefitsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ReconciliationOfUnrecognizedTaxBenefitsTable" name="ReconciliationOfUnrecognizedTaxBenefitsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_FederalStateAndLocalTaxMember" name="FederalStateAndLocalTaxMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_AccruedInterestMember" name="AccruedInterestMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_UnrecognizedIncomeTaxBenefitsMember" name="UnrecognizedIncomeTaxBenefitsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_NumberOfStateAndLocalJurisdictionsWhereCompanyFilesIncomeTaxReturns" name="NumberOfStateAndLocalJurisdictionsWhereCompanyFilesIncomeTaxReturns" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_NetIncomeLossAvailableToCommonStockholdersBasicBeforeUnvestedStockBasedCompensationAwardsAdjustment" name="NetIncomeLossAvailableToCommonStockholdersBasicBeforeUnvestedStockBasedCompensationAwardsAdjustment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_IncomeAttributableToUnvestedStockBasedCompensationAwardsBasic" name="IncomeAttributableToUnvestedStockBasedCompensationAwardsBasic" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_CommonSharesOutstandingIncludingCommonStockIssuableAndUnvestedStockBasedCompensationAwards" name="CommonSharesOutstandingIncludingCommonStockIssuableAndUnvestedStockBasedCompensationAwards" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_UnvestedStockBasedCompensationAwards" name="UnvestedStockBasedCompensationAwards" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_NetIncomeLossAvailableToCommonStockholdersDilutedBeforeUnvestedStockBasedCompensationAwardsAdjustment" name="NetIncomeLossAvailableToCommonStockholdersDilutedBeforeUnvestedStockBasedCompensationAwardsAdjustment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_IncomeAttributableToUnvestedStockBasedCompensationAwardsDiluted" name="IncomeAttributableToUnvestedStockBasedCompensationAwardsDiluted" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_CumulativeEffectOnRetainedEarningsBeforeTax" name="CumulativeEffectOnRetainedEarningsBeforeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_TaxCutsAndJobsActOf2017ReclassificationFromAOCIToRetainedEarnings" name="TaxCutsAndJobsActOf2017ReclassificationFromAOCIToRetainedEarnings" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_AccumulatedOtherMember" name="AccumulatedOtherMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_AccumulatedNetUnrealizedInvestmentGainLossAllOtherMember" name="AccumulatedNetUnrealizedInvestmentGainLossAllOtherMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_AccumulatedOtherComprehensiveIncomeLossIncomeTax" name="AccumulatedOtherComprehensiveIncomeLossIncomeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_CumulativeEffectOnRetainedEarningsTax" name="CumulativeEffectOnRetainedEarningsTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_TaxCutsAndJobsActOf2017ReclassificationFromAOCIToRetainedEarningsTax" name="TaxCutsAndJobsActOf2017ReclassificationFromAOCIToRetainedEarningsTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_CumulativeEffectOnRetainedEarningsNetOfTax" name="CumulativeEffectOnRetainedEarningsNetOfTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_AccumulatedOtherAdjustmentMember" name="AccumulatedOtherAdjustmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CreditRelatedFeeIncome" name="CreditRelatedFeeIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_CreditCardInterchangeFeeIncome" name="CreditCardInterchangeFeeIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_MerchantDiscountFeeIncome" name="MerchantDiscountFeeIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_RevenuesFromInternationalTrustRelatedServices" name="RevenuesFromInternationalTrustRelatedServices" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_InternationalActivitiesLineItems" name="InternationalActivitiesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_InternationalActivitiesTable" name="InternationalActivitiesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_AverageNotionalAmountOfInterestRateFairValueHedgeDerivatives" name="AverageNotionalAmountOfInterestRateFairValueHedgeDerivatives" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_ForeignCurrencyAndOtherOptionAndFuturesContractsMember" name="ForeignCurrencyAndOtherOptionAndFuturesContractsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_MaturityPeriodOneMember" name="MaturityPeriodOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_MaturityPeriodTwoMember" name="MaturityPeriodTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_MaturityPeriodThreeMember" name="MaturityPeriodThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CounterpartiesMember" name="CounterpartiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CreditRiskDerivativeMember" name="CreditRiskDerivativeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ClearinghouseCreditFacilitiesMember" name="ClearinghouseCreditFacilitiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_FixedRateLongTermBorrowingsMember" name="FixedRateLongTermBorrowingsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_InterestPaymentsOnVariableRateCommercialRealEstateLoansMember" name="InterestPaymentsOnVariableRateCommercialRealEstateLoansMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ReductionInEstimatedFairValueLossesOnHedgingInstruments" name="ReductionInEstimatedFairValueLossesOnHedgingInstruments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_ForwardStartingInterestRateSwapAgreementsMember" name="ForwardStartingInterestRateSwapAgreementsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_DerivativeNotionalAmountToExpireInNextTwelveMonths" name="DerivativeNotionalAmountToExpireInNextTwelveMonths" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mtb_DerivativeNotionalAmountToExpireInYearTwo" name="DerivativeNotionalAmountToExpireInYearTwo" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mtb_DerivativeNotionalAmountToExpireInYearSix" name="DerivativeNotionalAmountToExpireInYearSix" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mtb_CommitmentsToSellRealEstateLoansMember" name="CommitmentsToSellRealEstateLoansMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_MortgageRelatedCommitmentsToOriginateRealEstateLoansForSaleMember" name="MortgageRelatedCommitmentsToOriginateRealEstateLoansForSaleMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ForeignExchangeAndOtherOptionAndFuturesContractsMember" name="ForeignExchangeAndOtherOptionAndFuturesContractsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_IncreaseDecreaseInEstimatedFairValueOfInterestRateContractsInAssetPosition" name="IncreaseDecreaseInEstimatedFairValueOfInterestRateContractsInAssetPosition" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_IncreaseDecreaseInEstimatedFairValueOfInterestRateContractsInLiabilityPosition" name="IncreaseDecreaseInEstimatedFairValueOfInterestRateContractsInLiabilityPosition" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_GainLossOnHedgedItemInFairValueHedge" name="GainLossOnHedgedItemInFairValueHedge" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_DerivativeHedgedLoans" name="DerivativeHedgedLoans" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_VariableInterestEntityDisclosureAbstract" name="VariableInterestEntityDisclosureAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_OtherAssetsForItsInvestmentInCommonSecuritiesRecognizedByCompanyOfVariousTrusts" name="OtherAssetsForItsInvestmentInCommonSecuritiesRecognizedByCompanyOfVariousTrusts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_InvestmentsInVariableInterestEntityCarryingAmount" name="InvestmentsInVariableInterestEntityCarryingAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_UnfundedCommitmentsIncludesCarrryingAmountOfItsInvestments" name="UnfundedCommitmentsIncludesCarrryingAmountOfItsInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_MaximumExposureToLossOfInvestmentsInRealEstatePartnerships" name="MaximumExposureToLossOfInvestmentsInRealEstatePartnerships" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_MortgageBackedSecuritiesIssuedByPrivateEnterprisesResidentialMember" name="MortgageBackedSecuritiesIssuedByPrivateEnterprisesResidentialMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_OtherAssetsAndOtherLiabilitiesMember" name="OtherAssetsAndOtherLiabilitiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_MeasurementInputAdjustments" name="MeasurementInputAdjustments" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_IncreaseDecreaseInFairValueOfNonrecurringFairValueMeasuredLoansForChargeOffsAndImpairmentReserves" name="IncreaseDecreaseInFairValueOfNonrecurringFairValueMeasuredLoansForChargeOffsAndImpairmentReserves" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_HistoricalRecoveryRateOfCollateralValuesOfConsumerInstallmentLoans" name="HistoricalRecoveryRateOfCollateralValuesOfConsumerInstallmentLoans" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_DiscountedCashFlowsMember" name="DiscountedCashFlowsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_TwoIndependentPricingQuotesMember" name="TwoIndependentPricingQuotesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_PercentageOfFairValueInputsCommitmentExpirations" name="PercentageOfFairValueInputsCommitmentExpirations" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_OtherFinancialInstrumentsAbstract" name="OtherFinancialInstrumentsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CommitmentsToOriginateRealEstateLoansForSale" name="CommitmentsToOriginateRealEstateLoansForSale" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_CommitmentsToSellRealEstateLoansNet" name="CommitmentsToSellRealEstateLoansNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_OtherCreditRelatedCommitments" name="OtherCreditRelatedCommitments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_InterestRateSwapAgreementsUsedForInterestRateRiskManagement" name="InterestRateSwapAgreementsUsedForInterestRateRiskManagement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_ResidentialRealEstateLoansMember" name="ResidentialRealEstateLoansMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CommitmentsToExtendCreditAbstract" name="CommitmentsToExtendCreditAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_CommitmentsToExtendCreditForHomeEquityLinesOfCredit" name="CommitmentsToExtendCreditForHomeEquityLinesOfCredit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_CommitmentsToExtendCreditForCommercialRealEstateLoansToBeSold" name="CommitmentsToExtendCreditForCommercialRealEstateLoansToBeSold" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_CommitmentsToExtendCreditForOtherCommercialRealEstate" name="CommitmentsToExtendCreditForOtherCommercialRealEstate" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_CommitmentsToExtendCreditForResidentialRealEstateLoansToBeSold" name="CommitmentsToExtendCreditForResidentialRealEstateLoansToBeSold" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_CommitmentsToExtendCreditForOtherResidentialRealEstate" name="CommitmentsToExtendCreditForOtherResidentialRealEstate" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_CommitmentsToExtendCreditForCommercialAndOther" name="CommitmentsToExtendCreditForCommercialAndOther" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_CommitmentsRegardingCommercialLettersOfCredit" name="CommitmentsRegardingCommercialLettersOfCredit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_CommitmentsRegardingFinancialGuaranteesAndIndemnificationContracts" name="CommitmentsRegardingFinancialGuaranteesAndIndemnificationContracts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_CommitmentsToSellRealEstateLoansNotionalAmount" name="CommitmentsToSellRealEstateLoansNotionalAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_CommitmentsToExtendCreditToCommercialCustomers" name="CommitmentsToExtendCreditToCommercialCustomers" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_MaximumCreditRiskForRecourseAssociatedWithLoansSoldUnderFederalNationalMortgageAssociationDelegatedUnderwritingAndServicingProgram" name="MaximumCreditRiskForRecourseAssociatedWithLoansSoldUnderFederalNationalMortgageAssociationDelegatedUnderwritingAndServicingProgram" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_AverageAssets" name="AverageAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_TaxableEquivalentAdjustment" name="TaxableEquivalentAdjustment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_Expenses" name="Expenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_PercentOfMaximumRevenueFromSingleCustomerOnRevenue" name="PercentOfMaximumRevenueFromSingleCustomerOnRevenue" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="mtb_FundsAvailableForPaymentOfDividendsToParentCompanyFromBankingSubsidiaries" name="FundsAvailableForPaymentOfDividendsToParentCompanyFromBankingSubsidiaries" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_CommonEquityTierOneRiskBasedCapitalToRiskWeightedAssets" name="CommonEquityTierOneRiskBasedCapitalToRiskWeightedAssets" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mtb_CommonEquityTierOneRiskBasedCapitalToWellCapitalizedToRiskWeightedAssets" name="CommonEquityTierOneRiskBasedCapitalToWellCapitalizedToRiskWeightedAssets" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mtb_CapitalConservationBufferRatio" name="CapitalConservationBufferRatio" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="mtb_CommonEquityTierOneRiskBasedCapital" name="CommonEquityTierOneRiskBasedCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_WilmingtonTrustNaMember" name="WilmingtonTrustNaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_BayviewLendingGroupMember" name="BayviewLendingGroupMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_OtherRevenuesFromOperationsMember" name="OtherRevenuesFromOperationsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_BayviewLendingGroupAndBayviewFinancialMember" name="BayviewLendingGroupAndBayviewFinancialMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_BayviewFinancialMember" name="BayviewFinancialMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_SyndicatedLoanFacilityMember" name="SyndicatedLoanFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_MortgageLoansOfPrivatelyHeldCompany" name="MortgageLoansOfPrivatelyHeldCompany" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_SubServicedResidentialMortgageLoansOfPrivatelyHeldCompany" name="SubServicedResidentialMortgageLoansOfPrivatelyHeldCompany" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_RevenuesFromSubservicing" name="RevenuesFromSubservicing" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_DueFromSubsidiariesMoneyMarketSavings" name="DueFromSubsidiariesMoneyMarketSavings" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_DueFromSubsidiariesIncomeTaxReceivable" name="DueFromSubsidiariesIncomeTaxReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_InvestmentsInConsolidatedSubsidiariesAbstract" name="InvestmentsInConsolidatedSubsidiariesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_StockholdersEquityExcludingPortionAttributableToSubsidiariesNoncontrollingInterestAbstract" name="StockholdersEquityExcludingPortionAttributableToSubsidiariesNoncontrollingInterestAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ParentCompanyOnlyFinancialInformationLineItems" name="ParentCompanyOnlyFinancialInformationLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_ParentCompanyOnlyFinancialInformationTable" name="ParentCompanyOnlyFinancialInformationTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_IncomeLossBeforeExpensesAndTaxCreditsAttributableToParent" name="IncomeLossBeforeExpensesAndTaxCreditsAttributableToParent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_InterestAndNoninterestExpensesAttributableToParent" name="InterestAndNoninterestExpensesAttributableToParent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="mtb_IncomeLossBeforeIncomeTaxesAndEquityInUndistributedIncomeOfSubsidiaries" name="IncomeLossBeforeIncomeTaxesAndEquityInUndistributedIncomeOfSubsidiaries" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_ExpenseAbstract" name="ExpenseAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_EquityInUndistributedIncomeOfSubsidiariesAbstract" name="EquityInUndistributedIncomeOfSubsidiariesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="mtb_PaymentsForProceedsFromNetInvestmentInConsolidatedSubsidiaries" name="PaymentsForProceedsFromNetInvestmentInConsolidatedSubsidiaries" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="mtb_SeriesIAndSeriesGPreferredStockMember" name="SeriesIAndSeriesGPreferredStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
</xsd:schema>
